CN109588697A - 一种口服全营养组合物 - Google Patents
一种口服全营养组合物 Download PDFInfo
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- CN109588697A CN109588697A CN201710913707.5A CN201710913707A CN109588697A CN 109588697 A CN109588697 A CN 109588697A CN 201710913707 A CN201710913707 A CN 201710913707A CN 109588697 A CN109588697 A CN 109588697A
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- vitamin
- fat
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- emulsifier
- soluble
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- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 22
- 239000004615 ingredient Substances 0.000 claims abstract description 20
- 239000000470 constituent Substances 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 229940088594 vitamin Drugs 0.000 claims abstract description 15
- 229930003231 vitamin Natural products 0.000 claims abstract description 15
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
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- 108090000623 proteins and genes Proteins 0.000 claims abstract description 10
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- 239000011575 calcium Substances 0.000 claims abstract description 7
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- 239000011574 phosphorus Substances 0.000 claims abstract description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 5
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 3
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 20
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 20
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- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 15
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 14
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 13
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- 239000003765 sweetening agent Substances 0.000 claims description 13
- 235000019155 vitamin A Nutrition 0.000 claims description 13
- 239000011719 vitamin A Substances 0.000 claims description 13
- 235000019166 vitamin D Nutrition 0.000 claims description 13
- 239000011710 vitamin D Substances 0.000 claims description 13
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- 229940045997 vitamin a Drugs 0.000 claims description 13
- 229940046008 vitamin d Drugs 0.000 claims description 13
- 239000005913 Maltodextrin Substances 0.000 claims description 12
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- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 12
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
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- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 10
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Abstract
本发明涉及一种口服全营养组合物及其制备方法,该组合物含含有脂溶性成分及非脂溶性成分和纯化水;每1000mL该组合物包含的非脂溶性成分为蛋白质40‑60g、碳水化合物50‑120g、膳食纤维10‑50g、钠0.5‑2g、氯0.4‑2.0g、镁0.01‑0.6g、磷0.5‑1.5g、钾1‑4g、钙0.3‑2g、铁0.005‑0.05g、锌0.001‑0.05g、铜0‑0.01g、锰0‑0.01g、硒0.01‑0.5mg、碘0‑1.5mg、水溶性维生素0.1‑2g,含有的脂溶性成分为脂肪40‑120g、脂溶性维生素0.02‑1g,本发明所涉及组合物主要用来为肿瘤病人及其他对营养素没有特殊要求的患者提供全面而均衡的营养支持。
Description
技术领域
本发明属于医用食品领域,涉及一种口服全营养组合物及其制备方法,主要用于为肿瘤病人及其他对营养素没有特殊要求的患者提供全面而均衡的营养支持。
背景技术
卫生部的统计资料表明,目前中国每年新生肿瘤患者总数约有250万人左右,其中有一半以上为恶性肿瘤新生患者。因癌症死亡人数为140万。我国每年新增肿瘤患者呈逐渐增长趋势,年均增长率在10%左右。从跟踪数据来看,我国恶性肿瘤发病情况呈现出三个重要变化:一是发病人数逐年增多明显,这种情况与某些地区环境污染日趋严重有关。二是患者人群出现两个极端,即年龄小的人群和老年人群罹患癌症人数增长最快;三是所有恶性肿瘤中,结/直肠癌在人群中发病率激增,这与公众饮食结构的变化有关。从10种常见恶性肿瘤死亡水平看,我国已与美国、英国、法国接近,高于日本、澳大利亚、印度、泰国等国家。卫生部的统计资料表明,目前中国每年新生肿瘤患者总数约有250万人左右,其中有一半以上为恶性肿瘤新生患者。
营养不良是恶性肿瘤患者的常见并发病,约40-80%的肿瘤患者存在营养不良,营养不良引起抗肿瘤治疗手术、化疗、放疗的耐受性、有效性下降、毒付作用增加,机体体力状态下降,器官功能损害,生活质量低下,生存时间缩短。研究报道约20%的恶性肿瘤患者的直接死亡原因是因为营养不良。
目前市场上可供选择的适合肿瘤病人食用的肠内营养食品还比较缺乏,而通过营养支持改善肿瘤患者的营养状况具有至关重要的作用,因此开发一种稳定的、便于携带和使用,制备方法相对简单的口服肿瘤病人用全营养配方组合物,用来为肿瘤病人及其他对营养素没有特殊要求的患者提供全面而均衡的营养支持尤为重要。
