CN108853427A - 一种治疗超重/肥胖型多囊卵巢综合征的中药方剂 - Google Patents
一种治疗超重/肥胖型多囊卵巢综合征的中药方剂 Download PDFInfo
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Abstract
本发明公开了提供一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其基础方剂按下列中药原料及其重量份配比组成:党参10‑30份,白术5‑15份,茯苓5‑15份,桂枝3‑9份,大黄3‑9份,茵陈5‑15份,泽泻5‑15份,三棱5‑15份,莪术5‑15份,淫羊藿5‑15份,炙甘草3‑6份。本发明所述中药方剂配伍精炼,全部采用基础中药原料,兼顾代谢和生殖内分泌紊乱,顺利解决了目前超重/肥胖多囊卵巢综合征药物研发的难点,获得了满意的疗效。本方剂是一兼顾代谢和生殖内分泌的中药复方,配方简单,效果明确,临床上推广前景广阔,制成各种不同剂型的中成药,更是方便患者;而且总体成本低廉,能很大程度上减轻此类患者的经济负担,将一定程度上减轻国家的医疗负担。
Description
技术领域
本发明属于中医中药技术领域,具体是指一种治疗超重/肥胖型多囊卵巢综合征(PCOS)的中药方剂。
背景技术
多囊卵巢综合征(PCOS)是育龄妇女中最常见的妇科内分泌疾病,全球范围内5%-10%的育龄妇女受此病困扰,它是一种发病多因性,临床表现多态性,以无排卵性月经、不孕、高雄激素血症和胰岛素抵抗为特征的综合征,多在青春期前后发病。症状可表现为月经周期紊乱,通常为闭经或月经稀发,可引起多毛、痤疮、皮肤脂溢和脱发等临床症状,有相当一部分患者合并肥胖、胰岛素抵抗和脂代谢紊乱。33%PCOS患者不能生育,远期并发症包括子宫内膜癌、血脂异常、心血管疾病、高血压、糖尿病等,对患者健康危害很大。
目前,PCOS的发病机制尚不清楚,病因复杂,对其病因的研究主要集中于遗传因素、肥胖、环境因素、药物及疾病影响等。PCOS患者无论肥胖与否均存在胰岛素抵抗,而肥胖是胰岛素抵抗的重要危险因素,部分患者存在内脏型肥胖、TG水平升高、HDL-C水平降低;内脏脂肪和胰岛素抵抗呈线性相关关系(r=0.68),预测胰岛素抵抗的最佳指标是腹内脂肪和TG,提示腹内脂肪沉积是胰岛素抵抗的病因或早期影响因素之一。超重及肥胖PCOS患者占全部PCOS患者的67.0%,患者内脏脂肪增加明显,肥胖与不排卵、流产和妊娠中晚期并发症(如妊娠期糖尿病)关系密切。有研究表明,肥胖型PCOS患者体质量减轻5.0%,恢复规律月经的概率为89.0%;同时减轻体质量可以降低患者的血脂、胰岛素、雄激素水平。
西医的治疗方案主要包括针对不孕不育的药物促排卵、降低血清雄激素水平、提高胰岛素敏感性和手术治疗等。但上述方法存在促排卵后妊娠率低(仅有30%-40%)、对卵巢功能改善不明显、停药后病情反复、手术创伤继发的盆腔粘连等。随着对PCOS研究的深入,国内外越来越多的学者认识到超重/肥胖是PCOS病理形成的关键因素。减少体内脂肪(特别是内脏脂肪)是PCOS的重要和基础的治疗。然而,目前药物治疗方面,针对超重/肥胖患者减肥降脂的药物品种繁多,效果参差不齐,但绝大部分的药物不能解决此类女性患者因肥胖导致的月经紊乱及继发不孕,甚至不能用于有妊娠需求的女性患者;针对多囊卵巢综合征的大部分药物可针对月经紊乱及继发不孕改善生殖内分泌代谢情况,通过调节激素水平改善月经情况、一定程度上提高患者妊娠率,但不能有效、持久改善患者超重/肥胖及继发的代谢内分泌紊乱情况。
