CN1098106C - 可溶的合成聚合物结合的蒽环类化合物 - Google Patents

可溶的合成聚合物结合的蒽环类化合物 Download PDF

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Publication number
CN1098106C
CN1098106C CN94190242A CN94190242A CN1098106C CN 1098106 C CN1098106 C CN 1098106C CN 94190242 A CN94190242 A CN 94190242A CN 94190242 A CN94190242 A CN 94190242A CN 1098106 C CN1098106 C CN 1098106C
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CN
China
Prior art keywords
gly
leu
anthracycline
polymer combination
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94190242A
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English (en)
Chinese (zh)
Other versions
CN1108454A (zh
Inventor
F·安吉勤克
M·格兰迪
A·苏拉托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CN1108454A publication Critical patent/CN1108454A/zh
Application granted granted Critical
Publication of CN1098106C publication Critical patent/CN1098106C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CN94190242A 1993-05-11 1994-04-08 可溶的合成聚合物结合的蒽环类化合物 Expired - Fee Related CN1098106C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9309663.4 1993-05-11
GB939309663A GB9309663D0 (en) 1993-05-11 1993-05-11 Biologically active compounds

Publications (2)

Publication Number Publication Date
CN1108454A CN1108454A (zh) 1995-09-13
CN1098106C true CN1098106C (zh) 2003-01-08

Family

ID=10735264

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190242A Expired - Fee Related CN1098106C (zh) 1993-05-11 1994-04-08 可溶的合成聚合物结合的蒽环类化合物

Country Status (25)

Country Link
US (1) US5571785A (https=)
EP (1) EP0649312B1 (https=)
JP (1) JPH08502519A (https=)
KR (1) KR100330635B1 (https=)
CN (1) CN1098106C (https=)
AT (1) ATE203414T1 (https=)
AU (1) AU671741B2 (https=)
CA (1) CA2136438C (https=)
DE (1) DE69427799T2 (https=)
DK (1) DK0649312T3 (https=)
ES (1) ES2161764T3 (https=)
FI (1) FI112602B (https=)
GB (1) GB9309663D0 (https=)
GR (1) GR3036978T3 (https=)
HU (2) HUT70509A (https=)
IL (1) IL109528A (https=)
MY (1) MY110974A (https=)
NZ (1) NZ265266A (https=)
PL (1) PL175325B1 (https=)
PT (1) PT649312E (https=)
RU (1) RU2145965C1 (https=)
TW (1) TW268015B (https=)
UA (1) UA42695C2 (https=)
WO (1) WO1994026311A1 (https=)
ZA (1) ZA943212B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
EP1401875A4 (en) * 2001-05-04 2005-01-26 Univ Utah Res Found HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS
WO2003037915A1 (en) * 2001-10-31 2003-05-08 Biopolymed Inc. Biocompatible polymers including peptide spacer
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US9737556B2 (en) 2014-06-13 2017-08-22 Trustees Of Tufts College FAP-activated therapeutic agents, and uses related thereto
JP6744826B2 (ja) 2014-06-13 2020-08-19 バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC Ｆａｐ活性化治療剤及びそれに関連する使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
JPS60246400A (ja) * 1984-05-22 1985-12-06 Ajinomoto Co Inc アントラサイクリン系化合物及び制ガン剤
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5169937A (en) * 1986-11-18 1992-12-08 The Scripps Research Institute Method for producing stable glycosylated hemoglobin
DE3722699A1 (de) * 1987-07-09 1989-01-19 Behringwerke Ag Zytostatisch wirksame anthacyclin-konjugate
CA2014244A1 (en) * 1989-04-13 1990-10-13 Takeda Chemical Industries, Ltd. Stabilized composition of anthracyclines
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CONTROLLED RELEASE,18(2) 1992.2.1 V SUBR 等人"POLYMERS CONTAINING ENZYMATICALLY DEGRADED BONDS,XII.EFFECT OF SPA CER STRVCTURE ON THER *
MAKROMOLEKULARE CHEMIE,MACROMOLEUCULAR SYMPOSIA,70/71 1993.5.1 R.DUNCAN等人"DEVELOPMENT OF N-(2-HYDROXYPROPYL)-METHACRYLAMIDE COPOLYMER CONJVGATES FOR DELIVERYOF *

Also Published As

Publication number Publication date
GB9309663D0 (en) 1993-06-23
FI946128A0 (fi) 1994-12-28
KR100330635B1 (ko) 2002-09-17
JPH08502519A (ja) 1996-03-19
EP0649312A1 (en) 1995-04-26
HUT70509A (en) 1995-10-30
CA2136438C (en) 2004-09-14
FI946128A7 (fi) 1994-12-28
NZ265266A (en) 1996-06-25
AU6566694A (en) 1994-12-12
MY110974A (en) 1999-07-31
US5571785A (en) 1996-11-05
UA42695C2 (uk) 2001-11-15
HU211538A9 (en) 1995-12-28
FI112602B (fi) 2003-12-31
CN1108454A (zh) 1995-09-13
EP0649312B1 (en) 2001-07-25
IL109528A (en) 1998-08-16
HU9403811D0 (en) 1995-03-28
RU2145965C1 (ru) 2000-02-27
AU671741B2 (en) 1996-09-05
CA2136438A1 (en) 1994-11-24
ZA943212B (en) 1995-01-18
PL175325B1 (pl) 1998-12-31
PT649312E (pt) 2002-01-30
PL306861A1 (en) 1995-04-18
TW268015B (https=) 1996-01-11
WO1994026311A1 (en) 1994-11-24
KR950702201A (ko) 1995-06-19
IL109528A0 (en) 1994-08-26
ATE203414T1 (de) 2001-08-15
RU94046336A (ru) 1996-10-27
DE69427799T2 (de) 2002-05-02
DK0649312T3 (da) 2001-11-12
GR3036978T3 (en) 2002-01-31
ES2161764T3 (es) 2001-12-16
DE69427799D1 (de) 2001-08-30

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