CN109549985A - 一种透过皮肤吸收快速修复视力的小分子肽护眼液 - Google Patents
一种透过皮肤吸收快速修复视力的小分子肽护眼液 Download PDFInfo
- Publication number
- CN109549985A CN109549985A CN201811538632.8A CN201811538632A CN109549985A CN 109549985 A CN109549985 A CN 109549985A CN 201811538632 A CN201811538632 A CN 201811538632A CN 109549985 A CN109549985 A CN 109549985A
- Authority
- CN
- China
- Prior art keywords
- extract
- chamomile
- eye
- small
- eyesight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004438 eyesight Effects 0.000 title claims abstract description 20
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 17
- 150000003384 small molecules Chemical class 0.000 title description 4
- 239000007788 liquid Substances 0.000 title 1
- 239000000284 extract Substances 0.000 claims abstract description 51
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 19
- 240000001432 Calendula officinalis Species 0.000 claims abstract description 17
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 17
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 17
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 15
- 229940119217 chamomile extract Drugs 0.000 claims abstract description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 14
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims abstract description 13
- 244000042664 Matricaria chamomilla Species 0.000 claims abstract description 13
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000012153 distilled water Substances 0.000 claims abstract description 9
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004471 Glycine Substances 0.000 claims abstract description 8
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 8
- 239000004220 glutamic acid Substances 0.000 claims abstract description 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 7
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004472 Lysine Substances 0.000 claims abstract description 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract 2
- 239000011575 calcium Substances 0.000 claims abstract 2
- 229910052791 calcium Inorganic materials 0.000 claims abstract 2
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 16
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 9
- 230000005540 biological transmission Effects 0.000 claims description 8
- 230000008439 repair process Effects 0.000 claims description 8
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 7
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 6
- 229930003270 Vitamin B Natural products 0.000 claims description 6
- 229930014669 anthocyanidin Natural products 0.000 claims description 6
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 6
- 235000008758 anthocyanidins Nutrition 0.000 claims description 6
- 235000003704 aspartic acid Nutrition 0.000 claims description 6
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 6
- 235000019156 vitamin B Nutrition 0.000 claims description 6
