CN109414399A - Skin irritatin alleviation comprising hydrangea fermentation material and scytitis alleviate the composition that applies some make up - Google Patents
Skin irritatin alleviation comprising hydrangea fermentation material and scytitis alleviate the composition that applies some make up Download PDFInfo
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- CN109414399A CN109414399A CN201780040265.6A CN201780040265A CN109414399A CN 109414399 A CN109414399 A CN 109414399A CN 201780040265 A CN201780040265 A CN 201780040265A CN 109414399 A CN109414399 A CN 109414399A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The present invention relates to comprising hydrangea fermentation material as effective component skin irritatin alleviation and scytitis alleviation apply some make up composition.According to the present invention, cosmetic composition comprising hydrangea fermentation material of the invention as effective component, alleviate skin irritatin and scytitis by the expression of inhibition inflammation-induced cell factor (IL-6, IL-8, IL-1 β), to finally can be effectively applied to the purposes of skin allergy prevention and improvement, flushing improvement, dermatitis prevention and improvement etc..
Description
Technical field
The present invention relates to scytitis alleviations to apply some make up composition, more particularly, to including hydrangea fermentation material
Skin irritatin alleviation and scytitis alleviate the composition that applies some make up.
Background technique
One of most important function of skin is the defencive function as barrier.It is anti-for being directly exposed to the skin of external environment
Only loss of body fluids, and from hostile environment protect body most important first defence line.Also, for toxicant or micro- life
Object, physical stimulation or ultraviolet light execute barrier function.But if this skin barrier function by skin outside, it is internal a variety of
Stimulation, then skin barrier is impaired, and skin is caused to become drying, or skin is made to be inflamed reaction.Meanwhile it if can not effectively control
The Preliminary Irritation reaction occurred at this time, it is likely that deteriorate as serious dermatitis.
But with population increase, urbanization, industrialization and automobile increase etc. influence, atmosphere pollution become seriously, by
This, the type of pollutant becomes multiplicity.In particular, facing the Air Pollutants from China's discharge due to the positional factor of South Korea
Movement caused by yellow sand and micronic dust etc. it is aggrieved, seriousness is also got higher.Micronic dust (particulate matter) is according to grain
The size of son is divided into that diameter is 10 μm of micronic dusts (PM10) below and diameter is 2.5 μm of ultra micro dirt (PM2.5) below.South Korea's ring
PM10 is limited to Air Pollutants by border portion.It is well known that the Air Pollutants Induced respiration organ disease such as this micronic dust
And heart disease, meanwhile, the influence to the skin for occupying wide area in body is also more and more paid close attention to.In particular, according to report
It accuses, it is impaired that the micronic dust in Air Pollutants makes epidermal barrier function, and deteriorates allergic dermatitis.Also, with common skin
Skin is compared, and sensitive generates more sensitive reaction for external stimulation or environmental change, so that stimulation or skin be presented
Inflammation shape.It was found that being compared with normal people, the people with this sensitive is more sensitive to the exteroceptive degree of micronic dust,
The excitement of three times or more can be experienced.Therefore, the polluter of micronic dust etc. especially generates skin to the people with sensitive
A possibility that problem, is high.It has an effect on skin aging, according to nearest epidemiological study, is exposed to the wrinkle occurred in the skin of micronic dust
Line and color spot increase, directly related to aging.Micronic dust produces active oxygen to inhibit collagen synthesis, and can activate decomposition, inhales
The polycyclic aromatic hydrocarbon (PAH, polycyclic aromatic hydrocarbon) for investing micronic dust surface activates organism by AhR
Foreign body metabolism decomposes to increase collagen, so that skin aging occur.It should grope to reduce micronic dust as a result, and the direct of skin connects
The method of touching and new cure by molecular mechanism correlative study.
