CN109725141B - Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 - Google Patents
Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 Download PDFInfo
- Publication number
- CN109725141B CN109725141B CN201811571829.1A CN201811571829A CN109725141B CN 109725141 B CN109725141 B CN 109725141B CN 201811571829 A CN201811571829 A CN 201811571829A CN 109725141 B CN109725141 B CN 109725141B
- Authority
- CN
- China
- Prior art keywords
- freeze
- drying
- magnetic bead
- working solution
- dried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011324 bead Substances 0.000 title claims abstract description 82
- 238000004108 freeze drying Methods 0.000 title claims abstract description 74
- 239000012224 working solution Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims abstract description 18
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims abstract description 18
- 239000007853 buffer solution Substances 0.000 claims abstract description 14
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims abstract description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 13
- 239000011259 mixed solution Substances 0.000 claims abstract description 7
- 238000011065 in-situ storage Methods 0.000 claims abstract description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 32
- 239000004471 Glycine Substances 0.000 claims description 16
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 15
- 229920001202 Inulin Polymers 0.000 claims description 15
- 229930195725 Mannitol Natural products 0.000 claims description 15
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 15
- 108010090804 Streptavidin Proteins 0.000 claims description 15
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 15
- 229940029339 inulin Drugs 0.000 claims description 15
- 239000000594 mannitol Substances 0.000 claims description 15
- 235000010355 mannitol Nutrition 0.000 claims description 15
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 15
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 15
- QYYMDNHUJFIDDQ-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one Chemical compound CN1SC=CC1=O.CN1SC(Cl)=CC1=O QYYMDNHUJFIDDQ-UHFFFAOYSA-N 0.000 claims description 12
- 230000005496 eutectics Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 235000018102 proteins Nutrition 0.000 claims description 9
- 238000007710 freezing Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000003223 protective agent Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 239000005018 casein Substances 0.000 claims description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical group NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 4
- 235000021240 caseins Nutrition 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 238000000859 sublimation Methods 0.000 claims description 4
- 230000008022 sublimation Effects 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000003795 desorption Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
- 102000011632 Caseins Human genes 0.000 abstract description 14
- 108010076119 Caseins Proteins 0.000 abstract description 14
- 229940080237 sodium caseinate Drugs 0.000 abstract description 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract description 8
- 102000004190 Enzymes Human genes 0.000 abstract description 8
- 108090000790 Enzymes Proteins 0.000 abstract description 8
- 239000000427 antigen Substances 0.000 abstract description 6
- 102000036639 antigens Human genes 0.000 abstract description 6
- 108091007433 antigens Proteins 0.000 abstract description 6