发明内容
本发明主要涉及一种口服全营养组合物及其制备方法,具体如下:
一种口服全营养组合物,其特征在于所述组合物包含脂溶性成分、非脂溶性成分和纯化水;每1000mL所述组合物含有的非脂溶性成分为蛋白质40-60g、碳水化合物50-120g、膳食纤维10-50g、钠0.5-2g、氯0.4-2.0g、镁0.01-0.6g、磷0.5-1.5g、钾1-4g、钙0.3-2g、铁0.005-0.05g、锌0.001-0.05g、铜0-0.01g、锰0-0.01g、硒0.01-0.5mg、碘0-1.5mg、水溶性维生素0.1-2g,含有的脂溶性成分为脂肪40-120g、脂溶性维生素0.02-1g。
进一步地,所述组合物还含有甜味剂、乳化剂和复配乳化增稠剂。
进一步地,所述蛋白质选自乳清蛋白、酪蛋白、水解乳清蛋白或其混合;碳水化合物选自麦芽糊精、木薯淀粉、葡萄糖或其混合;脂肪选自葵花籽油、中连甘油三酯、鱼油提取物或其混合,优选葵花籽油、中连甘油三酯、鱼油提取物混合物;膳食纤维选自抗性糊精、阿拉伯胶或其混合,优选抗性糊精;水溶性维生素选自泛酸、生物素、维生素K1、叶酸、维生素C、维生素B1、维生素B2、烟酸、维生素B6、维生素B12或其混合;脂溶性维生素选自维生素E、维生素A、维生素D或其混合;甜味剂选自三氯蔗糖、甜菊糖苷或其混合;所述乳化剂选自柠檬酸脂肪酸甘油酯、单双甘油酯或其混合,优选柠檬酸脂肪酸甘油酯;所述复配乳化增稠剂为食品用乳化剂和增稠剂的混合,优选微晶纤维素、单/双甘油脂肪酸酯、结冷胶、硬酯酰乳酸钠、双乙酰酒石酸单双甘油酯、羧甲基纤维素钠的混合,进一步优选丹尼斯克公司复配乳化增稠剂9566-C。
一种口服全营养组合物,其特征在于所述组合物包含脂溶性成分、非脂溶性成分、甜味剂、乳化剂、复配乳化增稠剂和纯化水;每1000mL所述组合物含有的非脂溶性成分为乳清蛋白40-60g、麦芽糊精50-120g、抗性糊精10-50g、磷酸氢二钾3-8g、柠檬酸钠2-7g、乳酸钙1.5-10g、氯化镁0.1-5g、焦磷酸铁15-160mg、硫酸锌4-222mg、亚硒酸钠20-1000μg、碘化钾0-2mg、硫酸锰0-40mg、硫酸铜0-40mg、泛酸0-30mg、生物素0-20mg、叶酸0-20mg、维生素K10-2mg、维生素C 100-300mg、维生素B1 1-5mg、维生素B2 1-5mg、烟酸10-20mg、维生素B60.4-10mg、维生素B120.0006-0.3mg,含有的脂溶性成分为葵花籽油20-60g、中链甘油三酯10-30g、鱼油提取物2-10g、维生素E 30-80mg、维生素A 0.1-20mg、维生素D 20-60μg,甜味剂0-0.5g,乳化剂1-4g,复配乳化增稠剂1-4g。
进一步地,每1000mL所述组合物含有的非脂溶性成分为乳清蛋白55g、麦芽糊精77g、抗性糊精30g、磷酸氢二钾4.5g、柠檬酸钠3.6g、乳酸钙2.2g、氯化镁2.3g、焦磷酸铁50mg、硫酸锌60mg、亚硒酸钠400μg、碘化钾1.3mg、硫酸锰2.4mg、硫酸铜10mg、泛酸20mg、生物素10mg、叶酸10mg、维生素K1 0.5mg、维生素C 240mg、维生素B12mg、维生素B22mg、烟酸18mg、维生素B6 3mg、维生素B120.1mg,含有的脂溶性成分为葵花籽油26g、中链甘油三酯17g、鱼油提取物6g、维生素E 40mg、维生素A 2mg、维生素D 30μg,甜味剂0.2g,乳化剂3g,复配乳化增稠剂1g。
进一步地,每1000mL所述组合物含有的非脂溶性成分为乳清蛋白50g、麦芽糊精77g、抗性糊精30g、磷酸氢二钾4.5g、柠檬酸钠3.6g、乳酸钙2.2g、氯化镁0.3g、焦磷酸铁50mg、硫酸锌60mg、亚硒酸钠400μg、维生素C 240mg、维生素B12mg、维生素B22mg、烟酸18mg、维生素B6 1.6mg、维生素B120.00018mg,含有的脂溶性成分为葵花籽油29g、中链甘油三酯17g、鱼油提取物3g、维生素E 40mg、维生素A1mg、维生素D 30μg,甜味剂0.2g,乳化剂3g,复配乳化增稠剂1g。
同时,本发明还提供了上述组合物的制备方法,包含以下步骤:
步骤1:配料
a)按配方分别称量非脂溶性成分、复配乳化增稠剂及甜味剂,待用;
b)按配方分别称量脂溶性成分及乳化剂,待用;
