CN109224054A - 一种用于肥胖型pcos穴位贴敷的中药组合物及其制备方法 - Google Patents
一种用于肥胖型pcos穴位贴敷的中药组合物及其制备方法 Download PDFInfo
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- CN109224054A CN109224054A CN201811433539.0A CN201811433539A CN109224054A CN 109224054 A CN109224054 A CN 109224054A CN 201811433539 A CN201811433539 A CN 201811433539A CN 109224054 A CN109224054 A CN 109224054A
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及药物领域，特别是一种用于肥胖型PCOS穴位贴敷的中药组合物，包括以下组分：当归、黄芪、生姜、麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、姜黄、54°高粱酒、白芥子、医用透皮剂、乙醇衍生物。本发明中药组合物，采用20种中草药泡制淬炼，结合了精纯提取技术，不需口服，只需要贴敷于三阴交、丰隆、梁门、天枢、关元、带脉、水道、气海、子宫、中脘等冲任二脉及肝经、脾经、肾经上的要穴，诸穴配合，具有健脾化湿、疏肝理气、补肾调经之用，从而消脂减肥，调经助孕。
Description
技术领域
本发明涉及药物领域，特别是一种用于肥胖型PCOS穴位贴敷的中药组合物及其制备方法。
背景技术
多囊卵巢综合征(polycystic ovary syndrome，PCOS)是一种以月经紊乱、肥胖、不孕、多毛等症状表现为主的常见妇科疾病，多发生于育龄妇女，其中，生殖障碍是她们最大的烦恼。
多囊卵巢综合征属于闭经范畴，肥胖患者多辩证为痰湿体质，常因脾胃功能失常，痰湿瘀热积聚，导致肥胖的发生，同时，痰湿气滞血瘀壅塞经脉，可造成月经紊乱或闭经，月经不调则难以成孕。
根据临床观察，对多囊卵巢综合征并伴有明显肥胖的患者在常规治疗的同时，配合中医穴位减肥治疗，不但可有效减轻体重，而且可调节患者的内分泌激素水平，提高她们对排卵药物反应的敏感性，从而提高妊娠的成功率。中国专利CN104162094A公开了一种治疗肥胖型多囊卵巢综合征的中药组合物及其药物制剂，能对肥胖型PCOS综合征治疗且保健，其副作用小，停药后不容易复发，但是该药物制作成口服型药物，为了追求安全性能，对中草药原料的选择及中草药的药量有一定的局限性。而且很多女性同胞们难以忍受口服中药的痛苦。
发明内容
本发明为了克服上述技术问题的不足，提供了一种用于肥胖型PCOS穴位贴敷的中药组合物及其制备方法，可以完全解决上述技术问题。
解决上述技术问题的技术方案如下：
一种用于肥胖型PCOS穴位贴敷的中药组合物，中药组合物原料按质量份包括以下组分：
当归30～40份、黄芪30～40份、生姜65～80份、麦芽10～120份、山楂10～50份、白术5～30份、茯苓10～30份、陈皮3～25份、薏苡仁10～70份、荷叶3～20份、决明子10～30份、炙甘草3～10份、草乌5～8份、花椒2～4份、苏木2～4份、茜草2～4份、姜黄3～6份、54°高粱酒65～85份、白芥子和医用透皮剂按照质量比为1：10的混合物8～10份、乙醇衍生物0.01～0.02份，所述的医用透皮剂为北京杰瑞康医药生物科技有限公司生产的医用透皮剂。