- 239000011720 vitamin B Substances 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000029087 digestion Effects 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 241000432824 Asparagus densiflorus Species 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 235000007516 Chrysanthemum Nutrition 0.000 claims 1
- 240000005250 Chrysanthemum indicum Species 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 244000241838 Lycium barbarum Species 0.000 abstract description 3
- 235000015459 Lycium barbarum Nutrition 0.000 abstract description 3
- 235000001014 amino acid Nutrition 0.000 abstract description 3
- 208000003464 asthenopia Diseases 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 abstract description 3
- 230000002950 deficient Effects 0.000 abstract description 3
- 210000002569 neuron Anatomy 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 210000001525 retina Anatomy 0.000 abstract description 3
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 230000004304 visual acuity Effects 0.000 abstract description 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 abstract 1
- 235000003880 Calendula Nutrition 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 229930003451 Vitamin B1 Natural products 0.000 abstract 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 239000004410 anthocyanin Substances 0.000 abstract 1
- 235000010208 anthocyanin Nutrition 0.000 abstract 1
- 229930002877 anthocyanin Natural products 0.000 abstract 1
- 150000004636 anthocyanins Chemical class 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 235000005772 leucine Nutrition 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960003080 taurine Drugs 0.000 abstract 1
- 229960003495 thiamine Drugs 0.000 abstract 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 abstract 1
- 230000004382 visual function Effects 0.000 abstract 1
- 235000010374 vitamin B1 Nutrition 0.000 abstract 1
- 239000011691 vitamin B1 Substances 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 230000006872 improvement Effects 0.000 description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 5
- 239000001110 calcium chloride Substances 0.000 description 5
- 229910001628 calcium chloride Inorganic materials 0.000 description 5
- 206010002368 Anger Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- -1 compound amino acid Chemical class 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
一种透过皮肤吸收快速修复视力的小分子肽护眼液，包括以下组分：多肽、谷氨酸、甘氨酸、丙氨酸、亮氨酸、赖氨酸、氨基酸、核苷酸、牛磺酸、洋甘菊萃取物、金银花萃取物、枸杞子萃取物、决明子萃取物、花青素、维生素B1、维生素B12、微量钙、镁等其余为蒸馏水，护眼液中包含小分子肽，快速增加眼细胞所需营养物质，加入洋甘菊、金盏花、金银花、枸杞子、决明子萃取物，具有明目、退肝火、解除眼睛疲劳功效，促进眼部血液循环，提升视网膜系统和三级神经元细胞数量，提高双眼视敏度，快速纠正视力及双眼视觉功能不良状态。
Description
技术领域
本发明涉及护眼液，特别是一种透过皮肤吸收快速修复视力的小分子护眼液。
背景技术
随着现代人工作性质、工作环境的大幅改变，多数人长时间使用眼睛对着电脑等蓝光屏幕已成为常态，因此，对眼睛保养和预防眼疾日益重要，现代医学认为复合氨基酸能直接参与眼组织陈新代谢，对晶体中所含巯基的酶有激活作用，抑制晶体内蛋白转变，增加晶体透明度。
发明内容
本发明的目的是提供补充眼部营养物质和具有中药明目效果的一种透过皮肤吸收快速修复视力的小分子肽护眼液。
