CN109805224A - A kind of health drink and preparation method thereof with anti-cancer function - Google Patents
A kind of health drink and preparation method thereof with anti-cancer function Download PDFInfo
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Abstract
A kind of health drink and preparation method thereof with anti-cancer function, it is related to a kind of health drink, it is combined by ultrasonic wave with dynamic countercurrent circulation, ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in water-soluble functional components, polyphenols recovery rate improves 30%-70% compared to traditional extraction process recovery rate in the fluffy cauline leaf of alkali, polyphenols is good " anticarcinogen " in the fluffy cauline leaf of alkali, it can inhibit the activation of carcinogen, resist cell cancerization, conjugated linoleic acid in common seepweed seeds oil, the nutrients such as selenium and flavone compound, with antitumor, it is anti-oxidant, anticancer, the effect of improving immunity, selenium is referred to as " king of anti-cancer " in body trace element by scientist, appropriate selenium-supply is not only able to pre- preventing tumor, the generation of hepatopathy etc., in conjunction with hawthorn, Rose, the leaf of bamboo, honeysuckle, mulberries etc., which have, prevents cancer cell from spreading, and cell is made to grow normalization, and often drinking has effects that anti-cancer, anticancer.
Description
[technical field]
The present invention relates to a kind of health drinks, more particularly, to a kind of with the health drink of anti-cancer function and its preparation side
Method.
[background technique]
The situation is tense for whole world prevention and control of cancer at present, and the following situation also allows of no optimist, and almost everyone experiences cancer
It threatens.Because the whole world is up to 6,300,000 people because of the number of cancer mortality every year, the cancer threat that developing country faces seems outstanding
For sternness, global cancer mortality case in 2005 has 70% to appear in middle and low income country.It data show, developing country's cancer
The average age of disease patient is lower than developed country patient, this should draw attention.The number of cancer mortality has been drunk every year in China
Up to 1,300,000 people, and cancer patient is every year with 3% speed increase, be equivalent in every 200 families just have 1 family by
The torment of cancer.
Cancer how to be prevented, treated as people's increasingly concern, the World Health Organization be even more early in the eighties just
It is proposed 3 1/3 strategies of control cancer.I.e. 1/3 cancer is preventable, and 1/3 cancer is can be with early detection by treating
And fully recover, in addition 1/3 cancer patient can also improve the life quality of patient by existing medical measure.But it is more and more
Opinion tend to: the fundamental solution of mankind's beat cancer is to prevent.
For currently popular general beverage mainly using certain natural material as major ingredient, the auxiliary such as sugaring, water, food additives is former
Material is made.It only has the palatable effect quenched one's thirst, and cannot play for cancer and prevent, treat effect.It is best for cancer
Method be prevention, mainly by advocating the life style of science, the collocation of reasonable diet such as uses natural goods to be prevented
Expect synthetic beverage, virtually can be used to prevent illness, therefore there is an urgent need to a kind of health care productions of virtually cancer-resisting by people
Product.
Suaeda salsa is annual herb salification plant, and the fluffy middle nutritional ingredient of alkali is complete and enriches, the fluffy stem leaf protein matter of alkali,
Fat, carbohydrate three nutritious elements content are higher, and seed fat content accounts for the 36.5% of dry matter, are higher than soybean,
The protein content of fresh and tender cauline leaf accounts for the 40% of dry matter, measures 16 kinds of amino acid in Suaeda salsa altogether, wherein there is 8 kinds of human bodies must
Amino acid is needed, and content is higher, there is expansion blood vessel, enhance human immunity, be depressured, the function of hypoglycemic, prevention and cure of cardiovascular disease
Effect；The essential trace elements of the human body and vitamin abundant there are many also containing during alkali is fluffy, wherein calcium, magnesium, zinc, iron, nickel content are rich
Richness, calcium, phosphorus, iron and core yellow cellulose content are higher than or quite much higher than the vegetables such as spinach, tomato and carrot, Vitamin C content
In general vegetables, vitamin B content is 5-8 times of general vegetables, is much higher than spirulina；Invention Announce number is CN106578918A
Patent document disclose a kind of fluffy healthy and nutritious noodle of selenium-rich alkali and its production technology, it is fluffy that patent document research demonstrates alkali
Middle high 10 times of the more general food of Se content or so, and selenium is referred to as " king of anti-cancer " in body trace element by scientist, tool
There is the effect of anticancer, pre- preventing tumor, the generation of hepatopathy, raising body immunity；Invention Announce number are as follows: CN103027962A's
Patent document discloses a kind of Suaeda salsa extracting flavonoids and content assaying method, and patent document research demonstrates Suaeda salsa
(S.salsa) leaf flavonoids content is higher, and has stronger antioxidant activity, and plant flavone has anti-oxidant, antitumor, anti-dynamic
The multiple efficacies such as pulse atherosclerosis, anti-inflammatory.
