CN109805214A - A kind of health drink of patients with diabetes mellitus and preparation method thereof - Google Patents
A kind of health drink of patients with diabetes mellitus and preparation method thereof Download PDFInfo
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Abstract
A kind of patients with diabetes mellitus health drink and preparation method thereof, it is related to a kind of health drink, it is combined by ultrasonic wave with dynamic countercurrent circulation, ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in water-soluble functional components, the fluffy middle polyphenols recovery rate of alkali improves 30%-70% compared to traditional extraction process recovery rate, polyphenols has anti-mutation in the fluffy cauline leaf of alkali, it is anti-oxidant, the effect of blood pressure lowering, suitable diabetic takes and to diabetic complication such as hypertension, hyperlipidemia, artery sclerosis is protected, conjugated linoleic acid has antitumor in common seepweed seeds oil, it is anti-oxidant, antiatherosclerosis, norcholesterol, anticancer improves immunity, improve skeleton density, prevent and treat a variety of important physiological functions such as diabetes；There is blood sugar decreasing effect in conjunction with hawthorn, balsam pear, corn stigma, good seed extracting solution, pumpkin extracting solution etc., suitable for patients with diabetes mellitus has significant health-care effect to diabetic.
Description
[technical field]
The present invention relates to a kind of health drinks, more particularly, to the health drink and its preparation of a kind of patients with diabetes mellitus
Method.
[background technique]
Diabetes are a kind of common endocrine metabolism diseases, it is the third-largest serious after tumour, vascular lesion
The disease of human health is threatened, there is high lethality rate, the feature of high disability rate and high health care costs, become each Kuomintang-Communist of our times
With the public health problem faced.The statistical data of International Diabetes Federation is shown, is turned within diabetes mellitus in China illness rate nearly 10 years
Twice.2010, Chinese Adult diabetes prevalence was 9.7%, and patient populations become the first in the world glycosuria more than 90,000,000
Sick big country.Meanwhile the impaired glucose tolerance of prediabetes has reached 1.48 hundred million people, illness rate 15.5%.It is wherein main
It is 2 type patients.The above true explanation, with the raising of people's social and economic activities, diabetes (especially 2 types) patient has rapidly
The increased impetus can not be ignored.
Diabetic's complication pathomechanism is atherosclerosis, hyperglycemia, hypertension, high cholesterol, low-density
Lipoprotein increases, high-density lipoprotein declines, and the course of disease is reachable in the incidence of diabetic's cerebral arteriovenous malformation in 5 years or more
70%, it is mainly shown as the neurasthenia symptoms such as headache, giddy, insomnia, amnesia, absent minded, emotional instability.Nerve
The how no positive sign of system physical examination.Acute cerebrovascular disease is mainly shown as cerebral thrombosis, with arteriolar infarct and more
It is common to send out venereal disease stove, clinical symptoms are often relatively light, but normal recurrent exerbation, and progressive aggravates, and restore difficult.
Suaeda salsa is annual herb salification plant, and the fluffy middle nutritional ingredient of alkali is complete and enriches, the fluffy stem leaf protein matter of alkali,
Fat, carbohydrate three nutritious elements content are higher, and seed fat content accounts for the 36.5% of dry matter, are higher than soybean,
The protein content of fresh and tender cauline leaf accounts for the 40% of dry matter, measures 16 kinds of amino acid in Suaeda salsa altogether, wherein there is 8 kinds of human bodies must
Amino acid is needed, and content is higher, there is expansion blood vessel, enhance human immunity, be depressured, the function of hypoglycemic, prevention and cure of cardiovascular disease
Effect；The essential trace elements of the human body and vitamin abundant there are many also containing during alkali is fluffy, wherein calcium, magnesium, zinc, iron, nickel content are rich
Richness, calcium, phosphorus, iron and core yellow cellulose content are higher than or quite much higher than the vegetables such as spinach, tomato and carrot, Vitamin C content
In general vegetables, vitamin B content is 5-8 times of general vegetables, is much higher than spirulina；Invention Announce number is CN106578918
The patent document of A discloses a kind of fluffy healthy and nutritious noodle of selenium-rich alkali and its production technology, and patent document research demonstrates alkali
Fluffy middle high 10 times of the more general food of Se content or so, and selenium is referred to as " king of anti-cancer " in body trace element by scientist,
Have effects that anticancer, pre- preventing tumor, the generation of hepatopathy, raising body immunity；Invention Announce number are as follows: CN103027962A
Patent document disclose a kind of Suaeda salsa extracting flavonoids and content assaying method, patent document research demonstrates saline land alkali
Fluffy (S.salsa) leaf flavonoids content is higher, and has stronger antioxidant activity, and plant flavone has anti-oxidant, antitumor, anti-
The multiple efficacies such as atherosclerosis, anti-inflammatory.
The fluffy seed of alkali is rich in unsaturated fatty acid and conjugated linoleic acid, and the crude fat content of the fluffy seed of alkali is considerably beyond soybean
(crude fat content 23%-25%), unsaturated fatty acid content is abundant in seed, and the 90% of the total fat of Zhan, wherein needed by human
For the content of fatty acid up to 70% or more, linolenic acid accounts for 6.08%, has flax of important health-care efficacy in common seepweed seeds oil to human body
Acid content is suitable with soybean oil and wheat malt oil up to 6.08%, is much higher than other common edible oils.Common seepweed seeds oil is rich in micro member
Plain Se, and liposoluble vitamin content is higher, and especially vitamin E, content are up to 2mg/g, and numerous studies sufficiently show
Common seepweed seeds oil has high healthy nutritive value, is a kind of table oil, can be used as new oil resource and is developed；Alkali is fluffy
Contain conjugated linoleic acid in seed, the patent document of application publication number CN104710299A discloses the sub- oil of conjugation in a kind of fluffy seed of alkali
The extracting method of acid, which extracts common seepweed seeds oil from the fluffy seed of alkali using low boiling point solvent, then mentions from common seepweed seeds oil
Take purified conjugate linoleic acid；A large amount of scientific research proves that conjugated linoleic acid is with antitumor, anti-oxidant, anti-atherogenic is hard
Change, norcholesterol, anticancer improve immunity, improve a variety of important physiological functions such as skeleton density, prevention and treatment diabetes；And it can also
It reduces animal and body's cholesterol and triglycerides and low density lipoprotein cholesterol, animal and human body rouge can also be reduced
Fat increases muscle.
Pigment during alkali is fluffy is the valuable source of natural pigment, which is researched and analysed as water-soluble anthocyan color
Element.Anthocyanidin has anti-mutation, anti-oxidant, blood pressure lowering, protection liver as natural pigment, security performance with higher
Dirty equal healthcare functions, belong to functional food additives.Polyphenols is referred to as " the 7th class nutrient ".Polyphenol can promote rouge
Class and bile acid exclude external, the content of cholesterol and triglycerides in reduction blood plasma and liver, with prevention of arterial hardening, drop
The effects of low blood pressure and blood lipid, prevention and treatment thrombus.
In conclusion the fluffy middle polyphenols of alkali has remarkable efficacy for the defence of diabetic's complication, currently
There are no a kind of methods of energy fluffy middle polyphenol substance of high efficiency extraction alkali, also without a kind of that alkali is fluffy applied to patients with diabetes mellitus
Health drink.
[summary of the invention]
In order to overcome the shortcomings in the background art, the present invention develops a kind of health drink of patients with diabetes mellitus, leads to
Cross ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in it is water-soluble it is functional at
Point, the fluffy middle polyphenols recovery rate of alkali improves 30%-70%, the fluffy middle Polyphenols of alkali compared to traditional extraction process recovery rate
Substance has anti-mutation, anti-oxidant, blood pressure lowering, reduces the content of cholesterol and triglycerides in blood plasma and liver, has prevention
Artery sclerosis, the effects of reducing blood pressure with blood lipid, prevention and treatment thrombus, suitable diabetic take and such as high to diabetic complication
Blood pressure, hyperlipidemia, artery sclerosis are protected, and conjugated linoleic acid has antitumor, anti-oxidant, anti-atherogenic in common seepweed seeds oil
Hardening, norcholesterol, anticancer improve immunity, improve a variety of important physiological functions such as skeleton density, prevention and treatment diabetes；In conjunction with mountain
Short, bristly hair or beard, balsam pear, corn stigma, good seed extracting solution, pumpkin extracting solution etc. are with hypoglycemic, reduction animal tallow in the heavy of vascular wall
Product, mitigates the effect of artery sclerosis, and suitable for patients with diabetes mellitus has significant health-care effect to diabetic.
For achieving the above object, the present invention adopts the following technical scheme:
A kind of patients with diabetes mellitus health drink and preparation method thereof, includes the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3
Time, removal impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of 1cm~2cm；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, at colloid mill mashing
It manages to 30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
20~1:50 adds deionized water, adds 2%~4% (w/w) cellulase, is added 0.05%~0.08% vitamin C, when enzymatic hydrolysis
Between 20min~30min, 30 DEG C~50 DEG C of hydrolysis temperature, ultrasonic power 50w~200w, extraction time be 1~2 time, merge leaching
Extract；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, obtains the fluffy cauline leaf of saline-alkali land and extracts
Liquid is spare；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened,
Remove soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is small after screening
In 0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature
Degree is 40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed after vacuum drying with pulverizer, is crushed to mesh number as 60 mesh to 150
Mesh；
Step 10, the fluffy powder of seeds of saline-alkali land being subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, one
Grade separating still pressure is 8-10MPa, and the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, two fractions
35 DEG C are regulated to from kettle temperature degree, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, evaporates separation using spiral evaporator
Then ethyl alcohol in object further removes ethyl alcohol in a vacuum drying oven under the conditions of 40 DEG C；
Step 12, the isolate in level-one separating still and the second-order separation kettle is after step 5 removes ethyl alcohol, in level-one separating still
Isolate directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, centrifugal rotational speed
For 30r/min-50r/min, centrifugation time 20min, upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection are taken
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil mix according to the ratio of 4:1
Mixed liquor A；
Step 14, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution B spare, take good seed to crush,
It soaks in water 30 minutes, heating is boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, adds water logging
Bubble 20 minutes, heating boil 30 minutes, pour out supernatant and obtain pumpkin extracting solution；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B praises seed extracting solution, and pumpkin is extracted
Liquid is mixed to prepare mixed liquor C according to the ratio of 1:1.5:0.2:0.4；
Step 16, xylitol is added in mixed liquor C；
Step 17, mixed liquor C carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
Described patients with diabetes mellitus health drink and preparation method thereof, its minerals of the fluffy stem leaf extract of the alkali
Ingredient and content are as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, g/L~185 Fe2+162 μ
μ g/L, the μ g/L of Mn2+5.11 μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, the μ g/L of K+0.8 μ g/L~3.0, Na+1746 μ
μ g/L of g/L~6899,200 μ of μ g/L~400 g/L of total dissolved solid.
Described patients with diabetes mellitus health drink and preparation method thereof, reverse osmosis dress described in step 6 and step 17
Set system configuration are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system is by mechanical filter, adsorption filtration
Device, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is by water purification pot, electrical equipment control
System composition；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after can be with through adsorption filter filtering
Oil removal is removed, however the impurity such as algae can be removed through mechanical filter filtering.
Described patients with diabetes mellitus health drink and preparation method thereof, ultrafiltration described in step 6 and step 17 are hollow
Tunica fibrosa ultrafiltration is to remove the microorganisms such as bacterium in extracting solution, mould.
Described patients with diabetes mellitus health drink and preparation method thereof, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Due to the adoption of the technical scheme as described above, the invention has the following beneficial effects:
1, the present invention is directed to patients with diabetes mellitus health drink, selects balsam pear that can mend gallbladder profit liver in ingredient, and diuresis disappears
Heat solves spirits, and aid digestion, anti-flu can also control laryngitis and cough due to wind-heat evil, and the Charantin in balsam pear is known as " fatty killer ",
The Fresh sap of balsam pear, the substance containing Charantin and similar insulin, has good hypoglycemic effect, can make intake fat
It being reduced with polysaccharide, the alkaloid in balsam pear has good blood sugar reducing function, and it is especially significant to diabetes, it is known as plant pancreas islet
Element；Hawthorn, sour sweet, slightly warm in nature belong to liver and gallbladder the spleen channel, it contains ursolic acid, can reduce animal tallow in the deposition of vascular wall,
Mitigate artery sclerosis to a certain extent；Corn stigma tea, corn stigma is also known as " Dracaena ", sweet in flavor mild-natured, has appetizing in adjusting, beneficial lung
The functions such as calming heart, clearing away damp-heat, sharp liver and gallbladder；Good seed is rich in antioxidant, healthy fat, fiber, magnesium, zinc, iron, calcium, only 1 big belly
The good seed of department's (29.3495 grams) can provide 10 grams of fibers, this amount has reached daily for the women more than 50 years old
The half of recommended dose；Pumpkin, in content of magnesium it is high, two ladle pumpkins contain 74 milligrams of magnesium, are equivalent to daily
The a quarter of recommended intake, some researches show that be required to comprising 300 multinomial physiology courses including decomposition food energy
Magnesium, lacking magnesium will lead to insulin resistance, and every increases of magnesium intake 100mg/ days, diabetes B risk declines about 15%；Alkali
Fluffy middle polyphenols has anti-mutation, anti-oxidant, blood pressure lowering, reduces containing for cholesterol and triglycerides in blood plasma and liver
Amount has the effects that prevention of arterial hardening, reduces blood pressure and take with blood lipid, prevention and treatment thrombus, suitable diabetic and to glycosuria
Sick complication such as hypertension, hyperlipidemia, artery sclerosis are protected；Conjugated linoleic acid has antitumor, antioxygen in common seepweed seeds oil
Change, antiatherosclerosis, norcholesterol, anticancer improve immunity, improve a variety of important lifes such as skeleton density, prevention and treatment diabetes
Manage function；Simultaneously alkali it is fluffy in also rich in the mineral elements such as calcium, magnesium, iron, manganese, zinc, copper, strontium, sodium, and contain abundant amino acid kind
Class, up to 18 kinds, including must amino acid: threonine, valine, isoleucine, methionine, leucine, phenylalanine,
Lysine, tryptophan.Nonessential amino acid: asparatate, serine, glutamic acid, glycine, alanine, cystine, junket ammonia
Acid, histidine, arginine, proline.Wherein essential amino acids content accounts for total amino acid content difference 35.2%, proposes close to FAO
Reference model (36%), it is necessary to the ratio of amino acid and nonessential amino acid be 55%, close to FAO propose reference model
(0.56), comprehensive and abundant nutrition can be provided for liver and gallbladder patient.