2018年中国PCOS防治指南已经明确提出减重是本病治疗的首要措施,同时肯定了中医药对PCOS的治疗价值。目前兼顾代谢和生殖内分泌紊乱的药物是超重/肥胖多囊卵巢综合征药物研发的热点和难点。
发明内容
本发明的目的在于克服现有中西医治疗超重/肥胖型多囊卵巢综合征(PCOS)的药物存在的不足,提供一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,该中药方剂一方面可以迅速有效地减轻患者体重及体重指数,体重下降后不容易反弹、还能改善糖脂代谢、胰岛素抵抗等情况;另一方面可以改善PCOS患者不排卵/稀发排卵的情况,改善生殖内分泌紊乱,调节卵巢功能,提高合并不孕患者的妊娠率。
本发明的目的是通过以下措施实现的:
一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:
按下列中药原料及其重量份配比组成的基础方剂:
党参10-30份,白术5-15份,茯苓5-15份,桂枝3-9份,大黄3-9份,茵陈5-15份,泽泻5-15份,三棱5-15份,莪术5-15份,淫羊藿5-15份,炙甘草3-6份。
所述一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其基础方剂的重量份配比优选范围是:
党参20-30份,白术10-15份,茯苓10-15份,桂枝6-9份,大黄3-6份,茵陈10-15份,泽泻10-15份,三棱10-15份,莪术10-15份,淫羊藿10-15份,炙甘草3-6份。
所述中药方剂还包括巴戟天和菟丝子,针对肾精不足病证的配方,按下列重量份配比称取中药原料:
党参20份,白术5份,茯苓5份,桂枝6份,大黄3份,茵陈10份,泽泻10份,三棱10份,莪术10份,淫羊藿10份,巴戟天10份,菟丝子10份,炙甘草3份。
所述中药方剂还包括法半夏,针对痰湿内蕴型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝9份,大黄3份,茵陈5份,泽泻10份,三棱5份,莪术5份,淫羊藿10份,法半夏9份,炙甘草3份。
所述中药方剂还包括青皮和香附,针对肝郁气滞型病证配方,按下列重量份配比称取中药原料:
党参10份,白术10份,茯苓10份,桂枝3份,大黄3份,茵陈5份,泽泻5份,三棱10份,莪术10份,淫羊藿10份,青皮6份,香附10份,炙甘草6份。
所述中药方剂还包括赤芍、桃仁和红花,针对血瘀型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝6份,大黄9份,茵陈5份,泽泻5份,三棱10份,莪术10份,淫羊藿5份,赤芍10份,桃仁10份,红花9份,炙甘草6份。
所述中药方剂还包括当归和阿胶,针对气血两虚型病证配方,按下列重量份配比称取中药原料:
党参30份,白术10份,茯苓10份,桂枝6份,大黄3份,茵陈5份,泽泻5份,三棱5份,莪术5份,淫羊藿10份,当归8份,阿胶10份,炙甘草3份。
所述中药方剂还包括生地和龟板,针对阴虚内热型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝6份,大黄6份,茵陈10份,泽泻10份,三棱10份,莪术10份,淫羊藿10份,生地10份,龟板20份,炙甘草6份。
所述一种治疗超重/肥胖型多囊卵巢综合征(PCOS)的中药方剂是指任何一种药剂学上所说的剂型,包括传统汤药,还包括按常规方法制备成胶囊剂、颗粒剂、口服液或片剂。