步骤2:溶解
c)将称得的脂溶性成分及乳化剂加热搅拌至全溶,得到油相溶液;
d)将称得的非脂溶性成分蛋白质及碳水化合物干混,用配制总量60%的水50-80℃水温剪切搅拌至全溶;加入复配乳化增稠剂,剪切搅拌至全溶;
e)向步骤d)溶液中加入称得的除水溶性维生素外的剩余非脂溶性成分,搅匀;
步骤3:以高剪切转速向步骤e)溶液中缓慢加入步骤c)溶液,继续循环剪切30min,剪切结束前5min加入用水溶解的水溶性维生素,剪切均匀;
步骤4:磷酸氢二钾调节产品pH为6.0-6.9;
步骤5:定容至配制总体积,制得初乳;
步骤6:将步骤4制得的初乳自循环;定容至总体积,冷却到20℃以下;
步骤7:灌装,灭菌,温度≥100℃,灭菌时间≥8分钟,或UHT 130~135℃灭菌10~30秒,灌装。
另外,本发明还涉及上述组合物用于为肿瘤病人及其他对营养素没有特殊要求的患者提供全面而均衡营养支持的应用。
本发明在研发过程中发现,乳化剂的选择对产品稳定性影响很大,乳化剂选择不当则会产生大量沉淀和或浮油,出现分层现象,严重则导致产品变性凝固,因此对乳化剂的选择进行了实验研究:
将筛选出的乳化剂柠檬酸脂肪酸甘油酯和单双酸甘油酯,分别和复配的乳化增稠剂一起使用,结果显示柠檬酸脂肪酸甘油酯和复配乳化增稠剂一起使用时产品状态更稳定,加速(温度40℃,湿度:70%)放6个月产品呈均一液体,底部有少量沉淀,但摇晃即消失。
另外,钙的来源选择对产品的稳定性影响也很大,对氯化钙、碳酸钙、磷酸氢钙、乳酸钙进行制样筛选:
将筛选出的乳酸钙和磷酸氢钙,制备样品,加速(温度40℃,湿度:70%)放置6个月,其中选择乳酸钙的产品状态均一,包装瓶底部仅有少量沉淀,稍一晃动即消失,比加磷酸氢钙的产品更稳定。
同时,配方中磷酸二氢钾的含量选择较为重要,既要保证磷及钾的含量,同时要使产品pH在规定范围6.0-7.0以内。
本发明所涉及的口服全营养配方组合物,依据肿瘤病人营养代谢规律,在保证宏量营养素以及微量营养素符合GB 29922-2013要求,还保证了产品具有高能量,高蛋白、优质脂肪、低糖的特点。本发明富含高单不饱和脂肪酸葵花籽油、中连甘油三酯,低糖能够延缓肿瘤细胞的繁殖和扩散,有效改善糖脂代谢;本发明还含有鱼油提取物或其混合,其中优质脂肪鱼油提取物中含有丰富的不饱和脂肪酸(DHA、EPA),可减少炎性反应并防止体重减轻,提高免疫力,在对肿瘤病人的治疗中提供营养支持的同时能更好地帮助病人康复;本发明蛋白含量达到4%,摄入高能量的产品以减少肿瘤病人体重的丧失,促进细胞与组织的修复;另外产品中添加了抗性糊精作为膳食纤维,有效维护肠道功能。本发明可减少肿瘤并发症的发生,适用于肿瘤病人及其他对营养素没有特殊要求的患者,可以通过口服或鼻饲等方式为病人提供全面、充足机体所需的各种营养物质,以达到预防或纠正热量、蛋白质缺乏所致的营养不良的目的,同时起到增强病人对严重创伤的耐受力,促进病人康复的作用。
本发明中组合物中各成分含量符合规定;由于选择了柠檬酸脂肪酸甘油酯作为乳化剂,乳酸钙作为钙的来源,对磷酸氢二钾的量进行控制,使产品稳定性高;同时本产品便于携带和使用,制备方法简单,成本低,便于工业化大生产。
具体实施方式
下面将通过实施例对本发明作进一步的描述,这些描述并不是对本发明内容作进一步的限定。本领域的技术人员对发明内容所作的等同替换或改进,仍属于本发明的保护范围之内。
实施例1:
制备工艺:
步骤1:配料
1)按配方分别称量好各非脂溶性物料乳清蛋白、麦芽糊精、柠檬酸钠、氯化镁、磷酸氢二钾、乳酸钙、抗性糊精、焦磷酸铁、硫酸锌、硫酸铜、硫酸锰、亚硒酸钠、碘化钾、泛酸、生物素、维生素K1、叶酸、维生素C、维生素B1、维生素B2、烟酸、维生素B6、维生素B12、维生素A、维生素D、维生素E、乳化剂、复配乳化增稠剂、三氯蔗糖,待用;
2)于配料罐中加入配制总量60%水,待用;
3)按配方分别称量好脂溶性物料葵花籽油、鱼油提取物、中链甘油三酯(MCT)、乳化剂、维生素A、维生素D、维生素E,待用;
步骤2:溶解
1)将称好的葵花籽油、鱼油提取物、中链甘油三酯(MCT)、乳化剂、维生素A、维生素D、维生素E加热搅拌至全溶,得到油相溶液;
2)将称好的蛋白、麦芽糊精、抗性糊精干混好,投入配料罐,70℃左右水温剪切搅拌至全溶;
3)再将复配乳化增稠剂投入配料罐,分别剪切搅拌至全溶;
