CN109394743A - 用于治疗真菌感染的新的药物组合物 - Google Patents

用于治疗真菌感染的新的药物组合物 Download PDF

Info

Publication number
CN109394743A
CN109394743A CN201811088339.6A CN201811088339A CN109394743A CN 109394743 A CN109394743 A CN 109394743A CN 201811088339 A CN201811088339 A CN 201811088339A CN 109394743 A CN109394743 A CN 109394743A
Authority
CN
China
Prior art keywords
acid
composition
weight
nail
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811088339.6A
Other languages
English (en)
Chinese (zh)
Inventor
E·卡尔松
S·F·阿什卡尔
P·考夫曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Moberg Pharma AB
Original Assignee
Moberg Derma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48142011&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN109394743(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Moberg Derma AB filed Critical Moberg Derma AB
Publication of CN109394743A publication Critical patent/CN109394743A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201811088339.6A 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物 Pending CN109394743A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2013/050654 WO2014140507A1 (en) 2013-03-15 2013-03-15 Pharmaceutical composition for the treatment of fungal infections
GBPCT/GB2013/050654 2013-03-15
CN201480002472.9A CN104661639B (zh) 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480002472.9A Division CN104661639B (zh) 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物

Publications (1)

Publication Number Publication Date
CN109394743A true CN109394743A (zh) 2019-03-01

Family

ID=48142011

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811088339.6A Pending CN109394743A (zh) 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物
CN201480002472.9A Active CN104661639B (zh) 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480002472.9A Active CN104661639B (zh) 2013-03-15 2014-02-28 用于治疗真菌感染的新的药物组合物

Country Status (26)

Country Link
US (2) US8987330B2 (https=)
EP (1) EP2777689B1 (https=)
JP (1) JP6503303B2 (https=)
KR (1) KR101582448B1 (https=)
CN (2) CN109394743A (https=)
BR (1) BR112015022590B8 (https=)
CA (1) CA2883613C (https=)
CY (1) CY1116559T1 (https=)
DK (1) DK2777689T3 (https=)
ES (1) ES2543957T3 (https=)
HR (1) HRP20150823T1 (https=)
HU (1) HUE026887T2 (https=)
IL (1) IL241175B (https=)
ME (1) ME02199B (https=)
MX (1) MX375135B (https=)
MY (1) MY176291A (https=)
PH (1) PH12015502073B1 (https=)
PL (1) PL2777689T3 (https=)
PT (1) PT2777689E (https=)
RS (1) RS54131B1 (https=)
SA (1) SA515361162B1 (https=)
SG (1) SG11201505763QA (https=)
SI (1) SI2777689T1 (https=)
SM (1) SMT201500214B (https=)
WO (2) WO2014140507A1 (https=)
ZA (1) ZA201505343B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014140507A1 (en) 2013-03-15 2014-09-18 Moberg Pharma Ab Pharmaceutical composition for the treatment of fungal infections
KR101599260B1 (ko) * 2015-07-30 2016-03-03 (주)우신메딕스 조갑진균증의 예방 또는 치료용 약학 조성물 및 이의 제조방법
ITUB20153759A1 (it) * 2015-09-21 2017-03-21 Federica Livieri Composizione antifungina ad uso topico per il trattamento dell'onicomicosi e relativo metodo
US10258560B1 (en) 2016-08-08 2019-04-16 Marlinz Pharma, LLC Composition for topical treatment of nail conditions
US10543276B2 (en) 2016-08-08 2020-01-28 Marlinz Pharma, LLC Topical compositions
GB2554101B (en) * 2016-09-20 2021-05-05 Insense Ltd Composition for the treatment of a fungal infection
EP4552650A3 (en) * 2017-11-21 2025-08-13 Topix Pharmaceuticals, Inc. Methods and compositions for treatment of skin
WO2020131147A1 (en) * 2018-12-19 2020-06-25 Marlinz Pharma, LLC Topical compositions
US20220249859A1 (en) * 2021-02-09 2022-08-11 Scholl's Wellness Company Llc Formulation and device for cosmetic treatment of onychomycosis
US20240238227A1 (en) 2023-01-12 2024-07-18 Wooshin Labottach Co., Ltd. Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525635A (en) * 1986-02-04 1996-06-11 Moberg; Sven Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296130A (en) 1979-08-30 1981-10-20 Herschler R J Methylsulfonylmethane and methods of use
US4672078A (en) 1985-07-03 1987-06-09 Schering-Plough Corporation Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations
SE462139B (sv) 1986-02-04 1990-05-14 Sven Moberg Farmaceutisk komposition, innehaallande propylenglykol och karbamid, foer behandling av bl.a. nagelsvamp och seborroiskt eksem
US5696164A (en) * 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
JP3820805B2 (ja) 1999-07-08 2006-09-13 株式会社ノエビア 皮膚外用剤
JP2003095914A (ja) * 2001-09-21 2003-04-03 Toyo Beauty Kk 尿素含有外用剤
US6986896B2 (en) * 2002-03-20 2006-01-17 Bradley Pharmaceuticals, Inc. Method of treating fungal conditions of the skin
US6573301B1 (en) 2002-04-23 2003-06-03 Bradley Pharmaceuticals, Inc. Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use
US8158138B1 (en) * 2004-05-20 2012-04-17 Fougera Pharmaceuticals, Inc. Urea compositions and their methods of manufacture
JP4972895B2 (ja) * 2005-08-29 2012-07-11 大正製薬株式会社 尿素配合外用製剤
US8435500B2 (en) 2005-11-01 2013-05-07 L'oréal Nail whitening composition
EP2464334A4 (en) 2009-08-13 2014-03-26 Moberg Derma Ab COMPOSITIONS AND METHODS FOR TREATING FUNGAL INFECTION OF NAILS
WO2012110430A1 (en) * 2011-02-10 2012-08-23 Moberg Derma Ab Novel composition for topical use on a nail
WO2014140507A1 (en) 2013-03-15 2014-09-18 Moberg Pharma Ab Pharmaceutical composition for the treatment of fungal infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525635A (en) * 1986-02-04 1996-06-11 Moberg; Sven Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. FAERGEMANN ET AL: ""Treatment of Onychomycosis with a Propylene"", 《MYCOSES》 *
L. EMTESTAM ET AL: ""Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24‐week, double‐blind, placebo‐controlled study"", 《MYCOSES》 *