Inflammatory reaction (inflammatory response) in skin is arised from because of physical stimulation or chemical substance, bacterium
Deng and for defending its effect when causing skin damage, panimmunity cell and inflammation-induced cell factor are participated.It is white
Cytokine -6 (IL-6, interleukin-6), interleukin 8 (IL-8, interleukin-8), interleukin-1 ' beta '
(IL-1 β, interleukin- β) etc. is representative inflammation-induced cell factor.IL-1 β is thin by the mononuclear phagocyte activated
Born of the same parents, epithelial cell, vascular endothelial cell are formed and the typical cell factor of inducing inflammatory reaction, IL-6 be by T cell and
Macrophage is secreted, immune response stimulating, and adjusts the cell factor of inflammatory reaction.Also, it is not only inflammation-induced cell
The macrophage (macrophage) of the factor, activation also excessively generates nitric oxide (NO, nitric oxide) or prostaglandin
(prostagladin) E2 (PGE2), to more activate inflammatory process.It was reported that the micro dust particle of promotion and anti-inflammatory is in people
Increase the expression of this inflammation-induced cell factor in body keratinocyte.
In the past, the cosmetics of anti-inflammatory properties can be assigned using natural extract to skin by attempting exploitation in many ways,
Its typical case is as follows: the cosmetic combinations comprising Flos Camelliae Japonicae extract are proposed in KR published patent the 2007-0011939th
Object is proposed calm comprising mung bean fermentation-zyme extract skin and is stimulated in KR published patent the 2010-0086698th
Alleviate the composition that applies some make up, refers in KR published patent the 2013-0016930th comprising Salvia japonica, balm, parmelia saxatilis
Dish and Bulbus Allii Cepae extract apply some make up composition as the allergic skin of effective component and skin irritatin alleviation.Also, in Korea Spro
Itd is proposed in state's publication the 2015-0078948th comprising mistletoe, pine bark and watt lotus flower mixed extract as effectively at
The scytitis divided improves or the composition that applies some make up is alleviated in skin irritatin, in KR published patent the 2009-0091547th
It is proposed that the composition that applies some make up is alleviated in the anti-inflammatory and skin irritatin of the mixed extract comprising Eclipta prostrata and frutus cnidii.On but
State any skin irritatin alleviation and skin for all not recording hydrangea extractive from fermentative of the invention in cosmetic composition
Inflammation remission effect.
In this regard, the present inventor makes great efforts to study to overcome above-mentioned problem of the prior art, it is final to assert because of a variety of stimulations,
Especially increased inflammatory cytokine is related to skin irritatin and scytitis due to micronic dust stimulates, and improves this ask to excavate
The substance of topic screens the plant extracts for inhibiting the expression of inflammatory cytokine to be compared, wherein the just fermentation Eight Immortals
For the fermentation material of flower extract, confirming it has by inhibiting IL-6, IL-8 and IL- as inflammation-induced cell factor
The expression of 1 β is come the effect of alleviating skin irritatin and scytitis, so as to complete the present invention.
Summary of the invention
Technical problem
Therefore, it is a primary object of the present invention to provide the scytitis alleviation comprising hydrangea fermentation material and apply some make up
Composition, the hydrangea fermentation material have by inhibiting because of a variety of stimulations, especially increased because of micronic dust stimulation to lure as inflammation
The expression of IL-6, IL-8 and IL-1 β of the guided cell factor are come the effect of alleviating skin irritatin and scytitis.
Also, another object of the present invention is to provide following cosmetic composition, hydrangea fermentation material of the invention is answered
Skin irritatin alleviation and scytitis remission effect are assigned, with the basic formulation for functional cosmetic composition so as to reality
Now skin allergy prevention and improvement, flushing improvement, dermatitis prevention and improvement.
Technical solution
According to an embodiment of the present invention, the skin that the present invention provides comprising hydrangea fermentation material as effective component pierces
Swash alleviation and scytitis alleviates the composition that applies some make up.