The fluffy seed of alkali is rich in unsaturated fatty acid and conjugated linoleic acid, and the crude fat content of the fluffy seed of alkali is considerably beyond soybean
(crude fat content 23%-25%), unsaturated fatty acid content is abundant in seed, and the 90% of the total fat of Zhan, wherein needed by human
For the content of fatty acid up to 70% or more, linolenic acid accounts for 6.08%, has flax of important health-care efficacy in common seepweed seeds oil to human body
Acid content is suitable with soybean oil and wheat malt oil up to 6.08%, is much higher than other common edible oils.Common seepweed seeds oil is rich in micro member
Plain Se, and liposoluble vitamin content is higher, and especially vitamin E, content are up to 2mg/g, and numerous studies sufficiently show
Common seepweed seeds oil has high healthy nutritive value, is a kind of table oil, can be used as new oil resource and is developed；Alkali is fluffy
Contain conjugated linoleic acid in seed, the patent document of application publication number CN104710299A discloses the sub- oil of conjugation in a kind of fluffy seed of alkali
The extracting method of acid, which extracts common seepweed seeds oil from the fluffy seed of alkali using low boiling point solvent, then mentions from common seepweed seeds oil
Take purified conjugate linoleic acid；A large amount of scientific research proves that conjugated linoleic acid is with antitumor, anti-oxidant, anti-atherogenic is hard
Change, norcholesterol, anticancer improve immunity, improve a variety of important physiological functions such as skeleton density, prevention and treatment diabetes；And it can also
It reduces animal and body's cholesterol and triglycerides and low density lipoprotein cholesterol, animal and human body rouge can also be reduced
Fat increases muscle.
The one kind of pigment as polyphenol, the pigment during alkali is fluffy are the valuable sources of natural pigment, and the pigment is through researching and analysing
For water-soluble anthocyanidin.Anthocyanidin has anti-mutation, resists as natural pigment, security performance with higher
The healthcare functions such as oxidation, blood pressure lowering, protection liver, belong to functional food additives.Polyphenols is referred to as " the 7th class battalion
Support element ".Polyphenol is natural " antioxidant ", possesses superpower oxidation resistance, can prevent body from aoxidizing, and can remove human body
The free radical of generation, delaying skin aging；The decomposition for inhibiting collagen, plays crease-resistant function.Moreover, it or it is good
" anticarcinogen " inhibits the activation of carcinogen, resists cell cancerization.
In conclusion the fluffy middle polyphenols of alkali has anticancer health-care function, people also virtually prevent there is an urgent need to a kind of
The health product of cancer anticancer, at present on the market there are no the fluffy middle polyphenol of alkali is not extracted the beverage applied to anticancer, and
Tradition extracts method there are recovery rates low, the bad defect of health-care effect of polyphenol in plant.
[summary of the invention]
In order to overcome the shortcomings in the background art, the present invention develops a kind of health drink with anti-cancer function, passes through
Ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in water-soluble functional components,
The fluffy middle polyphenols recovery rate of alkali improves 30%-70%, the fluffy middle Polyphenols object of alkali compared to traditional extraction process recovery rate
Matter is good " anticarcinogen ", can inhibit the activation of carcinogen, resists cell cancerization, and the conjugation that common seepweed seeds oil is rich in is sub-
The nutrients such as oleic acid, selenium and flavone compound, conjugated linoleic acid have antitumor, anti-oxidant, antiatherosclerosis,
The effect of norcholesterol, anticancer improve immunity, selenium is referred to as " king of anti-cancer " in body trace element by scientist, in right amount
Selenium-supply is not only able to the generation of pre- preventing tumor, hepatopathy etc., and body immunity can be improved, the maintenance heart, liver, lung, stomach etc.
Vitals normal function prevents the generation of senile Cardial or cerebral vascular diseases, in conjunction with hawthorn, rose, the leaf of bamboo, honeysuckle, mulberry
Shen etc., which has, prevents cancer cell from spreading, and cell is made to grow normalization, and often drinking has effects that anti-cancer, anticancer.
For achieving the above object, the present invention adopts the following technical scheme:
A kind of health drink and preparation method thereof with anti-cancer function, includes the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3
Time, removal impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of 1cm~2cm；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, at colloid mill mashing
It manages to 30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
20~1:50 adds deionized water, adds 2%~4% (w/w) cellulase, is added 0.05%~0.08% vitamin C, when enzymatic hydrolysis
Between 20min~30min, 30 DEG C~50 DEG C of hydrolysis temperature, ultrasonic power 50w~200w, extraction time be 1~2 time, merge leaching
Extract；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, obtains the fluffy cauline leaf of saline-alkali land and extracts
Liquid is spare；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened,
Remove soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is small after screening
In 0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature
Degree is 40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed after vacuum drying with pulverizer, is crushed to mesh number as 60 mesh to 150
Mesh；
Step 10, the fluffy powder of seeds of saline-alkali land being subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, one
Grade separating still pressure is 8-10MPa, and the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, two fractions
35 DEG C are regulated to from kettle temperature degree, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, evaporates separation using spiral evaporator
Then ethyl alcohol in object further removes ethyl alcohol in a vacuum drying oven under the conditions of 40 DEG C；
Step 12, the isolate in level-one separating still and the second-order separation kettle is after step 5 removes ethyl alcohol, in level-one separating still
Isolate directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, centrifugal rotational speed
For 30r/min-50r/min, centrifugation time 20min, upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection are taken
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil mix according to the ratio of 4:1
Mixed liquor A；
Step 14, by rose and honeysuckle cleaned according to the ratio of 2:1 plus appropriate amount of water decoction to obtain extracting solution B spare, take
The leaf of bamboo is cleaned plus appropriate amount of water decoction obtains that bamboo juice is spare, by hawthorn, mulberries according to the ratio co-grinding of 3:1, is obtained powder and is added water
Appropriate decoction filters filter residue, takes supernatant to obtain extracting solution C spare；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B, bamboo juice, extracting solution C is according to 1:0.6:
The ratio of 0.3:0.9 is mixed to prepare mixed liquor D；
Step 16, xylitol is added in mixed liquor D；
Step 17, mixed liquor D carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
The health drink and preparation method thereof with anti-cancer function, the fluffy stem leaf extract of the saline-alkali land its
Mineral composition and content are as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, Fe2+162 μ g/
The μ g/L of L~185, the μ g/L of Mn2+5.11 μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, μ g/L of K+0.8 μ g/L~3.0, Na
+ 1746 μ g/L of μ g/L~6899,200 μ of μ g/L~400 g/L of total dissolved solid.
