CN109527340A - A kind of silicates functional form mold toxin sorbent - Google Patents
A kind of silicates functional form mold toxin sorbent Download PDFInfo
- Publication number
- CN109527340A CN109527340A CN201910001034.5A CN201910001034A CN109527340A CN 109527340 A CN109527340 A CN 109527340A CN 201910001034 A CN201910001034 A CN 201910001034A CN 109527340 A CN109527340 A CN 109527340A
- Authority
- CN
- China
- Prior art keywords
- silicates
- functional form
- form mold
- mold toxin
- toxin sorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003053 toxin Substances 0.000 title claims abstract description 32
- 231100000765 toxin Toxicity 0.000 title claims abstract description 32
- 150000004760 silicates Chemical class 0.000 title claims abstract description 26
- 239000002594 sorbent Substances 0.000 title claims description 28
- 229910052604 silicate mineral Inorganic materials 0.000 claims abstract description 26
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000003513 alkali Substances 0.000 claims abstract description 15
- 235000016068 Berberis vulgaris Nutrition 0.000 claims abstract description 14
- 241000335053 Beta vulgaris Species 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 14
- 239000002773 nucleotide Substances 0.000 claims abstract description 13
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 12
- 230000003213 activating effect Effects 0.000 claims abstract description 8
- 230000000813 microbial effect Effects 0.000 claims abstract description 8
- 230000001580 bacterial effect Effects 0.000 claims abstract description 6
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims description 12
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 12
- -1 cation quaternary ammonium salt Chemical class 0.000 claims description 10
- 229960000892 attapulgite Drugs 0.000 claims description 9
- 229910052625 palygorskite Inorganic materials 0.000 claims description 9
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical compound OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 claims description 8
- 239000004927 clay Substances 0.000 claims description 8
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical group O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 8
- 229930186217 Glycolipid Natural products 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- 235000019355 sepiolite Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000004575 stone Substances 0.000 claims description 7
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 6
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 6
- 229910052624 sepiolite Inorganic materials 0.000 claims description 6
- 239000011592 zinc chloride Substances 0.000 claims description 6
- 235000005074 zinc chloride Nutrition 0.000 claims description 6
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 5
- 239000004113 Sepiolite Substances 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- RDQMORJTLICVPR-UHFFFAOYSA-N phosphoric acid;2-(trimethylazaniumyl)acetate Chemical compound OP(O)([O-])=O.C[N+](C)(C)CC(O)=O RDQMORJTLICVPR-UHFFFAOYSA-N 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 235000010755 mineral Nutrition 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 241000194108 Bacillus licheniformis Species 0.000 claims description 2
- 244000063299 Bacillus subtilis Species 0.000 claims description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 2
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 2
- 241001474374 Blennius Species 0.000 claims description 2
- 241000186660 Lactobacillus Species 0.000 claims description 2
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 2
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 2
- 229950003143 basic zinc acetate Drugs 0.000 claims description 2
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 229910052900 illite Inorganic materials 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052622 kaolinite Inorganic materials 0.000 claims description 2
- 229940039696 lactobacillus Drugs 0.000 claims description 2
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 2
- VGIBGUSAECPPNB-UHFFFAOYSA-L nonaaluminum;magnesium;tripotassium;1,3-dioxido-2,4,5-trioxa-1,3-disilabicyclo[1.1.1]pentane;iron(2+);oxygen(2-);fluoride;hydroxide Chemical compound [OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[F-].[Mg+2].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[K+].[K+].[K+].[Fe+2].O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2 VGIBGUSAECPPNB-UHFFFAOYSA-L 0.000 claims description 2
- FCBUKWWQSZQDDI-UHFFFAOYSA-N rhamnolipid Chemical compound CCCCCCCC(CC(O)=O)OC(=O)CC(CCCCCCC)OC1OC(C)C(O)C(O)C1OC1C(O)C(O)C(O)C(C)O1 FCBUKWWQSZQDDI-UHFFFAOYSA-N 0.000 claims description 2
- LITQZINTSYBKIU-UHFFFAOYSA-F tetracopper;hexahydroxide;sulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[Cu+2].[O-]S([O-])(=O)=O LITQZINTSYBKIU-UHFFFAOYSA-F 0.000 claims description 2
- JCPDISNOORFYFA-UHFFFAOYSA-H tetrazinc;oxygen(2-);hexaacetate Chemical compound [O-2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O JCPDISNOORFYFA-UHFFFAOYSA-H 0.000 claims description 2
- 150000003751 zinc Chemical class 0.000 claims description 2
- 239000002028 Biomass Substances 0.000 claims 2
- 240000001046 Lactobacillus acidophilus Species 0.000 claims 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 claims 1
- 235000013351 cheese Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical class O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 231100000678 Mycotoxin Toxicity 0.000 abstract description 21
- 239000002636 mycotoxin Substances 0.000 abstract description 21
- 241001465754 Metazoa Species 0.000 abstract description 13
- 230000036039 immunity Effects 0.000 abstract description 7
- 230000004048 modification Effects 0.000 abstract description 7
- 238000012986 modification Methods 0.000 abstract description 7
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 244000144972 livestock Species 0.000 abstract description 5
- 244000144977 poultry Species 0.000 abstract description 5
- 210000000987 immune system Anatomy 0.000 abstract description 4
- 230000000968 intestinal effect Effects 0.000 abstract description 4
- 238000001784 detoxification Methods 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 10
- 238000001179 sorption measurement Methods 0.000 description 8
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000003463 adsorbent Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 229930195730 Aflatoxin Natural products 0.000 description 1
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241001147746 Lactobacillus delbrueckii subsp. lactis Species 0.000 description 1
- 244000046101 Sophora japonica Species 0.000 description 1
- 235000010586 Sophora japonica Nutrition 0.000 description 1
- HIWPGCMGAMJNRG-ACCAVRKYSA-N Sophorose Natural products O([C@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HIWPGCMGAMJNRG-ACCAVRKYSA-N 0.000 description 1
- 241000218636 Thuja Species 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- HIWPGCMGAMJNRG-UHFFFAOYSA-N beta-sophorose Natural products OC1C(O)C(CO)OC(O)C1OC1C(O)C(O)C(O)C(CO)O1 HIWPGCMGAMJNRG-UHFFFAOYSA-N 0.000 description 1
- 239000003876 biosurfactant Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 235000015141 kefir Nutrition 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- PZDOWFGHCNHPQD-VNNZMYODSA-N sophorose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PZDOWFGHCNHPQD-VNNZMYODSA-N 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- MBMQEIFVQACCCH-UHFFFAOYSA-N trans-Zearalenon Natural products O=C1OC(C)CCCC(=O)CCCC=CC2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-UHFFFAOYSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- MBMQEIFVQACCCH-QBODLPLBSA-N zearalenone Chemical compound O=C1O[C@@H](C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-QBODLPLBSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/273—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption using adsorption or absorption agents, resins, synthetic polymers, or ion exchangers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/143—Fermentum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/517—Bifidum
Abstract
It is to be sufficiently mixed by modified silicate mineral, yeast nucleotides, microbial bacterial agent and obtained the invention discloses a kind of silicates functional form mold toxin sorbent.Modified silicate mineral of the present invention is obtained by beet alkali modification-antibiotic property metal ion body phase load-Glycolipids Biosurfactantss and quaternary surfactant combined modification, with detoxification-reparation-growth promotion multi-efficiency, on the basis of realizing high-efficiency detoxicating, body immunity can be improved, livestock and poultry production performance is improved, raise benefit is effectively improved；Further composite yeast nucleotide and microbial bacterial agent; by three's perfect combination; it even more imparts product to adjust animal alimentary canal micro-ecological environment, keep intestinal flora balance, activating immune system, the function of improving immunity of organisms, enhancing liver detoxification functions of expelling toxin, protection and the infection of reparation germ and mycotoxin etc. and cause body harm, realizes the somatotrophic multi-efficiency of detoxification-reparation-.
Description
Technical field
The present invention relates to a kind of functional form mold toxin sorbent more particularly to a kind of silicates functional form mycotoxins
Adsorbent belongs to mycotoxin adsorption removing field and technical field of animal.
Background technique
Mycotoxin is the very strong mould secondary metabolite of toxicity, due to its superpower adaptability and heat-resisting ability,
It is usually present in during the plantation of feedstuff, the processing of harvest and feed, transport, storage, and then enters animal or people
In vivo, liver, kidney, immune system, respiratory system, digestive system and the reproductive system etc. of body are damaged.Mycotoxin is dirty
It dyes for the maximum hidden danger of feed safety.Mycotoxin is many kinds of, and what is had now been found that just has more than 300 kinds.Hundred it is difficult to understand it is bright
The investigation result of global mycotoxin contamination in 2017 shows that the mycotoxin contamination in Asia is serious, 83% feed and raw material sample
At least contain a kind of mycotoxin in product；It praises Ji 1-6 month mycotoxin analysis report in 2018 to show, the generally existing mould in the whole world
Endotoxin contamination problem, especially the most serious with North America, Europe and India, followed by China, South America, Southeast Asia.Build bright industry
Mycotoxin semiyearly report also indicates that within 2018, and the first half of the year in 2018, mycotoxin exceeding standard rate increased by a fairly big margin compared with 2017,
Exceeded also pollution level has exacerbation trend.For this purpose, how to solve mycotoxin contamination be cultivation industry development critical issue it
One.
Absorption method is one of processing mycotoxin most effective way.Natural silicate minerals are due to its preferable adsorptivity
The first choice of mycotoxin removal material can be become.But natural silicate minerals have preferable suction to the stronger aflatoxin of polarity
Attached ability is but very low to the low poles molecule removal rate such as zearalenone.In order to improve the absorption to low pole mycotoxin
Performance generallys use surfactant and is modified processing (CN 101890330 B, CN to natural silicate minerals
103521181 B of 102847509 A, CN 103521173 A, CN).Applicant also uses surfactant-modified clay early period
Mineral are prepared for different types of mold toxin sorbent, can realize the removal ability to mycotoxin to a certain extent
(CN 103846078A, CN 104888691A), but surfactant used by above-mentioned patented technology is synthesis class table
Face activating agent, such activating agent all have certain toxicity and cannot biodegrades.Applicant also uses less toxic betaine-like table
Face activating agent (CN 107243325A) and chitosan quaternary ammonium salt modified attapulgite (CN107159140A) are prepared for attapulgite
Class mold toxin sorbent achieves certain progress, imparts the preferable anti-microbial property of material, but in enhancing animal body
Also there is certain limitation in terms of the functions such as immunity.
As people advocate the enhancing of nature and environmental consciousness, it is necessary to select alternative chemically synthesized surfactant solution
The certainly above problem.In addition, applicant has excessively focused on product to the absorption property of toxin in early-stage study, animal is but had ignored
The possibility of the recovery of physical function and promotion growth of animal after poisoning.
Summary of the invention
The present invention existing antibacterial take off mould adsorbent there are aiming at the problem that, a kind of silicates functional form mycotoxin is provided
Adsorbent.
Silicates functional form mold toxin sorbent of the invention is by modified silicate mineral, yeast nucleotides, micro-
Bacteria agent is sufficiently mixed uniformly and obtains.
Yeast nucleotides are also rich in high-content nucleotide due to containing a large amount of immune polysaccharides, can activating immune system, enhancing supports
Drag restores intestinal physiology function, improves feed intake, perfects intestinal immunological barrier, defence virus infraction ability greatly increases, right
Endangering caused by the infectious diseases such as bacterium, virus, fungi and mycotoxin also has protection well and recovery function.Ferment
The mass percent of parent nucleus thuja acid is 5 ~ 15%.
Bacillus licheniformis, bacillus subtilis, bifidobacterium bifidum, lactoenterococcus, thermophilic can be used in microbial bacterial agent
At least one of Lactobacillus lactis, Lactobacillus casei, lactobacillus plantarum, lactobacillus cellobiosas, lactobacillus fermenti.Microbial bacteria
Agent can inhibit pathogen, adjust alimentary canal health, enhances animal body immunity function, and provide nutriment, it is raw to can promote animal
Length is improved food conversion ratio.The mass percent of microbial bacterial agent is 1 ~ 5%.
The silicate mineral modified technique is as follows: silicate mineral being configured to the ore pulp of mass concentration 5 ~ 20%, is added
15 ~ 30min of reaction is stirred at room temperature in beet alkali hydrochlorate or betaine phosphate；Antibiotic property metal ion is added to continue to stir
30min~60min；Then the Glycolipids Biosurfactantss dissolved are added dropwise, is added dropwise and dissolves after stirring 15min ~ 30min
Cation quaternary ammonium salt type surfactant, finally at 35 DEG C ~ 90 DEG C react 1 ~ 2h, be separated by solid-liquid separation, dry, pulverize, changed
Property silicate mineral.