本发明解决其技术问题所采用的技术方案是：一种透过皮肤吸收快速修复视力的小分子肽护眼液，100ml该护眼液包括以下组分：谷氨酸：0.18～1.8wt％、甘氨酸：0.18～0.27wt％、丝氨酸：0.44～0.9wt％、天冬氨酸：0.09～0.45wt％、亮氨酸：0.45～0.9wt％、赖氨酸：0.09～9wt％、洋甘菊萃取物：0.0009～0.005wt％、金盏花萃取物：0.003～0.009wt％、金银花萃取物：0.002～0.005wt％、枸杞子萃取物：0.009～0.02wt％、决明子萃取物：0.03～0.5wt％、花青素：0.02～0.03wt％、氯化钙：0.02～0.03wt％、氯化镁：0.009～0.02wt％、维生素B：0.9～4.5wt％，其余为蒸馏水。
作为本发明的进一步改进：所述所述洋甘菊萃取物由以下步骤制取：
(1)取洋甘菊洗净，加入2～3倍水，高温蒸煮3h；
(2)回流提取滤液重量为洋甘菊重量的1～2倍之间；
(3)中温无菌浓缩滤液重量至洋甘菊重量一半以下，得洋甘菊萃取物。
作为本发明的进一步改进：所述金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物的制备方法如洋甘菊萃取物。
作为本发明的进一步改进：所述洋甘菊萃取物、金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物制备完成后低温无菌储存。
作为本发明的进一步改进：按配比制备谷氨酸、甘氨酸、丝氨酸、天冬氨酸、亮氨酸、赖氨酸混合物，将混合物置于5～10℃无菌环境下搅拌2h。
作为本发明的进一步改进：所述氨基酸混合物在5～10℃环境，以较慢的速度通过游离的羧基和氨基脱水结合成小分子肽，形成较稳定的小分子活性肽。
作为本发明的进一步改进：将所述洋甘菊萃取物、金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物按配比加入氨基酸混合物，10～15℃下搅拌10min。
作为本发明的进一步改进：将花青素、氯化钙、氯化镁、维生素B按配比溶解于混合物中，加蒸馏水到相对配平容量，制备得护眼液。
与现有技术相比，本发明的有益效果是：护眼液中包含小分子肽，快速增加眼细胞所需营养物质，加入洋甘菊、金盏花、金银花、枸杞子、决明子萃取物，具有明目、退肝火、解除眼睛疲劳功效，促进眼部血液循环，提升视网膜系统和三级神经元细胞数量，提高双眼视敏度，快速纠正视力及双眼视觉功能不良状态。
具体实施方式
现结合实施例对本发明进一步说明：一种透过皮肤吸收快速修复视力的小分子肽护眼液，100ml该护眼液包括以下组分：谷氨酸：0.2～2g、甘氨酸：0.2～0.3g、丝氨酸：0.5～1g、天冬氨酸：0.1～0.5g、亮氨酸：0.5～1g、赖氨酸：0.1～10g、洋甘菊萃取物：1～5mg、金盏花萃取物：3～10mg、金银花萃取物：2～5mg、枸杞子萃取物：10～20mg、决明子萃取物：30～500mg、花青素：20～30mg、氯化钙：20～30mg、氯化镁：10～20mg、维生素B：1～5g，其余为蒸馏水。
由以下步骤获取洋甘菊萃取物、金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物：
(1)取洋甘菊/金盏花/金银花/枸杞子/决明子洗净，加入2～3倍水，高温蒸煮3h；
(2)回流提取滤液重量为洋甘菊/金盏花/金银花/枸杞子/决明子重量1～2倍之间；
(3)中温无菌浓缩滤液重量至洋甘菊/金盏花/金银花/枸杞子/决明子重量一半以下，得洋甘菊/金盏花/金银花/枸杞子/决明子萃取物。
将获得的洋甘菊萃取物、金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物于0～10℃无菌环境下冷藏储存。
实施案例一：
(1)取无菌蒸馏水50～70ml，加入谷氨酸0.5g、甘氨酸0.2g、丝氨酸0.8g、天冬氨酸0.2g、亮氨酸0.5g、赖氨酸1g。
(2)置于5℃无菌环境下搅拌2h。
(3)加入洋甘菊萃取物2mg、金盏花萃取物5mg、金银花萃取物3mg、枸杞子萃取物10mg、决明子萃取物100mg，置于10℃无菌环境下搅拌10min。
(4)加入花青素20mg、氯化钙20mg、氯化镁10mg、维生素B 1g，置于10℃无菌环境下搅拌10min。
(5)加入无菌蒸馏水将溶液定容到100ml，得护眼液。
实施案例二：
(1)取无菌蒸馏水50～70ml，加入谷氨酸1g、甘氨酸0.2g、丝氨酸0.7g、天冬氨酸0.3g、亮氨酸0.7g、赖氨酸3.4g。
(2)置于5℃无菌环境下搅拌2h。
(3)加入洋甘菊萃取物3mg、金盏花萃取物6mg、金银花萃取物3mg、枸杞子萃取物15mg、决明子萃取物240mg，置于10℃无菌环境下搅拌10min。
(4)加入花青素25mg、氯化钙25mg、氯化镁15mg、维生素B 2g，置于10℃无菌环境下搅拌10min。
(5)加入无菌蒸馏水将溶液定容到100ml，得护眼液。
本发明的工作原理：将氨基酸混合后置于低温下搅拌，以较慢速度结合为小分子活性肽，加入中草药萃取物，具有温和的药效。
本护眼液亦可与无纺布结合，经浸泡制成护眼贴膜使用。
本护眼液可直接滴入眼部，小分子成分直接由眼部血管吸收；亦可穿透进入眼角膜，进入水晶体和玻璃体，由视网膜血管吸收。
本发明的主要功能：护眼液中包含小分子肽，快速增加眼细胞所需营养物质，加入洋甘菊、金盏花、金银花、枸杞子、决明子萃取物，具有明目、退肝火、解除眼睛疲劳功效，促进眼部血液循环，提升视网膜系统和三级神经元细胞数量，提高双眼视敏度，快速纠正视力及双眼视觉功能不良状态。
综上所述，本领域的普通技术人员阅读本发明文件后，根据本发明的技术方案和技术构思无需创造性脑力劳动而作出其他各种相应的变换方案，均属于本发明所保护的范围。
Claims (4)
1.一种透过皮肤吸收快速修复视力的小分子肽护眼液，其特征在于该护眼液包括以下组分：谷氨酸：0.18～1.8wt％、甘氨酸：0.18～0.27wt％、丝氨酸：0.44～0.9wt％、天冬氨酸：0.09～0.45wt％、亮氨酸：0.45～0.9wt％、赖氨酸：0.09～9wt％、洋甘菊萃取物：0.0009～0.005wt％、金盏花萃取物：0.003～0.009wt％、金银花萃取物：0.002～0.005wt％、枸杞子萃取物：0.009～0.02wt％、决明子萃取物：0.03～0.5wt％、花青素：0.02～0.03wt％、氯化钙：0.02～0.03wt％、氯化镁：0.009～0.02wt％、维生素B：0.9～4.5wt％，其余为蒸馏水。
2.根据权利要求1所述的一种透过皮肤吸收快速修复视力的小分子肽护眼液，其特征在于，所述洋甘菊萃取物由以下步骤制取：
(1)取洋甘菊洗净，加入2～3倍水，高温蒸煮3h；
(2)回流提取滤液重量为洋甘菊重量的1～2倍之间；
(3)中温无菌浓缩滤液重量至洋甘菊重量一半以下，得洋甘菊萃取物。
