CN109640983A - 醛捕获化合物和其用途 - Google Patents
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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Applications Claiming Priority (3)
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| US201662378065P | 2016-08-22 | 2016-08-22 | |
| US62/378,065 | 2016-08-22 | ||
| PCT/US2017/047945 WO2018039192A1 (en) | 2016-08-22 | 2017-08-22 | Aldehyde trapping compounds and uses thereof |
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| CN109640983A true CN109640983A (zh) | 2019-04-16 |
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| EP (1) | EP3500256A4 (https=) |
| JP (1) | JP2019532029A (https=) |
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| CO (1) | CO2019001625A2 (https=) |
| MX (1) | MX2019001722A (https=) |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111356451A (zh) * | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
| WO2021136244A1 (zh) * | 2019-12-30 | 2021-07-08 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| CN113784954A (zh) * | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| WO2022143489A1 (zh) * | 2020-12-29 | 2022-07-07 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| CN115551507A (zh) * | 2020-04-13 | 2022-12-30 | 奥尔德拉医疗公司 | 用于治疗肺、肝脏和肾脏疾病、病症或病况的喹啉化合物 |
| CN115697336A (zh) * | 2020-05-13 | 2023-02-03 | 奥尔德拉医疗公司 | 药物制剂及其用途 |
| CN115843293A (zh) * | 2021-06-25 | 2023-03-24 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| US12006298B2 (en) | 2018-08-06 | 2024-06-11 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12097188B2 (en) | 2009-12-11 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Compositions and methods for the treatment of macular degeneration |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| US12128013B2 (en) | 2013-01-23 | 2024-10-29 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| US12240816B2 (en) | 2015-08-21 | 2025-03-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| WO2025140390A1 (zh) * | 2023-12-28 | 2025-07-03 | 珠海联邦制药股份有限公司 | Rasp抑制剂在制备治疗或预防慢性咳嗽、哮喘及酒精性肝病疾病的药物中的应用 |
| WO2025185553A1 (zh) * | 2024-03-06 | 2025-09-12 | 深圳湾实验室 | 预防和治疗醛代谢紊乱引起的相关疾病的化合物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1888548E (pt) | 2005-05-26 | 2012-10-30 | Neuron Systems Inc | Derivado de quinolina para o tratamento de doenças da retina |
| CA3016759A1 (en) | 2016-02-28 | 2017-08-31 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
| US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| MX2019010576A (es) | 2017-03-16 | 2019-10-07 | Aldeyra Therapeutics Inc | Compuestos polimorficos y usos de los mismos. |
| WO2020028820A1 (en) | 2018-08-03 | 2020-02-06 | Aldeyra Therapeutics, Inc. | Topical compositions and methods of preparation and use |
| EP3856478A4 (en) | 2018-09-25 | 2022-06-08 | Aldeyra Therapeutics, Inc. | FORMULATIONS FOR THE TREATMENT OF DRY EYE |
| US12091388B2 (en) | 2018-12-12 | 2024-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of Reproxalap |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| US20230228744A1 (en) * | 2020-06-04 | 2023-07-20 | Aldeyra Therapeutics, Inc. | Dry eye disease biomarkers and their use for treatment |
| WO2023192372A1 (en) * | 2022-03-29 | 2023-10-05 | Aldeyra Therapeutics, Inc. | Methods of treating sjögren-larssen syndrome |
Citations (2)
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| US20150209333A1 (en) * | 2005-05-26 | 2015-07-30 | Aldexa Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| US20150344432A1 (en) * | 2012-12-20 | 2015-12-03 | Aldexa Therapeutics, Inc. | Peri-carbinols |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2898631C (en) * | 2013-01-23 | 2023-06-13 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| KR101646666B1 (ko) * | 2015-03-26 | 2016-08-08 | 엘지이노텍 주식회사 | 발광 소자, 이 소자를 포함하는 발광 소자 패키지, 및 이 패키지를 포함하는 조명 장치 |
| CN118724806A (zh) * | 2015-08-21 | 2024-10-01 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| KR20180073553A (ko) * | 2015-08-21 | 2018-07-02 | 알데이라 테라퓨틱스, 아이엔씨. | 알데히드 접합체 및 이의 용도 |
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2017
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- 2017-08-22 EP EP17844261.2A patent/EP3500256A4/en not_active Withdrawn
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- 2017-08-22 WO PCT/US2017/047945 patent/WO2018039192A1/en not_active Ceased
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- 2019-02-22 CO CONC2019/0001625A patent/CO2019001625A2/es unknown
- 2019-04-04 US US16/374,845 patent/US20200062712A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150209333A1 (en) * | 2005-05-26 | 2015-07-30 | Aldexa Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| US20150344432A1 (en) * | 2012-12-20 | 2015-12-03 | Aldexa Therapeutics, Inc. | Peri-carbinols |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12097188B2 (en) | 2009-12-11 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Compositions and methods for the treatment of macular degeneration |
| US12128013B2 (en) | 2013-01-23 | 2024-10-29 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| US12240816B2 (en) | 2015-08-21 | 2025-03-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| CN111356451A (zh) * | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
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|---|---|
| WO2018039192A1 (en) | 2018-03-01 |
| US20200062712A1 (en) | 2020-02-27 |
| US20180050989A1 (en) | 2018-02-22 |
| EP3500256A1 (en) | 2019-06-26 |
| EP3500256A4 (en) | 2020-01-08 |
| MX2019001722A (es) | 2019-07-04 |
| CO2019001625A2 (es) | 2019-04-30 |
| CA3032521A1 (en) | 2018-03-01 |
| JP2019532029A (ja) | 2019-11-07 |
| AU2017317524A1 (en) | 2019-02-21 |
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