2, the fluffy middle polyphenol recovery rate of alkali of the present invention improves 30%-70% compared to traditional extraction process recovery rate, passes through
Ultrasonic wave is combined with dynamic countercurrent circulation, so that the fluffy middle polyphenol recovery rate of alkali greatly improves, is played a multiplier effect；It is logical
Cross ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in it is water-soluble it is functional at
Point, aqueous enzymatic method combination ultrasonic wave physical process, the very big acceleration generated using it, strong cavitation effect, high vibration etc.
Property is reduced and is asked when extracting, and temperature is avoided to change the activity change to effective component；Ultrasonic wave dynamic countercurrent auxiliary of the invention
Enzyme and ultrafiltration technology combine extract the fluffy middle polyphenols of alkali method simple production process, expend the time it is few, reduce life
Working strength is produced, has many advantages, such as that product effective component is high, temperature is reduced and changes bring adverse effect.
3, the present invention using coarse filtration and ultrafiltration effectively eliminate the impurity such as body refuse, suspended matter, algae in extracting solution and
The microorganisms such as bacterium, mould in extracting solution, high degree remain the fluffy extracting solution of alkali, hawthorn, balsam pear, corn stigma, good seed
Extracting solution, the various nutritional ingredients of pumpkin extracting solution and microelement, it is easy to operate, it is suitable for industrialized production, compared to biography
The filter method of system, hyperfiltration technique are a kind of purifications for being widely used in water, and pollution-free, low energy consumption, and separator is simple, process
Short, easy to operate, easily controllable and maintenance, installation area are small.Carry out at normal temperature, mild condition without component damage, because
And the separation and enrichment of the particularly suitable substance to this product (thermo-responsive), have very much to the recycling of the micro constitutent in this product
Effect.Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution in ultrafiltration technology pretreatment system, after through adsorbing
Filter filtering can remove the impurity such as oil removal and algae, and then pass through the hollow-fibre membrane of ultrafiltration technology essence filtration system
Ultrafiltration is to remove the microorganisms such as bacterium in extracting solution, mould.
4, the fluffy polyphenols recovery rate of alkali may be up to 5.9% in the present invention, and polyphenols is referred to as " the 7th class nutrition
Element ", polyphenols have anti-mutation, anti-oxidant, blood pressure lowering, reduce containing for cholesterol and triglycerides in blood plasma and liver
Amount has the effects that prevention of arterial hardening, reduces blood pressure and take with blood lipid, prevention and treatment thrombus, suitable diabetic and to glycosuria
Sick complication such as hypertension, hyperlipidemia, artery sclerosis have significant health-care effect, help health.
5, the present invention is directed to the critical CO of the fluffy seed part over-extraction of saline-alkali land2Extraction has extraction efficiency high, solvent-free
Residual toxicity, active skull cap components and heat-sensitive ingredients are not easy the destruction that is decomposed, and can keep the natural of extract to the maximum extent
Feature is, it can be achieved that the advantages of Selective Separation.
6, the fluffy raw material of alkali chooses alkali fluffy plant of the growth cycle within 45 days in the present invention, and the fluffy cauline leaf of alkali at this time is fresh
It is tender, rich in nutritional ingredients such as functional pigmented, vitamin, protein and alkaloids；The fluffy seed of saline-alkali land selects 10- in the present invention
November the fluffy seed of saline-alkali land, in addition, the fluffy raw material of alkali selected by the present invention is artificial cultivation, avoiding wild suaeda glauce raw material may
Existing heavy metals exceeding standard problem, artificial cultivation, good growing environment ensure that the safety of raw material.
7, sucrose, pure plant extracting solution, using xylose are free of in the health drink of patients with diabetes mellitus of the present invention
Alcohol, it is green safe.
8, physical and chemical index detection, every main indicator are carried out to the health drink of patients with diabetes mellitus provided by the invention
It is all satisfied requirements of the national standard.
[Detailed description of the invention]
Fig. 1 is influence of the liquid-solid ratio to the fluffy pigment extraction effect of alkali；
Fig. 2 is the response surface that solid-liquid ratio, cellulase, vitamin C and ultrasonic power influence polyphenol content.
