JP2019514905A - ３−［２−ブチル−１−（２−ジエチルアミノ−エチル）−１ｈ−ベンゾイミダゾール−５−イル］−ｎ−ヒドロキシ−アクリルアミドの多形体形態およびその使用 - Google Patents

３−［２−ブチル−１−（２−ジエチルアミノ−エチル）−１ｈ−ベンゾイミダゾール−５−イル］−ｎ−ヒドロキシ−アクリルアミドの多形体形態およびその使用 Download PDF

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Publication number
JP2019514905A
JP2019514905A JP2018555958A JP2018555958A JP2019514905A JP 2019514905 A JP2019514905 A JP 2019514905A JP 2018555958 A JP2018555958 A JP 2018555958A JP 2018555958 A JP2018555958 A JP 2018555958A JP 2019514905 A JP2019514905 A JP 2019514905A
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Prior art keywords
diethylamino
hydroxy
butyl
ethyl
benzoimidazol
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JP2018555958A
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Japanese (ja)
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JP2019514905A5 (https=
Inventor
ダンカン，デイビッド
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エムイーアイ ファーマ，インク．
エムイーアイ ファーマ，インク．
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Publication of JP2019514905A publication Critical patent/JP2019514905A/ja
Publication of JP2019514905A5 publication Critical patent/JP2019514905A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018555958A 2016-05-02 2017-05-01 ３−［２−ブチル−１−（２−ジエチルアミノ−エチル）−１ｈ−ベンゾイミダゾール−５−イル］−ｎ−ヒドロキシ−アクリルアミドの多形体形態およびその使用 Pending JP2019514905A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662330673P 2016-05-02 2016-05-02
US62/330,673 2016-05-02
PCT/US2017/030414 WO2017192451A1 (en) 2016-05-02 2017-05-01 Polymorphic forms of 3-[2-butyl-1-(2-diethylamino-ehtyl)-1h-benzoimidazol-5-yl]-n-hydroxy-acrylamide and uses thereof

Publications (2)

Publication Number Publication Date
JP2019514905A true JP2019514905A (ja) 2019-06-06
JP2019514905A5 JP2019514905A5 (https=) 2020-05-28

Family

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Family Applications (1)

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JP2018555958A Pending JP2019514905A (ja) 2016-05-02 2017-05-01 ３−［２−ブチル−１−（２−ジエチルアミノ−エチル）−１ｈ−ベンゾイミダゾール−５−イル］−ｎ−ヒドロキシ−アクリルアミドの多形体形態およびその使用

Country Status (20)

Country Link
US (2) US10626092B2 (https=)
EP (2) EP3939966A1 (https=)
JP (1) JP2019514905A (https=)
KR (1) KR20190005904A (https=)
CN (1) CN109414425A (https=)
AR (1) AR108257A1 (https=)
AU (1) AU2017261218A1 (https=)
BR (1) BR112018072439A2 (https=)
CA (1) CA3022011A1 (https=)
CL (1) CL2018003109A1 (https=)
CO (1) CO2018012941A2 (https=)
EA (1) EA201892341A1 (https=)
ES (1) ES2886495T3 (https=)
IL (1) IL262578A (https=)
MA (1) MA44880A (https=)
MX (1) MX382095B (https=)
PH (1) PH12018502296B1 (https=)
SG (1) SG11201809471UA (https=)
TW (1) TW201741286A (https=)
WO (1) WO2017192451A1 (https=)

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CN110291071B (zh) * 2017-02-28 2022-04-26 苏州科睿思制药有限公司 Sb-939的盐的晶型及其制备方法和用途
EP3728205A1 (en) 2017-12-19 2020-10-28 Assia Chemical Industries Ltd Crystalline polymorphs of pracinostat and pracinostat salts
WO2019149262A1 (zh) * 2018-02-05 2019-08-08 苏州科睿思制药有限公司 Sb-939的晶型及其制备方法和用途
WO2021217180A1 (en) 2020-04-22 2021-10-28 Johnson Matthey Public Limited Company Novel forms of pracinostat dihydrochloride

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US6642252B2 (en) 2000-11-07 2003-11-04 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
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Also Published As

Publication number Publication date
EP3452035A4 (en) 2019-09-25
EP3452035B1 (en) 2021-07-07
MX382095B (es) 2025-03-13
WO2017192451A1 (en) 2017-11-09
CO2018012941A2 (es) 2018-12-28
EP3939966A1 (en) 2022-01-19
IL262578A (en) 2018-12-31
AR108257A1 (es) 2018-08-01
SG11201809471UA (en) 2018-11-29
US20200317621A1 (en) 2020-10-08
ES2886495T3 (es) 2021-12-20
CA3022011A1 (en) 2017-11-09
US10626092B2 (en) 2020-04-21
TW201741286A (zh) 2017-12-01
PH12018502296B1 (en) 2022-04-06
EP3452035A1 (en) 2019-03-13
EA201892341A1 (ru) 2019-05-31
CN109414425A (zh) 2019-03-01
BR112018072439A2 (pt) 2019-02-19
KR20190005904A (ko) 2019-01-16
US20190152923A1 (en) 2019-05-23
MA44880A (fr) 2021-03-17
CL2018003109A1 (es) 2019-04-26
MX2018013349A (es) 2019-02-20
AU2017261218A1 (en) 2018-11-29
PH12018502296A1 (en) 2019-07-08

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