The health drink and preparation method thereof with anti-cancer function, reverse osmosis dress described in step 6 and step 17
Set system configuration are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system is by mechanical filter, adsorption filtration
Device, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is by water purification pot, electrical equipment control
System composition；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after can be with through adsorption filter filtering
Oil removal is removed, however the impurity such as algae can be removed through mechanical filter filtering.
The health drink and preparation method thereof with anti-cancer function, ultrafiltration described in step 6 and step 17 are hollow
Tunica fibrosa ultrafiltration is to remove the microorganisms such as bacterium in solution, mould.
The health drink and preparation method thereof with anti-cancer function, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Due to the adoption of the technical scheme as described above, the invention has the following beneficial effects:
1, the health drink with anti-cancer function of the invention can inhibit to cause by extracting the fluffy middle polyphenols of alkali
The activation of cancer substance resists cell cancerization, selects hawthorn energy prevention and cure of cardiovascular disease in ingredient, has expansion blood vessel, increases hat
Arteries and veins blood flow improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and calmness
It acts on, the substances such as flavonoids and vitamin C, carrotene contained by hawthorn can block and reduce the generation of free radical, can enhance machine
The immunity of body plays the role of anti-aging, anticancer；Rose, rose can inhibit tumour cell, the growth to cancer cell；The leaf of bamboo
In containing a large amount of flavone compound and bioactive polysaccharide and other effective components, such as phenolic acid compound, Anthraquinones
Object, terpene lactone, extraordinary amino acid and active skin, manganese, zinc, selenium and other trace elements are closed, bamboo extractive has excellent resist
Free radical, anti-oxidant, anti-aging, reducing blood lipid and cholesterolemia effect；Honeysuckle, honeysuckle Caprifoliaceae In Flower Buds of Lonicera Japonica Thunb is cold in nature,
It is sweet in flavor enter lung, the heart, stomach meridian.It is anti-inflammatory with clearing heat and detoxicating, the effect of qi-restoratives treats wind, cure mainly disease under turgor, diseases caused by dampness fever, heat toxin
The diseases such as large carbuncle and tumour, active ingredient be chlorogenic acid sweet-scented osmanthus element glycosides, have antibacterial, anti-inflammatory, protect liver, antitumor strengthen immunity it
Effect；Mulberry fruit, the maturescent fruit of moraceae plants mulberry tree is dried or is dried for standby, sweet, slightly cold, enters the heart, lung, kidney channel, this product
It is sweet in flavor can nourishing liver kidney, yin-nourishing blood, have effects that moist intestinal dryness, cure mainly kidney deficiency and liver and deficiency of blood essence having a dizzy spell thanks to；The soreness of waist
Tinnitus；Poliosis；Insomnia and dreamful sleep；The diseases such as injury thirst.Due to its rich in rutin sophorin, malic acid, carrotene, niacin and
Multivitamin has preventing tumour cell diffusion, avoids the effect of cancer development；Polyphenols object is rich in the fluffy stem leaf extract of alkali
Matter, the fluffy middle polyphenols of alkali are good " anticarcinogens ", can inhibit the activation of carcinogen, resist cell cancerization, alkali is fluffy
The nutrients such as conjugated linoleic acid, selenium and the flavone compound that seed oil is rich in, conjugated linoleic acid have antitumor, antioxygen
The effect of change, antiatherosclerosis, norcholesterol, anticancer improve immunity, selenium is referred to as body trace element by scientist
In " king of anti-cancer ", appropriate selenium-supply is not only able to the generation of pre- preventing tumor, hepatopathy etc., and immunity of organism energy can be improved
Power, the vitals normal functions such as the maintenance heart, liver, lung, stomach, prevents the generation of senile Cardial or cerebral vascular diseases；Simultaneously alkali it is fluffy in
Also rich in mineral elements such as calcium, magnesium, iron, manganese, zinc, copper, strontium, sodium, and contain abundant amino acid classes, up to 18 kinds, wherein
Including necessary amino acid: threonine, valine, isoleucine, methionine, leucine, phenylalanine, lysine, tryptophan.It is non-
Necessary amino acid: asparatate, serine, glutamic acid, glycine, alanine, cystine, tyrosine, histidine, smart ammonia
Acid, proline.Wherein essential amino acids content accounts for total amino acid content difference 35.2%, the reference model proposed close to FAO
(36%), it is necessary to which the ratio of amino acid and nonessential amino acid is 55%, the reference model (0.56) proposed close to FAO, can
To provide comprehensive and abundant nutrition.