[specific embodiment]
The present invention can be explained in more detail by the following examples, the open purpose of the present invention is intended to protect the present invention
All changes and improvements in range, the invention is not limited to the following examples；
A kind of patients with diabetes mellitus health drink and preparation method thereof, includes the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3
Time, removal impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of 1cm~2cm；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, at colloid mill mashing
It manages to 30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
20~1:50 adds deionized water, adds 2%~4% (w/w) cellulase, is added 0.05%~0.08% vitamin C, when enzymatic hydrolysis
Between 20min~30min, 30 DEG C~50 DEG C of hydrolysis temperature, ultrasonic power 50w~200w, extraction time be 1~2 time, merge leaching
Extract；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, obtains the fluffy cauline leaf of saline-alkali land and extracts
Liquid is spare；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened,
Remove soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is small after screening
In 0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature
Degree is 40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed after vacuum drying with pulverizer, is crushed to mesh number as 60 mesh to 150
Mesh；
Step 10, the fluffy powder of seeds of saline-alkali land being subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, one
Grade separating still pressure is 8-10MPa, and the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, two fractions
35 DEG C are regulated to from kettle temperature degree, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, evaporates separation using spiral evaporator
Then ethyl alcohol in object further removes ethyl alcohol in a vacuum drying oven under the conditions of 40 DEG C；
Step 12, the isolate in level-one separating still and the second-order separation kettle is after step 5 removes ethyl alcohol, in level-one separating still
Isolate directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, centrifugal rotational speed
For 30r/min-50r/min, centrifugation time 20min, upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection are taken
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil mix according to the ratio of 4:1
Mixed liquor A；
Step 14, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution B spare, take good seed to crush,
It soaks in water 30 minutes, heating is boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, adds water logging
Bubble 20 minutes, heating boil 30 minutes, pour out supernatant and obtain pumpkin extracting solution；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B praises seed extracting solution, and pumpkin is extracted
Liquid is mixed to prepare mixed liquor C according to the ratio of 1:1.5:0.2:0.4；
Step 16, xylitol is added in mixed liquor C；
Step 17, mixed liquor C carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
Described patients with diabetes mellitus health drink and preparation method thereof, its minerals of the fluffy stem leaf extract of the alkali
Ingredient and content are as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, g/L~185 Fe2+162 μ
μ g/L, the μ g/L of Mn2+5.11 μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, the μ g/L of K+0.8 μ g/L~3.0, Na+1746 μ
μ g/L of g/L~6899,200 μ of μ g/L~400 g/L of total dissolved solid.
Described patients with diabetes mellitus health drink and preparation method thereof, reverse osmosis dress described in step 6 and step 17
Set system configuration are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system is by mechanical filter, adsorption filtration
Device, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is by water purification pot, electrical equipment control
System composition；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after can be with through adsorption filter filtering
Oil removal is removed, however the impurity such as algae can be removed through mechanical filter filtering.
Described patients with diabetes mellitus health drink and preparation method thereof, ultrafiltration described in step 6 and step 17 are hollow
Tunica fibrosa ultrafiltration is to remove the microorganisms such as bacterium in extracting solution, mould.
Described patients with diabetes mellitus health drink and preparation method thereof, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Wherein, water used is deionized water, and the minerals in water have been filtered out in deionized water, have avoided calcium in water, magnesium
The interference of plasma.
Addition vitamin C can play the color protection fluffy to alkali, anti-oxidation efficacy in steps of 5, while also can be realized battalion
Support the purpose strengthened.
The detection of every physical and chemical index:
For nutritional ingredient composition and content situation in the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil, pass through
Micro-kjoldahl method measures crude protein content；Using determination of crude oil by Soxhlet extraction；It is thick using gravimetry
Fiber content；Moisture content is measured using atmosphere pressure desiccation；Carbohydrate content is measured using anthrone colorimetry；Using high temperature
Ash purification determining content of ashes；Amino acid content is measured using Hitachi 835-50 type high-speed amino acid analyzer；Using fluorescence point
Light photometry measures tryptophan composition and content；Using atomic absorption spectroscopy determination mineral element, wherein selenium element is used
Fluorescence spectrophotometry；Every nutritional ingredient and content are shown in Table 1-3 in the common seepweed seeds oil of salt-soda soil, and the fluffy cauline leaf of saline-alkali land mentions
Every nutritional ingredient and content in liquid is taken to be shown in Table 4-6:
Main nutrient composition content in 1 salt-soda soil common seepweed seeds oil of table
2 salt-soda soil common seepweed seeds oil Mineral Element Contents (μ g/g) of table
The composition and content (mg/g) of amino acid in 3 salt-soda soil common seepweed seeds oil of table
The fluffy stem leaf extract nutrient content of 4 saline-alkali land of table
The fluffy stem leaf extract Mineral Elements in Jadeite Shellfish content of 5 alkali of table
The fluffy stem leaf extract amino acid content of 6 saline-alkali land of table
Pass through nutritional ingredient composition and content situation in the fluffy stem leaf extract of measurement saline-alkali land and salt-soda soil common seepweed seeds oil
It can be seen that
The comparison of table 1 and table 4 can be seen that crude protein, crude fat content in the common seepweed seeds oil of salt-soda soil: 18.75% and
23.46%, much higher than crude protein, crude fat content in the fluffy stem leaf extract of saline-alkali land: 3.020% and 1.380%, and salt
Alkali in common seepweed seeds oil crude fat content account for 23.46%, be higher than soybean (crude fat content 18.80%), be good plant
Oil sources can be used as good protein sources, vitamin in the fluffy stem leaf extract of saline-alkali land since its crude protein content is also higher
Content is higher, in addition, the chemotrophy ingredient of the fluffy seed of saline-alkali land and the fluffy cauline leaf of saline-alkali land is complete and enriches.
