CN109831913B - 用于可逆地保护生物分子的试剂 - Google Patents

用于可逆地保护生物分子的试剂 Download PDF

Info

Publication number
CN109831913B
CN109831913B CN201780043621.XA CN201780043621A CN109831913B CN 109831913 B CN109831913 B CN 109831913B CN 201780043621 A CN201780043621 A CN 201780043621A CN 109831913 B CN109831913 B CN 109831913B
Authority
CN
China
Prior art keywords
group
biomolecule
protected
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780043621.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN109831913A (zh
Inventor
西尔万·柯休吉
阿兰·劳伦
阿里·拉尤恩
弗雷德里克·法比斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Universite de Caen Normandie
Original Assignee
Biomerieux SA
Universite de Caen Normandie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA, Universite de Caen Normandie filed Critical Biomerieux SA
Publication of CN109831913A publication Critical patent/CN109831913A/zh
Application granted granted Critical
Publication of CN109831913B publication Critical patent/CN109831913B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780043621.XA 2016-07-13 2017-07-13 用于可逆地保护生物分子的试剂 Active CN109831913B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1656791A FR3053968A1 (fr) 2016-07-13 2016-07-13 Reactifs pour la protection reversible de molecules biologiques
FR1656791 2016-07-13
PCT/FR2017/051925 WO2018011527A1 (fr) 2016-07-13 2017-07-13 Réactifs pour la protection réversible de molécules biologiques

Publications (2)

Publication Number Publication Date
CN109831913A CN109831913A (zh) 2019-05-31
CN109831913B true CN109831913B (zh) 2022-01-21

Family

ID=57286588

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780043621.XA Active CN109831913B (zh) 2016-07-13 2017-07-13 用于可逆地保护生物分子的试剂

Country Status (7)

Country Link
US (1) US11708375B2 (https=)
EP (1) EP3484891B1 (https=)
JP (1) JP7231540B2 (https=)
CN (1) CN109831913B (https=)
ES (1) ES2878581T3 (https=)
FR (1) FR3053968A1 (https=)
WO (1) WO2018011527A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230322804A1 (en) * 2016-07-13 2023-10-12 bioMérieux Reagents for reversibly protecting biological molecules
CA3020818C (en) 2017-10-13 2020-10-20 Smith Optics, Inc. Goggle with replaceable lens
CN116410951A (zh) * 2021-12-30 2023-07-11 广州达安基因股份有限公司 一种提高化学修饰的Taq酶的活性的方法和经该方法处理的Taq酶

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052312A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Anti-infectives
WO2008149168A8 (en) * 2007-06-07 2010-01-07 Sanofi-Aventis Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1257526A (fr) 1960-05-23 1961-03-31 Leffman Ltd S Perfectionnements apportés aux soutien-gorge
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
WO2009151921A1 (en) 2008-05-27 2009-12-17 Trilink Biotechnologies Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid
US8800174B2 (en) 2010-07-13 2014-08-12 Mission Product Holdings, Inc. Shoe soles for enhancing gripping with a smooth hard surface
WO2012094343A1 (en) 2011-01-05 2012-07-12 Trilink Biotechnologies Chemically substituted thermosensitive probes and cofactors for hot start ligation
FR2994184B1 (fr) * 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
WO2016003929A1 (en) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052312A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Anti-infectives
WO2008149168A8 (en) * 2007-06-07 2010-01-07 Sanofi-Aventis Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase;Rosanna Tedesco等;《J. Med. Chem.》;20060110;第49卷;第971-983页 *
Chemical reactivity and conjugation. II. The reactivity of the 2-methyl group in the 4-quinazoline series;Heilbron, I. M.等;《Journal of the Chemical Society, Transactions》;19250101;第127卷;第2167-2175页 *
New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure−Activity Relationship Analysis and Biological Evaluations;Guoqiang Dong等;《J. Med. Chem.》;20120806;第55卷;第7593-7613页 *
Stereoselective Synthesis of Tilivalline;Tatsuo Nagasaka等;《J. Org. Chem.》;第6797-6801页;19980911;第63卷;第6797-6801页 *

Also Published As

Publication number Publication date
JP2019522058A (ja) 2019-08-08
US11708375B2 (en) 2023-07-25
US20190375763A1 (en) 2019-12-12
ES2878581T3 (es) 2021-11-19
EP3484891B1 (fr) 2021-04-14
CN109831913A (zh) 2019-05-31
JP7231540B2 (ja) 2023-03-01
WO2018011527A1 (fr) 2018-01-18
WO2018011527A9 (fr) 2018-05-03
EP3484891A1 (fr) 2019-05-22
FR3053968A1 (fr) 2018-01-19

Similar Documents

Publication Publication Date Title
US20230114671A1 (en) Nucleoside analogue, preparation method and application
AU2006309096B2 (en) Methods for identifying compounds of interest using encoded libraries
CN109831913B (zh) 用于可逆地保护生物分子的试剂
JP4939527B2 (ja) 抗ウィルス剤の機能を有する両複素環連結化合物、その応用および当該化合物を含有する組成物
JP2014039550A (ja) コードされたライブラリーの合成のための方法
Weisbrod et al. A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation
JP2021523133A (ja) ケトキサール誘導体に関連する組成物および方法
WO2013019794A1 (en) Protein and peptide libraries
Matyašovský et al. 2-Substituted 2′-deoxyinosine 5′-triphosphates as substrates for polymerase synthesis of minor-groove-modified DNA and effects on restriction endonuclease cleavage
Talukder et al. Synthesis of alanyl nucleobase amino acids and their incorporation into proteins
US20230322804A1 (en) Reagents for reversibly protecting biological molecules
Gondela et al. Versatile synthesis of 2′-amino-2′-deoxyuridine derivatives with a 2′-amino group carrying linkers possessing a reactive terminal functionality
EP1806400B1 (en) Inactivation method
JP2009221168A (ja) ヌクレオシドまたはヌクレオチド誘導体、核酸誘導体、標的物質捕捉材料、標的物質を捕捉および／または放出する方法、ならびにヘミンアプタマー
Hausch et al. Multifunctional dinucleotide analogs for the generation of complex RNA conjugates
JP2015526076A (ja) アザイサト酸無水物又はその誘導体の一つを用いた官能化の方法及びこの方法において使用される試薬、このように処置された生物学的分子及びキット
JP2015526076A5 (https=)
JP2022512471A (ja) ポリメラーゼ阻害剤ならびに関連する組成物及び方法
Huang et al. Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides
Tripathi et al. Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy-and ribo purinenucleosides using active esters
RU2380417C2 (ru) Средство для ингибирования фермента 8-оксогуанин-днк-гликозилазы человека
JP7104399B2 (ja) 光反応性人工アミノ酸、及び光架橋性人工ポリペプチド
Janoušková Interaction of nucleic acids with RNA polymerase
KR20250032915A (ko) 아실화된 tRNA, 리보솜 촉매를 이용한 약리 활성 모티프가 도입된 펩타이드 및 그의 제조방법
Zhao et al. A new efficient synthesis of n-(2-(2-(3-methoxy-4-(oxazol-5-yl) phenylamino) oxazol-5-yl) phenyl)-N-methyl-2-morpholinoacetamide (BMS-337197), a novel IMPDH inhibitor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant