CN109414425A - 3-[2-丁基-1-(2-二乙基氨基-乙基)-1h-苯并咪唑-5-基]-n-羟基-丙烯酰胺的多晶型形式及其用途 - Google Patents

3-[2-丁基-1-(2-二乙基氨基-乙基)-1h-苯并咪唑-5-基]-n-羟基-丙烯酰胺的多晶型形式及其用途 Download PDF

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Publication number
CN109414425A
CN109414425A CN201780041511.XA CN201780041511A CN109414425A CN 109414425 A CN109414425 A CN 109414425A CN 201780041511 A CN201780041511 A CN 201780041511A CN 109414425 A CN109414425 A CN 109414425A
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CN
China
Prior art keywords
base
ethyl
butyl
diethylamino
benzimidazole
Prior art date
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Pending
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CN201780041511.XA
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English (en)
Chinese (zh)
Inventor
大卫·邓肯
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Pathway Therapeutics Inc
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Pathway Therapeutics Inc
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Publication date
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Publication of CN109414425A publication Critical patent/CN109414425A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780041511.XA 2016-05-02 2017-05-01 3-[2-丁基-1-(2-二乙基氨基-乙基)-1h-苯并咪唑-5-基]-n-羟基-丙烯酰胺的多晶型形式及其用途 Pending CN109414425A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662330673P 2016-05-02 2016-05-02
US62/330,673 2016-05-02
PCT/US2017/030414 WO2017192451A1 (en) 2016-05-02 2017-05-01 Polymorphic forms of 3-[2-butyl-1-(2-diethylamino-ehtyl)-1h-benzoimidazol-5-yl]-n-hydroxy-acrylamide and uses thereof

Publications (1)

Publication Number Publication Date
CN109414425A true CN109414425A (zh) 2019-03-01

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Family Applications (1)

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CN201780041511.XA Pending CN109414425A (zh) 2016-05-02 2017-05-01 3-[2-丁基-1-(2-二乙基氨基-乙基)-1h-苯并咪唑-5-基]-n-羟基-丙烯酰胺的多晶型形式及其用途

Country Status (20)

Country Link
US (2) US10626092B2 (https=)
EP (2) EP3939966A1 (https=)
JP (1) JP2019514905A (https=)
KR (1) KR20190005904A (https=)
CN (1) CN109414425A (https=)
AR (1) AR108257A1 (https=)
AU (1) AU2017261218A1 (https=)
BR (1) BR112018072439A2 (https=)
CA (1) CA3022011A1 (https=)
CL (1) CL2018003109A1 (https=)
CO (1) CO2018012941A2 (https=)
EA (1) EA201892341A1 (https=)
ES (1) ES2886495T3 (https=)
IL (1) IL262578A (https=)
MA (1) MA44880A (https=)
MX (1) MX382095B (https=)
PH (1) PH12018502296B1 (https=)
SG (1) SG11201809471UA (https=)
TW (1) TW201741286A (https=)
WO (1) WO2017192451A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110291071B (zh) * 2017-02-28 2022-04-26 苏州科睿思制药有限公司 Sb-939的盐的晶型及其制备方法和用途
EP3728205A1 (en) 2017-12-19 2020-10-28 Assia Chemical Industries Ltd Crystalline polymorphs of pracinostat and pracinostat salts
WO2019149262A1 (zh) * 2018-02-05 2019-08-08 苏州科睿思制药有限公司 Sb-939的晶型及其制备方法和用途
WO2021217180A1 (en) 2020-04-22 2021-10-28 Johnson Matthey Public Limited Company Novel forms of pracinostat dihydrochloride

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008108741A1 (en) * 2007-03-07 2008-09-12 S*Bio Pte Ltd Combination of benzimidazole anti-cancer agent and a second anti-cancer agent
CN101287712A (zh) * 2005-09-08 2008-10-15 S*Bio私人有限公司 杂环化合物
US8143282B2 (en) * 2005-09-08 2012-03-27 S*Bio Pte Ltd. Heterocyclic compounds
US20150258068A1 (en) * 2012-10-30 2015-09-17 Mei Pharma, Inc. Combination therapies

