CN109673637A - 用于防腐的液体浓缩物 - Google Patents
用于防腐的液体浓缩物 Download PDFInfo
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Abstract
本发明涉及一种组合物,其包含:a)15重量%至25重量%的1,2‑辛二醇,b)15重量%至25重量%的苯甲酸,c)50重量%至70重量%的丙二醇,其中芳族醇的含量相对于液体浓缩物的重量为小于或等于5重量%;该组合物在化妆品产品、家用产品或技术产品防腐中的用途。
Description
本发明涉及一种抗微生物液体浓缩物和所述液体浓缩物用于防腐的用途,特别是用于化妆品产品即湿巾的防腐的用途。
基于羧酸如苯甲酸、山梨酸、脱氢乙酸、十一碳烯酸或其盐的防腐剂是已知的。尽管这些酸和盐在毒理学上是安全的,但是单独使用时它们不够有效。因此化妆品行业继续寻求改进的基于有机酸的防腐剂。
DE 19922538 A1描述了包含羧酸、芳族醇和溶剂的液体浓缩物,其中这些组分的总含量大于45重量%。然而,芳族醇在化妆品防腐剂中的使用越来越受到批评。
DE 4026756 A1公开了一种防腐剂,其包含5重量%至60重量%(wt%)的选自苯甲酸、4-羟基苯甲酸、水杨酸、甲酸、乙酸、丙酸、山梨酸、十一碳烯酸和/或脱氢乙酸的有机酸及其盐;10重量%至95重量%的芳族醇和0.1重量%至20重量%的聚(六亚甲基双胍)盐;任选地0.1重量%至20重量%的取代的甘油醚和/或溶剂如水,二醇如丙二醇、二丙二醇和三甘醇,或二醇醚如丁基二甘醇,以改善低温稳定性。
另一种已知的产品是由Schülke&Mayr GmbH(Norderstedt,德意志联邦共和国)生产的K 702,其包含苯甲酸、聚(六亚甲基双胍)盐酸盐、脱氢乙酸和苯氧基乙醇。然而,在基于阴离子表面活性剂的产品例如洗发剂中使用阳离子表面活性剂(例如聚(六亚甲基双胍)盐),特别是以大量(例如1重量%)使用是有问题的,因为这会导致相互作用而形成沉淀或失活。此外,根据欧盟法规944/2013,聚(六亚甲基双胍)盐自2015年以来被归类为致癌、致突变或生殖毒性物质(CMR2物质),过去禁止在化妆品产品中使用。虽然目前再次被允许,但市场接受度还是有疑问的。
DE10122380A1公开了一种例如用于化妆品防腐的无醇液体浓缩物,其包含羧酸组分(A)、稳定剂组分(B)和溶剂(C)。羧酸组分(A)包含苯甲酸,丙酸,水杨酸,山梨酸,4-羟基苯甲酸,脱氢乙酸或10-十一碳烯酸中至少一种的盐,以及任选地一种或多种上述游离酸。所述文献中描述的说明性浓缩物另外含有至多约45重量%的苯甲酸钠与山梨酸钾,甲醛或甲醛储存化合物(例如二羟甲基二甲基乙内酰脲)的混合物。然而,越来越多批评含有甲醛或甲醛储存化合物的化妆品防腐剂。
WO2012/151441A1描述了抗微生物制剂,其包含脂肪酸和至少一种天然产品或天然来源的产品,例如1,3-丙二醇或含醇溶剂,或有机酸或其盐如山梨酸钾或苯甲酸。例如WO2012/151441A1公开了包含约80重量%的1,3-丙二醇,10重量%(乙基己基)甘油和10重量%的山梨酸钾的无水混合物。根据该文件的防腐剂用于护肤产品如洗发剂,化妆水,调理剂和肥皂中。然而,已经发现,如果山梨酸盐和苯甲酸盐的含量过高和/或1,3-丙二醇的含量是2,则含有例如山梨酸钾和苯甲酸钠的组合物不能配制成透明溶液。尽管1,3-丙二醇单独易溶于水,但不可能制备含有45重量%水,15重量%山梨酸钾和30重量%苯甲酸钠和10重量%的1,3-丙二醇的澄清溶液。而且,根据WO2012/151441A1的配制剂起到增稠剂的作用,这是用于湿巾防腐的缺点。
于2017年8月3日提交的PCT/EP2017/069722公开了一种含水抗微生物液体浓缩物,其包含5重量%至20重量%的一种或多种选自具有6至20个碳原子的链烷二醇的二醇和具有4至18个碳原子的单烷基甘油醚,20重量%至60重量%的一种或多种选自山梨酸,苯甲酸,茴香酸,水杨酸,4-羟基苯甲酸,肉桂酸,琥珀酸和乙酰丙酸的有机酸的一种或多种盐,以及任选地一种或多种上述游离酸,以及30重量%至70重量%的水,其中相对于液体浓缩物的重量芳族醇最多为5重量%,及其用于化妆品产品、家用产品和技术产品防腐的用途。但是,由于水是微生物生长所必需的,因此最终化妆品产品中微生物污染的可能性增加。
有机酸和芳族醇的组合物已经以浓缩物的形式已知。芳族醇正在公开讨论,因为可能具有致敏作用。因此,需要不含任何芳族醇的微生物活性组合物。另外的组合伙伴必须符合化妆品成分的标准。它们必须是储存稳定的,可溶解的,可加工的并且在最终浓缩物中产生透明的组合物。无水化妆品需要无水防腐,以避免额外量的为微生物生长提供条件的水。因此,该组合物必须具有抗微生物活性和良好的适应性,结合在无水系统的低水中使用。
