ES2161764T3 - Conjugados de antraciclina, su preparacion y su utilizacion como agente antitumorales. - Google Patents

Conjugados de antraciclina, su preparacion y su utilizacion como agente antitumorales.

Info

Publication number
ES2161764T3
ES2161764T3 ES94913560T ES94913560T ES2161764T3 ES 2161764 T3 ES2161764 T3 ES 2161764T3 ES 94913560 T ES94913560 T ES 94913560T ES 94913560 T ES94913560 T ES 94913560T ES 2161764 T3 ES2161764 T3 ES 2161764T3
Authority
ES
Spain
Prior art keywords
preparation
mol
anthracicline
conjugates
antitumor agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913560T
Other languages
English (en)
Spanish (es)
Inventor
Francesco Angelucci
Maria Grandi
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2161764T3 publication Critical patent/ES2161764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
ES94913560T 1993-05-11 1994-04-08 Conjugados de antraciclina, su preparacion y su utilizacion como agente antitumorales. Expired - Lifetime ES2161764T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309663A GB9309663D0 (en) 1993-05-11 1993-05-11 Biologically active compounds

Publications (1)

Publication Number Publication Date
ES2161764T3 true ES2161764T3 (es) 2001-12-16

Family

ID=10735264

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913560T Expired - Lifetime ES2161764T3 (es) 1993-05-11 1994-04-08 Conjugados de antraciclina, su preparacion y su utilizacion como agente antitumorales.

Country Status (25)

Country Link
US (1) US5571785A (https=)
EP (1) EP0649312B1 (https=)
JP (1) JPH08502519A (https=)
KR (1) KR100330635B1 (https=)
CN (1) CN1098106C (https=)
AT (1) ATE203414T1 (https=)
AU (1) AU671741B2 (https=)
CA (1) CA2136438C (https=)
DE (1) DE69427799T2 (https=)
DK (1) DK0649312T3 (https=)
ES (1) ES2161764T3 (https=)
FI (1) FI112602B (https=)
GB (1) GB9309663D0 (https=)
GR (1) GR3036978T3 (https=)
HU (2) HUT70509A (https=)
IL (1) IL109528A (https=)
MY (1) MY110974A (https=)
NZ (1) NZ265266A (https=)
PL (1) PL175325B1 (https=)
PT (1) PT649312E (https=)
RU (1) RU2145965C1 (https=)
TW (1) TW268015B (https=)
UA (1) UA42695C2 (https=)
WO (1) WO1994026311A1 (https=)
ZA (1) ZA943212B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
EP1401875A4 (en) * 2001-05-04 2005-01-26 Univ Utah Res Found HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS
WO2003037915A1 (en) * 2001-10-31 2003-05-08 Biopolymed Inc. Biocompatible polymers including peptide spacer
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US9737556B2 (en) 2014-06-13 2017-08-22 Trustees Of Tufts College FAP-activated therapeutic agents, and uses related thereto
JP6744826B2 (ja) 2014-06-13 2020-08-19 バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC Ｆａｐ活性化治療剤及びそれに関連する使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
JPS60246400A (ja) * 1984-05-22 1985-12-06 Ajinomoto Co Inc アントラサイクリン系化合物及び制ガン剤
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5169937A (en) * 1986-11-18 1992-12-08 The Scripps Research Institute Method for producing stable glycosylated hemoglobin
DE3722699A1 (de) * 1987-07-09 1989-01-19 Behringwerke Ag Zytostatisch wirksame anthacyclin-konjugate
CA2014244A1 (en) * 1989-04-13 1990-10-13 Takeda Chemical Industries, Ltd. Stabilized composition of anthracyclines
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates

Also Published As

Publication number Publication date
GB9309663D0 (en) 1993-06-23
FI946128A0 (fi) 1994-12-28
KR100330635B1 (ko) 2002-09-17
JPH08502519A (ja) 1996-03-19
EP0649312A1 (en) 1995-04-26
HUT70509A (en) 1995-10-30
CA2136438C (en) 2004-09-14
FI946128A7 (fi) 1994-12-28
NZ265266A (en) 1996-06-25
AU6566694A (en) 1994-12-12
MY110974A (en) 1999-07-31
US5571785A (en) 1996-11-05
UA42695C2 (uk) 2001-11-15
HU211538A9 (en) 1995-12-28
FI112602B (fi) 2003-12-31
CN1108454A (zh) 1995-09-13
EP0649312B1 (en) 2001-07-25
IL109528A (en) 1998-08-16
HU9403811D0 (en) 1995-03-28
RU2145965C1 (ru) 2000-02-27
AU671741B2 (en) 1996-09-05
CA2136438A1 (en) 1994-11-24
ZA943212B (en) 1995-01-18
PL175325B1 (pl) 1998-12-31
PT649312E (pt) 2002-01-30
PL306861A1 (en) 1995-04-18
TW268015B (https=) 1996-01-11
CN1098106C (zh) 2003-01-08
WO1994026311A1 (en) 1994-11-24
KR950702201A (ko) 1995-06-19
IL109528A0 (en) 1994-08-26
ATE203414T1 (de) 2001-08-15
RU94046336A (ru) 1996-10-27
DE69427799T2 (de) 2002-05-02
DK0649312T3 (da) 2001-11-12
GR3036978T3 (en) 2002-01-31
DE69427799D1 (de) 2001-08-30

Similar Documents

Publication Publication Date Title
UY27368A1 (es) Nuevos compuestos
BR0308261A (pt) Métodos extrativos para puruficação de sucralose
BR0007781A (pt) Conjugado fisiologicamente ativo, composição, e, processo para a produção de um conjugado de peg-gcsf
BR9713465A (pt) Inibidores metalotprotease de amina cìclica sibstituìda
AR015432A1 (es) Compuestos derivados de oxindol sustituidos, composiciones farmaceuticas, uso de dichos compuestos para la preparacion de medicamentos
ATE71375T1 (de) Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
ATE94547T1 (de) Pharmazeutische zubereitung enthaltend eine tetrahydropyrrolverbindung als aktiven bestandteil und verfahren zur herstellung dieser tetrapyrrolverbindung.
BR9801126A (pt) 1,4-benzotiazepina-1,1-dióxidos hipolipidêmicos.
BR0112420A (pt) Composto, composição farmacêutica, uso de um composto, e, método para produzir um efeito inibidor de ciclo celular (anti-proliferação celular) em um animal de sangue quente
AR003440A1 (es) Nuevos derivados de aminoacidos, formulacion farmaceutica que los contiene, uso de dichos derivados para preparar medicamentos y procedimiento para la preparacion de dichos derivados.
BR9707064A (pt) Novos derivados 19-nor-pregneno
ATE32728T1 (de) Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel.
ES2128519T3 (es) Nuevas pirido-tiadiazinas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ES2161764T3 (es) Conjugados de antraciclina, su preparacion y su utilizacion como agente antitumorales.
BR0315958A (pt) Composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto
BR9916680A (pt) Derivados da 3,3-biarilpiperidina e2,2-biarilmorfolina
ES2074492T3 (es) Derivados de acidos biliares, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DE3064835D1 (en) 2-hydroxyalkyl-3,4,5,trihydroxy piperidines, processes for their preparation and their use as medicaments
DE3164763D1 (en) Anthracycline glycosides, process for the preparation thereof, intermediate compounds and their preparation and pharmaceutical compositions
BR9911250A (pt) Processo para preparação de compostos
MX9302327A (es) Aminoacidos ciclicos novedosos y derivados de los mismos.
DK149091C (da) Analogifremgangsmaade til fremstilling af peptider indeholdende 2-7 aminosyrerester, desaminodipeptider eller amider deraf med ubiquitin-lignende aktivitet eller farmaceutisk acceptable syreadditionssalte deraf
DK102792D0 (da) Spergualinderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat, hvori de indgaar, og fremgangsmaade til fremstilling af praeparatet
ATE3552T1 (de) Verfahren zur herstellung von phosphono-hydroxy- essigsaeure und salzen derselben sowie diese enthaltende autivirale mittel.
IL108856A0 (en) Hydroxymethyl-furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 649312

Country of ref document: ES