2, polyphenol recovery rate compared to traditional extraction process recovery rate improves 30%-70% in the fluffy cauline leaf of alkali of the present invention,
It is combined by ultrasonic wave with dynamic countercurrent circulation, so that the fluffy middle polyphenol recovery rate of alkali greatly improves, plays the effect got twice the result with half the effort
Fruit；By ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination greatly remain alkali it is fluffy in water-soluble function
Property ingredient, aqueous enzymatic method combination ultrasonic wave physical process, utilize it generate very big acceleration, strong cavitation effect, acutely vibration
The properties such as dynamic, reduce and ask when extracting, and temperature is avoided to change the activity change to effective component；Ultrasonic wave dynamic countercurrent of the invention
Auxiliary enzymes and ultrafiltration technology combine extract the fluffy middle polyphenols of alkali method simple production process, expend the time it is few, drop
Low production work intensity has many advantages, such as that product effective component is high, reduces temperature and changes bring adverse effect.
3, the present invention using coarse filtration and ultrafiltration effectively eliminate the impurity such as body refuse, suspended matter, algae in extracting solution and
The microorganisms such as bacterium, mould in extracting solution, high degree remain the fluffy extracting solution of alkali, rose and Flos Lonicerae extractive solution, bamboo
The various nutritional ingredients and microelement of the sub- extracting solution of leaf juice, hawthorn, mulberries, it is easy to operate, it is suitable for industrialized production, compares
Traditional filter method, hyperfiltration technique are a kind of purifications for being widely used in water, and pollution-free, low energy consumption, and separator is simple, process
Short, easy to operate, easily controllable and maintenance, installation area are small.Carry out at normal temperature, mild condition without component damage, because
And the separation and enrichment of the particularly suitable substance to this product (thermo-responsive), have very much to the recycling of the micro constitutent in this product
Effect.Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution in ultrafiltration technology pretreatment system, after through adsorbing
Filter filtering can remove the impurity such as oil removal and algae, and then pass through the hollow-fibre membrane of ultrafiltration technology essence filtration system
Ultrafiltration is to remove the microorganisms such as bacterium in extracting solution, mould.
4, the fluffy polyphenols recovery rate of alkali may be up to 5.9% in the present invention, and polyphenols is referred to as " the 7th class nutrition
Element ", the fluffy middle polyphenols of alkali are good " anticarcinogens ", can inhibit the activation of carcinogen, resist cell cancerization, for
Anticancer has significant health-care effect, helps health.
5, the present invention is directed to the critical CO of the fluffy seed part over-extraction of saline-alkali land2Extraction has extraction efficiency high, solvent-free
Residual toxicity, active skull cap components and heat-sensitive ingredients are not easy the destruction that is decomposed, and can keep the natural of extract to the maximum extent
Feature is, it can be achieved that the advantages of Selective Separation.
6, the fluffy raw material of alkali chooses alkali fluffy plant of the growth cycle within 45 days in the present invention, and the fluffy cauline leaf of alkali at this time is fresh
It is tender, rich in nutritional ingredients such as functional pigmented, vitamin, protein and alkaloids；The fluffy seed of saline-alkali land selects 10- in the present invention
November the fluffy seed of saline-alkali land, in addition, the fluffy raw material of alkali selected by the present invention is artificial cultivation, avoiding wild suaeda glauce raw material may
Existing heavy metals exceeding standard problem, artificial cultivation, good growing environment ensure that the safety of raw material.
7, the present invention, which has, is free of sucrose in the health drink of anti-cancer function, pure plant extracting solution, using xylitol,
It is green safe.
8, the health drink to provided by the invention with anti-cancer function carries out physical and chemical index detection, and every main indicator is equal
Meet requirements of the national standard.
[Detailed description of the invention]
Fig. 1 is influence of the liquid-solid ratio to the fluffy pigment extraction effect of alkali；
Fig. 2 is the response surface that solid-liquid ratio, cellulase, vitamin C and ultrasonic power influence polyphenol content.
[specific embodiment]
The present invention can be explained in more detail by the following examples, the open purpose of the present invention is intended to protect the present invention
All changes and improvements in range, the invention is not limited to the following examples；
A kind of health drink and preparation method thereof with anti-cancer function, includes the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3
Time, removal impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of 1cm~2cm；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, at colloid mill mashing
It manages to 30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:
20~1:50 adds deionized water, adds 2%~4% (w/w) cellulase, is added 0.05%~0.08% vitamin C, when enzymatic hydrolysis
Between 20min~30min, 30 DEG C~50 DEG C of hydrolysis temperature, ultrasonic power 50w~200w, extraction time be 1~2 time, merge leaching
Extract；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, obtains the fluffy cauline leaf of saline-alkali land and extracts
Liquid is spare；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened,
Remove soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is small after screening
In 0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature
Degree is 40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed after vacuum drying with pulverizer, is crushed to mesh number as 60 mesh to 150
Mesh；
Step 10, the fluffy powder of seeds of saline-alkali land being subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, one
Grade separating still pressure is 8-10MPa, and the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, two fractions
35 DEG C are regulated to from kettle temperature degree, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, evaporates separation using spiral evaporator
Then ethyl alcohol in object further removes ethyl alcohol in a vacuum drying oven under the conditions of 40 DEG C；
Step 12, the isolate in level-one separating still and the second-order separation kettle is after step 5 removes ethyl alcohol, in level-one separating still
Isolate directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, centrifugal rotational speed
For 30r/min-50r/min, centrifugation time 20min, upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection are taken
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil mix according to the ratio of 4:1
Mixed liquor A；
Step 14, by rose and honeysuckle cleaned according to the ratio of 2:1 plus appropriate amount of water decoction to obtain extracting solution B spare, take
The leaf of bamboo is cleaned plus appropriate amount of water decoction obtains that bamboo juice is spare, by hawthorn, mulberries according to the ratio co-grinding of 3:1, is obtained powder and is added water
Appropriate decoction filters filter residue, takes supernatant to obtain extracting solution C spare；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B, bamboo juice, extracting solution C is according to 1:0.6:
The ratio of 0.3:0.9 is mixed to prepare mixed liquor D；
Step 16, xylitol is added in mixed liquor D；
Step 17, mixed liquor D carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
The health drink and preparation method thereof with anti-cancer function, the fluffy stem leaf extract of the saline-alkali land its
Mineral composition and content are as follows: Ca2+2985 μ g/L~5200 μ g/L, the μ g/L of Mg2+1743 μ g/L~2791, Fe2+162 μ g/
The μ g/L of L~185, the μ g/L of Mn2+5.11 μ g/L~8.03, the μ g/L of Zn+5.27 μ g/L~8.51, μ g/L of K+0.8 μ g/L~3.0, Na
+ 1746 μ g/L of μ g/L~6899,200 μ of μ g/L~400 g/L of total dissolved solid.