因此,本发明旨在提供作为浓缩物的防腐剂,即使在水稀释液中也可容易地将其配制成透明溶液。
此外,防腐剂应该对最终产品的性能具有很小的影响或没有影响,因此不一定需要含有表面活性剂、乳化剂、溶剂或芳族醇。
在第一方面,本发明因此涉及一种组合物,其包含:
a)15重量%至25重量%的1,2-辛二醇,
b)15重量%至25重量%的苯甲酸,
c)50重量%至70重量%的丙二醇,
其中芳族醇的含量相对于液体浓缩物的重量为小于或等于5重量%。
根据具体的实施方案,如上文所定义的组合物不含芳族醇。
在本发明的上下文中,芳族醇主要是指醇如苯氧乙醇、苯氧丙醇、苯乙醇、苯丙醇和苄醇,其通常用于化妆品产品、家用产品或技术产品的制剂中。
根据另一个具体实施方案,如上文所定义的组合物不含水。
根据另一具体实施方案,本发明涉及如上所定义的组合物,其中1,2-辛二醇/苯甲酸的重量比等于1。
根据其它具体实施方案,本发明涉及如上文所定义的组合物,其中1,2-辛二醇/丙二醇的重量比大于或等于0.2且小于或等于0.5;和/或如上文定义的组合物,其中苯甲酸/丙二醇的重量比大于或等于0.2且小于或等于0.5。
根据更具体的实施方案,本发明涉及如上文所定义的组合物,其100%重量由以下组分组成:
a)15重量%至25重量%的1,2-辛二醇,
b)15重量%至25重量%的苯甲酸,和
c)50重量%至70重量%的丙二醇。
根据该更具体的实施方案的一个非常具体的实施方案,如上所定义的组合物的特征在于1,2-辛二醇/苯甲酸的重量比等于1;并且所述组合物更具体地其100%重量由以下组分组成:
a)20重量%的1,2-辛二醇,
b)20重量%的苯甲酸,和
c)60重量%的丙二醇。
本发明还涉及如上所定义的组合物用于化妆品产品、家用产品或技术产品的防腐的用途和/或作为消毒剂的用途。
根据一个优选的实施方案,本发明涉及如上所定义的组合物用于湿巾防腐的用途。
本发明还涉及一种化妆品产品、家用产品或技术产品的防腐方法,其特征在于,在制备所述化妆品产品、家用产品或技术产品如湿巾期间,在所述化妆品产品、家用产品或技术产品的成分的混合物中加入有效量的如上定义的组合物。
在本发明的上下文中,有效量近似地意指所述化妆品产品、家用产品或技术产品的大约0.05重量%至3重量%的重量比例。
细菌计数减少试验
生产下列浓缩物(组成以wt%表示,表1a):
表1a
组合物 | I | II | III |
苯甲酸 | 20.00 | 0.00 | 20.00 |
1,2-辛二醇 | 0.00 | 20.00 | 20.00 |
丙二醇 | 80.00 | 80.00 | 60.00 |
测试以下微生物:
表1b
物种 | |
金黄色葡萄球菌(Staphylococcus aureus) | ATCC n°6538 |
大肠杆菌(Escherichia coli) | ATCC n°11229 |
绿脓杆菌(Pseudomonas aeruginosa) | ATCC n°15442 |
制备浓度为1重量%的浓缩物在去离子水中的稀释液,并且对于金黄色葡萄球菌和大肠杆菌调节至pH=5.0,并且对于绿脓杆菌调节至pH=5.5。
从金黄色葡萄球菌、大肠杆菌和绿脓杆菌的24小时胰蛋白胨-大豆琼脂(TSA)培养物制备24小时的CASO(酪蛋白蛋白胨-大豆蛋白胨溶液)培养物。培育发生在30℃(TSA)和(CASO)37℃。
将25cm3的端部溶液(end solution)各自接种0.1cm3微生物悬浮液(初始微生物计数:大约109cfu/ml)。
在3、6、24和48小时后将溶液划线到TSA上。培养物在37℃培育48小时。
条纹的微生物生长的评价是半定量的。
结果见下表1c
表1c
符号 | 结果 | 细菌计数/ml |
- | 无生长 | <100 |
+ | 稍微生长 | 约10<sup>2</sup> |
++ | 中等生长 | 约10<sup>3</sup> |
+++ | 生长旺盛 | 约10<sup>4</sup> |
++++ | 大规模生长 | 约10<sup>5</sup> |
C | 表面被覆盖 | 约10<sup>6</sup> |
实验结果表明,苯甲酸和1,2-辛二醇在丙二醇中的组合显示出比单独的苯甲酸或单独的1,2-辛二醇在相同溶剂中更快效力的抗微生物活性。使用丙二醇作为溶剂在无水系统中提供了可用性。该浓缩物是一种客户认可而且还储存稳定的透明溶液。
