CN109350763A - 一种替代子宫垫的止血纱布 - Google Patents

一种替代子宫垫的止血纱布 Download PDF

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CN109350763A
CN109350763A CN201811067303.XA CN201811067303A CN109350763A CN 109350763 A CN109350763 A CN 109350763A CN 201811067303 A CN201811067303 A CN 201811067303A CN 109350763 A CN109350763 A CN 109350763A
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林昌伟
陈怡霏
宋业勋
李小荣
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Third Xiangya Hospital of Central South University
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Abstract

本发明公开了一种替代子宫垫的止血纱布，包含以下重量份的原料：脂肪族聚酯材料10‑20份、疏水壳聚糖5‑10份、纤维蛋白胶3‑7份、氧化纤维素1‑3份、丝素蛋白1‑3份，由脂肪族聚酯材料、疏水壳聚糖、纤维蛋白胶、氧化纤维素、丝素蛋白复合或抽丝纺织而成。本发明替代子宫垫的止血纱布除了可以快速止血外，还可以促进创面修复，具有消炎、镇痛的效果，适合推广应用。

Description

一种替代子宫垫的止血纱布
技术领域
本发明涉及一种止血材料，具体地说，涉及一种替代子宫垫的止血纱布。
背景技术
可吸收止血纱布，是一种用于体内止血用纱布。具有止血快速、吸收完全、效果可靠、使用方便的特点，现有技术中，速即纱止血纱布作为止血基质，凝结血块，加速止血过程。它的功效不依赖人体内正常的凝血机制。速即纱控制小血管出血十分有效，其内源性止血机制在2-8分钟内达到快速止血。速即纱可留置体内。通常在7-10天可完全吸收(比其它止血产品快)，几乎无组织反应，未有发生毒性、过敏性和排斥反应的报道。经过30多年的外科应用经验和多次临床试验，在外科界赢得了广泛的信任。速即纱性质如织物，因此很容易附着在任何不规则出血组织表面，但不黏附于手套及器械。使用时可采取包、缝、敷、填等方法，被证实可广泛用于几乎所有的外科手术。在结扎或其他传统止血方法无法实施或不能奏效时，帮助控制毛细血管、静脉和小动脉的出血。速即纱止血纱布快速有效地控制宫颈表面出血，可以和不规则表面贴合。
如果使用临床常用的止血材料做替代子宫垫的止血纱布，由于用量很大，价格较高，给患者带来一定的经济负担。临床上普通的可吸收止血材料用的量都是小剂量，如果用来压迫止血的话，需要的剂量较大，长时间停留在体内会对患者身体带来一定的影响。现有技术中的止血纱布只有止血的作用，没有硝烟、镇痛的作用，作用比较单一，不适合推广应用。
发明内容
本发明的目的在于提供一种替代子宫垫的止血纱布。该止血纱布成分对身体无刺激，可以长时间留在体内，除了可以快速止血外，还可以促进创面修复，具有消炎、镇痛的效果，适合推广应用。
其具体技术方案为：
一种替代子宫垫的止血纱布，包含以下重量份的原料：脂肪族聚酯材料10-20份、疏水壳聚糖5-10份、纤维蛋白胶3-7份、氧化纤维素1-3份、丝素蛋白1-3份，由脂肪族聚酯材料、疏水壳聚糖、纤维蛋白胶、氧化纤维素、丝素蛋白复合或抽丝纺织而成。
进一步，包含以下重量份的原料：脂肪族聚酯材料15份、疏水壳聚糖8份、纤维蛋白胶5份、氧化纤维素2份、丝素蛋白2份，
进一步，所述丝素蛋白从天然蚕丝或茧壳中提取丝素蛋白分为以下步骤:脱胶、水解、溶解、活性基化合物合成、分子修饰、分离、干燥、溶胶制备、得到丝素蛋白材料。
进一步，还包括钙、锌制剂。
再进一步，所述钙、锌制剂的重量份为0.1-1份。
再进一步，所述钙、锌制剂的重量份为0.5份。
有益效果：
本发明替代子宫垫的止血纱布，壳聚糖具有快速止血、组织相容性好和降解吸收快等优点。但是对于广泛出血的创面,壳聚糖的止血效果是有限的，用复合其他止血剂的方法来弥补壳聚糖止血的局限性。本发明的配方中加入钙、锌制剂。纤维蛋白胶是从人活哺乳动物血液中提取的一种生物止血黏合剂,具有良好的止血、组织相容性和黏合性能，可应用于术中止血和术后伤口的愈合。氧氧化纤维素是由棉纤维经处理后获得的一种局部止血材料,有着棉纱的外观和质地以及均匀的网孔；纤维素经氧化处理成为纤维素酸的薄沙状或面布状止血材料,外观似棉纱,质地柔软而菲薄,具有良好的生物相容性、可降解性和安全性等特点。本发明的止血纱布的成分对身体无刺激，可以长时间留在体内，除了可以快速止血外，还可以促进创面修复，具有消炎、镇痛的效果，适合推广应用。
具体实施方式
下面结合具体实施例对本发明的技术方案作进一步详细地说明。
实施例1
一种替代子宫垫的止血纱布，包含以下重量份的原料：脂肪族聚酯材料10份、疏水壳聚糖5份、纤维蛋白胶3份、氧化纤维素1份、丝素蛋白1份，由脂肪族聚酯材料、疏水壳聚糖、纤维蛋白胶、氧化纤维素、丝素蛋白复合或抽丝纺织而成。
还包括钙、锌制剂，所述钙、锌制剂的重量份为0.1份。
进一步，所述丝素蛋白从天然蚕丝或茧壳中提取丝素蛋白分为以下步骤:脱胶、水解、溶解、活性基化合物合成、分子修饰、分离、干燥、溶胶制备、得到丝素蛋白材料。
实施例2
一种替代子宫垫的止血纱布，包含以下重量份的原料：脂肪族聚酯材料15份、疏水壳聚糖8份、纤维蛋白胶5份、氧化纤维素2份、丝素蛋白2份，
还包括钙、锌制剂，所述钙、锌制剂的重量份为0.5份。
所述丝素蛋白从天然蚕丝或茧壳中提取丝素蛋白分为以下步骤:脱胶、水解、溶解、活性基化合物合成、分子修饰、分离、干燥、溶胶制备、得到丝素蛋白材料。
实施例3
一种替代子宫垫的止血纱布，包含以下重量份的原料：脂肪族聚酯材料20份、疏水壳聚糖10份、纤维蛋白胶7份、氧化纤维素3份、丝素蛋白3份，由脂肪族聚酯材料、疏水壳聚糖、纤维蛋白胶、氧化纤维素、丝素蛋白复合或抽丝纺织而成。
还包括钙、锌制剂，所述钙、锌制剂的重量份为1份。
所述丝素蛋白从天然蚕丝或茧壳中提取丝素蛋白分为以下步骤:脱胶、水解、溶解、活性基化合物合成、分子修饰、分离、干燥、溶胶制备、得到丝素蛋白材料。
本发明的替代子宫垫的止血纱布在具体应用过程中，替代子宫垫的止血纱布，溶解较慢，通过引流管连着一根线，使用完毕后，可以通过引流管的线将没有被溶解的纱布部分扯出来。
以上所述，仅为本发明较佳的具体实施方式，本发明的保护范围不限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，可显而易见地得到的技术方案的简单变化或等效替换均落入本发明的保护范围内。