The silicate mineral be montmorillonite, sepiolite, kaolinite, illite, rectorite, attapulgite, medical stone, she
Cover one or more of clay, galapectite.
Beet alkali hydrochlorate or betaine phosphate (preferably beet alkali hydrochlorate), additional amount are silicate mineral quality
1 ~ 10%.Using beet alkali hydrochlorate or betaine phosphate modified silicate mineral, can not only dissolve in silicate mineral
The impurity such as carbonate are realized the effect of dredging cellular structure, exposure adsorption site, while being had as the glycine betaine of feed addictive
There is good function of detoxification, can promote Animal lipid metabolism and protein synthesis, by adjusting enteron aisle osmotic pressure, after avoiding poisoning
The disorder function of enteron aisle, to promote growth of animal and improve food conversion ratio.
Mantoquita or zinc salt of the antibiotic property metal ion in feed addictive microelement, such as copper chloride, sulfuric acid
At least one of copper, basic copper sulfate, zinc chloride, zinc sulfate, zinc acetate, basic zinc chloride.Its additional amount is silicate mine
The 2.5 ~ 5% of amount of substance.Bulk phase-doped Zn2+、Cu2+It can be desorbed in acid condition, effect microelement supply, while
Good antibacterial action, substitution or the use for reducing antibiotic can be played.
Glycolipids Biosurfactantss are at least one of sophorolipid, seaweed glycolipid, rhamnolipid, preferably sophorose
Rouge, and sophorolipid is divided to lactone type and two kinds of acid type, preferably acid type sophorolipid.Cation quaternary ammonium salt type surfactant selects C atom
The alkyl trimethyl chlorine (bromine) for measuring 12-18 changes ammonium, preferably octadecyltrimethylammonium chloride.Glycolipids Biosurfactantss by
It is nontoxic in its, can natural metabolism, degradation, not will cause residual in animal body, do not influence the characteristics such as animal product quality and raising
It is used in material as biological emulsifier；Such emulsifier can be improved livestock and poultry fat digestion utilization rate, improve the price of deed, drop
Low livestock and poultry blood cholesterol and triglyceride levels improve livestock and poultry production performance, improve carcass quality, improve immunity of organism function
Can, reduce morbidity and mortality.It is compounded and modified Portland mine with synthesis class quaternary ammonium salt cationic surfactant
Object will reduce the dosage of synthesis class surfactant by the solubilized effect Improving The Quality of Products of the two.Therefore, glycolipid class
Biosurfactant and cation quaternary ammonium salt type surfactant are as modified synergic agent, the quality proportioning of the two are as follows: and 0.25:1 ~
1:1, and the total amount of modified synergic agent is the 1 ~ 5% of silicate mineral quality.
The modified silicate mineral of the above method is raw by beet alkali modification-antibiotic property metal ion body phase load-glycolipid class
Object surfactant and quaternary surfactant combined modification and obtain, with detoxification-reparation-growth promotion multi-efficiency, in reality
On the basis of existing high-efficiency detoxicating, body immunity can be improved, livestock and poultry production performance is improved, effectively improve raise benefit.It is modified
The mass percent of silicate mineral is 80 ~ 90%.
In conclusion the present invention uses beet alkali hydrochlorate or betaine phosphate with strong acidity to handle silicate
On the one hand mineral dissolve the impurity such as carbonate contained in silicate mineral under highly acid effect, sufficiently release is intrinsic inhales
Attached site；On the other hand, change clay mineral surface charge by loading a certain amount of glycine betaine；Then drawn by bulk phase-doped
Enter Zn, Cu microelement with antibacterial functions, then surface is carried out to silicate mineral using compound surface-treating agent and is modified, adjusts
The hydrophilicity and hydrophobicity of product is controlled, the interaction with low pole lps molecule is improved.On the basis of modified silicate mineral again into
Three's perfect combination is even more imparted product and adjusts animal alimentary canal by one step composite yeast nucleotide and microbial bacterial agent
Micro-ecological environment keeps intestinal flora balance, activating immune system, improves immunity of organisms, enhancing liver detoxification toxin expelling function
The function that germ and mycotoxin etc. infect and cause body harm can, be protected and be repaired, detoxification-reparation-growth-promoting is realized
Long multi-efficiency.