药理分析:
《医宗必读》提到:“生痰之源为脾也,治痰不理脾胃,非其治也”,本发明从健脾化痰利湿,兼顾肾精出发,根据临床观察结果,通过反复斟酌完善而成基础中药原料的精炼配伍。
其中党参,甘、平,归脾、肺经,《本草从新》中描述党参:“补中益气、和脾胃、除烦渴。如若中气微弱,则可用其以调补,甚为平妥。”党参在本方中大补元气,补益脾气,健运脾胃,为君药。《本草汇言》曰:“脾虚不健者,可加用白术补之”、《本草正》提到:“茯苓可以利窍去湿……,祛除湿气则可以逐水燥脾,补中健胃……可以作为治痰之本,助药之降”。在本方中白术、茯苓健脾渗湿,燥湿行水,助君药加强健脾利湿的功效,为臣药。桂枝温化痰饮,助君药加强温化痰湿之效,茵陈味苦、辛,性微寒,归脾、胃、肝、胆经,功擅清热利湿,为臣药。三棱、莪术为臣药,性味苦辛,归肝经、脾经,二药功效均为破血行气,消积止痛,两药配伍以消除癥瘕。淫羊藿为臣药,味辛、甘,性温;入肝、肾经,具有温肾阳、补肾精之效,助君药加强补肾温阳、恢复肾-天癸-冲任-胞宫功能。大黄苦,寒,荡涤肠道,清利痰浊,使邪有去路,从大便排出。泽泻甘,寒,入肾、膀胱经,利水渗湿,清利小便,二药相辅,使邪有去路,从小便排出。
本方剂中桂枝、白术、茯苓的配伍在《金匮要略》中即有记载:苓桂术甘方用于治疗痰饮证(包括现代医学的超重/肥胖等相关疾病)。脾主运化水湿,治湿不补气健脾,非其治也,因此,本发明在桂枝、白术、茯苓基础上,加入了党参,设置为君药,量最大,功专补益脾气,恢复脾运。又根据广东地区气候炎热、多湿多热,湿多夹热,针对地域特点,加入了清热祛湿的良药-茵陈,加强清利湿热的力度。PCOS在传统医学被归类为癥瘕,针对盆腔附件的癥瘕包块,必须加入软坚散结、破血行气的药物才能软化消除,因此本方中加入了三棱、莪术,两药是治疗妇科癥瘕的有名药对,破血行气,消积止痛,疏通结痰,削坚癥老癖,而且对于久病顽症之癥瘕,更有推墙倒壁之力而愈显神通,大量的现代研究也证实三棱、莪术能明显改善盆腔、卵巢的血液供应,抑制盆腔炎症反应,两药配伍使得原方改善卵巢不排卵或稀发排卵的功效明显提高。针对超重/肥胖PCOS患者除超重/肥胖外,还合并存在稀发排卵、不排卵、卵巢功能不全、妊娠率低等,我们特设淫羊藿作为臣药,专补肾精。值得一提的是,大黄、泽泻在本方中为臣药,用量虽小,但在临床观察中发现大黄与泽泻配伍,通过清利痰湿,使痰湿从二便排出,能明显减轻患者体重、减少体重指数,是本方中起到减肥功效的主要药对。还意外发现,加入大黄、泽泻药对,随着患者体重、体重指数的下降,患者胰岛素抵抗继发性地改善,卵巢功能也逐渐改善,患者不排卵或稀发排卵的情况明显改善。因此,大黄、泽泻二药配伍有意想不到的临床效果,使得有妊娠需求的超重/肥胖PCOS患者卵巢功能随着体重下降、胰岛素抵抗的改善而迅速改善,妊娠率明显提高。
总的来说,本方兼顾了超重/肥胖多囊卵巢综合征的代谢及生殖内分泌紊乱情况,从本病的痰湿病理基础出发,针对痰湿泛溢躯体肌肤四肢形成的超重/肥胖,有效持久减轻体重、减小体重指数,调节代谢内分泌紊乱;针对痰湿蕴结胞宫、阻滞胞络导致的月经不调、不孕等,祛湿化痰,疏通胞络,从而调经助孕。
疗效分析及其突出的效果:
1、本发明所述中药方剂配伍精炼,全部采用基础中药原料,兼顾代谢和生殖内分泌紊乱,顺利解决了目前超重/肥胖多囊卵巢综合征药物研发的难点,获得了满意的疗效:
⑴大部分合并闭经或月经稀发的超重/肥胖PCOS患者经本发明治疗后,患者能逐渐恢复正常月经,可以改善PCOS患者不排卵/稀发排卵的情况,改善内分泌紊乱,调节卵巢功能,能提高70%不孕患者的妊娠率;能减轻体重和减小体重指数,并且减重后不容易反弹。