The comparison of table 2 and table 5 can be seen that salt-soda soil common seepweed seeds oil Mineral Elements potassium and the content of sodium is the abundantest,
This is related with the saline-alkali environment that it grows, close with human health in salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land
It is higher to cut the constituent contents such as relevant iron, calcium, zinc, copper, manganese, it is seen then that the fluffy seed of saline-alkali land and the fluffy cauline leaf of saline-alkali land are one
Kind good mineral matter nutritional source, in addition, also contain selenium in the common seepweed seeds oil of salt-soda soil, it is micro that selenium by scientist is referred to as human body
" king of anti-cancer " in element therefore develops the fluffy seed of saline-alkali land and can be the mankind using the selenium contained by the fluffy seed of saline-alkali land
Bring high value medical health care.
The comparison of table 3 and table 6, which can be seen that in salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land, contains 18
Middle amino acid, rich content, it is necessary to which amino acid composition is complete, and wherein it is total to account for amino acid for the fluffy seed essential amino acids content of saline-alkali land
The 36.44% of amount is higher than FAO mode (36.00%), while the ratio between the fluffy seed essential amino acid of saline-alkali land and nonessential amino acid
It (E/N) is 0.573, also above FAO mode (0.56), it is seen then that the fluffy seed albumen of alkali belongs to quality plant albumen；The fluffy stem of saline-alkali land
It is 35.5% that essential amino acids content, which accounts for total amino acid content, in leaf, the reference model (36%) proposed close to FAO, it is necessary to amino acid
Ratio with nonessential amino acid is 55.1%, the reference model (0.56) proposed close to FAO；In addition, the research discovery fluffy seed of alkali
The common seepweed seeds oil obtained after processing is refined has the physicochemical property of general edible oil, and it is next to can be used as a kind of new edible oil
Exploitation, it is rich in unsaturated fatty acid in addition, and especially linoleic acid content is higher than many plants, it can be seen that, common seepweed seeds oil is one
Kind of vegetable oil new resources containing high linoleic acid, have important a nutrition health-care functions and biggish Development volue, in common seepweed seeds oil
Rich in unsaturated fatty acid, total unsaturated fatty acid content is up to 90.65%, and wherein linoleic acid content accounts for 68.74%, is current
It was found that one of the higher oil sources of linoleic acid content, physical and chemical index also substantially conforms to edible oil standard, is a kind of ideal
The good material of edible health-care oil and preparation conjugated linoleic acid.
By above-mentioned analysis it is found that since the fluffy seed of saline-alkali land and the fluffy stem and leaf part of saline-alkali land are rich in
Nutritional ingredient be biased to different, the present invention is by pressing salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land
Ratio allotment, can be made the health drink of patients with diabetes mellitus, and fluffy middle the be rich in nutritional ingredient effect of alkali is maximized,
The fluffy edible value of saline-alkali land is played to greatest extent.
Preparation method described in Example preparation patients with diabetes mellitus health drink, by GB/T12143.1,
GB8537-1995, GB4789 examination criteria compare indices, the results are shown in Table 7.
The health drink indices of 7 patients with diabetes mellitus of table
It is visible full according to the health drink items main indicator of patients with diabetes mellitus prepared by the present invention by 7 result of table
Sufficient requirements of the national standard.
In order to determine the solid-liquid ratio in the fluffy stem leaf extract preparation process of alkali, the present invention is directed to the feed liquid of alkali fluffy cauline leaf and water
Than carrying out experimental study, liquid-solid ratio is obtained to the influence diagram of the fluffy pigment extraction effect of alkali, as shown in Figure 1, as shown in Figure 1, with
The absorbance of the increase of liquid-solid ratio, pigment solution gradually rises, and when liquid-solid ratio is 40:1, light absorption value is significantly increased, and obtains alkali
Fluffy pigment recovery rate also significantly increases, and when liquid-solid ratio is greater than 40:1, curve tends towards stability, and absorbance changes less, and synthesis is examined
Consider energy-saving and emission-reduction, selects liquid-solid ratio for 40:1 (mL/g).
