RU2145965C1 - Биологически активные полимерсвязанные антрациклины, промежуточные соединения, способы получения и фармацевтическая композиция - Google Patents
Биологически активные полимерсвязанные антрациклины, промежуточные соединения, способы получения и фармацевтическая композиция Download PDFInfo
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- RU2145965C1 RU2145965C1 RU94046336A RU94046336A RU2145965C1 RU 2145965 C1 RU2145965 C1 RU 2145965C1 RU 94046336 A RU94046336 A RU 94046336A RU 94046336 A RU94046336 A RU 94046336A RU 2145965 C1 RU2145965 C1 RU 2145965C1
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- general formula
- anthracycline
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- 229940045799 anthracyclines and related substance Drugs 0.000 title claims abstract description 74
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
- CCBIBMKQNXHNIN-ZETCQYMHSA-N Gly-Leu-Gly Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O CCBIBMKQNXHNIN-ZETCQYMHSA-N 0.000 claims abstract description 6
- IGOYNRWLWHWAQO-JTQLQIEISA-N Gly-Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 IGOYNRWLWHWAQO-JTQLQIEISA-N 0.000 claims abstract description 6
- YOKVEHGYYQEQOP-QWRGUYRKSA-N Leu-Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O YOKVEHGYYQEQOP-QWRGUYRKSA-N 0.000 claims abstract description 6
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- SMFGCTXUBWEPKM-KBPBESRZSA-N Phe-Leu-Gly Chemical compound OC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CC=CC=C1 SMFGCTXUBWEPKM-KBPBESRZSA-N 0.000 claims abstract 5
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9309663.4 | 1993-05-11 | ||
| GB9309663,4 | 1993-05-11 | ||
| GB939309663A GB9309663D0 (en) | 1993-05-11 | 1993-05-11 | Biologically active compounds |
| PCT/EP1994/001100 WO1994026311A1 (en) | 1993-05-11 | 1994-04-08 | Anthracycline conjugates, their preparation and their use as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94046336A RU94046336A (ru) | 1996-10-27 |
| RU2145965C1 true RU2145965C1 (ru) | 2000-02-27 |
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| RU94046336A RU2145965C1 (ru) | 1993-05-11 | 1994-04-08 | Биологически активные полимерсвязанные антрациклины, промежуточные соединения, способы получения и фармацевтическая композиция |
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| US (1) | US5571785A (https=) |
| EP (1) | EP0649312B1 (https=) |
| JP (1) | JPH08502519A (https=) |
| KR (1) | KR100330635B1 (https=) |
| CN (1) | CN1098106C (https=) |
| AT (1) | ATE203414T1 (https=) |
| AU (1) | AU671741B2 (https=) |
| CA (1) | CA2136438C (https=) |
| DE (1) | DE69427799T2 (https=) |
| DK (1) | DK0649312T3 (https=) |
| ES (1) | ES2161764T3 (https=) |
| FI (1) | FI112602B (https=) |
| GB (1) | GB9309663D0 (https=) |
| GR (1) | GR3036978T3 (https=) |
| HU (2) | HUT70509A (https=) |
| IL (1) | IL109528A (https=) |
| MY (1) | MY110974A (https=) |
| NZ (1) | NZ265266A (https=) |
| PL (1) | PL175325B1 (https=) |
| PT (1) | PT649312E (https=) |
| RU (1) | RU2145965C1 (https=) |
| TW (1) | TW268015B (https=) |
| UA (1) | UA42695C2 (https=) |
| WO (1) | WO1994026311A1 (https=) |
| ZA (1) | ZA943212B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2341530C2 (ru) * | 2003-07-02 | 2008-12-20 | Солакс Корпорейшн | Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| GB9721070D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Bioactive derivatives of camptothecin |
| EP1401875A4 (en) * | 2001-05-04 | 2005-01-26 | Univ Utah Res Found | HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS |
| WO2003037915A1 (en) * | 2001-10-31 | 2003-05-08 | Biopolymed Inc. | Biocompatible polymers including peptide spacer |
| US20050169883A1 (en) * | 2002-05-06 | 2005-08-04 | Prestwich Glenn D. | Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents |
| US9737556B2 (en) | 2014-06-13 | 2017-08-22 | Trustees Of Tufts College | FAP-activated therapeutic agents, and uses related thereto |