The health drink and preparation method thereof with anti-cancer function, reverse osmosis dress described in step 6 and step 17
Set system configuration are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system is by mechanical filter, adsorption filtration
Device, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Corollary system is by water purification pot, electrical equipment control
System composition；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after can be with through adsorption filter filtering
Oil removal is removed, however the impurity such as algae can be removed through mechanical filter filtering.
The health drink and preparation method thereof with anti-cancer function, ultrafiltration described in step 6 and step 17 are hollow
Tunica fibrosa ultrafiltration is to remove the microorganisms such as bacterium in solution, mould.
The health drink and preparation method thereof with anti-cancer function, the hollow-fibre membrane diameter be 0.01 μm~
0.001 μm, feed rate be 900L/h~1500L/h, pressure 0.045Mpa~0.18Mpa, feed concentration be 200 μ g/L~
400 μ g/L, ultrafiltration time 100min~400min, backwash cycle 10min~40min, backwash time 20min~120min, on
Run 10min~40min, upper backwash 20s~120s, lower operation 10min~40min, lower backwash 20s~120s.
Wherein, water used is deionized water, and the minerals in water have been filtered out in deionized water, have avoided calcium in water, magnesium
The interference of plasma.
Addition vitamin C can play the color protection fluffy to alkali, anti-oxidation efficacy in steps of 5, while also can be realized battalion
Support the purpose strengthened.
The detection of every physical and chemical index:
For nutritional ingredient composition and content situation in the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil, pass through
Micro-kjoldahl method measures crude protein content；Using determination of crude oil by Soxhlet extraction；It is thick using gravimetry
Fiber content；Moisture content is measured using atmosphere pressure desiccation；Carbohydrate content is measured using anthrone colorimetry；Using high temperature
Ash purification determining content of ashes；Amino acid content is measured using Hitachi 835-50 type high-speed amino acid analyzer；Using fluorescence point
Light photometry measures tryptophan composition and content；Using atomic absorption spectroscopy determination mineral element, wherein selenium element is used
Fluorescence spectrophotometry；Every nutritional ingredient and content are shown in Table 1-3 in the common seepweed seeds oil of salt-soda soil, and the fluffy cauline leaf of saline-alkali land mentions
Every nutritional ingredient and content in liquid is taken to be shown in Table 4-6:
Main nutrient composition content in 1 salt-soda soil common seepweed seeds oil of table
2 salt-soda soil common seepweed seeds oil Mineral Element Contents (μ g/g) of table
The composition and content (mg/g) of amino acid in 3 salt-soda soil common seepweed seeds oil of table
Note: band * person is essential amino acid.
The fluffy stem leaf extract nutrient content of 4 saline-alkali land of table
The fluffy stem leaf extract Mineral Elements in Jadeite Shellfish content of 5 alkali of table
The fluffy stem leaf extract amino acid content of 6 saline-alkali land of table
Pass through nutritional ingredient composition and content situation in the fluffy stem leaf extract of measurement saline-alkali land and salt-soda soil common seepweed seeds oil
It can be seen that
The comparison of table 1 and table 4 can be seen that crude protein, crude fat content in the common seepweed seeds oil of salt-soda soil: 18.75% and
23.46%, much higher than crude protein, crude fat content in the fluffy stem leaf extract of saline-alkali land: 3.020% and 1.380%, and salt
Alkali in common seepweed seeds oil crude fat content account for 23.46%, be higher than soybean (crude fat content 18.80%), be good plant
Oil sources can be used as good protein sources, vitamin in the fluffy stem leaf extract of saline-alkali land since its crude protein content is also higher
Content is higher, in addition, the chemotrophy ingredient of the fluffy seed of saline-alkali land and the fluffy cauline leaf of saline-alkali land is complete and enriches.