⑵超重/肥胖PCOS患者采用本发明联合热量控制治疗后,随着体重、体重指数及糖脂代谢的改善,胰岛素抵抗改善,糖化血红蛋白下降,月经恢复规律。
⑶对于45例合并糖耐量异常的超重/肥胖PCOS患者采用本方治疗,发现本发明可明显降低冠心病风险。对于合并新发糖尿病的超重/肥胖PCOS患者,运用本发明联合热量控制可明显改善糖代谢和胰岛素抵抗,部分病例的糖尿病可获痊愈。
⑷对合并高脂血症、脂肪肝、高血压、代谢综合征等近60例超重/肥胖PCOS患者采用本发明联合热量控制治疗,发现可明显改善胰岛素抵抗、降低血压、减小体重指数、调节糖脂代谢、改善血管内皮功能、减少内脏脂肪。克服了常规减肥方法饥饿感明显、内脏脂肪动员不足的缺点。
2、本中药方剂全部采用基础中药原料,经过科学组方,特别是大黄、泽泻二药配伍有意想不到的临床效果,使得有妊娠需求的超重/肥胖PCOS患者卵巢功能随着体重下降、胰岛素抵抗的改善而迅速改善,妊娠率明显提高。自2009年开始在中山大学附属第一医院院内对超重/肥胖PCOS患者的观察和治疗,每日嘱患者口服本中药方剂1日1次,1次1剂,根据患者具体情况疗程持续12-24周不等。经临床病例观察证实,安全而无明显毒副作用,且患者接受程度高、依从性好。
3、本中药方剂的组成中无毒性致畸、滑胎堕胎药物,除体质虚寒型患者禁服外,其他体质患者均可服用,服药期间患者可不避孕,确认妊娠后暂停即可。
4、本中药方剂是一兼顾代谢和生殖内分泌的中药复方,配方简单,效果明确,临床上推广本方剂治疗超重/肥胖多囊卵巢综合征具有非常广阔和良好的前景,能采用常规方法制成各种不同剂型的中成药,不仅方便患者,而且总体成本低廉,能很大程度上减轻此类患者的经济负担,将一定程度上减轻国家的医疗负担。
5、有望在全世界有适应症的人群中推广使用,更是对人类医学界的贡献。
具体实施方式
下面结合病例对本发明作进一步详细的说明,但本发明的实施方式不限于此。
实施例1
一种治疗超重/肥胖型多囊卵巢综合征(PCOS)的中药方剂的11味药基础配方,按下列配比称取中药原料:
党参20千克,白术10千克,茯苓10千克,桂枝6千克,大黄3千克,茵陈10千克,泽泻10千克,三棱10千克,莪术10千克,淫羊藿10千克,炙甘草3千克。
首先取按上述所述重量配比的中药原料,加水浸泡,置多功能提取罐中提取1~3次,每次提取1~3小时,过滤,将每次滤液相合并,浓缩至1.0g生药/ml左右。然后,可以按常规方法制备成胶囊剂、颗粒剂、口服液或片剂等任何一种药剂学上所说的剂型。
实施例2
一种治疗超重/肥胖型PCOS的中药方剂,针对肾精不足病证的配方,按下列配比称取中药原料:
党参20千克,白术5千克,茯苓5千克,桂枝6千克,大黄3千克,茵陈10千克,泽泻10千克,三棱10千克,莪术10千克,淫羊藿10千克,巴戟天10千克,菟丝子10千克,炙甘草3千克。制备方法同实施例1。
李某,女,18岁,未婚未育。因“月经迟发3月”就诊,测体重:77.8kg,身高:154cm,BMI:33kg/m2。初潮12岁,平素月经量正常,颜色正常,少量血块,痛经,周期40-90天。妇科B超示:卵巢呈多囊样变化。西医诊断为肥胖型PCOS,中医辨证为肾精不足证,给予以下方剂口服连服3个月:党参20克,白术5克,茯苓5克,桂枝6克,大黄3克,茵陈10克,泽泻10克,三棱10克,莪术10克,淫羊藿10克,巴戟天10克,菟丝子10克,炙甘草3克。3个月后复测体重66kg,BMI:27kg/m2,月经周期较前缩短,为28-32天,随访半年病情稳定。
