CN109125162A - Skin improves the composition that applies some make up - Google Patents
Skin improves the composition that applies some make up Download PDFInfo
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- CN109125162A CN109125162A CN201710651761.7A CN201710651761A CN109125162A CN 109125162 A CN109125162 A CN 109125162A CN 201710651761 A CN201710651761 A CN 201710651761A CN 109125162 A CN109125162 A CN 109125162A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
Skin the present invention relates to the mixed fermentation extract comprising marjoram, corchorus olitorius and lemon balm as effective component improves the composition that applies some make up.Above-mentioned marjoram, corchorus olitorius and lemon balm mixed fermentation extract are presented outstanding wrinkle of skin improvement, skin-whitening, skin moisture-keeping, alleviate skin irritatin and antioxidant effect.
Description
Technical field
Change the present invention relates to the mixed fermentation extract comprising marjoram, corchorus olitorius and lemon balm as effective component
Cosmetic compositions, it is excellent more particularly to having by the inclusion of the mixed fermentation extract of marjoram, corchorus olitorius and lemon balm
Elegant skin improves active cosmetic composition.
Background technique
Skin is present in the outermost layer for surrounding human body as the maximum organ of human body, to not only protect the important dirty of human body
Device, and protect human body from external impact.Skin constantly with ultraviolet light, temperature change, moisture, dust, atmosphere pollution
Etc. the variations of external environments be in contact, and there is itself additional for protecting skin to prescribed level from outside harm
Function.
Skin is roughly divided into epidermis and corium, is tightly attached to subcutaneous fat.Epidermis as the epithelial tissue formed by multilayer,
Principal component is mainly keratin, and corium is strong with the combination tissue film that interleaved order is formed as the skin layer formed near skin
Turn to the active net of elastomer.It include the combination tissue from corium, multiple combination tissues and blood inside hypodermic layer
Pipe and nerve intricately weave in and are tightly attached to integumentary musculature interlacedly, so that muscle is connected with skin corium.Picture
In this way, percutaneous each layer plays intrinsic effect, to play the important function of protection human body.Therefore, skin for a long time
Management occupies the major part of human lives.However, the allergin relevant to air environmental pollution of such as haze and sandstorm
Increase, the eating habit of modern and living environment etc. have an impact skin.Therefore, it is attempt to carry out from these harmful rings
Border protection skin simultaneously improves skin disease.
The present inventor prepares marjoram, length when research has the natural materials of the skin improvement effects such as anti-oxidant, anti-inflammatory
The mixed extract of capsule jute and lemon balm studies its activity, at this point, marjoram, corchorus olitorius and lemon balm
Outstanding skin improvement effects are presented in mixed fermentation extract, so that having found can be used for cosmetics and complete the present invention.
Existing technical literature
Patent document
Patent document 1: KR published patent spy 2003-0065095 (on 08 06th, 2003)
Patent document 2: KR published patent 10-2013-0085012 (on 07 26th, 2013)
Summary of the invention
The object of the present invention is to provide the mixed fermentation extract conducts comprising marjoram, corchorus olitorius and lemon balm
Effective component is presented the cosmetic compositions of outstanding skin improvement effects.
To achieve the goals above, the present invention provides the mixed fermentation comprising marjoram, corchorus olitorius and lemon balm and extracts
The skin of object improves cosmetic composition.At this point, the above-mentioned Ma Yu relative to cosmetic composition total weight, as effective component
Blue, corchorus olitorius and the mixed fermentation extract of lemon balm include 0.01~90 weight percent.
Also, above-mentioned mixed fermentation extract by by marjoram, corchorus olitorius and lemon balm respectively with 1~2:1~2:1
~2 weight rate mixes to extract, it is highly preferred that being mixed with the ratio of 2:1:2 to extract.
Above-mentioned extractive from fermentative be yeast extractive from fermentative, lactobacillus-fermented extract or vinegar fermentation extract, more preferably
For vinegar fermentation extract.
At this point, above-mentioned vinegar fermentation is by selected from the fruit vinegar by such as apple vinegar, persimmon vinegar or grape vinegar or such as malt vinegar or profound rice
At least one of the group vinegar of the grain vinegar composition of vinegar is formed.
