CN108714242A - 一种纳米医用胶黏剂的制备方法 - Google Patents

一种纳米医用胶黏剂的制备方法 Download PDF

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CN108714242A
CN108714242A CN201810547467.6A CN201810547467A CN108714242A CN 108714242 A CN108714242 A CN 108714242A CN 201810547467 A CN201810547467 A CN 201810547467A CN 108714242 A CN108714242 A CN 108714242A
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nanometer
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吕少波
李卓才
李苏杨
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Suzhou Jonathan New Materials Technology Co Ltd
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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Abstract

本发明公开了一种纳米医用胶黏剂的制备方法，由以下重量份的组分制得：聚乙烯基吡咯烷酮55‑65份、聚醚砜醚酮8‑15份、聚乙烯醇50‑60份、黄原胶25‑40份、琼脂3‑8份、纤维蛋白胶10‑15份、甘薯淀粉5‑10份、乙酸乙酯3‑8份、纳米氧化钙粉4‑6份、甘胆酸钠2‑6份、三聚甘油单硬脂酸酯3‑5份、盐酸曲马多5‑8份、聚醚三元醇10‑15份、氧化锌3‑5份、羧甲基纤维素钠5‑10份、海藻酸钠15‑20份、纤维素11‑14份。本发明制备的纳米医用胶黏剂具有较高的粘结强度和抗压强度，对生物体组织刺激小，不添加任何有害试剂，还具有抗菌止血的功效，适合用于外科手术中，尤其是适合软组织的粘合。

Description

一种纳米医用胶黏剂的制备方法
技术领域
本发明涉及一种纳米医用胶黏剂的制备方法。
背景技术
现有人体组织创伤的修复手段有手术线缝合、医用胶带和医用胶黏剂，手术线缝合使用时造成病人疼痛、难以用于微创伤的修复、易造成感染。医用胶带强度太低、对复杂创面适应性较差。医用胶黏剂能强力黏合肌体组织，黏合速度迅速，无毒，对组织反应小，不会造成血栓，可简单灭菌。医用胶黏剂主要用于各种创伤伤口、外科整容、计划生育等外科各种手术，其对人体生物组织具有快速粘合、促进伤口愈合等作用，可部分代替伤口缝合。医用胶黏剂的使用历史悠久，在临床中有十分重要的作用。随着医学的进步，临床上对手术技术和辅助材料效果的要求越来越高。现代医学的理念是要最大限度地减少病人的痛苦，最快速度地让病人康复，而且在最大程度地恢复功能的同时，希望外观也能完美地恢复。因此临床需求的不断增加推动了医用胶黏剂研究的发展和粘合技术在临床的应用。同时目前医学界常用的胶黏剂，存在一些不足，如粘度较低、粘合强度不够、功能单一，不可降解等。
发明内容
本发明的目的在于提供一种纳米医用胶黏剂的制备方法。
为了实现上述目的，本发明提供了一种纳米医用胶黏剂的制备方法，该方法包括以下步骤：按重量份称取各原料：聚乙烯基吡咯烷酮55-65份、聚醚砜醚酮8-15份、聚乙烯醇50-60份、黄原胶25-40份、琼脂3-8份、纤维蛋白胶10-15份、甘薯淀粉5-10份、乙酸乙酯3-8份、纳米氧化钙粉4-6份、甘胆酸钠2-6份、三聚甘油单硬脂酸酯3-5份、盐酸曲马多5-8份、聚醚三元醇10-15份、氧化锌3-5份、羧甲基纤维素钠5-10份、海藻酸钠15-20份、纤维素11-14份，将原料加入容器中，于室温下超声1-6h后，然后加热至80-100℃，搅拌1-3h，再进行消毒处理即可。
所述超声频率为30-50KHz。
所述加热至90℃。
所述搅拌速度为200-400转/分钟。
所述氧化锌为纳米氧化锌。
有益效果：本发明制备的纳米医用胶黏剂具有较高的粘结强度和抗压强度，对生物体组织刺激小，不添加任何有害试剂，还具有抗菌止血的功效，适合用于外科手术中，尤其是适合软组织的粘合。
具体实施方式
实施例1
一种纳米医用胶黏剂的制备方法，该方法包括以下步骤：按重量份称取各原料：聚乙烯基吡咯烷酮55份、聚醚砜醚酮8份、聚乙烯醇50份、黄原胶25份、琼脂3份、纤维蛋白胶10份、甘薯淀粉5份、乙酸乙酯3份、纳米氧化钙粉4份、甘胆酸钠2份、三聚甘油单硬脂酸酯3份、盐酸曲马多5份、聚醚三元醇10份、氧化锌3份、羧甲基纤维素钠5份、海藻酸钠15份、纤维素11份，将原料加入容器中，于室温下超声1-6h后，然后加热至80℃，搅拌1-3h，再进行消毒处理即可。
所述超声频率为30-50KHz。
所述搅拌速度为200-400转/分钟。
所述氧化锌为纳米氧化锌。
实施例2
一种纳米医用胶黏剂的制备方法，该方法包括以下步骤：按重量份称取各原料：聚乙烯基吡咯烷酮65份、聚醚砜醚酮15份、聚乙烯醇60份、黄原胶40份、琼脂8份、纤维蛋白胶15份、甘薯淀粉10份、乙酸乙酯8份、纳米氧化钙粉6份、甘胆酸钠6份、三聚甘油单硬脂酸酯5份、盐酸曲马多8份、聚醚三元醇15份、氧化锌5份、羧甲基纤维素钠10份、海藻酸钠20份、纤维素14份，将原料加入容器中，于室温下超声1-6h后，然后加热至100℃，搅拌1-3h，再进行消毒处理即可。
所述超声频率为30-50KHz。
所述搅拌速度为200-400转/分钟。
所述氧化锌为纳米氧化锌。
实施例3
一种纳米医用胶黏剂的制备方法，该方法包括以下步骤：按重量份称取各原料：聚乙烯基吡咯烷酮60份、聚醚砜醚酮12份、聚乙烯醇55份、黄原胶32份、琼脂5份、纤维蛋白胶13份、甘薯淀粉7份、乙酸乙酯5份、纳米氧化钙粉5份、甘胆酸钠4份、三聚甘油单硬脂酸酯4份、盐酸曲马多7份、聚醚三元醇13份、氧化锌4份、羧甲基纤维素钠7份、海藻酸钠18份、纤维素13份，将原料加入容器中，于室温下超声1-6h后，然后加热至90℃，搅拌1-3h，再进行消毒处理即可。
所述超声频率为30-50KHz。
所述搅拌速度为200-400转/分钟。
所述氧化锌为纳米氧化锌。
将实施例3制备纳米医用胶黏剂进行测试，纳米医用胶黏剂的透明度达到60％，抗拉强度为 11.3MPa，撕裂 强度为17.6kN·m-1，拉断伸长率为159％，固含量为72％。