Machaka of the hydrangea (Hydrangea macrophylla) as Rosales Saxifragaceae, is opened in 6~July
Flower is in initially lilac, becomes sky blue later, eventually become light red.If soil is neutrality, flower is white, if soil
For acidity, then flower is blue, if soil is alkalinity, flower is pink.As machaka, ovate leaf is to life, edge tool
There is sawtooth, length is 10~15cm, and blade tip comes to a point suddenly.It is commonly called as flower garden tree due to early summer opening rich spend, it is known that
Also there is the effect of Chinese medicine and antipyretic as treatment heart disease.It is main to use the whole strain grass comprising root.In addition, many institute's weeks
Know there are also whitening effect (KR published patent the 2014-0082555th), (South Korea discloses skin ageing phenomenon improvement
Patent the 2009-0081178th) etc..But do not refer to that the hydrangea fermentation fermented for such as present invention by pear flower is extracted yet
The scytitis improvement of the outside stimulus of object.
The expression of inflammation-induced cell factor can be inhibited to alleviate by hydrangea fermentation material in this regard, the present inventor confirms
Skin irritatin and scytitis, so as to complete the present invention.
The Eight Immortals flower extract it is a feature of the present invention that above-mentioned hydrangea fermentation material is fermented using pear flower song and obtain.
Above-mentioned " being fermented using pear flower song " refers to mixing pear flower song and water to be cultivated, specifically referring at 25 DEG C
At a temperature of, pear flower song 10%, Eight Immortals flower extract 1%, water 89% are mixed, made of Anaerobic culturel 4 days.
It is a feature of the present invention that above-mentioned pear flower song refers to meter Qu, it is preferable that beaten made of rice in cake and cultivate song
Object and yeast liquid culture are inoculated with to prepare.
Above-mentioned song culture sterilizes the rice for being tuned into moisture 38~42% 30 minutes specifically, at a temperature of 121 DEG C
Afterwards, yellow aspergillus (Aspergillus oryzae) is inoculated with, the solid culture (Koji) cultivated and dried.Also, ferment
Female liquid culture (Saccharomyces cerevisiae) refers in potato glucose (potato dextrose) liquid
Culture obtained by being cultivated yeast in culture medium.
It is a feature of the present invention that above-mentioned Eight Immortals flower extract can be extracted using any solvent used in the past,
Preferably, it is extracted using water, the lower alcohol of carbon number 1 to 4, butanediol, propylene glycol, glycerol or their mixed solvent.
As the extracting method using said extracted solvent, the extracting method of common plant can be used, for example, hot water mentions
Take, flow back the methods of cooling extraction, ultrasonic wave extraction, means of supercritical extraction, specifically, broken hydrangea prepares powder, and soaks
Stain in Extraction solvent as described above, extract 24 to 72 hours by room temperature.
It is a feature of the present invention that including the upper of 0.001 to 30 weight percent relative to cosmetic composition total weight
State hydrangea fermentation material.If hydrangea fermentation material has scytitis remission effect faint less than 0.001 weight percent
Worry, so not preferably, on the contrary, if hydrangea fermentation material is greater than 30 weight percent, in economic aspect, not preferably.
It is a feature of the present invention that above-mentioned hydrangea fermentation material by inhibit inflammatory cytokine come alleviate skin irritatin and
Scytitis.
Experimental example according to the present invention confirms the inhibitory effect of the increased inflammatory cytokine because of micronic dust, result
As it can be seen that outstanding inhibitory effect is presented for hydrangea fermentation material of the invention, in particular, confirming compared to unfermentable eight
Celestial flower extract, scytitis inhibitory effect are more excellent.By this result as it can be seen that hydrangea fermentation material of the invention can not only lead to
The skin irritatin for crossing inhibition inflammation-induced cell factor to alleviate scytitis, but also can be relieved micronic dust etc.
Also, the remission effect of the stimulation of epidermis caused by micronic dust is confirmed, result is as it can be seen that with regard to hydrangea of the invention
For fermentation material, because of stimulation, impaired epidermis and epidermal cell recover.By this result as it can be seen that hydrangea fermentation material
It is impaired to can be relieved epidermis caused by stimulating caused by micronic dust.
It is a feature of the present invention that above-mentioned cosmetic composition is selected from by soft toner, nutrition toner, nutritious extract
Hua Su, nutritional oil, moisturizing oil, nourishing cream, muffin, facial mask, foundation cream, sun screen, mildy wash, shampoo, lotion and ointment composition
One or more of group dosage form.