The comparison of table 2 and table 5 can be seen that salt-soda soil common seepweed seeds oil Mineral Elements potassium and the content of sodium is the abundantest,
This is related with the saline-alkali environment that it grows, close with human health in salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land
It is higher to cut the constituent contents such as relevant iron, calcium, zinc, copper, manganese, it is seen then that the fluffy seed of saline-alkali land and the fluffy cauline leaf of saline-alkali land are one
Kind good mineral matter nutritional source, in addition, also contain selenium in the common seepweed seeds oil of salt-soda soil, it is micro that selenium by scientist is referred to as human body
" king of anti-cancer " in element therefore develops the fluffy seed of saline-alkali land and can be the mankind using the selenium contained by the fluffy seed of saline-alkali land
Bring high value medical health care.
The comparison of table 3 and table 6, which can be seen that in salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land, contains 18
Middle amino acid, rich content, it is necessary to which amino acid composition is complete, and wherein it is total to account for amino acid for the fluffy seed essential amino acids content of saline-alkali land
The 36.44% of amount is higher than FAO mode (36.00%), while the ratio between the fluffy seed essential amino acid of saline-alkali land and nonessential amino acid
It (E/N) is 0.573, also above FAO mode (0.56), it is seen then that the fluffy seed albumen of alkali belongs to quality plant albumen；The fluffy stem of saline-alkali land
It is 35.5% that essential amino acids content, which accounts for total amino acid content, in leaf, the reference model (36%) proposed close to FAO, it is necessary to amino acid
Ratio with nonessential amino acid is 55.1%, the reference model (0.56) proposed close to FAO；In addition, the research discovery fluffy seed of alkali
The common seepweed seeds oil obtained after processing is refined has the physicochemical property of general edible oil, and it is next to can be used as a kind of new edible oil
Exploitation, it is rich in unsaturated fatty acid in addition, and especially linoleic acid content is higher than many plants, it can be seen that, common seepweed seeds oil is one
Kind of vegetable oil new resources containing high linoleic acid, have important a nutrition health-care functions and biggish Development volue, in common seepweed seeds oil
Rich in unsaturated fatty acid, total unsaturated fatty acid content is up to 90.65%, and wherein linoleic acid content accounts for 68.74%, is current
It was found that one of the higher oil sources of linoleic acid content, physical and chemical index also substantially conforms to edible oil standard, is a kind of ideal
The good material of edible health-care oil and preparation conjugated linoleic acid.
By above-mentioned analysis it is found that the nutritional ingredient being rich in by the fluffy seed of saline-alkali land and the fluffy stem and leaf part of saline-alkali land
It is biased to difference, the present invention can be made by deploying salt-soda soil common seepweed seeds oil and the fluffy stem leaf extract of saline-alkali land in proportion
Fluffy middle the be rich in nutritional ingredient effect of alkali is maximized, is played to greatest extent saline and alkaline by the health drink with anti-cancer function
The fluffy edible value of ground alkali.
Preparation method described in Example preparation the health drink with anti-cancer function, by GB/T12143.1,
GB8537-1995, GB4789 examination criteria compare indices, the results are shown in Table 7.
Table 7 has the health drink indices of anti-cancer function
It is all satisfied by the visible health drink items main indicator according to prepared by the present invention with anti-cancer function of 7 result of table
Requirements of the national standard.
In order to determine the solid-liquid ratio in the fluffy stem leaf extract preparation process of alkali, the present invention is directed to the feed liquid of alkali fluffy cauline leaf and water
Than carrying out experimental study, liquid-solid ratio is obtained to the influence diagram of the fluffy pigment extraction effect of alkali, as shown in Figure 1, as shown in Figure 1, with
The absorbance of the increase of liquid-solid ratio, pigment solution gradually rises, and when liquid-solid ratio is 40:1, light absorption value is significantly increased, and obtains alkali
Fluffy pigment recovery rate also significantly increases, and when liquid-solid ratio is greater than 40:1, curve tends towards stability, and absorbance changes less, and synthesis is examined
Consider energy-saving and emission-reduction, selects liquid-solid ratio for 40:1 (mL/g).
On the basis of above-mentioned single factor experiment, solid-liquid ratio, 4 cellulase, vitamin C and ultrasonic power factors are chosen
Box-Behnken design is carried out, the maximum value of polyphenol content in the fluffy stem leaf extract of alkali is studied, the results are shown in Table 8:
Table 8Box-Behnken experimental design scheme and result
Regression fit is carried out to 8 test data of table using 8.0 design software of Design-Expert, obtains polyphenol content pair
Solid-liquid ratio, cellulase, 4 factors of vitamin C and ultrasonic power secondary multinomial regression model:
Polyphenol content=5.55+0.13A+0.19B+0.32C+0.19D-0.33A2-0.39B2-0.28C2-0.96D2
9 response surface design quadratic regression equation model the results of analysis of variance of table
Note: * significant difference p < 0.05；The extremely significant p < 0.01 of * difference.
Make response surface figure according to regression equation, investigate the shape of be fitted response surface, analysis solid-liquid ratio, cellulase,
Fig. 2 is met personally in the influence of vitamin C and ultrasonic power to polyphenol content, response.As shown in Table 9, mutation model p value < 0.0001,
Reach extremely significant level, illustrates that the models fitting degree is fine.It as shown in Figure 2, is 1:50, cellulase 3%, dimension in solid-liquid ratio
Raw element C 0.05%, ultrasonic power 125w, polyphenol content reach peak, and the result and experiment of single factor result one
It causes.