The skin of mixed fermentation extract comprising above-mentioned marjoram, corchorus olitorius and lemon balm improves cosmetic composition
It can be used as wrinkle and improve use, skin-whitening is used, skin moisture-keeping is used, scytitis alleviation is used or anti-oxidant use.
The mixed fermentation extract of marjoram of the invention, corchorus olitorius and lemon balm improves wrinkle of skin, skin beauty
White, skin moisture-keeping, scytitis alleviate and antioxidant effect is outstanding, thus can be used as skin improvement and applies some make up.
Specific embodiment
Hereinafter, present invention be described in more detail.
Change the present invention relates to the mixed fermentation extract comprising marjoram, corchorus olitorius and lemon balm as effective component
Cosmetic compositions.
Reportedly, marjoram (Origanum majorana) used in the present invention be love with the goddess Venus of beauty from
It prepares, and is planted on highest mountain in seawater, it is made to receive sufficient sunlight, brilliant fragrance is the hand due to Venus
Touching.Marjoram is presented with the symbol of beauty, or even is made a mistake by A Fuluodi and be considered as the degree of most precious vanilla, and be used as and change
Adornment water, shower cream, purification with skin are releived and bactericidal effect.
Corchorus olitorius (Corchorus olitorius) has " vegetables because vitality is indomitable, the ability of disease and insect resistance is strong
King " title.Reportedly, ancient egypt persons of royal lineage eat to rebuild one's physical constitution, at present also referred to as mysterious medicinal herbs.Long capsule is yellow
Fiber crops facilitate human body detoxication beta carotene and as antioxidant polyphenol and to moisture-keeping function and skin problem
Effectively.
Lemon balm (Melissa officianalis) is referred to as Mei Lisha, derives from the honeybee of Greece.Because honeybee likes
The honey of joyous Mei Lisha and the name risen, the honey of Mei Lisha is also used for treating wound or inflammatory disease of digestive tract etc..Lemon balm tool
There is the effect for making smooth blood circulation, being in a cheerful frame of mind, is commonly used in because of the inflammation treatment effect that melissa oil has inflammatory
Skin disease.
The present invention provides skin of the mixed fermentation extract comprising marjoram, corchorus olitorius and lemon balm as effective component
Skin improves cosmetic composition.It is outstanding to confirmed that the mixed extract of marjoram, corchorus olitorius and lemon balm itself is also presented
Skin improves activity, however these mixed fermentation extracts are presented more outstanding skin and improve activity.
Come after above-mentioned extractive from fermentative is extracted by mixing marjoram, corchorus olitorius and lemon balm or with fermentation simultaneously is extracted
Preparation.As fermentation strain, can be used selected from least one of the group being made of yeast, lactic acid bacteria and acetic acid bacteria.According to this
One concrete example of invention, uses saccharomyces cerevisiae (Saccharomyces cerevisiae) as above-mentioned saccharomycete, plant cream bar
Bacterium (Lactobacillus plantarum) is used as above-mentioned lactic acid bacteria.
It is highly preferred that above-mentioned extractive from fermentative is the mixing vinegar extractive from fermentative of marjoram, corchorus olitorius and lemon balm.Phase
Than more outstanding skin is presented in the mixing vinegar extractive from fermentative of other extractive from fermentative, marjoram, corchorus olitorius and lemon balm
The improvement of skin wrinkle, skin-whitening, skin moisture-keeping, scytitis alleviates and the effect of antioxidant activity.
Before for a long time, no matter between east and west vinegar is all liked.It is well known that the Confucius in China has gone out in the epoch
Vinegar is showed, South Korea is to be passed to the method to make vinegar from China in three state's epoch.Whole world all regions are just opened before from for a long time
Beginning has made the vinegar for being referred to alternatively as the sweetener with the longest history as the mankind, according to the natural conditions and social customs of a place of each department or production crops
Diversity, the type of vinegar is also a variety of, and have recover from fatigue, bactericidal effect, detoxication, anti-aging and immunity enhancing
Equal multi-effects.In the present invention, above-mentioned vinegar is used for the mixing vinegar extractive from fermentative of marjoram, corchorus olitorius and lemon balm
Preparation.
A concrete example according to the present invention, in above-mentioned vinegar fermentation, using by such as apple vinegar, persimmon vinegar, grape vinegar etc.