实施例3
一种治疗超重/肥胖型PCOS的中药方剂,针对痰湿内蕴型病证配方,
按下列配比称取中药原料:
党参20千克,白术10千克,茯苓10千克,桂枝9千克,大黄3千克,茵陈5千克,泽泻10千克,三棱5千克,莪术5千克,淫羊藿10千克,法半夏9千克,炙甘草3千克。制备方法同实施例1。
王某,女,29岁,已婚育有1子,因“肥胖、停经3月”就诊。体重66kg,身高159cm,体重指数26.1kg/m2。初潮13岁,月经周期30天至半年。月经稀发,经量少,有痛经病史,既往有多囊卵巢综合征,中医辨证为痰湿内蕴型。给予以下方剂口服连服3个月:党参20克,白术10克,茯苓10克,桂枝9克,大黄3克,茵陈5克,泽泻10克,三棱5克,莪术5克,淫羊藿10克,法半夏9克,炙甘草3克。服药7天后月经来潮,月经量、色均正常,无痛经。3个月后复测体重58kg,BMI:22.9kg/m2,月经周期较前缩短,为30-35天,月经量增加,痛经改善,随访半年病情稳定。
实施例4
一种治疗超重/肥胖型PCOS的中药方剂,针对肝郁气滞型病证配方,按下列配比称取中药原料:
党参10千克,白术10千克,茯苓10千克,桂枝3千克,大黄3千克,茵陈5千克,泽泻5千克,三棱10千克,莪术10千克,淫羊藿10千克,青皮6千克,香附10千克,炙甘草6千克。制备方法同实施例1。
鲁某,女,21岁,学生,未婚未育,平素学习压力大,心烦易怒。体重84kg,身高:160cm,BMI:32.8kg/m2。13岁月经初潮,周期紊乱一般30-60天,经期偏长7-8天。平素月经量不多,颜色暗红,无痛经、血块,无异常阴道流血史。既往西医已经确诊多囊卵巢综合征,中医辨证为肝郁气滞型。给予以下方剂口服先连服3个月:党参10克,白术10克,茯苓10克,桂枝3克,大黄3克,茵陈5克,泽泻5克,三棱10克,莪术10克,淫羊藿10克,青皮6克,香附10克,炙甘草6克。除服药外,嘱其每周运动至少3次。3个月后复测体重72kg,BMI:28.1kg/m2,月经周期较前缩短,为30-35天,月经量增加,痛经改善。因患者体重未达标,嘱其再继续服用上方3个月。服药满半年后复测体重60kg,BMI:23.4kg/m2,月经周期恢复正常,为28-30天。经期5-7天。月经量正常,痛经发作次数明显减少,随访半年病情稳定。
实施例5
一种治疗超重/肥胖型PCOS的中药方剂,针对血瘀型病证配方
按下列配比称取中药原料:
党参20千克,白术10千克,茯苓10千克,桂枝6千克,大黄9千克,茵陈5千克,泽泻5千克,三棱10千克,莪术10千克,淫羊藿5千克,赤芍10千克,桃仁10千克,红花9千克,炙甘草6千克。制备方法同实施例1。
陈某,女,34岁,因“肥胖伴不孕3年”就诊。就诊时体重:65kg,身高:156cm,BMI:26.7kg/m2。G1P1,28岁时足月顺产1单活男胎。31岁开始备孕,一直未孕。平素月经周期45-60天,经期7天,月经量少,血块少,时有痛经。曾完善各项检查,西医诊断为多囊卵巢综合征。中医证型为血瘀型。嘱其暂时避孕,并给予以下方剂口服3个月:党参20克,白术10克,茯苓10克,桂枝6克,大黄9克,茵陈5克,泽泻5克,三棱10克,莪术10克,淫羊藿5克,赤芍10克,桃仁10克,红花9克,炙甘草6克。3个月后复测体重58kg,BMI:23.8kg/m2。月经周期35-40天,月经量增加,无痛经发作。考虑患者有妊娠需求,故上方减大黄,红花,加上桑寄生15克,组方如下:党参20克,白术10克,茯苓10克,桂枝6克,茵陈10克,泽泻10克,三棱10克,莪术10克,淫羊藿10克,赤芍10克,桃仁10克,桑寄生10克,炙甘草6克嘱其再服3个月,可备孕。服第二方的第三个月患者诉月经超过40天未来,测尿HCG(+),考虑怀孕,嘱患者停药,并长期随访,患者9个月后足月顺产一单活男胎。