4)将称好备用的氯化镁、柠檬酸钠、乳酸钙、硫酸锰、硫酸铜、碘化钾、硫酸锌、亚硒酸钠、焦磷酸铁、磷酸氢二钾,再分别加入上述水相溶液中,搅匀;
步骤3:将水相置剪切机下,以高剪切转速缓慢加入油相,油相加入完毕后继续循环剪切约30min,在剪切结束前5min将所有的水溶性维生素用水溶好,投入配料罐,剪切均匀;
步骤4:定容至配制总体积,搅匀制得初乳;
步骤5:将制得的初乳先在配料罐中自循环,待均质参数调好后,再均质到另一个罐子,将罐中剩余未均质到的料液排净;将上述料液定容至总体积,冷却到20℃以下;
步骤6:灌装,灭菌,温度≥100℃,灭菌时间≥12分钟,或UHT 130~135℃灭菌10~30秒,灌装。
稳定性试验:
实施例2
制备工艺:
步骤1:配料
1)按配方分别称量好各非脂溶性物料乳清蛋白、麦芽糊精、柠檬酸钠、氯化镁、磷酸氢二钾、乳酸钙、焦磷酸铁、硫酸锌、亚硒酸钠、维生素C、维生素B1、维生素B2、烟酸、维生素B6、维生素B12、维生素A、维生素D、维生素E、复配乳化增稠剂、三氯蔗糖,待用;
2)按配方分别称量好脂溶性物料葵花籽油、中链甘油三酯、鱼油提取物、乳化剂柠檬酸脂肪酸甘油酯、维生素A、维生素D、维生素E,待用;
3)于配料罐中加入配制总量60%水,待用;
步骤2:溶解
1)将称好的葵花籽油、MCT、鱼油提取物、乳化剂柠檬酸脂肪酸甘油酯、维生素A、维生素D、维生素E加热搅拌至全溶,得到油相溶液;
2)将称好的蛋白、麦芽糊精干混好,投入配料罐,70℃左右水温剪切搅拌至全溶;
3)再将复配乳化增稠剂、三氯蔗糖投入配料罐,分别剪切搅拌至全溶;
4)将称好备用的氯化镁、柠檬酸钠、乳酸钙、硫酸铜、硫酸锌、亚硒酸钠、焦磷酸铁、磷酸氢二钾,再分别加入上述水相溶液中,搅匀;
步骤3:将水相置剪切机下,以高剪切转速缓慢加入油相,油相加入完毕后继续循环剪切约30min,在剪切结束前5min将所有的水溶性维生素用水溶好,投入配料罐,剪切均匀;
步骤4:定容至配制总体积,搅匀制得初乳;
步骤5:将制得的初乳先在配料罐中自循环,待均质参数调好后,再均质到另一个罐子,将罐中剩余未均质到的料液排净;之后将上述料液定容至总体积,冷却到20℃以下;
步骤6:灌装,灭菌,温度≥100℃,灭菌时间≥8分钟,或UHT 130~135℃灭菌10~30秒,灌装。
稳定性试验:
实施例3-5:
制备工艺:同实施例1。
稳定性试验检测结果与实施例1及2对比在允许误差范围内。
Claims (10)
1.一种口服全营养组合物,其特征在于所述组合物包含脂溶性成分、非脂溶性成分和纯化水;每1000mL所述组合物含有的非脂溶性成分为蛋白质40-60g、碳水化合物50-120g、膳食纤维10-50g、钠0.5-2g、氯0.4-2.0g、镁0.01-0.6g、磷0.5-1.5g、钾1-4g、钙0.3-2g、铁0.005-0.05g、锌0.001-0.05g、铜0-0.01g、锰0-0.01g、硒0.01-0.5mg、碘0-1.5mg、水溶性维生素0.1-2g,含有的脂溶性成分为脂肪40-120g、脂溶性维生素0.02-1g。
2.根据权利要求1所述的组合物,其特征在于所述组合物还含有甜味剂、乳化剂和复配乳化增稠剂。
3.根据权利要求1或2所述的组合物,其特征在于所述蛋白质选自乳清蛋白、酪蛋白、水解乳清蛋白或其混合;碳水化合物选自麦芽糊精、木薯淀粉、葡萄糖或其混合;脂肪选自葵花籽油、中连甘油三酯、鱼油提取物或其混合;膳食纤维选自抗性糊精、阿拉伯胶或其混合;水溶性维生素选自泛酸、生物素、维生素K1、叶酸、维生素C、维生素B1、维生素B2、烟酸、维生素B6、维生素B12或其混合;脂溶性维生素选自维生素E、维生素A、维生素D或其混合;甜味剂选自三氯蔗糖、甜菊糖苷或其混合;所述乳化剂选自单双酸甘油酯、柠檬酸脂肪酸甘油酯或其混合;所述复配乳化增稠剂为食品用乳化剂和增稠剂的混合。
4.据权利要求3所述的组合物,其特征在于所述蛋白质为乳清蛋白;所述脂肪为葵花籽油、中连甘油三酯及鱼油提取物混合物;所述膳食纤维为抗性糊精;所述乳化剂为柠檬酸脂肪酸甘油酯。