Ingredient contained in the cosmetic composition of invention may include other than above-mentioned fermentation material as effective component
The Multiple components usually utilized in cosmetic composition, for example, including stabilizer, solubilizer, vitamin, pigment and fragrance etc
Conventional accessory agent and carrier.
The effect of invention
As described above, hydrangea fermentation material of the invention can be effectively suppressed because of a variety of stimulations, especially overexpressed because of micronic dust
The expression of inflammation-induced cell factor (IL-6, IL-8, IL-1 β) alleviate skin irritatin and scytitis.
Detailed description of the invention
Fig. 1 is the result for indicating to present the experimental example 1 of IL-6 gene expression inhibition degree in inflammation-induced cell factor
Figure.
Fig. 2 is the result for indicating to present the experimental example 1 of IL-8 gene expression inhibition degree in inflammation-induced cell factor
Figure.
Fig. 3 is the result for indicating to present the experimental example 1 of IL-1 beta gene expression inhibition level in inflammation-induced cell factor
Figure.
Fig. 4 is the measurement result for indicating to restore when the epidermis processing hydrangea pear flower extractive from fermentative impaired because of micronic dust
Photo figure.
Specific embodiment
Hereinafter, by embodiment, the present invention will be described in more detail.These embodiments are only used for illustrating the present invention, because
And the scope of the present invention is not construed as limited to these embodiments.
Embodiment 1: the preparation of Eight Immortals flower extract
After hydrangea is carried out powdered, each 100g that extracts is put into individual container, is impregnated in as Extraction solvent
It in the ethanol water 1L of 70 weight percent, shelves at room temperature 24 hours, obtains extracting solution.Using filter paper come to acquisition
After extracting solution is filtered, filtrate is concentrated under reduced pressure using rotary evaporation drying machine, obtains extract.
Embodiment 2: the preparation of hydrangea fermentation material
Hydrangea fermentation material is to be made the Eight Immortals flower extract obtained in above-described embodiment 1 fermentation using pear flower song
's.It is a feature of the present invention that pear flower song uses two various bacterium, that is, bent culture and yeast liquid culture.
Bent culture refers at a temperature of 121 DEG C, will be yellow after the rice for being tuned into moisture 38~42% is sterilized 30 minutes
Aspergillus (Aspergillus oryzae) is inoculated with, the solid culture (Koji) cultivated and dried.The training of yeast liquid
Object (Saccharomyces cerevisiae) is supported to refer in potato glucose (potato dextrose) fluid nutrient medium
The culture that yeast is cultivated.
Pear flower song of the invention is made by the following method, firstly, at a temperature of 60 DEG C, 100 parts by weight that will clean
Rice dry 20~24 hours after, crush.Recycling by the sieve of about 40 mesh powder so that moisture content reach 40~
After 45% mode adds water, it is made round and forms.After round rice is shaped to hole shape rice cake again, in 100 DEG C of temperature
It spends boiling 1 hour lower.The two koji cultures and yeast Liquid Culture that will be cultivated in advance in a manner of reaching the 1% of each parts by weight
Object is inoculated with, cooperation.At a temperature of 25 DEG C, it is bent to complete pear flower for aerobic culture 4 days.
Hydrangea pear flower fermentation material is to mix pear flower song 10%, Eight Immortals flower extract 1%, water 89%, and 25
Anaerobic culturel is manufactured over 4 days at a temperature of DEG C, and above-mentioned hydrangea pear flower fermentation material is used in experimental example 1 below.
Experimental example 1: the evaluation of anti-inflammatory effect
In order to evaluate the anti-inflammatory effect of extractive from fermentative, to IL-1 β, IL-6, IL- as inflammation-induced cell factor
8 processing micronic dust (PM10), measure its expression quantity.In more detail, micronic dust is handled to the HaCaT cell as keratinocyte,
And the ultimate density of manufactured each raw material in embodiment 1 and embodiment 2 is made to reach 10 μ g/ml, it cultivates 4 hours.Then, thin
Extraction mRNA intracellular, is synthesized with cDNA, and implements real-time (real-time) polymerase chain using target template (primer)
Formula reacts (PCR), to finally have rated the degree of gene expression of inflammatory cytokine.The results are shown in FIG. 1 to FIG. 3.