It is above-mentioned the experimental results showed that, the present invention passes through ultrasonic wave auxiliary, aqueous enzymatic extraction and ultrafiltration technology triple combination pole
It is big remain alkali it is fluffy in water-soluble functional components, polyphenols recovery rate is mentioned compared to tradition in the fluffy stem and leaf part of alkali
The method recovery rate of taking improves 30%-70%, and polyphenols is good " anticarcinogen " in the fluffy stem and leaf part of alkali, can inhibit
Cell cancerization is resisted in the activation of carcinogen, is had significant health-care effect for anticancer, is helped health, common seepweed seeds oil institute
The nutrients such as the conjugated linoleic acid, selenium and the flavone compound that are rich in, conjugated linoleic acid have antitumor, anti-oxidant, anti-
The effect of atherosclerosis, norcholesterol, anticancer improve immunity, selenium is referred to as in body trace element by scientist
" king of anti-cancer ", appropriate selenium-supply are not only able to the generation of pre- preventing tumor, hepatopathy etc., and body immunity can be improved, dimension
The vitals normal function such as shield heart, liver, lung, stomach, prevents the generation of senile Cardial or cerebral vascular diseases, in conjunction with hawthorn, rose
Flower, the leaf of bamboo, honeysuckle, mulberries etc. have prevent cancer cell from spreading, make cell grow normalization, often drink with anti-cancer,
The effect of anticancer.
Health drink produced by the present invention with anti-cancer function is tested for the mouse after obtaining induction adenocarcinoma of lung,
Since a portion mouse starting induction, and daily feeding anticancer health beverage of the present invention, feeding amount are daily 2mL respectively,
By anticancer health beverage of the present invention dilute 100 times, control group be not feeding the present invention in anticancer health beverage product control group；
Physiological saline group is the physiological saline of feeding dosage as the present invention；After induction after 40 days, puts to death mouse and is detected,
Acquired results such as the following table 10:
10 control mice experimental result of table
| Mouse quantity | Dosage | Canceration result after induction 40 days | |
| Beverage of the invention | 30 | 2ml | Have no obvious lesion |
| Physiological saline group | 30 | 2ml | There is cancer nests |
| Control group | 30 | --- | There is cancer nests |
Part not in the detailed description of the invention is the prior art.
Claims (5)
1. a kind of health drink and preparation method thereof with anti-cancer function, it is characterized in that: including the following steps:
The fluffy stem leaf extract preparation of saline-alkali land:
Step 1, the fluffy stem of fresh saline-alkali land and blade are acquired, is put into guarantor's food peace food purifying machine and cleans 1 time~3 times, go
Except impurity and agriculture are residual, kill bacterium, guarantee that safety edible is used；
Step 2, by after cleaning Jian Peng stem and blade be put into vegetable-chopper and be cut into every section of cm of 1 cm~2；
Step 3, the Jian Peng stem cut and blade are mixed with deionized water 1:0.5~1:2, using colloid mill mashing handle to
30 mesh~50 mesh；
Step 4, continue the slurries in pulverising step 3 to 60 mesh~200 mesh using high-accuracy Wet ultrafine grinding equipment；
Step 5, smashed material is put into ultrasonic wave dynamic countercurrent circulation extracting concentrating equipment, by feed liquid mass ratio 1:20~
1:50 adds deionized water, adds 2%~4%(w/w) cellulase, 0.05%~0.08% vitamin C, 20 min of enzymolysis time is added
~30 min, 30 DEG C~50 DEG C of hydrolysis temperature, the ultrasonic power w of 50 w~200, extraction time is 1~2 time, merges extraction
Liquid；
Step 6, the leaching liquor of step 5 is subjected to coarse filtration, ultrafiltration by reverse osmosis unit, it is standby obtains the fluffy stem leaf extract of saline-alkali land
With；
The preparation of salt-soda soil common seepweed seeds oil:
Step 7, the fluffy seed of saline-alkali land is acquired, impurity elimination is screened, is sent into cleaning screen after the fluffy seed metering of saline-alkali land and is screened, removed
Soil, rubble, seed shell and dust；Through magnetic separator except de-iron is miscellaneous, stone remover removes rubble, clod, and impurity content is less than after screening
0.1%；
Step 8, the fluffy seed of saline-alkali land is put into vacuum oven, uniformly spreads out, is dried in vacuo, vacuum drying temperature is
40-60 DEG C, vacuum degree 10Pa-200Pa, vacuum drying time 3h-6h；
Step 9, the fluffy seed of saline-alkali land is crushed with pulverizer after vacuum drying, being crushed to mesh number is 60 mesh to 150 mesh；
Step 10, the fluffy powder of seeds of saline-alkali land is subjected to supercritical carbon dioxide extracting, separate mode is the second-order separation, a fraction
It is 8-10MPa from kettle pressure, the second-order separation kettle pressure is 5-8MPa, and level-one separating still temperature is regulated to 55 DEG C, the second-order separation kettle
Temperature is regulated to 35 DEG C, extraction time 2.5h-4.5h；
Step 11, the isolate in level-one separating still and the second-order separation kettle is collected, is evaporated in isolate using spiral evaporator
Ethyl alcohol, then under the conditions of 40 DEG C in a vacuum drying oven further removal ethyl alcohol；
Step 12, point of the isolate in level-one separating still and the second-order separation kettle after step 5 removes ethyl alcohol, in level-one separating still
From object directly as salt-soda soil common seepweed seeds oil, the isolate in the second-order separation kettle is centrifuged with centrifuge, and centrifugal rotational speed is
30r/min -50r/min, centrifugation time 20min take upper layer oil reservoir, the saline-alkali land being incorporated in level-one separating still after collection
In fluffy seed oil, it is spare that salt-soda soil common seepweed seeds oil is obtained after mixing；
Step 13, it carries out the fluffy stem leaf extract of saline-alkali land and salt-soda soil common seepweed seeds oil to mix to obtain mixing according to the ratio of 4:1
Liquid A；
Step 14, by rose and honeysuckle cleaned according to the ratio of 2:1 plus appropriate amount of water decoction to obtain extracting solution B spare, take the leaf of bamboo
It cleans plus appropriate amount of water decoction obtains that bamboo juice is spare, by hawthorn, mulberries according to the ratio co-grinding of 3:1, obtain powder and add appropriate amount of water
Decoction filters filter residue, takes supernatant to obtain extracting solution C spare；
Step 15, by mixed liquor A made from step 13 and step 14, extracting solution B, bamboo juice, extracting solution C is according to 1:0.6:0.3:
0.9 ratio is mixed to prepare mixed liquor D；
Step 16, xylitol is added in mixed liquor D；
Step 17, mixed liquor D carries out coarse filtration, ultrafiltration by reverse osmosis unit, and sterile filling to obtain the final product.