At least one of the group of grain vinegar composition of fruit vinegar and such as malt vinegar, profound rice vinegar vinegar.
At this point, above-mentioned marjoram, corchorus olitorius and honeybee relative to cosmetic composition total weight, as effective component
Colored mixed fermentation extract includes 0.01~90 weight percent, it is highly preferred that including 0.1~20 weight percent.
A concrete example according to the present invention, when preparing above-mentioned mixed fermentation extract, by by marjoram, corchorus olitorius
And lemon balm is mixed respectively with 1~2:1~2:1~2 weight rate to extract.It is extracted with the ratio of 2:1:2 mixing
In the case of, highest yield and outstanding skin, which is presented, improves activity, therefore for most preferably.
The mixed fermentation extract of the marjoram, corchorus olitorius and the lemon balm that prepare in this way is by based on mixing
The enhancement of effect of increasing and the effect based on fermentation presents more outstanding wrinkle correlative factor expression and increases effect (test
Example 1), whitening correlative factor expression reduce effect (test example 2), moisturizing correlative factor expression increase effect (test example 3), inflammation
Medium factor expresses inhibitory effect (test example 4) and antioxidant effect (test example 5).
The cosmetic composition of mixed fermentation extract comprising marjoram, corchorus olitorius and lemon balm of the invention can also
It is prepared as usually prepared arbitrary dosage form, for example, toner, face cream, Essence, facial cleanser, makeup remover, facial mask, body
Body cream, body oil, body gels, shampoo, hair conditioner, conditioner milk, hair jelly, foundation cream, lipstick, mascara, sun screen, facial mask
Patch, sunscreen product, perfumed soap etc..
Embodiment
Hereinafter, by following embodiments and test example come the present invention will be described in detail, but the present invention is not limited to these examples.
Embodiment 1: the mixing vinegar extractive from fermentative of preparation marjoram, corchorus olitorius and lemon balm
In lemon balm (dry weight ratio=1:1:1) examination for being mixed with the marjoram of dry 3g, the corchorus olitorius of 3g, 3g
In sample, be added 900g containing 1% profound rice vinegar (South Korea's tumbler (ottogi) company production, total acidity be 6~7%) steaming
Distilled water makes it be impregnated in solution and impregnate one at room temperature.Later, filter paper (qualitative filter paper (Qualitive Filter is utilized
Papers) NO.2) filtering after, with filtrate state acquisition.
Embodiment 2~7: the mixing vinegar extractive from fermentative of preparation marjoram, corchorus olitorius and lemon balm
Be adjusted with the weight ratio of such as 1 pair of dry marjoram of following table, corchorus olitorius and lemon balm, with embodiment
1 identical method is extracted and is filtered.
Table 1
| It distinguishes | Mixed proportion | Yield (%) |
| Embodiment 2 | Marjoram: corchorus olitorius: lemon balm=1:1:2 | 68 |
| Embodiment 3 | Marjoram: corchorus olitorius: lemon balm=1:2:1 | 72 |
| Embodiment 4 | Marjoram: corchorus olitorius: lemon balm=1:2:2 | 80 |
| Embodiment 5 | Marjoram: corchorus olitorius: lemon balm=2:1:1 | 78 |
| Embodiment 6 | Marjoram: corchorus olitorius: lemon balm=2:1:2 | 95 |
| Embodiment 7 | Marjoram: corchorus olitorius: lemon balm=2:2:1 | 88 |
Embodiment 8: the mixed yeast fermentation extract of preparation marjoram, corchorus olitorius and lemon balm
Dry marjoram, corchorus olitorius and lemon balm are mixed into (9g) with the weight ratio of 2:1:2, and 1 with 1500g,
The ratio of 3- butanediol and distilled water is that the mixed solvent of 3:7 (w/w) is mixed.It is mixed object to impregnate 3 days, with cold
In the extraction apparatus of cooler condenser, 8 hours are heated with 100 DEG C of temperature to extract.After extract is inoculated with saccharomyces cerevisiae,
After fermenting 3 days at a temperature of 25 DEG C, 95 DEG C at a temperature of sterilizing 1 hour after, after being filtered using filter paper, obtained with filtrate state
It takes.