3.根据权利要求1所述的一种透过皮肤吸收快速修复视力的小分子肽护眼液，其特征在于，所述金盏花萃取物、金银花萃取物、枸杞子萃取物和决明子萃取物的制备方法如洋甘菊萃取物。
4.根据权利要求1所述的一种透过皮肤吸收快速修复视力的小分子肽护眼液，其特征在于，按权利要求1配比制备谷氨酸、甘氨酸、丝氨酸、天冬氨酸、亮氨酸、赖氨酸混合物，将混合物置于5～10℃无菌环境下搅拌。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811538632.8A CN109549985A (zh) | 2018-12-17 | 2018-12-17 | 一种透过皮肤吸收快速修复视力的小分子肽护眼液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811538632.8A CN109549985A (zh) | 2018-12-17 | 2018-12-17 | 一种透过皮肤吸收快速修复视力的小分子肽护眼液 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109549985A true CN109549985A (zh) | 2019-04-02 |
Family
ID=65870218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811538632.8A Pending CN109549985A (zh) | 2018-12-17 | 2018-12-17 | 一种透过皮肤吸收快速修复视力的小分子肽护眼液 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109549985A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114470022A (zh) * | 2020-10-27 | 2022-05-13 | 河北科星药业有限公司 | 猫眼部护理液及其制备方法和应用 |
| CN117618497A (zh) * | 2023-12-13 | 2024-03-01 | 广州圣康生物医药有限公司 | 护眼液及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053746A (zh) * | 2012-12-28 | 2013-04-24 | 崇左市江州区生产力促进中心 | 明目茶及其生产方法 |
| CN103566068A (zh) * | 2012-08-09 | 2014-02-12 | 大江生医股份有限公司 | 具视网膜保护功能的复方组成物及应用 |
| CN108261421A (zh) * | 2018-03-31 | 2018-07-10 | 深圳中科锐智糖尿病研究所 | 一种治疗眼疾的药物 |
-
2018
- 2018-12-17 CN CN201811538632.8A patent/CN109549985A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566068A (zh) * | 2012-08-09 | 2014-02-12 | 大江生医股份有限公司 | 具视网膜保护功能的复方组成物及应用 |
| CN103053746A (zh) * | 2012-12-28 | 2013-04-24 | 崇左市江州区生产力促进中心 | 明目茶及其生产方法 |
| CN108261421A (zh) * | 2018-03-31 | 2018-07-10 | 深圳中科锐智糖尿病研究所 | 一种治疗眼疾的药物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114470022A (zh) * | 2020-10-27 | 2022-05-13 | 河北科星药业有限公司 | 猫眼部护理液及其制备方法和应用 |
| CN117618497A (zh) * | 2023-12-13 | 2024-03-01 | 广州圣康生物医药有限公司 | 护眼液及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109105690A (zh) | 一种含胶原蛋白肽的果味饮品及其加工方法 | |
| CN103981068B (zh) | 一种浆果、植物香料和可食用花组合搭配的奶酒 | |
| CN104256827A (zh) | 一种改善视力的口服液及其制备方法 | |
| CN109549985A (zh) | 一种透过皮肤吸收快速修复视力的小分子肽护眼液 | |
| CN110881666A (zh) | 一种航天员专用营养体质的小分子复合肽制剂 | |
| CN101228902B (zh) | 一种具有美容功能的酸奶及制备方法 | |
| CN105876442A (zh) | 一种羊骨髓肽提取方法 | |
| CN105581212A (zh) | 一种缓解视疲劳的蓝莓固体饮品生产方法 | |
| CN106306948A (zh) | 一种饮料及其制备方法 | |
| WO2017041459A1 (zh) | 一种明目保健醋饮料及其制备方法 | |
| CN105661235A (zh) | 一种补充复合营养素的饮料及制备方法 | |
| CN104312878B (zh) | 含鹿茸血和玛卡的滋补保健酒及其制备方法 | |
| CN107653289A (zh) | 一种工业化生产红花籽活性肽及制备方法 | |
| CN105602803A (zh) | 一种山捻子酒及其酿制方法 | |
| CN103468507A (zh) | 一种玛咖黄酒及其制备方法 | |
| CN105558685B (zh) | 一种护眼红曲醋饮料及其制备方法 | |
| CN107455753A (zh) | 一种海参肽口服液及其制备工艺 | |
| CN110279054A (zh) | 一种改善“屏幕肌”的胶原蛋白固体饮料及其制备方法 | |
| CN106148092A (zh) | 一种雪莲人参多肽养生酒及其制备方法 | |
| CN103981079B (zh) | 一种玛咖香醋及其制备方法 | |
| CN104939093A (zh) | 低糖瓜蒌籽油乳剂 | |
| CN107312085A (zh) | 一种藻蓝蛋白降血糖多肽 | |
| CN106107966A (zh) | 明目酵素及其制备方法 | |
| CN102389074B (zh) | 含有多种氨基酸的地龙液及其制备方法 | |
| CN104223220A (zh) | 乳酸决明子饮料 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190402 |