- 238000006243 chemical reaction Methods 0.000 abstract description 6
- 239000000758 substrate Substances 0.000 abstract description 6
- 230000027455 binding Effects 0.000 abstract description 5
- 229960002685 biotin Drugs 0.000 abstract description 4
- 235000020958 biotin Nutrition 0.000 abstract description 4
- 239000011616 biotin Substances 0.000 abstract description 4
- 230000006287 biotinylation Effects 0.000 abstract description 4
- 238000007413 biotinylation Methods 0.000 abstract description 4
- 238000006555 catalytic reaction Methods 0.000 abstract description 2
- 239000000872 buffer Substances 0.000 description 13
- 238000001514 detection method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000005092 sublimation method Methods 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XYIPYISRNJUPBA-UHFFFAOYSA-N [3-(3'-methoxyspiro[adamantane-2,4'-dioxetane]-3'-yl)phenyl] dihydrogen phosphate Chemical compound O1OC2(C3CC4CC(C3)CC2C4)C1(OC)C1=CC=CC(OP(O)(O)=O)=C1 XYIPYISRNJUPBA-UHFFFAOYSA-N 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036046 immunoreaction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Enzymes And Modification Thereof (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811571829.1A CN109725141B (zh) | 2018-12-21 | 2018-12-21 | Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811571829.1A CN109725141B (zh) | 2018-12-21 | 2018-12-21 | Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109725141A CN109725141A (zh) | 2019-05-07 |
CN109725141B true CN109725141B (zh) | 2022-04-29 |
Family
ID=66296286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811571829.1A Active CN109725141B (zh) | 2018-12-21 | 2018-12-21 | Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109725141B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110426513A (zh) * | 2019-05-23 | 2019-11-08 | 武汉三鹰生物技术有限公司 | 一种无外源蛋白干扰的elisa标准品的制备方法 |
CN110632322B (zh) * | 2019-08-27 | 2021-07-13 | 迪瑞医疗科技股份有限公司 | 载脂蛋白c2校准品的冻干制备工艺 |
CN111999509A (zh) * | 2020-08-10 | 2020-11-27 | 深圳市宇诺生物技术有限公司 | 抗缪勒氏管激素测定试剂盒、制备方法及检测方法 |
CN112748242B (zh) * | 2020-12-21 | 2023-07-21 | 珠海碳云智能科技有限公司 | 用于多肽芯片技术平台检测的二抗缓冲封闭液、包括其的试剂盒及其应用 |
CN113005117B (zh) * | 2021-02-26 | 2021-11-09 | 北京中科生仪科技有限公司 | 一种磁珠干化保护液、干化磁珠及其制备方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103472235A (zh) * | 2013-08-26 | 2013-12-25 | 河北省科学院生物研究所 | 一种长效蛋白质溶液稳定剂 |
CN104730253A (zh) * | 2015-03-20 | 2015-06-24 | 国家纳米科学中心 | 一种基于点击化学的检测试纸条、检测方法和应用 |
CN105445463A (zh) * | 2014-09-25 | 2016-03-30 | 苏州新波生物技术有限公司 | 一种戊肝IgG抗体检测试剂盒及其制备方法和应用 |
CN107656043A (zh) * | 2017-09-21 | 2018-02-02 | 苏州新波生物技术有限公司 | 一种c反应蛋白磁微粒检测试剂盒及其使用方法 |
CN108008125A (zh) * | 2017-12-18 | 2018-05-08 | 江苏浩欧博生物医药股份有限公司 | 一种适用于免疫磁珠的冻干工作液和免疫磁珠冻干品及其制备方法 |
CN108226481A (zh) * | 2018-01-08 | 2018-06-29 | 宁波紫园医疗器械有限公司 | 一种用于化学发光免疫检测试剂的磁珠试剂 |
CN108445214A (zh) * | 2018-02-02 | 2018-08-24 | 浙江艾明德生物科技有限公司 | 一种定量检测d-二聚体的试剂盒及制备方法 |
CN108780088A (zh) * | 2015-11-06 | 2018-11-09 | 维蒂卡实验室公司 | 在伴侣动物中检测炎症标志物和治疗炎性病症的方法 |
CN108993621A (zh) * | 2018-07-09 | 2018-12-14 | 浙江大学 | 一种用于数字酶联免疫检测的微小室阵列微流控芯片及方法 |
-
2018
- 2018-12-21 CN CN201811571829.1A patent/CN109725141B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103472235A (zh) * | 2013-08-26 | 2013-12-25 | 河北省科学院生物研究所 | 一种长效蛋白质溶液稳定剂 |
CN105445463A (zh) * | 2014-09-25 | 2016-03-30 | 苏州新波生物技术有限公司 | 一种戊肝IgG抗体检测试剂盒及其制备方法和应用 |
CN104730253A (zh) * | 2015-03-20 | 2015-06-24 | 国家纳米科学中心 | 一种基于点击化学的检测试纸条、检测方法和应用 |
CN108780088A (zh) * | 2015-11-06 | 2018-11-09 | 维蒂卡实验室公司 | 在伴侣动物中检测炎症标志物和治疗炎性病症的方法 |