As a result, as shown in FIG. 1 to 3, when inducing each cell factor because of micronic dust, can be evaluated Eight Immortals flower extract and
Its inhibition level of hydrangea extractive from fermentative, pear flower extractive from fermentative present highest to all cell factors and significantly lure
Lead inhibitory effect.Therefore, confirming extractive from fermentative of the invention is to compared to higher antiphlogistic effects before fermenting
The highly useful raw material of cosmetic composition.
Experimental example 2: the evaluation of epidermis stimulation remission effect
In order to evaluate skin epidermis stimulation remission effect, evaluated using the artificial skin tissue of dimensional culture due to micronic dust
The remission effect for the epidermis be stimulated, being damaged.The dust micronic dust (PM10) of 50 μ g/ml is coated on artificial skin surface,
In the medium, the Eight Immortals flower extract and hydrangea pears to be obtained in the concentration Processing Example 1 and embodiment 2 of 10 μ g/ml
Flower extractive from fermentative.It after additional cultivation 24 hours, is fixed on after formalin, prepares paraffin mass (paraffin block)
To carry out H&E dyeing.The cuticula of epidermis and the form of keratinocyte are determined as a result,.Also, measurement result is shown
In Fig. 4.
As a result, as shown in figure 4, the cuticula for confirming the artificial skin tissue being damaged by micronic dust processing is delayed
Solution.Also, the density and shape for confirming the keratinocyte of base will be resumed.Therefore, it confirms of the invention
Extractive from fermentative is highly useful to the cosmetic composition for having effects that the stimulation of the epidermis impaired because of stimulation is alleviated
Raw material.
Dosage form example 1: the preparation of toner
According to constituent shown in following table 1 and ratio of components, it is prepared for by conventional method comprising above-mentioned implementation
The toner of the extractive from fermentative obtained in example 2.
Table 1
Dosage form example 2: the preparation of nutrition essence
According to constituent shown in following table 2 and ratio of components, it is prepared for by conventional method comprising in embodiment 2
The water replenishing cream of the extractive from fermentative of acquisition.
Table 2
Dosage form example 3: moisturiser
According to constituent shown in following table 3 and ratio of components, it is prepared for by conventional method comprising in embodiment 2
The moisturiser of the extractive from fermentative of acquisition.
Table 3
Industrial applicibility
As described above, according to the present invention, the cosmetic combinations comprising hydrangea fermentation material of the invention as effective component
Object alleviates skin irritatin by inhibiting the expression of inflammation-induced cell factor (IL-6, IL-8, IL-1 β) and scytitis is slow
It solves, to finally can be effectively applied to the purposes of skin allergy prevention and improvement, flushing improvement, dermatitis prevention and improvement etc..
Bibliography
(patent document 0001) KR 10-2007-0011939 A
(patent document 0002) KR 10-2010-0086698 A
(patent document 0003) KR 10-2013-0016930 A
(patent document 0004) KR 10-2015-0078948 A
(patent document 0005) KR 10-2009-0091547 A
Claims (7)
- The composition 1. a kind of skin irritatin alleviation and scytitis alleviation apply some make up, which is characterized in that ferment comprising hydrangea Object is as effective component.
- The composition 2. skin irritatin alleviation according to claim 1 and scytitis alleviation apply some make up, which is characterized in that The hydrangea fermentation material is made using pear flower song Eight Immortals flower extract be fermented and is obtained.
- The composition 3. skin irritatin alleviation according to claim 2 and scytitis alleviation apply some make up, which is characterized in that Bent culture and yeast liquid culture are inoculated in the rice cake made of rice to be prepared by the pear flower song.
- The composition 4. skin irritatin alleviation according to claim 1 and scytitis alleviation apply some make up, which is characterized in that The Eight Immortals flower extract utilizes water, lower alcohol, butanediol, propylene glycol, glycerol or their mixed solvent that carbon number is 1 to 4 To extract.