Claims (13)
1.组合物,其包含:
a)15重量%至25重量%的1,2-辛二醇,
b)15重量%至25重量%的苯甲酸,
c)50重量%至70重量%的丙二醇,
其中芳族醇的含量相对于液体浓缩物的重量为小于或等于5重量%。
2.根据权利要求1所述的组合物,其不含芳族醇。
3.根据权利要求1或2中任一项所述的组合物,其不含水。
4.根据权利要求1至3中任一项所述的组合物,其中1,2-辛二醇/苯甲酸的重量比等于1。
5.根据权利要求1至4中任一项所述的组合物,其中1,2-辛二醇/丙二醇的重量比大于或等于0.2且小于或等于0.5。
6.根据权利要求1至5中任一项所述的组合物,其中苯甲酸/丙二醇的重量比大于或等于0.2且小于或等于0.5。
7.根据权利要求1至6中任一项所述的组合物,其100%重量由以下组分组成:
a)15重量%至25重量%的1,2-辛二醇,
b)15重量%至25重量%的苯甲酸,和
c)50重量%至70重量%的丙二醇。
8.根据权利要求7的组合物,其中1,2-辛二醇/苯甲酸的重量比等于1。
9.下述组合物,其100%重量由以下组分组成:
a)20重量%的1,2-辛二醇,
b)20重量%的苯甲酸,和
c)60重量%的丙二醇。
10.根据权利要求1至9中任一项所述的组合物在化妆品产品、家用产品或技术产品防腐中的用途。
11.根据权利要求1至9中任一项所述的组合物作为消毒剂的用途。
12.根据权利要求10或11所述的组合物的用途,其用于湿巾防腐。
13.一种化妆品产品、家用产品或技术产品防腐的方法,其特征在于,在制备所述化妆品产品、家用产品或技术产品期间,在所述化妆品产品、家用产品或技术产品的成分的混合物中加入有效量的根据权利要求1至9中任一项的组合物。
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CN106511120A (zh) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | 一种具有防腐功效的组合物及其制备方法和应用 |
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JP5302239B2 (ja) | 1998-02-24 | 2013-10-02 | 株式会社マンダム | 防腐殺菌剤及び人体施用組成物 |
DE19922538A1 (de) | 1999-05-10 | 2000-11-16 | Schuelke & Mayr Gmbh | Flüssig-Konzentrat zur Konservierung von Kosmetika |
WO2006057616A1 (en) | 2004-11-29 | 2006-06-01 | Ambria Dermatology Ab | A composition comprising at least 3 different diols |
DE10122380A1 (de) | 2001-05-09 | 2002-11-28 | Schuelke & Mayr Gmbh | Alkoholfreies Flüssig-Konzentrat zur Konservierung von kosmetischen, Haushalts- und technischen Produkten |
US9273272B2 (en) | 2011-05-04 | 2016-03-01 | Lincoln Manufacturing Inc. | Natural antimicrobial compositions |
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CN106511120A (zh) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | 一种具有防腐功效的组合物及其制备方法和应用 |
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BR112020007102A2 (pt) | 2020-09-24 |
KR20200067165A (ko) | 2020-06-11 |
CN109673637B (zh) | 2022-10-14 |
US20230225318A1 (en) | 2023-07-20 |
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