Embodiment 9: the mixed plant lactobacillus ferment extract of preparation marjoram, corchorus olitorius and lemon balm
Dry marjoram, corchorus olitorius and lemon balm are mixed into (9g) with the weight ratio of 2:1:2, and 1 with 1500g,
The ratio of 3- butanediol and distilled water is that the mixed solvent of 3:7 (w/w) is mixed.It is mixed object to impregnate 3 days, with cold
In the extraction apparatus of cooler condenser, 8 hours are heated with 100 DEG C of temperature to extract.After extract inoculated plant lactobacillus,
25 DEG C at a temperature of fermentation 3 days after, 95 DEG C at a temperature of sterilizing 1 hour after, after being filtered using filter paper, obtained with filtrate state
It takes.
Comparative example 1: the mixed hot water extract of preparation marjoram, corchorus olitorius and lemon balm
Dry marjoram, corchorus olitorius and lemon balm are mixed into (9g) with the weight ratio of 2:1:2, and 1 with 1500g,
The ratio of 3- butanediol and distilled water is that the mixed solvent of 3:7 (w/w) is mixed.It is mixed object to impregnate 3 days, with cold
In the extraction apparatus of cooler condenser, 8 hours are heated come after extracting, after filtering using filter paper, with filtrate shape with 100 DEG C of temperature
State obtains.
Comparative example 2: preparation marjoram hot water extract
It is the mixed solvent of 3:7 (w/w) by the ratio of the 1,3-BDO of dry marjoram 9g and 1500g and distilled water
It is mixed.It is mixed object to impregnate 3 days, in the extraction apparatus with cooling condenser, be heated 8 hours with 100 DEG C of temperature
After extracting, after being filtered using filter paper, with the acquisition of filtrate state.
Comparative example 3: corchorus olitorius hot water extract is prepared
The ratio of the 1,3-BDO of dry corchorus olitorius 9g and 1500g and distilled water is molten for the mixing of 3:7 (w/w)
Agent is mixed.Object is mixed to impregnate 3 days, it is small with 100 DEG C of temperature heating 8 in the extraction apparatus with cooling condenser
When come after extracting, after being filtered using filter paper, with the acquisition of filtrate state.
Comparative example 4: preparation lemon balm hot water extract
It is the mixed solvent of 3:7 (w/w) by the ratio of the 1,3 butylene glycol of dry lemon balm 9g and 1500g and distilled water
It is mixed.It is mixed object to impregnate 3 days, in the extraction apparatus with cooling condenser, be heated 8 hours with 100 DEG C of temperature
After extracting, after being filtered using filter paper, with the acquisition of filtrate state.
Test example 1: confirmation wrinkle correlative factor expression increases effect
It, will be at using the improved Dulbecco of Yi Sikaofu (IMDM) culture medium of the fetal calf serum (FBS) containing 10%
Fibrocyte (HDFa) is adjusted to 5 × 106After cells/well (cell/well), it is inoculated into 6 orifice plates (well plate) and cultivates
24 hours.After culture, the sample of above-described embodiment and comparative example is handled and is cultivated 48 hours.In the cell cultivated
In, it extracts RNA and passes through reverse transcriptase polymerase chain reaction (RT-PCR, Reverse transcription polymerase
Chain reaction) it confirmed the expression increment rate of collagen (collagen).Collagen (Collagen) expression
Increment rate is calculated by following formula, and result is shown in following table 2.As a control group, adenosine (Adenosine) has been used.
Collagen expression rate (%)=(sample collagen expression quantity/control group collagen expression quantity) × 100
Table 2
| Sample name | Concentration for the treatment of (w/v%) | Collagen expression rate (%) |
| Embodiment 6 | 0.5 | 92.4 |
| Embodiment 8 | 0.5 | 83.6 |
| Embodiment 9 | 0.5 | 84.9 |
| Comparative example 1 | 0.5 | 81.5 |
| Comparative example 2 | 0.5 | 84.5 |
| Comparative example 3 | 0.5 | 80.2 |
| Comparative example 4 | 0.5 | 80.7 |
| Adenosine | 0.01 | 83.8 |
As shown in Table 2 above, when handling identical concentration, the extractive from fermentative of the embodiment of the present invention is identical as control group
Or it is higher than control group, the collagen expression rate for being higher than comparative example is presented.Especially in the vinegar fermentation extract of embodiment 6, it is in
Existing highest collagen expression rate.
