CN109071517A - 依匹哌唑的晶型及其制备方法 - Google Patents

依匹哌唑的晶型及其制备方法 Download PDF

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Publication number
CN109071517A
CN109071517A CN201780018599.3A CN201780018599A CN109071517A CN 109071517 A CN109071517 A CN 109071517A CN 201780018599 A CN201780018599 A CN 201780018599A CN 109071517 A CN109071517 A CN 109071517A
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China
Prior art keywords
crystal form
piperazine azoles
piperazine
azoles
water
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CN201780018599.3A
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Inventor
焦英陆
李函达
汪博宇
黄鲁宁
陈茜
顾虹
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Zhejiang Huahai Pharmaceutical Co Ltd
Shanghai Aobo Bio Pharmaceutical Technology Co Ltd
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Zhejiang Huahai Pharmaceutical Co Ltd
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Publication of CN109071517A publication Critical patent/CN109071517A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一种依匹哌唑晶型及其制备方法。所述的依匹哌唑晶型在使用Cu‑Kα辐射检测的X射线粉末衍射图谱中，在2θ为约9.1±0.2，15.2±0.2，15.7±0.2，17.6±0.2，18.1±0.2，24.4±0.2处有特征峰。该依匹哌唑晶型I纯度高、稳定性好并且重现性好，适于工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (6)

  1. PCT国内申请，权利要求书已公开。
CN201780018599.3A 2016-05-12 2017-05-12 依匹哌唑的晶型及其制备方法 Pending CN109071517A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610316062.2A CN107365305A (zh) 2016-05-12 2016-05-12 一种依匹哌唑新晶型及其制备方法
CN2016103160622 2016-05-12
PCT/CN2017/084171 WO2017194002A1 (zh) 2016-05-12 2017-05-12 依匹哌唑的晶型及其制备方法

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CN109071517A true CN109071517A (zh) 2018-12-21

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CN201610316062.2A Pending CN107365305A (zh) 2016-05-12 2016-05-12 一种依匹哌唑新晶型及其制备方法
CN201780018599.3A Pending CN109071517A (zh) 2016-05-12 2017-05-12 依匹哌唑的晶型及其制备方法

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US (1) US10550109B2 (zh)
EP (1) EP3444248A1 (zh)
JP (1) JP2019515001A (zh)
CN (2) CN107365305A (zh)
WO (1) WO2017194002A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440158A (zh) * 2020-03-24 2020-07-24 石药集团中奇制药技术（石家庄）有限公司 一种盐酸依匹哌唑新晶型及其制备方法

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CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN103717587A (zh) * 2011-07-28 2014-04-09 大塚制药株式会社 制造苯并[b]噻吩化合物的方法
CN104254530A (zh) * 2012-04-23 2014-12-31 大塚制药株式会社 苯并噻吩化合物或其盐的二水合物及其制备方法
CN104829602A (zh) * 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN104844585A (zh) * 2015-04-15 2015-08-19 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN105061414A (zh) * 2015-07-21 2015-11-18 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
CN105461703A (zh) * 2014-12-29 2016-04-06 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4315393B2 (ja) 2005-04-14 2009-08-19 大塚製薬株式会社 複素環化合物
CN104844586A (zh) 2015-04-16 2015-08-19 重庆医药工业研究院有限责任公司 一种依匹哌唑无定型物及其制备方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN103717587A (zh) * 2011-07-28 2014-04-09 大塚制药株式会社 制造苯并[b]噻吩化合物的方法
CN104254530A (zh) * 2012-04-23 2014-12-31 大塚制药株式会社 苯并噻吩化合物或其盐的二水合物及其制备方法
CN105461703A (zh) * 2014-12-29 2016-04-06 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN104829602A (zh) * 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN104844585A (zh) * 2015-04-15 2015-08-19 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN105061414A (zh) * 2015-07-21 2015-11-18 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
CN105175401A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种依匹哌唑的制备方法
CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440158A (zh) * 2020-03-24 2020-07-24 石药集团中奇制药技术（石家庄）有限公司 一种盐酸依匹哌唑新晶型及其制备方法

Also Published As

Publication number Publication date
EP3444248A4 (en) 2019-02-20
US20190119262A1 (en) 2019-04-25
WO2017194002A1 (zh) 2017-11-16
US10550109B2 (en) 2020-02-04
JP2019515001A (ja) 2019-06-06
EP3444248A1 (en) 2019-02-20
CN107365305A (zh) 2017-11-21

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