CN109868298A - 四氢呋喃-2-甲酸的制备方法 - Google Patents
四氢呋喃-2-甲酸的制备方法 Download PDFInfo
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- CN109868298A CN109868298A CN201711250755.7A CN201711250755A CN109868298A CN 109868298 A CN109868298 A CN 109868298A CN 201711250755 A CN201711250755 A CN 201711250755A CN 109868298 A CN109868298 A CN 109868298A
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- Prior art keywords
- tetrahydrofuran
- formic acid
- lipase
- reaction
- polypeptide
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- UJJLJRQIPMGXEZ-UHFFFAOYSA-N tetrahydro-2-furoic acid Chemical compound OC(=O)C1CCCO1 UJJLJRQIPMGXEZ-UHFFFAOYSA-N 0.000 title abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract description 62
- 238000000034 method Methods 0.000 claims abstract description 44
- UJJLJRQIPMGXEZ-BYPYZUCNSA-N (2s)-oxolane-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCO1 UJJLJRQIPMGXEZ-BYPYZUCNSA-N 0.000 claims abstract description 36
- 239000004367 Lipase Substances 0.000 claims abstract description 35
- 108090001060 Lipase Proteins 0.000 claims abstract description 33
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- 235000019421 lipase Nutrition 0.000 claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 229920001184 polypeptide Polymers 0.000 claims description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 11
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 9
- 238000006555 catalytic reaction Methods 0.000 claims description 8
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- ZJGQFXVQDVCVOK-MSUXKOGISA-N cefovecin Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1[C@@H]1CCCO1 ZJGQFXVQDVCVOK-MSUXKOGISA-N 0.000 description 2
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