5.一种口服全营养组合物,其特征在于所述组合物包含脂溶性成分、非脂溶性成分、甜味剂、乳化剂、复配乳化增稠剂和纯化水;每1000mL所述组合物含有的非脂溶性成分为乳清蛋白40-60g、麦芽糊精50-120g、抗性糊精10-50g、磷酸氢二钾3-8g、柠檬酸钠2-7g、乳酸钙1.5-10g、氯化镁0.1-5g、焦磷酸铁15-160mg、硫酸锌4-222mg、亚硒酸钠20-1000μg、碘化钾0-2mg、硫酸锰0-40mg、硫酸铜0-40mg、泛酸0-30mg、生物素0-20mg、叶酸0-20mg、维生素K10-2mg、维生素C 100-300mg、维生素B11-5mg、维生素B21-5mg、烟酸10-20mg、维生素B60.4-10mg、维生素B120.0006-0.3mg,含有的脂溶性成分为葵花籽油20-60g、中链甘油三酯10-30g、鱼油提取物2-10g、维生素E 30-80mg、维生素A 0.1-20mg、维生素D 20-60μg,甜味剂0-0.5g,乳化剂1-4g,复配乳化增稠剂1-4g。
6.根据权利要求5所述的组合物,其特征在于每1000mL所述组合物含有的非脂溶性成分为乳清蛋白55g、麦芽糊精77g、抗性糊精30g、磷酸氢二钾4.5g、柠檬酸钠3.6g、乳酸钙2.2g、氯化镁2.3g、焦磷酸铁50mg、硫酸锌60mg、亚硒酸钠400μg、碘化钾1.3mg、硫酸锰2.4mg、硫酸铜10mg、泛酸20mg、生物素10mg、叶酸10mg、维生素K1 0.5mg、维生素C 240mg、维生素B12mg、维生素B22mg、烟酸18mg、维生素B6 3mg、维生素B120.1mg,含有的脂溶性成分为葵花籽油26g、中链甘油三酯17g、鱼油提取物6g、维生素E 40mg、维生素A 2mg、维生素D 30μg,甜味剂0.2g,乳化剂3g,复配乳化增稠剂1g。
7.根据权利要求5所述的组合物,其特征在于每1000mL所述组合物含有的非脂溶性成分为乳清蛋白50g、麦芽糊精77g、抗性糊精30g、磷酸氢二钾4.5g、柠檬酸钠3.6g、乳酸钙2.2g、氯化镁0.3g、焦磷酸铁50mg、硫酸锌60mg、亚硒酸钠400μg、维生素C 240mg、维生素B12mg、维生素B22mg、烟酸18mg、维生素B6 1.6mg、维生素B120.00018mg,含有的脂溶性成分为葵花籽油29g、中链甘油三酯17g、鱼油提取物3g、维生素E 40mg、维生素A 1mg、维生素D 30μg,甜味剂0.2g,乳化剂3g,复配乳化增稠剂1g。
8.权利要求1-7中任一项组合物的制备方法,其特征在于包含以下步骤:
步骤1:配料
a)按配方分别称量非脂溶性成分、复配乳化增稠剂及甜味剂,待用;
b)按配方分别称量脂溶性成分及乳化剂,待用;
步骤2:溶解
c)将称得的脂溶性成分及乳化剂加热搅拌至全溶,得到油相溶液;
d)将称得的非脂溶性成分蛋白质及碳水化合物干混,用配制总量60%的水50-80℃水温剪切搅拌至全溶;加入复配乳化增稠剂,剪切搅拌至全溶;
e)向步骤d)溶液中加入称得的除水溶性维生素外的剩余非脂溶性成分,搅匀;
步骤3:以高剪切转速向步骤e)溶液中缓慢加入步骤c)溶液,继续循环剪切30min,剪切结束前5min加入用水溶解的水溶性维生素,剪切均匀;
步骤4:用碱调节产品pH为6.0-6.9;
步骤5:定容至配制总体积,制得初乳;
步骤6:将步骤4制得的初乳自循环;定容至总体积,冷却到20℃以下;
步骤7:灌装,灭菌,温度≥100℃,灭菌时间≥8分钟,或UHT 130~135℃灭菌10~30秒,灌装。
9.根据权利要求8所述的制备方法,其特征在于步骤4所述碱为磷酸氢二钾。
10.权利要求1-8中任一项所述的组合物在为肿瘤病人及其他对营养素没有特殊要求的患者提供全面而均衡营养支持的应用。
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Cited By (1)
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---|---|---|---|---|
CN112641090A (zh) * | 2020-12-18 | 2021-04-13 | 广州白云山汉方现代药业有限公司 | 一种高能量密度高蛋白全营养乳及其制备方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58162517A (ja) * | 1982-03-19 | 1983-09-27 | Green Cross Corp:The | 脂溶性ビタミン含有脂肪乳剤 |
CN102630760A (zh) * | 2012-05-11 | 2012-08-15 | 光明乳业股份有限公司 | 一种婴儿配方浓缩奶及其制备方法 |