| JP6744826B2 (ja) | 2014-06-13 | 2020-08-19 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Ｆａｐ活性化治療剤及びそれに関連する使用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0298385A2 (de) * | 1987-07-09 | 1989-01-11 | BEHRINGWERKE Aktiengesellschaft | Zytostatisch wirksame Anthracyclin-Derivate |
| SU1590045A3 (ru) * | 1986-06-12 | 1990-08-30 | Фармиталиа Карло Эрба С.П.А.(Фирма) | Способ получени гликозида |
| EP0392487A2 (en) * | 1989-04-13 | 1990-10-17 | Takeda Chemical Industries, Ltd. | Stabilized composition of anthracyclines |
| EP0514515A1 (en) * | 1990-12-05 | 1992-11-25 | Erba Carlo Spa | ANTHRACYCLINE CONJUGATE. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162512A (en) * | 1982-03-09 | 1992-11-10 | Cytogen Corporation | Amine derivatives of anthracycline antibodies |
| JPS60246400A (ja) * | 1984-05-22 | 1985-12-06 | Ajinomoto Co Inc | アントラサイクリン系化合物及び制ガン剤 |
| US5169937A (en) * | 1986-11-18 | 1992-12-08 | The Scripps Research Institute | Method for producing stable glycosylated hemoglobin |
| GB9017024D0 (en) * | 1990-08-03 | 1990-09-19 | Erba Carlo Spa | New linker for bioactive agents |
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1993
- 1993-05-11 GB GB939309663A patent/GB9309663D0/en active Pending
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1994
- 1994-04-08 DE DE69427799T patent/DE69427799T2/de not_active Expired - Fee Related
- 1994-04-08 HU HU9403811A patent/HUT70509A/hu unknown
- 1994-04-08 WO PCT/EP1994/001100 patent/WO1994026311A1/en not_active Ceased
- 1994-04-08 UA UA94129260A patent/UA42695C2/uk unknown
- 1994-04-08 RU RU94046336A patent/RU2145965C1/ru not_active IP Right Cessation
- 1994-04-08 AU AU65666/94A patent/AU671741B2/en not_active Ceased
- 1994-04-08 NZ NZ265266A patent/NZ265266A/en unknown
- 1994-04-08 KR KR1019940704830A patent/KR100330635B1/ko not_active Expired - Fee Related
- 1994-04-08 JP JP6524851A patent/JPH08502519A/ja not_active Ceased
- 1994-04-08 ES ES94913560T patent/ES2161764T3/es not_active Expired - Lifetime
- 1994-04-08 CA CA002136438A patent/CA2136438C/en not_active Expired - Fee Related
- 1994-04-08 EP EP94913560A patent/EP0649312B1/en not_active Expired - Lifetime
- 1994-04-08 PT PT94913560T patent/PT649312E/pt unknown
- 1994-04-08 US US08/351,474 patent/US5571785A/en not_active Expired - Fee Related
- 1994-04-08 CN CN94190242A patent/CN1098106C/zh not_active Expired - Fee Related
- 1994-04-08 DK DK94913560T patent/DK0649312T3/da active
- 1994-04-08 AT AT94913560T patent/ATE203414T1/de not_active IP Right Cessation
- 1994-04-08 PL PL94306861A patent/PL175325B1/pl not_active IP Right Cessation
- 1994-04-11 TW TW083103180A patent/TW268015B/zh active
- 1994-05-03 IL IL10952894A patent/IL109528A/en not_active IP Right Cessation
- 1994-05-09 ZA ZA943212A patent/ZA943212B/xx unknown
- 1994-05-09 MY MYPI94001149A patent/MY110974A/en unknown
- 1994-12-28 FI FI946128A patent/FI112602B/fi not_active IP Right Cessation
-
1995
- 1995-06-19 HU HU95P/P00250P patent/HU211538A9/hu unknown
-
2001
- 2001-10-22 GR GR20010401848T patent/GR3036978T3/el not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1590045A3 (ru) * | 1986-06-12 | 1990-08-30 | Фармиталиа Карло Эрба С.П.А.(Фирма) | Способ получени гликозида |
| EP0298385A2 (de) * | 1987-07-09 | 1989-01-11 | BEHRINGWERKE Aktiengesellschaft | Zytostatisch wirksame Anthracyclin-Derivate |
| EP0392487A2 (en) * | 1989-04-13 | 1990-10-17 | Takeda Chemical Industries, Ltd. | Stabilized composition of anthracyclines |
| EP0514515A1 (en) * | 1990-12-05 | 1992-11-25 | Erba Carlo Spa | ANTHRACYCLINE CONJUGATE. |
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| Title |
|---|
| Macromolekulare chemie, Macromolecular Symposia 70/71, 1993, Basel CH, p.157 - 162. R.Duncan et al. "Development of N-(2-hydroxypropyl) methacrylamide copolymer conjugates for delivery of cancer chemotherapy". Аркамон А.Ф. Доксорубицин. - Medical chemistry monograph, т.17, Academic Press, 1981. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2341530C2 (ru) * | 2003-07-02 | 2008-12-20 | Солакс Корпорейшн | Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения |
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