Test example 2: confirmation skin-whitening correlative factor expression inhibiting
Yi Geer culture medium (DMEM) is improved using the Du Shi of the fetal calf serum containing 10%, B16F10 melanoma is thin
Born of the same parents (melanome) are adjusted to 1 × 106After cells/well, it is inoculated into 6 orifice plates and cultivates 18 hours.After culture, it is exchanged into processing
After the Du Shi improvement Yi Geer culture medium of α-melanotropin (MSH), the sample of above-described embodiment and comparative example is handled simultaneously
Culture 48 hours.From the cell cultivated, extracts RNA and tyrosinase confirmed by reverse transcriptase polymerase chain reaction
(tyrosinase) expression inhibiting rate.Tyrosinase expression inhibiting rate is calculated by following formula, and result is shown in following table 3.
As a control group, arbutin (Arbutin) has been used.
Tyrosinase expression rate (%)=(sample expression quantity of tyrosinase/control group expression quantity of tyrosinase) × 100
Table 3
| Sample name | Concentration for the treatment of (w/v%) | Tyrosinase expression rate (%) |
| Embodiment 6 | 0.5 | 50.8 |
| Embodiment 8 | 0.5 | 66.4 |
| Embodiment 9 | 0.5 | 60.2 |
| Comparative example 1 | 0.5 | 62.8 |
| Comparative example 2 | 0.5 | 62.3 |
| Comparative example 3 | 0.5 | 63.4 |
| Comparative example 4 | 0.5 | 64.8 |
| Arbutin | 0.01 | 56.4 |
As shown in Table 3 above, when handling identical concentration, outstanding junket is presented in the extractive from fermentative of the embodiment of the present invention
Propylhomoserin expression of enzymes reduces effect, the mixing hair of the marjoram of the embodiment 6 as vinegar fermentation extract, corchorus olitorius and lemon balm
Classic effect is presented in ferment extract.
Test example 3: confirmation skin moisture-keeping correlative factor expression increases
Using the improved Dulbecco culture medium of the Yi Sikaofu of the fetal calf serum containing 10%, fibroblast is adjusted
To 1 × 106After cells/well, it is inoculated into 6 orifice plates and cultivates inoculation 24 hours.After culture, sample is handled and cultivates 48
Hour.In the cell cultivated, extracts RNA and confirmed that hyaluronic acid is synthesized by reverse transcriptase polymerase chain reaction
The expression increment rate of enzyme -2 (Hyaluronan Synthase-2, HAS-2).Hyaluronic acid synthetase -2 expresses increment rate under
Formula calculates, and result is shown in following table 4.As a control group, hyaluronic acid (Hyaluronic Acid) has been used.
- 2 expression rate of hyaluronic acid synthetase (%)=(- 2 expression quantity of sample hyaluronic acid synthetase/control group hyalomitome
- 2 expression quantity of acid enzyme) × 100
Table 4
| Sample name | Concentration for the treatment of (w/v%) | - 2 expression rate of hyaluronic acid synthetase (%) |
| Embodiment 6 | 0.5 | 90.3 |
| Embodiment 8 | 0.5 | 88.3 |
| Embodiment 9 | 0.5 | 85.7 |
| Comparative example 1 | 0.5 | 84.5 |
| Comparative example 2 | 0.5 | 82.6 |
| Comparative example 3 | 0.5 | 80.6 |
| Comparative example 4 | 0.5 | 80.2 |
| Hyaluronic acid | 0.01 | 86.3 |
As shown in Table 4 above, when handling identical concentration, relative to the extract of comparative example, the embodiment of the present invention
Extractive from fermentative is presented outstanding moisturizing factor expression and increases effect.
Test example 4: confirmation scytitis correlative factor expression inhibiting
Yi Geer culture medium is improved using the Du Shi of the fetal calf serum containing 10%, people is immortalized into epidermal cell
(HaCaT) it is adjusted to 1 × 106After cells/well, it is inoculated into 6 orifice plates and cultivates 24 hours.After culture, by outdoor ultraviolet light
(UVB) after being radiated at cell, sample is handled and is cultivated 48 hours.From the cell cultivated, RNA is extracted and by inverse
Transcriptional polymerase chain reaction confirmed the expression inhibiting rate of neoplasm necrosis factor-α (TNF-α).Expression inhibiting rate is by following formula
It calculates, result is shown in following table 5.As a control group, dexamethasone (Dexamethason) has been used.
