CN109863149A - 一种依匹哌唑新晶型及其制备方法 - Google Patents

一种依匹哌唑新晶型及其制备方法 Download PDF

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Publication number
CN109863149A
CN109863149A CN201780047454.6A CN201780047454A CN109863149A CN 109863149 A CN109863149 A CN 109863149A CN 201780047454 A CN201780047454 A CN 201780047454A CN 109863149 A CN109863149 A CN 109863149A
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China
Prior art keywords
piperazine azoles
crystal form
follows
crystal forms
piperazine
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CN201780047454.6A
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Inventor
陈茜
焦英陆
汪博宇
黄鲁宁
顾虹
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Zhejiang Huahai Pharmaceutical Co Ltd
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Zhejiang Huahai Pharmaceutical Co Ltd
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Priority to CN202210780490.6A priority Critical patent/CN114957230A/zh
Publication of CN109863149A publication Critical patent/CN109863149A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种依匹哌唑新晶型及其制备方法。所述的依匹哌唑新晶型命名为晶型Ⅱ，使用Cu‑Kα辐射检测的X射线粉末衍射图谱中，在约5.2°，7.4°，9.8°，10.5°，14.3°，14.8°，18.6°，19.7°，23.6°(2θ)处有特征峰。本发明还提供一种制备依匹哌唑晶型Ⅱ的方法，该方法简便、重现性好，所得依匹哌唑的晶型Ⅱ纯度高、稳定性好，适于工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201780047454.6A 2016-10-13 2017-10-09 一种依匹哌唑新晶型及其制备方法 Pending CN109863149A (zh)

Priority Applications (1)

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CN202210780490.6A CN114957230A (zh) 2016-10-13 2017-10-09 一种依匹哌唑新晶型及其制备方法

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CN2016108917253 2016-10-13
CN201610891725.3A CN107936005A (zh) 2016-10-13 2016-10-13 一种依匹哌唑新晶型ii及其制备方法
PCT/CN2017/105367 WO2018068690A1 (zh) 2016-10-13 2017-10-09 一种依匹哌唑新晶型及其制备方法

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CN109863149A true CN109863149A (zh) 2019-06-07

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ID=61905175

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CN201610891725.3A Pending CN107936005A (zh) 2016-10-13 2016-10-13 一种依匹哌唑新晶型ii及其制备方法
CN201780047454.6A Pending CN109863149A (zh) 2016-10-13 2017-10-09 一种依匹哌唑新晶型及其制备方法
CN202210780490.6A Pending CN114957230A (zh) 2016-10-13 2017-10-09 一种依匹哌唑新晶型及其制备方法

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CN (3) CN107936005A (zh)
WO (1) WO2018068690A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440158A (zh) * 2020-03-24 2020-07-24 石药集团中奇制药技术（石家庄）有限公司 一种盐酸依匹哌唑新晶型及其制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN103717587A (zh) * 2011-07-28 2014-04-09 大塚制药株式会社 制造苯并[b]噻吩化合物的方法
CN104254530A (zh) * 2012-04-23 2014-12-31 大塚制药株式会社 苯并噻吩化合物或其盐的二水合物及其制备方法
CN104829602A (zh) * 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN104844585A (zh) * 2015-04-15 2015-08-19 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN105061414A (zh) * 2015-07-21 2015-11-18 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法
CN105461703A (zh) * 2014-12-29 2016-04-06 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN103717587A (zh) * 2011-07-28 2014-04-09 大塚制药株式会社 制造苯并[b]噻吩化合物的方法
CN104254530A (zh) * 2012-04-23 2014-12-31 大塚制药株式会社 苯并噻吩化合物或其盐的二水合物及其制备方法
CN105461703A (zh) * 2014-12-29 2016-04-06 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN104829602A (zh) * 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN104844585A (zh) * 2015-04-15 2015-08-19 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN105061414A (zh) * 2015-07-21 2015-11-18 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440158A (zh) * 2020-03-24 2020-07-24 石药集团中奇制药技术（石家庄）有限公司 一种盐酸依匹哌唑新晶型及其制备方法

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Publication number Publication date
CN107936005A (zh) 2018-04-20
WO2018068690A1 (zh) 2018-04-19
CN114957230A (zh) 2022-08-30

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