优选地，所述中药组合物原料按质量份包括以下组分：
当归35份、黄芪35份、生姜72份、麦芽50份、山楂30份、白术10份、茯苓20份、陈皮8份、薏苡仁60份、荷叶15份、决明子20份、炙甘草8份、草乌5份、花椒3份、苏木3份、茜草3份、姜黄5份、54°高粱酒70份、白芥子和医用透皮剂按照质量比为1：10的混合物9份、乙醇衍生物0.01份。
进一步地说，乙醇衍生物为乙醚、乙酸和乙二醇按照质量比为1:5:2的混合物。
该用于肥胖型PCOS穴位贴敷的中药组合物的制备方法，包括以下步骤：
(1)采用电子秤按照配方要求称取中药原料，误差允许在±0.1范围内，完成原料配料；
(2)将当归、黄芪、生姜放入瓦锅内加水适量，炖至烂熟，得到混合药物；
(3)将麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、姜黄、白芥子用蒸笼入锅蒸制1～2小时，间隔20～30min，重复一遍，再间隔20～30min，重复第二遍；
(4)将步骤(3)得到的混合药物加入步骤(2)得到的混合药液中并置于带盖坛内，再向带盖坛内加入54°高粱酒，静置1～1.5个月，完成泡制淬炼过程；
(5)将带盖坛内浸泡过的物料去渣、静置30～40min后过滤，取滤液，使用乙醇衍生物，在50～55℃条件下，保温回流4～5小时，减压回收乙醇衍生物，完成精纯提取过程；
(6)将上述纯净滤液加入黄丹、冰片、羊毛脂和医用透皮剂混合成膏状即得产品。
该用于肥胖型PCOS穴位贴敷的中药组合物的使用方法，是将含有原料药重量为10-20g膏状药贴敷在患者的三阴交、丰隆、梁门、天枢、关元、带脉、水道、气海、子宫、中脘的任意一处或多处，每一贴持续72-96小时，连续贴敷30-90天为一个疗程。
本发明的有益效果是：
本发明提供的用于肥胖型PCOS穴位贴敷的中药组合物，采用20种中草药泡制淬炼，结合了精纯提取技术，不需口服，只需要贴敷于三阴交、丰隆、梁门、天枢、关元、带脉、水道、气海、子宫、中脘等冲任二脉及肝经、脾经、肾经上的要穴，诸穴配合，具有健脾化湿、疏肝理气、补肾调经、气调血行、冲任调达之用，从而消脂减肥，调经助孕，容易让患者放松心情，坚持长期使用。
具体实施方式
下面结合具体实施方式对本发明作进一步详细的说明。
实施例1：
(1)采用电子秤按照以下配方要求称取中药原料，误差允许在±0.1范围内，完成原料配料；
当归30份、黄芪30份、生姜65份、麦芽10份、山楂10份、白术5份、茯苓10份、陈皮3份、薏苡仁10份、荷叶3份、决明子10份、炙甘草3份、草乌5份、花椒2份、苏木2份、茜草2份、姜黄3份、54°高粱酒65份、白芥子和医用透皮剂按照质量比为1：10的混合物8份、乙醇衍生物0.01份，所述的医用透皮剂为北京杰瑞康医药生物科技有限公司生产的医用透皮剂。乙醇衍生物为乙醚、乙酸和乙二醇按照质量比为1:5:2的混合物。
(2)将当归、黄芪、生姜放入瓦锅内加水适量，炖至烂熟，得到混合药物；
(3)将麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、白芥子、姜黄用蒸笼入锅蒸制1小时，间隔20min，重复一遍，再间隔20min，重复第二遍；
(4)将步骤(3)得到的混合药物加入步骤(2)得到的混合药液中并置于带盖坛内，再向带盖坛内加入54°高粱酒，静置1月，完成泡制淬炼过程；
(5)将带盖坛内浸泡过的物料去渣、静置30min后过滤，取滤液，使用乙醇衍生物，在50℃条件下，保温回流4小时，减压回收乙醇衍生物，完成精纯提取过程；
(6)将上述纯净滤液加入黄丹、冰片、羊毛脂和医用透皮剂混合成膏状即得产品。
