NZ265266A - Anthracycline conjugates, their preparation and use as antitumor agents - Google Patents

Anthracycline conjugates, their preparation and use as antitumor agents

Info

Publication number
NZ265266A
NZ265266A NZ265266A NZ26526694A NZ265266A NZ 265266 A NZ265266 A NZ 265266A NZ 265266 A NZ265266 A NZ 265266A NZ 26526694 A NZ26526694 A NZ 26526694A NZ 265266 A NZ265266 A NZ 265266A
Authority
NZ
New Zealand
Prior art keywords
anthracycline
gly
polymer
formula
bound
Prior art date
Application number
NZ265266A
Other languages
English (en)
Inventor
Francesco Angelucci
Maria Grandi
Antonino Suarato
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of NZ265266A publication Critical patent/NZ265266A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NZ265266A 1993-05-11 1994-04-08 Anthracycline conjugates, their preparation and use as antitumor agents NZ265266A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309663A GB9309663D0 (en) 1993-05-11 1993-05-11 Biologically active compounds

Publications (1)

Publication Number Publication Date
NZ265266A true NZ265266A (en) 1996-06-25

Family

ID=10735264

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ265266A NZ265266A (en) 1993-05-11 1994-04-08 Anthracycline conjugates, their preparation and use as antitumor agents

Country Status (25)

Country Link
US (1) US5571785A (https=)
EP (1) EP0649312B1 (https=)
JP (1) JPH08502519A (https=)
KR (1) KR100330635B1 (https=)
CN (1) CN1098106C (https=)
AT (1) ATE203414T1 (https=)
AU (1) AU671741B2 (https=)
CA (1) CA2136438C (https=)
DE (1) DE69427799T2 (https=)
DK (1) DK0649312T3 (https=)
ES (1) ES2161764T3 (https=)
FI (1) FI112602B (https=)
GB (1) GB9309663D0 (https=)
GR (1) GR3036978T3 (https=)
HU (2) HUT70509A (https=)
IL (1) IL109528A (https=)
MY (1) MY110974A (https=)
NZ (1) NZ265266A (https=)
PL (1) PL175325B1 (https=)
PT (1) PT649312E (https=)
RU (1) RU2145965C1 (https=)
TW (1) TW268015B (https=)
UA (1) UA42695C2 (https=)
WO (1) WO1994026311A1 (https=)
ZA (1) ZA943212B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
EP1401875A4 (en) * 2001-05-04 2005-01-26 Univ Utah Res Found HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS
WO2003037915A1 (en) * 2001-10-31 2003-05-08 Biopolymed Inc. Biocompatible polymers including peptide spacer
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US9737556B2 (en) 2014-06-13 2017-08-22 Trustees Of Tufts College FAP-activated therapeutic agents, and uses related thereto
JP6744826B2 (ja) 2014-06-13 2020-08-19 バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC Ｆａｐ活性化治療剤及びそれに関連する使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
JPS60246400A (ja) * 1984-05-22 1985-12-06 Ajinomoto Co Inc アントラサイクリン系化合物及び制ガン剤
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5169937A (en) * 1986-11-18 1992-12-08 The Scripps Research Institute Method for producing stable glycosylated hemoglobin
DE3722699A1 (de) * 1987-07-09 1989-01-19 Behringwerke Ag Zytostatisch wirksame anthacyclin-konjugate
CA2014244A1 (en) * 1989-04-13 1990-10-13 Takeda Chemical Industries, Ltd. Stabilized composition of anthracyclines
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates

Also Published As

Publication number Publication date
GB9309663D0 (en) 1993-06-23
FI946128A0 (fi) 1994-12-28
KR100330635B1 (ko) 2002-09-17
JPH08502519A (ja) 1996-03-19
EP0649312A1 (en) 1995-04-26
HUT70509A (en) 1995-10-30
CA2136438C (en) 2004-09-14
FI946128A7 (fi) 1994-12-28
AU6566694A (en) 1994-12-12
MY110974A (en) 1999-07-31
US5571785A (en) 1996-11-05
UA42695C2 (uk) 2001-11-15
HU211538A9 (en) 1995-12-28
FI112602B (fi) 2003-12-31
CN1108454A (zh) 1995-09-13
EP0649312B1 (en) 2001-07-25
IL109528A (en) 1998-08-16
HU9403811D0 (en) 1995-03-28
RU2145965C1 (ru) 2000-02-27
AU671741B2 (en) 1996-09-05
CA2136438A1 (en) 1994-11-24
ZA943212B (en) 1995-01-18
PL175325B1 (pl) 1998-12-31
PT649312E (pt) 2002-01-30
PL306861A1 (en) 1995-04-18
TW268015B (https=) 1996-01-11
CN1098106C (zh) 2003-01-08
WO1994026311A1 (en) 1994-11-24
KR950702201A (ko) 1995-06-19
IL109528A0 (en) 1994-08-26
ATE203414T1 (de) 2001-08-15
RU94046336A (ru) 1996-10-27
DE69427799T2 (de) 2002-05-02
DK0649312T3 (da) 2001-11-12
GR3036978T3 (en) 2002-01-31
ES2161764T3 (es) 2001-12-16
DE69427799D1 (de) 2001-08-30

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