CN108653788A - 一种负载纳米银的医用敷料的制备方法 - Google Patents

一种负载纳米银的医用敷料的制备方法 Download PDF

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CN108653788A
CN108653788A CN201810547454.9A CN201810547454A CN108653788A CN 108653788 A CN108653788 A CN 108653788A CN 201810547454 A CN201810547454 A CN 201810547454A CN 108653788 A CN108653788 A CN 108653788A
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吕少波
李卓才
李苏杨
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Suzhou Jonathan New Materials Technology Co Ltd
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract

本发明公开了一种负载纳米银的医用敷料的制备方法，由以下重量份的组分制得：聚酯纤维15‑20份、壳聚糖30‑40份、柠檬皮果胶3‑10份、聚乙醇酸12‑20份、二癸基二甲基氯化铵10‑14份、果胶3‑10份、羧甲基纤维素钠5‑10份、海藻酸盐3‑12份、磷酸锆载银10‑20份、纳米银10‑20份、纳米氧化锌10‑20份、蜂蜜10‑20份、脱氢醋酸钠5‑8份、二硫代氨基甲酸钼3‑10份和水30‑40份。通过本发明的方法制备负载纳米银的医用敷料，刺激性小，无毒副作用，不易复发，具有良好的生物相容性和抗菌性。

Description

一种负载纳米银的医用敷料的制备方法
技术领域
本发明涉及一种负载纳米银的医用敷料的制备方法。
背景技术
创面愈合困难是整形外科中经常会遇到的问题。临床上对于小型创面处理方式主要通过活力碘消毒后，予以喷涂人表皮生长因子等药物，最后覆盖无菌纱布。对于大型创面则主要采用皮片、皮瓣移植手术治疗后，表面覆盖凡士林纱布，最后覆盖无菌纱布。以上处理方式虽已较为成熟，但仍然存在以下不足：(1)药物难以长期于伤口处保持有效浓度，无法稳定、持续发挥药物作用；(2)医用脱脂纱布的生物相容性稍差，无可降解性，需要以3天/次的频率更换。医用敷料，是包伤的用品，用以覆盖疮、伤口或其他损害的医用材料。随着对创面愈合过程的病理生理的深入研究，人们对创面愈合过程的理解也越来越深刻，从而导致了医用创面敷料的不断改进与发展。今天，新型的创面护理用敷料相对于早期而言，已经发生了革命性的变化，而且多种不同性能的医用敷料可供临床护理人员选用。在伤口形成的初期，伴有大量的伤口渗出液流出，市场已有敷料一般能满足低到中等渗出液的需求，但对于高渗出液的伤口或是创面，难以满足需求。已有的敷料延展性比较差，在臀部、关节等特殊部位，往往由于拉伸强度有限，不能具有很好的舒适性。而且伤口感染是影响伤口愈合的关键因素，也是导致患者伤口反复甚至死亡的重要原因。因此，作为好的医用敷料，还应具有较好的抗菌性能。
发明内容
本发明的目的在于提供一种负载纳米银的医用敷料的制备方法。
为了实现上述目的，本发明提供了一种负载纳米银的医用敷料的制备方法，该方法包括以下步骤：按重量份配比称取：聚酯纤维15-20份、壳聚糖 30-40 份、柠檬皮果胶3-10份、聚乙醇酸 12-20 份、二癸基二甲基氯化铵10-14份、果胶 3-10 份、羧甲基纤维素钠5-10份、海藻酸盐 3-12 份、磷酸锆载银10-20份、纳米银10-20份、纳米氧化锌10-20份、蜂蜜10-20份、脱氢醋酸钠5-8份、二硫代氨基甲酸钼3-10 份和水30-40份；将上述原料放置于高速搅拌机中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述超声波频率为20-40KHz。
所述分散速度4000-5000r/min，分散时间为30-60min。
有益效果：通过本发明的方法制备负载纳米银的医用敷料，刺激性小，无毒副作用，不易复发，具有良好的生物相容性和抗菌性。
具体实施方式
实施例1
一种负载纳米银的医用敷料的制备方法，该方法包括以下步骤：按重量份配比称取：聚酯纤维15份、壳聚糖 30 份、柠檬皮果胶3份、聚乙醇酸 12 份、二癸基二甲基氯化铵10份、果胶 3 份、羧甲基纤维素钠5份、海藻酸盐 3份、磷酸锆载银10份、纳米银10份、纳米氧化锌10-20份、蜂蜜10份、脱氢醋酸钠5份、二硫代氨基甲酸钼3份和水30份；将上述原料放置于高速搅拌机中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。 所述基布层为无纺布或PU防水透气膜。所述粘结剂为压敏胶。所述超声波频率为20-40KHz。所述分散速度4000-5000r/min，分散时间为30-60min。
实施例2
一种负载纳米银的医用敷料的制备方法，该方法包括以下步骤：按重量份配比称取：聚酯纤维20份、壳聚糖40 份、柠檬皮果胶10份、聚乙醇酸 20 份、二癸基二甲基氯化铵14份、果胶10 份、羧甲基纤维素钠10份、海藻酸盐 12 份、磷酸锆载银20份、纳米银20份、纳米氧化锌20份、蜂蜜20份、脱氢醋酸钠8份、二硫代氨基甲酸钼10 份和水40份；将上述原料放置于高速搅拌机中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。所述基布层为无纺布或PU防水透气膜。所述粘结剂为压敏胶。所述超声波频率为20-40KHz。所述分散速度4000-5000r/min，分散时间为30-60min。
实施例3
一种负载纳米银的医用敷料的制备方法，该方法包括以下步骤：按重量份配比称取：聚酯纤维17份、壳聚糖 35份、柠檬皮果胶6份、聚乙醇酸 16份、二癸基二甲基氯化铵12份、果胶 6 份、羧甲基纤维素钠8份、海藻酸盐 8 份、磷酸锆载银15份、纳米银15份、纳米氧化锌15份、蜂蜜15份、脱氢醋酸钠6份、二硫代氨基甲酸钼6份和水35份；将上述原料放置于高速搅拌机中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。 所述基布层为无纺布或PU防水透气膜。所述粘结剂为压敏胶。所述超声波频率为20-40KHz。所述分散速度4000-5000r/min，分散时间为30-60min。