- The composition 5. skin irritatin alleviation according to claim 1 and scytitis alleviation apply some make up, which is characterized in that The total weight for alleviating the composition that applies some make up relative to skin irritatin alleviation and scytitis includes 0.001 to 30 weight percent The hydrangea fermentation material of ratio.
- The composition 6. skin irritatin alleviation according to claim 1 and scytitis alleviation apply some make up, which is characterized in that The hydrangea fermentation material alleviates skin irritatin and scytitis by inhibiting inflammatory cytokine.
- The composition 7. skin irritatin alleviation according to claim 1 and scytitis alleviation apply some make up, which is characterized in that The skin irritatin alleviation and scytitis alleviation apply some make up composition as selected from by soft toner, nutrition toner, battalion Support essence, nutritional oil, moisturizing oil, nourishing cream, muffin, facial mask, foundation cream, sun screen, mildy wash, shampoo, lotion and ointment The dosage form of one or more of the group of composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160082366A KR101867308B1 (en) | 2016-06-30 | 2016-06-30 | Cosmetic composition comprising Hydrangea macrophylla fermented extract for alleviating skin irritation and alleviating skin inflammation |
| KR10-2016-0082366 | 2016-06-30 | ||
| PCT/KR2017/006952 WO2018004293A2 (en) | 2016-06-30 | 2017-06-30 | Cosmetic composition containing hydrangea macrophylla fermented product for soothing skin irritation and skin inflammation |
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| CN109414399A true CN109414399A (en) | 2019-03-01 |
| CN109414399B CN109414399B (en) | 2020-10-30 |
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| CN201780040265.6A Active CN109414399B (en) | 2016-06-30 | 2017-06-30 | Cosmetic composition for skin irritation reduction and skin inflammation reduction comprising hydrangea fermentation product |
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| Country | Link |
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| KR (1) | KR101867308B1 (en) |
| CN (1) | CN109414399B (en) |
| WO (1) | WO2018004293A2 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20200027140A (en) | 2018-09-04 | 2020-03-12 | 이수향 | Cosmetic composition comprising natural fermented extracts and preparation method of the same |
| KR102034773B1 (en) * | 2019-01-07 | 2019-10-21 | 충남대학교산학협력단 | Composition for anti-inflammation comprising ginsenoside Rh1 and Rg2 and extract of Hydrangea macrophylla |
| KR102354148B1 (en) | 2019-11-18 | 2022-01-20 | 이호 | A Method for Extracting an Effective Component from a Barley Sprout and a Composition for Alleviating a Skin Irritation |
| KR102308618B1 (en) * | 2019-12-30 | 2021-10-01 | 안동대학교 산학협력단 | Composition for immune-enhancing containing Hydrangea serrata |
| KR102342409B1 (en) | 2020-03-09 | 2021-12-23 | 주식회사 더가든오브내추럴솔루션 | Hydrolysate of whole plant of Hydrangea macrophylla and Novel use of the same |
| KR102283096B1 (en) | 2020-04-02 | 2021-07-29 | 주식회사 휴먼피부임상시험센터 | Composition for prevention or improvement skin inflammation induced by particlulate matter containing fermented blueberry and black rice extracts |
| KR102184985B1 (en) | 2020-07-14 | 2020-12-01 | (주)피앤스토리 | Functional cosmetic composition comprising hydrogen and phytoncide as active ingredients |
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| US6352685B2 (en) * | 1999-12-24 | 2002-03-05 | KOSé CORPORATION | External preparation for skin |
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| KR101492074B1 (en) * | 2012-12-24 | 2015-02-12 | 재단법인 홍천메디칼허브연구소 | Compositions containing an extract of hydrangea macrophylla for. otaksa for skin whitening |
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- 2017-06-30 WO PCT/KR2017/006952 patent/WO2018004293A2/en active Application Filing
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Also Published As
| Publication number | Publication date |
|---|---|
| CN109414399B (en) | 2020-10-30 |
| WO2018004293A3 (en) | 2018-08-09 |
| WO2018004293A2 (en) | 2018-01-04 |
| KR20180003664A (en) | 2018-01-10 |
| KR101867308B1 (en) | 2018-07-18 |
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