CN109790164B - 作为胆碱激酶抑制剂的嘌呤和3-去氮杂嘌呤类似物 - Google Patents

作为胆碱激酶抑制剂的嘌呤和3-去氮杂嘌呤类似物 Download PDF

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Publication number
CN109790164B
CN109790164B CN201780058594.3A CN201780058594A CN109790164B CN 109790164 B CN109790164 B CN 109790164B CN 201780058594 A CN201780058594 A CN 201780058594A CN 109790164 B CN109790164 B CN 109790164B
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compound
amino
purin
cis
cyclohexanecarboxamide
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Chinese (zh)
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CN109790164A (zh
Inventor
E·卡萨莱
艾米丽亚娜·科尔蒂
P·戈奇
M·内斯
S·C·奥兰纽斯
F·夸尔蒂耶里
费德里科·里卡尔迪西尔托里
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Nerviano Medical Sciences SRL
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Nerviano Medical Sciences SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780058594.3A 2016-07-25 2017-07-19 作为胆碱激酶抑制剂的嘌呤和3-去氮杂嘌呤类似物 Active CN109790164B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16181105 2016-07-25
EP16181105.4 2016-07-25
PCT/EP2017/068255 WO2018019681A1 (en) 2016-07-25 2017-07-19 Purine and 3-deazapurine analogues as choline kinase inhibitors

Publications (2)

Publication Number Publication Date
CN109790164A CN109790164A (zh) 2019-05-21
CN109790164B true CN109790164B (zh) 2022-01-25

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Country Status (6)

Country Link
US (1) US10683292B2 (cg-RX-API-DMAC10.html)
EP (1) EP3487857B1 (cg-RX-API-DMAC10.html)
JP (1) JP6920411B2 (cg-RX-API-DMAC10.html)
CN (1) CN109790164B (cg-RX-API-DMAC10.html)
ES (1) ES2899114T3 (cg-RX-API-DMAC10.html)
WO (1) WO2018019681A1 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310695B (zh) 2016-04-21 2022-04-01 阿斯特罗赛特制药公司 治疗神经和心血管病况的化合物和方法
CN110183442A (zh) * 2019-06-06 2019-08-30 无锡合全药业有限公司 一种1 -(乙氧羰基)咪唑并[1, 5]吡啶-6-羧酸的合成方法
US20240368164A1 (en) * 2021-04-28 2024-11-07 Astrocyle Pharmaceuticals, Inc. Purine nucleosides, their intermediates, and methods of preparation thereof
JP7856405B2 (ja) 2021-11-17 2026-05-11 信越化学工業株式会社 有機膜形成用組成物、パターン形成方法並びに有機膜形成用化合物及び重合体
WO2023205366A1 (en) * 2022-04-20 2023-10-26 Carthronix, Inc. Small molecule modulators of gp130 signaling pathways
WO2024044751A2 (en) * 2022-08-26 2024-02-29 Wake Forest University Health Sciences Peroxiredoxin 3 inhibitors and methods of use for treating cancer
CN115403593B (zh) * 2022-09-22 2024-02-02 河南师范大学 一种环加成合成手性嘌呤[3,2-c]并噁唑化合物的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009116074A2 (en) * 2008-02-13 2009-09-24 Cadila Healthcare Limited Substituted benzimidazoles as cannabinoid modulator
CN103687964A (zh) * 2011-06-20 2014-03-26 特拉斯雷神诺癌症医药有限公司 用于预测患有癌症之对象对化疗之临床响应的方法
WO2014151761A1 (en) * 2013-03-15 2014-09-25 Ariad Pharmaceuticals, Inc. Novel choline kinase inhibitors
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
WO2015151006A1 (en) * 2014-03-29 2015-10-08 Lupin Limited Substituted purine compounds as btk inhibitors
CN109311882A (zh) * 2016-05-04 2019-02-05 Bci制药公司 作为蛋白激酶抑制剂的腺嘌呤衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2528107B2 (ja) * 1985-03-15 1996-08-28 サマ−トン，ジエ−ムス ポリヌクレオチド測定試薬と方法
DE10139730A1 (de) * 2001-08-13 2003-02-27 Nanogen Recognomics Gmbh Verfahren zur Herstellung CNA
ES2385219T3 (es) * 2003-09-12 2012-07-19 Merck Serono Sa Derivados de sulfonamida para el tratamiento de diabetes
ES2237332B1 (es) 2004-01-14 2006-11-01 Consejo Sup. Investig. Cientificas Derivados de piridinio y quinolinio.
ES2277568B1 (es) 2005-12-30 2008-04-01 Consejo Superior De Investigaciones Cientificas Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
US9273028B2 (en) * 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
US20130281445A1 (en) 2011-09-22 2013-10-24 Simon Everitt Compounds useful as inhibitors of choline kinase
KR20140064987A (ko) 2011-09-22 2014-05-28 버텍스 파마슈티칼스 인코포레이티드 콜린 키나제의 억제제로서 유용한 화합물
CN104507923B (zh) * 2012-08-02 2018-02-09 内尔维阿诺医学科学有限公司 作为激酶抑制剂的取代的吡咯类活性剂
ES2482290B1 (es) 2014-06-05 2015-05-19 Universidad De Granada Inhibidores polares simétricos de colina cinasa con actividad antitumoral
EP3912979B1 (en) * 2015-06-03 2026-03-25 Principia Biopharma Inc. Tyrosine kinase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009116074A2 (en) * 2008-02-13 2009-09-24 Cadila Healthcare Limited Substituted benzimidazoles as cannabinoid modulator
CN103687964A (zh) * 2011-06-20 2014-03-26 特拉斯雷神诺癌症医药有限公司 用于预测患有癌症之对象对化疗之临床响应的方法
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
WO2014151761A1 (en) * 2013-03-15 2014-09-25 Ariad Pharmaceuticals, Inc. Novel choline kinase inhibitors
WO2015151006A1 (en) * 2014-03-29 2015-10-08 Lupin Limited Substituted purine compounds as btk inhibitors
CN109311882A (zh) * 2016-05-04 2019-02-05 Bci制药公司 作为蛋白激酶抑制剂的腺嘌呤衍生物

Also Published As

Publication number Publication date
JP2019522018A (ja) 2019-08-08
ES2899114T3 (es) 2022-03-10
EP3487857A1 (en) 2019-05-29
JP6920411B2 (ja) 2021-08-18
EP3487857B1 (en) 2021-09-01
US20190225615A1 (en) 2019-07-25
CN109790164A (zh) 2019-05-21
WO2018019681A1 (en) 2018-02-01
US10683292B2 (en) 2020-06-16

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