Also Published As

Publication number Publication date
US9782372B2 (en) 2017-10-10
HK1208378A1 (en) 2016-03-04
CA2883613A1 (en) 2014-09-18
MY176291A (en) 2020-07-27
DK2777689T3 (da) 2015-06-22
RS54131B1 (sr) 2015-12-31
SA515361162B1 (ar) 2016-11-09
HUE026887T2 (en) 2016-07-28
CA2883613C (en) 2016-04-12
IL241175A0 (en) 2015-11-30
PL2777689T3 (pl) 2015-10-30
KR101582448B1 (ko) 2016-01-04
JP2016514121A (ja) 2016-05-19
ZA201505343B (en) 2017-06-28
CN104661639B (zh) 2019-06-28
SG11201505763QA (en) 2015-08-28
HRP20150823T1 (hr) 2015-09-11
WO2014140507A1 (en) 2014-09-18
US20150306052A1 (en) 2015-10-29
BR112015022590B8 (pt) 2023-03-21
MX375135B (es) 2025-03-06
BR112015022590B1 (pt) 2020-08-25
SI2777689T1 (sl) 2015-08-31
ME02199B (me) 2016-02-20
PH12015502073B1 (en) 2018-09-05
ES2543957T3 (es) 2015-08-26
IL241175B (en) 2019-10-31
CY1116559T1 (el) 2017-03-15
JP6503303B2 (ja) 2019-04-17
BR112015022590A2 (pt) 2017-07-18
PH12015502073A1 (en) 2016-01-25
SMT201500214B (it) 2015-10-30
MX2015012273A (es) 2016-01-25
KR20150054824A (ko) 2015-05-20
PT2777689E (pt) 2015-09-11
US20140275254A1 (en) 2014-09-18
US8987330B2 (en) 2015-03-24
CN104661639A (zh) 2015-05-27
EP2777689B1 (en) 2015-05-27
EP2777689A1 (en) 2014-09-17
WO2014140524A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
CN109394743A (zh) 用于治疗真菌感染的新的药物组合物
KR101409792B1 (ko) 항진균성 약제학적 조성물
JP6516759B2 (ja) 安定化エフィナコナゾール組成物
CN101808639B (zh) 抗真菌医药组合物
EP1272201B1 (de) Verwendung von kompatiblen soluten als substanzen mit radikalfangenden eigenschaften
KR101373955B1 (ko) 외용의 의약 조성물
TWI225407B (en) An acidified composition for topical treatment of nail and skin conditions
JP5184342B2 (ja) 外用の医薬組成物
EP2214658B1 (de) Osmolythaltige zubereitung zur anwendung bei trockenen schleimhäuten
EP4368169A2 (en) Use of sublingual dexmedetomidine for the treatment of agitation
Savin Diagnosis and treatment of tinea versicolor
US10070644B2 (en) Antimicrobial composition
JPS63500171A (ja) 経皮流動を減少せしめたるための医薬ビヒクル
KR20120065341A (ko) 항진균성 약제학적 조성물
CN102427811A (zh) 适于局部治疗皮肤和指(趾)甲真菌感染的组合物
US20090209604A1 (en) Topical combination therapy for treating acne
RU2574962C1 (ru) Фармацевтическая композиция для лечения грибковых инфекций
JPS611615A (ja) 水虫外用薬
JP6016085B2 (ja) 抗真菌外用組成物及び抗真菌外用組成物の適用方法
JP2006347990A (ja) 爪用の抗真菌医薬組成物
HK1208378B (zh) 用於治疗真菌感染的新的药物组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190301