In practical application, the dosage of silicates functional form mold toxin sorbent are as follows: add 0.5 ~ 2kg in feed per ton
Adsorbent.
Detailed description of the invention
Vitro Adsorption effect of Fig. 1 embodiment 1-5 to mycotoxin.
Specific embodiment
Below with reference to embodiment to the preparation method and adsorptivity of silicates functional form mold toxin sorbent of the present invention
It can be described further.
Embodiment 1
(1) it the modification of sepiolite: measures 1L distilled water and is injected into the reaction flask of 2L, 100g sepiolite is added, wait be uniformly dispersed
Afterwards, 1g beet alkali hydrochlorate is added, after 30min is stirred at room temperature, 5g zinc chloride is added, continues to stir 45min；What dropwise addition had been dissolved
The octadecyltrimethylammonium chloride 2.625g dissolved is added dropwise after sophorolipid 0.875g, 15min, continues at 60 ± 5 DEG C anti-
2h is answered, is separated by solid-liquid separation, be dry, pulverize, obtain modified meerschaum；
(2) 8.75 g modified meerschaums, 1g yeast nucleotides, 0.25g bifid the preparation of functional form mold toxin sorbent: are weighed
Bacillus obtains sepiolite class functional form mold toxin sorbent after being sufficiently mixed；Vitro Adsorption effect is specifically shown in Fig. 1.
Embodiment 2
(1) it the modification of montmorillonite: measures 2L distilled water and is injected into the reaction flask of 3L, 100g montmorillonite is added, wait be uniformly dispersed
Afterwards, the beet alkali hydrochlorate of montmorillonite amount 5g is added, after 15min is stirred at room temperature, 3.5g zinc sulfate is added, the Chinese scholartree dissolved is added dropwise
The octadecyltrimethylammonium chloride 2.5g that has dissolved is added dropwise after glycolipid 2.5g, 15min, the reaction was continued at 80 ± 5 DEG C 2h, Gu
Liquid separation, dry, pulverize, obtain modified montmorillonite used；
(2) preparation of functional form mold toxin sorbent: it is modified montmorillonite used to weigh 9g, 0.5g yeast nucleotides, 0.5g withered grass bud
Spore bacillus obtains smectites functional form mold toxin sorbent after being sufficiently mixed；Vitro Adsorption effect is specifically shown in Fig. 1.
Embodiment 3
(1) it the modification of medical stone: measures 1L distilled water and is injected into the reaction flask of 2L, 100g medical stone is added, wait be uniformly dispersed
Afterwards, 10g beet alkali hydrochlorate is added, after 60min is stirred at room temperature, the copper sulphate of 5g is added, continues to stir 20min, dissolution is added dropwise
The octadecyltrimethylammonium chloride 0.6g dissolved is added dropwise after good sophorolipid 0.4g, 15min, continues at 50 ± 5 DEG C anti-
2h is answered, is separated by solid-liquid separation, dry, pulverize, obtains modified medical stone；
(2) the modified medical stone of 8g, 1.5g yeast nucleotides, 0.5g plant cream the preparation of functional form mold toxin sorbent: are weighed
Bacillus obtains medical stone class functional form mold toxin sorbent after being sufficiently mixed；Vitro Adsorption effect is specifically shown in Fig. 1.
Embodiment 4
(1) it the modification of Yi Meng clay: measures 1L distilled water and is injected into the reaction flask of 2L, 100g Yi Meng clay is added, wait disperse
After uniformly, the beet alkali hydrochlorate of 7.5g is added, after 30min is stirred at room temperature, the zinc chloride of 3.5g is added, continues to stir 30min,
The octadecyltrimethylammonium chloride 2.5g dissolved is added dropwise after the sophorolipid 2g, 15min dissolved is added dropwise, at 70 ± 5 DEG C
The reaction was continued 2h is separated by solid-liquid separation, dry, pulverize, and obtains modified Yi Meng clay；
(2) the modified Yi Meng clay of 9g, 0.9g yeast nucleotides, 0.1 withered grass bud the preparation of functional form mold toxin sorbent: are weighed
Spore bacillus obtains Yi Meng clay class functional form mold toxin sorbent after being sufficiently mixed；Vitro Adsorption effect is specifically shown in Fig. 1.