Claims (5)

1.一种纳米医用胶黏剂的制备方法，其特征在于该方法包括以下步骤：按重量份称取各原料：聚乙烯基吡咯烷酮55-65份、聚醚砜醚酮8-15份、聚乙烯醇50-60份、黄原胶25-40份、琼脂3-8份、纤维蛋白胶10-15份、甘薯淀粉5-10份、乙酸乙酯3-8份、纳米氧化钙粉4-6份、甘胆酸钠2-6份、三聚甘油单硬脂酸酯3-5份、盐酸曲马多5-8份、聚醚三元醇10-15份、氧化锌3-5份、羧甲基纤维素钠5-10份、海藻酸钠15-20份、纤维素11-14份，将原料加入容器中，于室温下超声1-6h后，然后加热至80-100℃，搅拌1-3h，再进行消毒处理即可。
2.根据权利要求1所述的一种纳米医用胶黏剂的制备方法，其特征在于：所述超声频率为30-50KHz。
3.根据权利要求1所述的一种纳米医用胶黏剂的制备方法，其特征在于：所述加热至90℃。
4.根据权利要求1所述的一种纳米医用胶黏剂的制备方法，其特征在于：所述搅拌速度为200-400转/分钟。
5.根据权利要求1所述的一种纳米医用胶黏剂的制备方法，其特征在于：所述氧化锌为纳米氧化锌。
CN201810547467.6A 2018-05-31 2018-05-31 一种纳米医用胶黏剂的制备方法 Withdrawn CN108714242A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544202A (zh) * 2019-09-29 2020-08-18 华中科技大学同济医学院附属协和医院 一种自粘式纱布及其制备方法
CN113042106A (zh) * 2021-03-07 2021-06-29 蒋先敏 一种光催化纳米纤维膜

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544202A (zh) * 2019-09-29 2020-08-18 华中科技大学同济医学院附属协和医院 一种自粘式纱布及其制备方法
CN113042106A (zh) * 2021-03-07 2021-06-29 蒋先敏 一种光催化纳米纤维膜

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