Claims (5)

1.一种负载纳米银的医用敷料的制备方法，其特征在于该方法包括以下步骤：按重量份配比称取：聚酯纤维15-20份、壳聚糖 30-40 份、柠檬皮果胶3-10份、聚乙醇酸 12-20份、二癸基二甲基氯化铵10-14份、果胶 3-10 份、羧甲基纤维素钠5-10份、海藻酸盐 3-12份、磷酸锆载银10-20份、纳米银10-20份、纳米氧化锌10-20份、蜂蜜10-20份、脱氢醋酸钠5-8份、二硫代氨基甲酸钼3-10 份和水30-40份；将上述原料放置于高速搅拌机中，超声高速分散；然后将分散后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
2.根据权利要求1所述的一种负载纳米银的医用敷料的制备方法，其特征在于：所述基布层为无纺布或PU防水透气膜。
3.根据权利要求1所述的一种负载纳米银的医用敷料的制备方法，其特征在于：所述粘结剂为压敏胶。
4.根据权利要求1所述的一种负载纳米银的医用敷料的制备方法，其特征在于：所述超声波频率为20-40KHz。
5.根据权利要求1所述的一种负载纳米银的医用敷料的制备方法，其特征在于：所述分散速度4000-5000r/min，分散时间为30-60min。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276742A (zh) * 2018-11-08 2019-01-29 广州润虹医药科技股份有限公司 一种速效止血杀菌纱、其制备方法及其应用
CN109350762A (zh) * 2018-11-23 2019-02-19 北京诺康达医药科技股份有限公司 一种应用于慢性创面的医用敷料及其制备方法
WO2022248890A1 (en) * 2021-05-28 2022-12-01 Medtrade Products Limited Antimicrobial component for a wound dressing

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276742A (zh) * 2018-11-08 2019-01-29 广州润虹医药科技股份有限公司 一种速效止血杀菌纱、其制备方法及其应用
CN109350762A (zh) * 2018-11-23 2019-02-19 北京诺康达医药科技股份有限公司 一种应用于慢性创面的医用敷料及其制备方法
CN109350762B (zh) * 2018-11-23 2021-07-23 北京诺康达医药科技股份有限公司 一种应用于慢性创面的医用敷料及其制备方法
WO2022248890A1 (en) * 2021-05-28 2022-12-01 Medtrade Products Limited Antimicrobial component for a wound dressing
GB2608270A (en) * 2021-05-28 2022-12-28 Medtrade Products Ltd Antimicrobial component for a wound dressing

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