2. the health drink and preparation method thereof according to claim 1 with anti-cancer function, it is characterized in that: the salt
Alkali its mineral composition of the fluffy stem leaf extract of alkali and content it is as follows: the 2985 μ g/L of μ g/L~5200 of Ca2+, 1743 Mg2+
The μ g/L of μ g/L~2791,162 the Fe2+ μ g/L of μ g/L~185,5.11 the Mn2+ μ g/L of μ g/L~8.03,5.27 Zn+ μ
The μ g/L of g/L~8.51,0.8 the K+ μ g/L of μ g/L~3.0,1746 Na+ μ g/L of μ g/L~6899, total dissolved solid 200
The μ of μ g/L~400 g/L.
3. the health drink and preparation method thereof according to claim 1 with anti-cancer function, it is characterized in that: step 6 and
Reverse osmosis unit system configuration described in step 17 are as follows: pretreatment system, smart filtration system, corollary system；Pretreatment system by
Mechanical filter, adsorption filter, cartridge filter composition；Smart filtration system is made of hollow-fibre ultrafiltration device；Breed system
System is made of water purification pot, electrical control system；Mechanical filter filtering can remove body refuse and fiber etc. in extracting solution, after pass through
Adsorption filter filtering can remove oil removal, however can remove the impurity such as algae through mechanical filter filtering.
4. the health drink and preparation method thereof according to claim 3 with anti-cancer function, it is characterized in that: step 6 and
Ultrafiltration described in step 17 is hollow-fibre membrane ultrafiltration to remove the microorganisms such as bacterium in extracting solution, mould.
5. the health drink and preparation method thereof according to claim 3 or 4 with anti-cancer function, it is characterized in that: described
Hollow-fibre membrane diameter be 0.01 μm~0.001 μm, feed rate be the L/h of 900 L/h~1500,0.045 Mpa of pressure~
0.18 Mpa, feed concentration are the 200 μ g/L of μ g/L~400, ultrafiltration time 100 min~400 min, 10 min of backwash cycle
~40 min, backwash time 20 min~120 min, upper operation 10 min~40 min, upper backwash 20 s~120 s, lower fortune
Row 10 min~40 min, lower backwash 20 s~120 s.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117018755A (en) * | 2023-10-10 | 2023-11-10 | 北京逯博士行为医学科技研究院有限公司 | Preparation method of mixture with anticancer component |
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|---|---|---|---|---|
| CN101074405A (en) * | 2007-07-13 | 2007-11-21 | 杨庆利 | Extraction of common seepweed seeds oil by supercritical CO2 fluid |
| CN105029632A (en) * | 2015-07-30 | 2015-11-11 | 潍坊友容实业有限公司 | Suaeda salsa fermented beverage and preparation method thereof |
| CN106071555A (en) * | 2016-06-27 | 2016-11-09 | 青岛铭晨信息技术有限公司 | A kind of Herba suadeae glaucae health beverage with function of delaying senility |
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2017
- 2017-11-22 CN CN201711169442.9A patent/CN109805224A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101074405A (en) * | 2007-07-13 | 2007-11-21 | 杨庆利 | Extraction of common seepweed seeds oil by supercritical CO2 fluid |
| CN105029632A (en) * | 2015-07-30 | 2015-11-11 | 潍坊友容实业有限公司 | Suaeda salsa fermented beverage and preparation method thereof |
| CN106071555A (en) * | 2016-06-27 | 2016-11-09 | 青岛铭晨信息技术有限公司 | A kind of Herba suadeae glaucae health beverage with function of delaying senility |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117018755A (en) * | 2023-10-10 | 2023-11-10 | 北京逯博士行为医学科技研究院有限公司 | Preparation method of mixture with anticancer component |
| CN117018755B (en) * | 2023-10-10 | 2023-12-22 | 北京逯博士行为医学科技研究院有限公司 | Preparation method of mixture with anticancer component |
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