On the basis of above-mentioned single factor experiment, solid-liquid ratio, 4 cellulase, vitamin C and ultrasonic power factors are chosen
Box-Behnken design is carried out, the maximum value of polyphenol content in the fluffy stem leaf extract of alkali is studied, the results are shown in Table 8:
Table 8Box-Behnken experimental design scheme and result
Regression fit is carried out to 8 test data of table using 8.0 design software of Design-Expert, obtains polyphenol content pair
Solid-liquid ratio, cellulase, 4 factors of vitamin C and ultrasonic power secondary multinomial regression model:
Polyphenol content=5.55+0.13A+0.19B+0.32C+0.19D-0.33A2-0.39B2-0.28C2-0.96D2
9 response surface design quadratic regression equation model the results of analysis of variance of table
Note: * significant difference p < 0.05；The extremely significant p < 0.01 of * difference.
Make response surface figure according to regression equation, investigate the shape of be fitted response surface, analysis solid-liquid ratio, cellulase,
Fig. 2 is met personally in the influence of vitamin C and ultrasonic power to polyphenol content, response.As shown in Table 9, mutation model p value <
0.0001, reach extremely significant level, illustrates that the models fitting degree is fine.It as shown in Figure 2, is 1:50, cellulose in solid-liquid ratio
Enzyme 3%, vitamin C 0.05%, ultrasonic power 125w, polyphenol content reach peak, and the result and experiment of single factor
As a result consistent.
It is above-mentioned the experimental results showed that, the present invention passes through ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination pole
It is big remain alkali it is fluffy in water-soluble functional components, the fluffy middle polyphenols recovery rate of alkali mentions compared to traditional extraction process
Rate is taken to improve 30%-70%, the fluffy polyphenol recovery rate of alkali of the invention may be up to 5.9%, and polyphenols has in the fluffy cauline leaf of alkali
There are anti-mutation, anti-oxidant, blood pressure lowering, reduce the content of cholesterol and triglycerides in blood plasma and liver, has prevention of arterial hard
Change, reduce blood pressure with blood lipid, prevention and treatment thrombus the effects of, suitable diabetic take and to diabetic complication such as hypertension,
Hyperlipidemia, artery sclerosis are protected, in common seepweed seeds oil conjugated linoleic acid have antitumor, anti-oxidant, antiatherosclerosis,
Norcholesterol, anticancer improve immunity, improve a variety of important physiological functions such as skeleton density, prevention and treatment diabetes；In conjunction with hawthorn, hardship
Melon, corn stigma, good seed extracting solution, pumpkin extracting solution etc. have hypoglycemic, reduction animal tallow in the deposition of vascular wall, subtract
The effect of light artery sclerosis, suitable for patients with diabetes mellitus have significant health-care effect to diabetic.
Patients with diabetes mellitus health drink clinical observation data produced by the present invention is as follows:
Name: Mr. Wang, male suffer from diabetes 5 years in 60 years old, height 170m, weight 80kg.Often there is hunger, eats
It is more.And the symptoms such as shake with hand and foot numbness, unprovoked can usually feel fatigue, especially it is upper downstairs when be even more
Obviously.XXXX of the present invention was taken later, was not influenced under living habit, drank health drink of the present invention when hungry or before the meal, every time
After taking one month, there are not dizzy, out of strength and other uncomfortable phenomenons 3 times a day in 220ml.Face is clearly better, to just
It advises hospital to check, blood glucose value reverts to normal value.
Name: Korea Spro's ××, female, diabetic, in 10 years sugared ages, 56 years old, eyes were particularly easy to fatigue, eyesight sharply under
Drop, does not see Chu Dongxi, and dark and dim eyesight when standing up sees that thing is smudgy, and eyes become myopia suddenly, occurs
The symptoms such as presbyopia are easy to appear Hypoglycemic symptoms, and abdominal distension, diarrhea are usually had difficulty in breathing, or even stupor is hospitalized and participates in this later
The clinical effectiveness of invention is tested, and is not influenced under living habit, before taking medicine daily and drinks health drink of the present invention before sleeping, every time
220ml adheres to Hypoglycemic symptoms and other side effects do not occur 6 weeks, and respiratory quotient smoothly, sees that thing is gradually clear before, depending on
Power is improved, and somatosensory is become better and better.
Name: Lee's ××, male, diabetes 6 years, 47 years old, height 1.74m, weight: 90kg often had hunger, Er Qierong
Fatiguability, and often there is ineffective hand and foot numbness, tremble hands and feet, finger movement and throe sense, violent neuritic foot pain,
Crural paralysis, pain in the loins are not desired to walk, night Leg Cramps.Health drink of the present invention was drunk later, and each 220ml takes surrounding
Afterwards, hunger disappears, numbness in hands and feet, and the symptoms such as shake are alleviated substantially, and blood glucose value is restored to normal value.Qiang Eryou before body ratio
Power.
Part not in the detailed description of the invention is the prior art.