Claims (6)

1.一种替代子宫垫的止血纱布，其特征在于，包含以下重量份的原料：脂肪族聚酯材料10-20份、疏水壳聚糖5-10份、纤维蛋白胶3-7份、氧化纤维素1-3份、丝素蛋白1-3份，由脂肪族聚酯材料、疏水壳聚糖、纤维蛋白胶、氧化纤维素、丝素蛋白复合或抽丝纺织而成。
2.根据权利要求1所述的替代子宫垫的止血纱布，其特征在于，包含以下重量份的原料：脂肪族聚酯材料15份、疏水壳聚糖8份、纤维蛋白胶5份、氧化纤维素2份、丝素蛋白2份。
3.根据权利要求1所述的替代子宫垫的止血纱布，其特征在于，所述丝素蛋白从天然蚕丝或茧壳中提取丝素蛋白分为以下步骤:脱胶、水解、溶解、活性基化合物合成、分子修饰、分离、干燥、溶胶制备、得到丝素蛋白材料。
4.根据权利要求1所述的替代子宫垫的止血纱布，其特征在于，还包括钙、锌制剂。
5.根据权利要求4所述的替代子宫垫的止血纱布，其特征在于，所述钙、锌制剂的重量份为0.1-1份。
6.根据权利要求5所述的替代子宫垫的止血纱布，其特征在于，所述钙、锌制剂的重量份为0.5份。
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CN105169459A (zh) * 2015-10-26 2015-12-23 广东泰宝医疗科技股份有限公司 一种多聚糖止血粉及其制备方法
CN108276506A (zh) * 2018-02-06 2018-07-13 西南科技大学 疏水壳聚糖的制备方法及其产物、及其产物用于制备止血材料的用途

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CN103418024A (zh) * 2012-05-18 2013-12-04 无锡圆容生物医药股份有限公司 一种新型可吸收医用材料
CN105169459A (zh) * 2015-10-26 2015-12-23 广东泰宝医疗科技股份有限公司 一种多聚糖止血粉及其制备方法
CN108276506A (zh) * 2018-02-06 2018-07-13 西南科技大学 疏水壳聚糖的制备方法及其产物、及其产物用于制备止血材料的用途

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