CN104116028A (zh) * | 2014-07-23 | 2014-10-29 | 沧州恩际生物制品有限公司 | 一种短肽免疫增强型肠内营养乳剂及其制备方法 |
CN105768109A (zh) * | 2016-02-25 | 2016-07-20 | 李宏 | 一种含维生素d钙的微乳及其制备方法和应用 |
CN106256346A (zh) * | 2015-06-15 | 2016-12-28 | 浙江医药股份有限公司新昌制药厂 | 一种透明型维生素e醋酸酯干粉及其制备方法 |
CN106307504A (zh) * | 2016-08-24 | 2017-01-11 | 华仁药业股份有限公司 | 一种用于慢性肾病患者的肠内营养组合物及其制备方法 |
CN106473153A (zh) * | 2016-09-21 | 2017-03-08 | 河南汇博医疗股份有限公司 | 全营养配方食品及其制备方法 |
CN106668835A (zh) * | 2015-11-06 | 2017-05-17 | 北京康爱营养科技股份有限公司 | 一种用于肿瘤治疗的肠内营养剂及其制备方法 |
CN106890312A (zh) * | 2015-12-18 | 2017-06-27 | 北京康爱营养科技股份有限公司 | 一种适用于肝癌患者的肠内营养剂及其制备方法 |
-
2017
- 2017-09-30 CN CN201710913707.5A patent/CN109588697A/zh active Pending
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58162517A (ja) * | 1982-03-19 | 1983-09-27 | Green Cross Corp:The | 脂溶性ビタミン含有脂肪乳剤 |
CN102630760A (zh) * | 2012-05-11 | 2012-08-15 | 光明乳业股份有限公司 | 一种婴儿配方浓缩奶及其制备方法 |
CN104116028A (zh) * | 2014-07-23 | 2014-10-29 | 沧州恩际生物制品有限公司 | 一种短肽免疫增强型肠内营养乳剂及其制备方法 |
CN106256346A (zh) * | 2015-06-15 | 2016-12-28 | 浙江医药股份有限公司新昌制药厂 | 一种透明型维生素e醋酸酯干粉及其制备方法 |
CN106668835A (zh) * | 2015-11-06 | 2017-05-17 | 北京康爱营养科技股份有限公司 | 一种用于肿瘤治疗的肠内营养剂及其制备方法 |
CN106890312A (zh) * | 2015-12-18 | 2017-06-27 | 北京康爱营养科技股份有限公司 | 一种适用于肝癌患者的肠内营养剂及其制备方法 |
CN105768109A (zh) * | 2016-02-25 | 2016-07-20 | 李宏 | 一种含维生素d钙的微乳及其制备方法和应用 |
CN106307504A (zh) * | 2016-08-24 | 2017-01-11 | 华仁药业股份有限公司 | 一种用于慢性肾病患者的肠内营养组合物及其制备方法 |
CN106473153A (zh) * | 2016-09-21 | 2017-03-08 | 河南汇博医疗股份有限公司 | 全营养配方食品及其制备方法 |
Non-Patent Citations (2)
Title |
---|
刘锡钧主编: "《实用药物指南》", 31 October 2000, 人民军医出版社 * |
国家药典委员会编: "《中华人民共和国药典 2010年版 2部》", 31 January 2010, 中国医药科技出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112641090A (zh) * | 2020-12-18 | 2021-04-13 | 广州白云山汉方现代药业有限公司 | 一种高能量密度高蛋白全营养乳及其制备方法 |
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