Claims (5)
1. a kind of patients with diabetes mellitus health drink and preparation method thereof, it is characterized in that: including the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3 times, go
Except impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of cm of 1 cm~2；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, using colloid mill mashing handle to
30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:20~
1:50 adds deionized water, adds 2%~4%(w/w) cellulase, 0.05%~0.08% vitamin C, 20 min of enzymolysis time is added
~30 min, 30 DEG C~50 DEG C of hydrolysis temperature, the ultrasonic power w of 50 w~200, extraction time is 1~2 time, merges extraction
Liquid；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, it is standby obtains the fluffy stem leaf extract of saline-alkali land
With；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened, removed
Soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is less than after screening
0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature is
40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed with pulverizer after vacuum drying, being crushed to mesh number is 60 mesh to 150 mesh；
Step 10, the fluffy powder of seeds of saline-alkali land is subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, a fraction
It is 8-10MPa from kettle pressure, the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, the second-order separation kettle
Temperature is regulated to 35 DEG C, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, is evaporated in isolate using spiral evaporator
Ethyl alcohol, then under the conditions of 40 DEG C in a vacuum drying oven further removal ethyl alcohol；
Step 12, point of the isolate in level-one separating still and the second-order separation kettle after step 5 removes ethyl alcohol, in level-one separating still
From object directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, and centrifugal rotational speed is
30r/min -50r/min, centrifugation time 20min take upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, it carries out the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil to mix to obtain mixing according to the ratio of 4:1
Liquid A；
Step 14, take hawthorn, balsam pear, corn stigma clean plus appropriate amount of water decoction to obtain extracting solution B spare, take good seed to crush, add water
It impregnates 30 minutes, heating is boiled 20-40 minutes, and seed extracting solution must be praised by pouring out supernatant；It takes pumpkin to crush, soaks in water
20 minutes, heating was boiled 30 minutes, is poured out supernatant and is obtained pumpkin extracting solution；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B praises seed extracting solution, and pumpkin extracting solution is pressed
Mixed liquor C is mixed to prepare according to the ratio of 1:1.5:0.2:0.4；
Step 16, xylitol is added in mixed liquor C；
Step 17, mixed liquor C carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
2. patients with diabetes mellitus health drink according to claim 1 and preparation method thereof, it is characterized in that: the alkali
Its mineral composition of fluffy liquid and content are as follows: the 2985 μ g/L of μ g/L~5200 of Ca2+, 1743 the Mg2+ μ of μ g/L~2791 g/
L, the 162 μ g/L of μ g/L~185 of Fe2+, 5.11 the Mn2+ μ g/L of μ g/L~8.03,5.27 Zn+ μ g/L of μ g/L~8.51,
The 0.8 μ g/L of μ g/L~3.0 of K+, 1746 Na+ μ g/L of μ g/L~6899,200 μ of μ g/L~400 g/ of total dissolved solid
L。
3. patients with diabetes mellitus health drink according to claim 1 and preparation method thereof, it is characterized in that: step 6 and
Reverse osmosis unit system configuration described in step 17 are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system by
Mechanical filter, adsorption filter, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Breed system
System is made of water purification pot, electrical control system；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after pass through
Adsorption filter filtering can remove oil removal, however can remove the impurity such as algae through mechanical filter filtering.
4. patients with diabetes mellitus health drink according to claim 3 and preparation method thereof, it is characterized in that: step 6 and
Ultrafiltration described in step 17 is hollow-fibre membrane ultrafiltration to remove the microorganisms such as bacterium in extracting solution, mould.
5. patients with diabetes mellitus health drink according to claim 3 or 4 and preparation method thereof, it is characterized in that: described
Hollow-fibre membrane diameter be 0.01 μm~0.001 μm, feed rate be the L/h of 900 L/h~1500,0.045 Mpa of pressure~
0.18 Mpa, feed concentration are the 200 μ g/L of μ g/L~400, ultrafiltration time 100 min~400 min, 10 min of backwash cycle
~40 min, backwash time 20 min~120 min, upper operation 10 min~40 min, upper backwash 20 s~120 s, lower fortune
Row 10 min~40 min, lower backwash 20 s~120 s.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112889970A (en) * | 2021-01-14 | 2021-06-04 | 黄祥 | Preparation process and equipment of seed tea |
| CN115517306A (en) * | 2021-01-23 | 2022-12-27 | 辽宁海水碱蓬生物科技有限公司 | Saline-alkali soil tea |
-
2017
- 2017-11-22 CN CN201711169441.4A patent/CN109805214A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112889970A (en) * | 2021-01-14 | 2021-06-04 | 黄祥 | Preparation process and equipment of seed tea |
| CN115517306A (en) * | 2021-01-23 | 2022-12-27 | 辽宁海水碱蓬生物科技有限公司 | Saline-alkali soil tea |
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