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2291749A1 (fr) 1974-11-20 1976-06-18 Delalande Sa Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique
CA2135173A1 (en) 1992-05-20 1993-11-25 Bruce E. Witzel Ester derivatives of 4-aza-steroids
SE9804212D0 (sv) 1998-12-04 1998-12-04 Astra Pharma Prod Compounds
CA2355470C (en) 1999-01-13 2008-09-30 Warner-Lambert Company Benzoheterocycles and their use as mek inhibitors
AU5636900A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
JP2003503351A (ja) 1999-06-30 2003-01-28 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害化合物
CA2377092A1 (en) 1999-07-16 2001-01-25 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
JP2003504401A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤を用いる慢性疼痛の治療方法
GB9919558D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
KR20020070285A (ko) 1999-11-23 2002-09-05 메틸진, 인크. 히스톤 디아세틸라제의 억제제
EP1162196A4 (en) 1999-12-27 2003-04-16 Japan Tobacco Inc COMPOUNDS WITH JOINED CYCLES AND THEIR USE AS MEDICAMENTS
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US6642252B2 (en) 2000-11-07 2003-11-04 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
CA2450555A1 (en) 2001-06-25 2003-01-03 Merck & Co., Inc. (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
JP2005517007A (ja) 2002-02-07 2005-06-09 アクシス・ファーマスーティカルズ ヒストンデアセチラーゼ阻害剤としての新規二環式ヒドロキサメート
EP1482944A4 (en) 2002-03-13 2006-04-19 Array Biopharma Inc NZ ALKYL BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
JP4429733B2 (ja) 2002-04-16 2010-03-10 帝人株式会社 Ｃｃｒ３拮抗作用を有するピペリジン誘導体
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
WO2004078682A2 (en) 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
CA2518318A1 (en) 2003-03-17 2004-09-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
PT1673349E (pt) 2003-09-22 2010-09-28 S Bio Pte Ltd Derivados benzimidazole: preparação e aplicações farmacêuticas
US20050137234A1 (en) 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
WO2005065681A1 (en) 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
WO2006101456A1 (en) 2005-03-21 2006-09-28 S*Bio Pte Ltd Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287712A (zh) * 2005-09-08 2008-10-15 S*Bio私人有限公司 杂环化合物
US8143282B2 (en) * 2005-09-08 2012-03-27 S*Bio Pte Ltd. Heterocyclic compounds
WO2008108741A1 (en) * 2007-03-07 2008-09-12 S*Bio Pte Ltd Combination of benzimidazole anti-cancer agent and a second anti-cancer agent
US20150258068A1 (en) * 2012-10-30 2015-09-17 Mei Pharma, Inc. Combination therapies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAYMAN CHEMICAL COMPANY: "《Cayman Chemical》", 1 March 2015 *
JAYARAMAN ET AL: "Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone", 《DRUG METABOLISM & DISPOSITION》 *
STEPHEN BYRN, ET AL: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", 《PHARMACEUTICAL RESEARCH》 *
傅晓沧: "药物的多晶型", 《医药工业》 *

Also Published As

Publication number Publication date
EP3452035A4 (en) 2019-09-25
EP3452035B1 (en) 2021-07-07
JP2019514905A (ja) 2019-06-06
MX382095B (es) 2025-03-13
WO2017192451A1 (en) 2017-11-09
CO2018012941A2 (es) 2018-12-28
EP3939966A1 (en) 2022-01-19
IL262578A (en) 2018-12-31
AR108257A1 (es) 2018-08-01
SG11201809471UA (en) 2018-11-29
US20200317621A1 (en) 2020-10-08
ES2886495T3 (es) 2021-12-20
CA3022011A1 (en) 2017-11-09
US10626092B2 (en) 2020-04-21
TW201741286A (zh) 2017-12-01
PH12018502296B1 (en) 2022-04-06
EP3452035A1 (en) 2019-03-13
EA201892341A1 (ru) 2019-05-31
BR112018072439A2 (pt) 2019-02-19
KR20190005904A (ko) 2019-01-16
US20190152923A1 (en) 2019-05-23
MA44880A (fr) 2021-03-17
CL2018003109A1 (es) 2019-04-26
MX2018013349A (es) 2019-02-20
AU2017261218A1 (en) 2018-11-29
PH12018502296A1 (en) 2019-07-08

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