Neoplasm necrosis factor-alpha expression rate (%)=(sample neoplasm necrosis factor-alpha expression amount/control group tumor necrosis factor
Element-alpha expression amount) × 100
Table 5
As shown in Table 5 above, when handling identical concentration, outstanding inflammation is presented in the extractive from fermentative of the embodiment of the present invention
The expression of disease correlative factor reduces effect, especially with respect to control group, the marjoram of embodiment 6, corchorus olitorius and lemon balm it is mixed
It closes vinegar fermentation extract and more outstanding effect is also presented.
Test example 5: confirmation antioxidant effect
Using the improved Dulbecco culture medium of the Yi Sikaofu of the fetal calf serum containing 10%, by fibroblast
(CCD-986Sk) it is adjusted to 1 × 106After cells/well, it is inoculated into 6 orifice plates and cultivates inoculation 18 hours.After culture, to sample
It is handled and is cultivated 48 hours.In the cell cultivated, extracts RNA and confirmed by reverse transcriptase polymerase chain reaction
The expression increment rate of superoxide dismutase -2 (superoxide dismutase-2, SOD-2).Superoxide dismutase -2
Expression increment rate is calculated by following formula, and result is shown in following table 6.As a control group, vitamin C has been used.
- 2 expression rate of superoxide dismutase (%)=(- 2 expression quantity of sample superoxide dismutase/control group super oxygen
- 2 expression quantity of object mutase) × 100
Table 6
As shown in Table 6 above, when handling identical concentration, relative to the extract of comparative example, the embodiment of the present invention
Outstanding antioxidant effect is presented in extractive from fermentative.
Embodiment 10: it is prepared by the dosage form of the mixing vinegar extractive from fermentative of marjoram, corchorus olitorius and lemon balm
According to usual way, composition and the content preparation of following list 7 include marjoram, corchorus olitorius and lemon balm
The skin cream of mixing vinegar extractive from fermentative.
Table 7
| (weight percent) | Reference examples | Embodiment 10 |
| Mixed fermentation extract (embodiment 6) | - | 2 |
| Glycerol | 8 | 8 |
| Butanediol | 4 | 4 |
| Octanoic acid and Triglyceride DDD | 10 | 10 |
| Cetearyl glucoside | 1.5 | 1.5 |
| Sorbitan stearate | 0.4 | 0.4 |
| Cetostearyl alcohol | 1 | 1 |
| Phenoxyethanol | 0.3 | 0.3 |
| Sensiva SC50 | 0.05 | 0.05 |
| Fragrance | 0.15 | 0.15 |
| Distilled water | To 100 | To 100 |
Test example 6: confirmation skin irritatin remission effect
Using 10 20 years old to 30 years old men and women currently without skin allergy symptom as object, cause in the inside line of lower wrist
After skin irritatin by adhesive tape stripping method (Tape Stripping Method), above-described embodiment 10 and reference examples are applied
Skin cream carries out relative evaluation come the degree releived to caused stimulation.Firstly, utilization is general at the two of the inside line of lower wrist
Logical transparent adhesive tape brings 30 circle of binding, so as to cause erythema.After causing erythema, coating includes marjoram of the invention, length
The skin cream of the embodiment 10 of the mixing vinegar extractive from fermentative of capsule jute and lemon balm, coating do not include compound of the invention
The skin cream of reference examples.After coating by evaluating skin irritatin degree after 3 hours.
<skin irritatin degree (erythema) evaluation>
0: reactionless
1: very slight erythema trace
2: fuzzy or light erythema
3: the obvious or weak erythema in boundary
4: apparent erythema
5: dark erythema
Table 8
As shown in Table 8 above, mixing vinegar extractive from fermentative comprising marjoram of the invention, corchorus olitorius and lemon balm
Outstanding skin irritatin remission effect is presented in skin cream.
Claims (10)
- A kind of composition 1. skin improvement applies some make up, which is characterized in that the mixing comprising marjoram, corchorus olitorius and lemon balm Extractive from fermentative.