该中药组合物的使用方法，是含有原料药重量为10g膏状药贴敷在患者的三阴交穴和子宫穴，每一贴持续72小时，连续贴敷90天为一个疗程，后测试体重指数和治疗效果参考值。
实施例2：
(1)采用电子秤按照以下配方要求称取中药原料，误差允许在±0.1范围内，完成原料配料；
当归40份、黄芪40份、生姜80份、麦芽120份、山楂50份、白术30份、茯苓30份、陈皮25份、薏苡仁70份、荷叶20份、决明子30份、炙甘草10份、草乌8份、花椒4份、苏木4份、茜草4份、姜黄6份、54°高粱酒85份、白芥子和医用透皮剂按照质量比为1：10的混合物9份、乙醇衍生物0.02份，所述的医用透皮剂为北京杰瑞康医药生物科技有限公司生产的医用透皮剂。乙醇衍生物为乙醚、乙酸和乙二醇按照质量比为1:5:2的混合物。
(2)将当归、黄芪、生姜放入瓦锅内加水适量，炖至烂熟，得到混合药物；
(3)将麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、白芥子、姜黄用蒸笼入锅蒸制2小时，间隔30min，重复一遍，再间隔30min，重复第二遍；
(4)将步骤(3)得到的混合药物加入步骤(2)得到的混合药液中并置于带盖坛内，再向带盖坛内加入54°高粱酒，静置1.5个月，完成泡制淬炼过程；
(5)将带盖坛内浸泡过的物料去渣、静置40min后过滤，取滤液，使用乙醇衍生物，在55℃条件下，保温回流5小时，减压回收乙醇衍生物，完成精纯提取过程；
(6)将上述纯净滤液加入黄丹、冰片、羊毛脂和医用透皮剂混合成膏状即得产品。
该中药组合物的使用方法，是含有原料药重量为20g膏状药贴敷在患者的三阴交、丰隆、梁门、天枢、关元、带脉、水道、气海、子宫、中脘穴位的每一处，每一贴持续84小时，连续贴敷30天为一个疗程，后测试体重指数和治疗效果参考值。
实施例3：
(1)采用电子秤按照以下配方要求称取中药原料，误差允许在±0.1范围内，完成原料配料；
当归35份、黄芪35份、生姜72份、麦芽50份、山楂30份、白术10份、茯苓20份、陈皮8份、薏苡仁60份、荷叶15份、决明子20份、炙甘草8份、草乌5份、花椒3份、苏木3份、茜草3份、姜黄5份、54°高粱酒70份、白芥子和医用透皮剂按照质量比为1：10的混合物10份、乙醇衍生物0.01份，所述的医用透皮剂为北京杰瑞康医药生物科技有限公司生产的医用透皮剂。
(2)将当归、黄芪、生姜放入瓦锅内加水适量，炖至烂熟，得到混合药物；
(3)将麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、白芥子、姜黄用蒸笼入锅蒸制1.5小时，间隔25min，重复一遍，再间隔25min，重复第二遍；
(4)将步骤(3)得到的混合药物加入步骤(2)得到的混合药液中并置于带盖坛内，再向带盖坛内加入54°高粱酒，静置1.5个月，完成泡制淬炼过程；
(5)将带盖坛内浸泡过的物料去渣、静置35min后过滤，取滤液，使用乙醇衍生物，在50℃条件下，保温回流5小时，减压回收乙醇衍生物，完成精纯提取过程；
(6)将上述纯净滤液加入黄丹、冰片、羊毛脂和医用透皮剂混合成膏状即得产品。
该中药组合物的使用方法，是含有原料药重量为15g膏状药贴敷在患者的天枢穴，每一贴持续96小时，连续贴敷60天为一个疗程，后测试体重指数和治疗效果参考值。
实施例1-3的患者均为符合西医诊断标准及中医症候诊断标准，且体重指数BMI≥25kg/m2(BMI＝体重(kg)/身高(m)2)。