CN107656043A (zh) * | 2017-09-21 | 2018-02-02 | 苏州新波生物技术有限公司 | 一种c反应蛋白磁微粒检测试剂盒及其使用方法 |
CN108008125A (zh) * | 2017-12-18 | 2018-05-08 | 江苏浩欧博生物医药股份有限公司 | 一种适用于免疫磁珠的冻干工作液和免疫磁珠冻干品及其制备方法 |
CN108226481A (zh) * | 2018-01-08 | 2018-06-29 | 宁波紫园医疗器械有限公司 | 一种用于化学发光免疫检测试剂的磁珠试剂 |
CN108445214A (zh) * | 2018-02-02 | 2018-08-24 | 浙江艾明德生物科技有限公司 | 一种定量检测d-二聚体的试剂盒及制备方法 |
CN108993621A (zh) * | 2018-07-09 | 2018-12-14 | 浙江大学 | 一种用于数字酶联免疫检测的微小室阵列微流控芯片及方法 |
Also Published As
Publication number | Publication date |
---|---|
CN109725141A (zh) | 2019-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109725141B (zh) | Sa-磁珠冻干工作液、sa-磁珠冻干品及冻干品的制备方法 | |
CA1098824A (en) | Stabilized peroxidase reagent for enzyme immunoassay | |
US20040171087A1 (en) | Quantitative single-step immunoassay in lyophilized form | |
CA2459211C (en) | Products containing quantum of bioparticles and method for production thereof | |
JPH07500417A (ja) | 特異的結合アッセイ用の使用単位の試薬組成物 | |
US20210048247A1 (en) | Method of microwave vacuum drying spherical-shaped pellets of biological materials | |
CN114002443A (zh) | 可滤血色素冻干球均相发光免疫检测试剂盒及其制备方法 | |
CN111965344A (zh) | 一种冻干磁微粒化学发光免疫检测试剂盒及其制备方法 | |
CN113355388B (zh) | 一种基于核酸外切酶ⅲ辅助信号放大的免疫吸附检测氯霉素的方法 | |
CN113484258A (zh) | 一种c-反应蛋白检测试剂冻干微球及制备方法 | |
WO2023142398A1 (zh) | 一种新冠rbd蛋白荧光微球复合制剂 | |
CN116183903A (zh) | 一种用于AlphaLISA检测的冻干保护剂组合物及其制备方法 | |
JP2008203135A (ja) | 検査デバイスの標識体部の形成方法及びラテラルフロー免疫測定用検査デバイス | |
EP0609265B1 (en) | Unit-of-use reagent composition for specific binding assays | |
CN107502567B (zh) | 发光杆菌冻干粉及其制备方法 | |
US20030175827A1 (en) | Stable thin film dried protein composition or device and related methods | |
JP2021505878A5 (zh) | ||
CN116479088A (zh) | 一种生物试剂冻干保存的试剂组合、试剂盒、方法及应用 | |
CN113005117B (zh) | 一种磁珠干化保护液、干化磁珠及其制备方法 | |
Berge et al. | Preservation of enteroviruses by freeze-drying | |
CN106248976A (zh) | 一种检测四种硝基呋喃代谢物胶体金试纸条及其制备方法 | |
EP0607209B1 (en) | Unit-of-use reagent compositions for specific binding assays | |
JPS62194459A (ja) | 固相化試薬の安定化剤 | |
JPS62151758A (ja) | 免疫測定用材料の製造方法 | |
RU2749355C1 (ru) | Способ лиофилизации эритроцитарных диагностикумов туляремийных |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190729 Address after: 523871 Room 301, 3rd floor, 368 Zhenan Middle Road, Sha Community, Chang'an Town, Dongguan City, Guangdong Province Applicant after: Dongguan Dongyang Sunshine Medical Intelligent Device R&D Co.,Ltd. Address before: 523871 No. 368 Zhenan Middle Road, Chang'an Town, Dongguan City, Guangdong Province Applicant before: DONGGUAN HEC TECH R&D Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of SA magnetic bead freeze-drying working solution, SA magnetic bead freeze-drying product and freeze-drying product Effective date of registration: 20221114 Granted publication date: 20220429 Pledgee: China Development Bank Shenzhen Branch Pledgor: Dongguan Dongyang Sunshine Medical Intelligent Device R&D Co.,Ltd. Registration number: Y2022980021906 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231117 Granted publication date: 20220429 Pledgee: China Development Bank Shenzhen Branch Pledgor: Dongguan Dongyang Sunshine Medical Intelligent Device R&D Co.,Ltd. Registration number: Y2022980021906 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation methods for SA magnetic bead lyophilized working solution, SA magnetic bead lyophilized product, and lyophilized product Effective date of registration: 20231121 Granted publication date: 20220429 Pledgee: China Development Bank Shenzhen Branch Pledgor: Dongguan Dongyang Sunshine Medical Intelligent Device R&D Co.,Ltd. Registration number: Y2023980066753 |