- The composition 2. skin improvement according to claim 1 applies some make up, which is characterized in that improve useization relative to skin Cosmetic compositions total weight, the mixed fermentation extract of above-mentioned marjoram, corchorus olitorius and lemon balm include 0.01~90 weight Percentage.
- The composition 3. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned mixed fermentation extract It is extracted by mixing marjoram, corchorus olitorius and lemon balm with 1~2:1~2:1~2 weight rate respectively.
- The composition 4. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned mixed fermentation extract For yeast extractive from fermentative, lactobacillus-fermented extract or vinegar fermentation extract.
- The composition 5. skin according to claim 4 improvement applies some make up, which is characterized in that above-mentioned vinegar fermentation extract by It is formed selected from least one of the group being made of apple vinegar, persimmon vinegar, grape vinegar, malt vinegar and profound rice vinegar vinegar.
- The composition 6. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned skin improves with makeup Product composition is for improving wrinkle of skin.
- The composition 7. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned skin improves with makeup Product composition is used for skin-whitening.
- The composition 8. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned skin improves with makeup Product composition is used for skin moisture-keeping.
- The composition 9. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned skin improves with makeup Product composition is for alleviating skin irritatin.
- The composition 10. skin improvement according to claim 1 applies some make up, which is characterized in that above-mentioned skin improves useization Cosmetic compositions are for anti-oxidant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170076911A KR101926263B1 (en) | 2017-06-16 | 2017-06-16 | Cosmetic compositions containing fermented extract of Origanum majorana, Corchorus olitorius and Melissa officianalis |
| KR10-2017-0076911 | 2017-06-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109125162A true CN109125162A (en) | 2019-01-04 |
| CN109125162B CN109125162B (en) | 2021-05-07 |
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ID=64671496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710651761.7A Active CN109125162B (en) | 2017-06-16 | 2017-08-02 | Cosmetic composition for improving skin |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR101926263B1 (en) |
| CN (1) | CN109125162B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113101253A (en) * | 2020-01-10 | 2021-07-13 | 惠州绵俪生物科技有限公司 | Cosmetic composition for improving skin comprising mixed extract of edible flowers |
| CN114642615A (en) * | 2020-12-02 | 2022-06-21 | 汇升(香港)实业有限公司 | Cosmetic composition containing mixed fermented extract of natural plants |
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| WO2018079997A1 (en) | 2016-10-27 | 2018-05-03 | 국민대학교 산학협력단 | Aglycosylated antibody fc region for treating cancer |
| KR102411428B1 (en) | 2019-04-26 | 2022-06-22 | 한국식품연구원 | Composition for improvementing, preventing or treating obesity and metabolic diseases comprising fractions or extract of molokhia leave |
| KR102233749B1 (en) | 2019-04-03 | 2021-03-30 | 한국식품연구원 | Composition for improvementing, preventing or treating intestinal inflammation or leaky gut syndrome comprising fractions or extract of molokhia leave |
| KR102512796B1 (en) | 2021-02-08 | 2023-03-24 | 이주운 | Extract of Molokhia with high antioxidant effect, and use thereof |
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| JP2003201208A (en) * | 2001-12-28 | 2003-07-18 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
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| KR20080020853A (en) * | 2006-09-01 | 2008-03-06 | 애경산업(주) | Extracts from corchorus olitorius l. and anti-inflammatory cosmetic composition including the same |
| JP2011236149A (en) * | 2010-05-10 | 2011-11-24 | Ogawa & Co Ltd | In-vivo antioxidant |
| KR20130085012A (en) * | 2012-01-18 | 2013-07-26 | 주식회사 엘지생활건강 | Cosmetic composition comprising fermented material and manufacturing method thereof |
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| CN113101253A (en) * | 2020-01-10 | 2021-07-13 | 惠州绵俪生物科技有限公司 | Cosmetic composition for improving skin comprising mixed extract of edible flowers |
| CN114642615A (en) * | 2020-12-02 | 2022-06-21 | 汇升(香港)实业有限公司 | Cosmetic composition containing mixed fermented extract of natural plants |
| CN114642615B (en) * | 2020-12-02 | 2024-01-23 | 汇升(香港)实业有限公司 | Cosmetic composition comprising natural plant mixed fermentation extract |
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| CN109125162B (en) | 2021-05-07 |
| KR101926263B1 (en) | 2018-12-06 |
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