1、西医诊断标准：2003年鹿特丹会议修正的欧洲人类生殖胚胎学会与美国生殖医学会(ESHRE/ASRM)的诊断标准：(1)稀发排卵或无排卵(2)临床和(或)生化的高雄激素症(3)B超多囊卵巢：表现为每侧卵巢可见直径2～9mm的卵泡≥10～12个，和(或)卵巢体积≥10ml。
2、中医诊断标准：症见月经后期或闭经，体胖，脘腹痞闷，口淡不渴，口腻，食少纳呆，大便溏泄，倦怠乏力，头身困重或怯寒，恶心欲呕，白带量多色白，舌苔白腻，舌体胖有齿痕，舌质淡，脉缓或濡或滑等。
每个实施例通过三位患者分别从体重指数降低程度和半年内受孕成功与否的角度作为参考：
由上表可知，本发明方法制备的中药组合物在肥胖型女性使用1-4个疗程后，均有明显的减肥作用，且78％的女性在贴敷半年内成功受孕。
以上所述，仅是本发明的较佳实施例，并非对本发明做任何形式上的限制，凡是依据本发明的技术实质上对以上实施例所作的任何简单修改、等同变化，均落入本发明的保护范围之内。
Claims (5)
1.一种用于肥胖型PCOS穴位贴敷的中药组合物，其特征在于，所述中药组合物原料按质量份包括以下组分：
当归30～40份、黄芪30～40份、生姜65～80份、麦芽10～120份、山楂10～50份、白术5～30份、茯苓10～30份、陈皮3～25份、薏苡仁10～70份、荷叶3～20份、决明子10～30份、炙甘草3～10份、草乌5～8份、花椒2～4份、苏木2～4份、茜草2～4份、姜黄3～6份、54°高粱酒65～85份、白芥子和医用透皮剂按照质量比为1：10的混合物8～10份、乙醇衍生物0.01～0.02份。
2.根据权利要求1所述的用于肥胖型PCOS穴位贴敷的中药组合物，其特征在于，所述中药组合物原料按质量份包括以下组分：
当归35份、黄芪35份、生姜72份、麦芽50份、山楂30份、白术10份、茯苓20份、陈皮8份、薏苡仁60份、荷叶15份、决明子20份、炙甘草8份、草乌5份、花椒3份、苏木3份、茜草3份、姜黄5份、54°高粱酒70份、白芥子和医用透皮剂按照质量比为1：10的混合物9份、乙醇衍生物0.01份。
3.根据权利要求1或2所述的用于肥胖型PCOS穴位贴敷的中药组合物，其特征在于，所述的乙醇衍生物为乙醚、乙酸和乙二醇按照质量比为1:5:2的混合物。
4.一种如权利要求1或2所述的用于肥胖型PCOS穴位贴敷的中药组合物的制备方法，其特征在于，包括以下步骤：
(1)采用电子秤按照配方要求称取中药原料，误差允许在±0.1范围内，完成原料配料；
(2)将当归、黄芪、生姜放入瓦锅内加水适量，炖至烂熟，得到混合药物；
(3)将麦芽、山楂、白术、茯苓、陈皮、薏苡仁、荷叶、决明子、炙甘草、草乌、花椒、苏木、茜草、姜黄、白芥子用蒸笼入锅蒸制1～2小时，间隔20～30min，重复一遍，再间隔20～30min，重复第二遍；
(4)将步骤(3)得到的混合药物加入步骤(2)得到的混合药液中并置于带盖坛内，再向带盖坛内加入54°高粱酒，静置1～1.5个月，完成泡制淬炼过程；
(5)将带盖坛内浸泡过的物料去渣、静置30～40min后过滤，取滤液，使用乙醇衍生物，在50～55℃条件下，保温回流4～5小时，减压回收乙醇衍生物，完成精纯提取过程；
(6)将上述纯净滤液加入黄丹、冰片、羊毛脂和医用透皮剂混合成膏状即得产品。
5.根据权利要求1所述的用于肥胖型PCOS穴位贴敷的中药组合物的使用方法，其特征在于，将含有原料药重量为10-20g膏状药贴敷在患者的三阴交、丰隆、梁门、天枢、关元、带脉、水道、气海、子宫、中脘的任意一处或多处，每一贴持续72-96小时，连续贴敷30-90天为一个疗程。
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