Embodiment 5
(1) it the modification of attapulgite: measures 500mL distilled water and is injected into the reaction flask of 1L, 100g attapulgite is added, wait divide
After dissipating uniformly, 2.5g beet alkali hydrochlorate is added, after 30min is stirred at room temperature, montmorillonite quality 2.5g zinc sulfate is added, continues
30min is stirred, the octadecyltrimethylammonium chloride 3.5g dissolved is added dropwise after the sophorolipid 1.5g, 15min dissolved is added dropwise,
The reaction was continued at 40 ± 5 DEG C 2h is separated by solid-liquid separation, dry, pulverize, obtain modified attapulgite；
(2) 8.5g modified attapulgite, 1.25g yeast nucleotides, 0.25 hair the preparation of functional form mold toxin sorbent: are weighed
Kefir milk bacillus obtains attapulgite class functional form mold toxin sorbent after being sufficiently mixed；Vitro Adsorption effect is specifically shown in Fig. 1.
Claims (10)
1. a kind of silicates functional form mold toxin sorbent is by modified silicate mineral, yeast nucleotides, microbial bacteria
Agent is sufficiently mixed uniformly and obtains.
2. a kind of silicates functional form mold toxin sorbent as described in claim 1, it is characterised in that: each component is by following
Mass percent mixing: yeast nucleotides 5 ~ 15%, microbial bacterial agent 1 ~ 5%, modified silicate mineral 80 ~ 90%.
3. a kind of silicates functional form mold toxin sorbent as claimed in claim 1 or 2, it is characterised in that: described is micro-
Bacteria agent is bacillus licheniformis, bacillus subtilis, bifidobacterium bifidum, lactoenterococcus, lactobacillus acidophilus, cheese cream
At least one of bacillus, lactobacillus plantarum, lactobacillus cellobiosas, lactobacillus fermenti.
4. a kind of silicates functional form mold toxin sorbent as claimed in claim 1 or 2, it is characterised in that: the silicic acid
Salt mineral modified technique is as follows: silicate mineral being configured to the ore pulp of mass concentration 5 ~ 20%, beet alkali hydrochlorate or sweet tea is added
15 ~ 30min of reaction is stirred at room temperature in dish alkali phosphate；Antibiotic property metal ion is added to continue to stir 30min ~ 60min；Then it drips
The cation quaternary ammonium salt surface dissolved is added dropwise after stirring 15min ~ 30min in the good Glycolipids Biosurfactantss of solubilization solution
Activating agent finally reacts 1 ~ 2h at 35 DEG C ~ 90 DEG C, is separated by solid-liquid separation, dry, pulverize, obtain modified silicate mineral.
5. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: the silicate mine
Object is montmorillonite, sepiolite, kaolinite, illite, rectorite, attapulgite, medical stone, Yi Meng clay, one in galapectite
Kind is several.
6. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: beet alkali hydrochlorate
Or betaine phosphate, additional amount are the 1 ~ 10% of silicate mineral quality.
7. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: antibiotic property metal from
Mantoquita or zinc salt of the son in the feed addictive microelement, as copper chloride, copper sulphate, basic copper sulfate, zinc chloride,
At least one of zinc sulfate, zinc acetate, basic zinc chloride, additional amount are the 2.5 ~ 5% of silicate mineral quality.
8. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: sugared lipidic biomass table
Face activating agent is at least one of sophorolipid, seaweed glycolipid, rhamnolipid.
9. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: cation quaternary ammonium salt
Surfactant selects the alkyl trimethyl chlorine (bromine) of C atomic weight 12-18 to change ammonium.
10. a kind of silicates functional form mold toxin sorbent as claimed in claim 4, it is characterised in that: sugared lipidic biomass
The mass ratio of surfactant and cation quaternary ammonium salt type surfactant are as follows: 0.25:1 ~ 1:1, and glycolipid class Bio-surface active
The total amount of agent and cation quaternary ammonium salt type surfactant is the 1 ~ 5% of silicate mineral quality.
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Effective date of registration: 20220608 Address after: 730000 No. 18 Tianshui Middle Road, Chengguan District, Gansu, Lanzhou Patentee after: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Patentee after: Yixing Tianshi Feed Co., Ltd Address before: 730000 No. 18 Tianshui Middle Road, Chengguan District, Gansu, Lanzhou Patentee before: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Patentee before: Jiangsu Tianshi Biotechnology Co., Ltd |