实施例6
一种治疗超重/肥胖型PCOS中药方剂,针对气血两虚型病证配方,按下列配比称取中药原料:
党参30千克,白术10千克,茯苓10千克,桂枝6千克,大黄3千克,茵陈5千克,泽泻5千克,三棱5千克,莪术5千克,淫羊藿10千克,当归8千克,阿胶10千克,炙甘草3千克。制备方法同实施例1。
杨某,女,38岁,已婚已育,G2P2。因“肥胖伴月经频发半年”就诊。体重78kg,身高:170cm,BMI:26.9kg/m2。13岁月经初潮,周期紊乱一般20-30天,经期偏长7-8天。平素月经量多,颜色淡红,无痛经、血块,无异常阴道流血史,面色苍白,语音低弱,唇甲色淡。既往西医已经确诊多囊卵巢综合征,中医辨证为气血两虚型。给予以下方剂口服先连服3个月:党参30克,白术10克,茯苓10克,桂枝6克,大黄3克,茵陈5克,泽泻5克,三棱5克,莪术5克,淫羊藿10克,当归8克,阿胶10克,炙甘草3克。3个月后复测体重68kg,BMI:23.5kg/m2,月经周期恢复正常,为28-30天,月经量较前减少,颜色鲜红,面色转红润,唇甲颜色恢复正常,随访半年病情稳定。
实施例7
一种治疗超重/肥胖型PCOS的中药方剂,针对阴虚内热型病证配方,按下列配比称取中药原料:
党参20千克,白术10千克,茯苓10千克,桂枝6千克,大黄6千克,茵陈10千克,泽泻10千克,三棱10千克,莪术10千克,淫羊藿10千克,生地10千克,龟板20千克,炙甘草6千克。制备方法同实施例1。
张某,女,40岁,已婚已育,G1P1,因“超重伴月经迟发1年”就诊。体重62kg,身高:158cm,BMI:24.8kg/m2。12岁月经初潮,周期紊乱,一般,40-50天,经期偏长7-8天。平素月经量少,颜色淡红,无痛经、血块,无异常阴道流血史,两颧潮红,口舌易干燥,易盗汗潮热。既往西医已经确诊多囊卵巢综合征,中医辨证为阴虚内热型。给予以下方剂口服先连服3个月:党参20克,白术10克,茯苓10克,桂枝6克,大黄6克,茵陈10克,泽泻10克,三棱10克,莪术10克,淫羊藿10克,生地10克,龟板20克,炙甘草6克。3个月后复测体重56kg,BMI:22.4g/m2,月经周期恢复正常,为28-30天,月经量较前增加,颜色鲜红,两颧潮红、口舌干燥、潮热盗汗较前改善,随访半年病情稳定。
实施例8
一种治疗超重/肥胖型多囊卵巢综合征(PCOS)的中药方剂的11味药基础配方,按下列重量份配比及其设备的容积称取中药原料:
党参30份,白术15份,茯苓15份,桂枝9份,大黄9份,茵陈15份,泽泻15份,三棱15份,莪术15份,淫羊藿15份,炙甘草6份。
首先取按上述所述重量配比的中药原料,加水浸泡,置多功能提取罐中提取1~3次,每次提取1~3小时,过滤,将每次滤液相合并,浓缩至1.0g生药/ml左右。然后,可以按常规方法制备成胶囊剂、颗粒剂、口服液或片剂等任何一种药剂学上所说的剂型。
Claims (9)
1.一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:按下列中药原料及其重量份配比组成的基础方剂:
党参10-30份,白术5-15份,茯苓5-15份,桂枝3-9份,大黄3-9份,茵陈5-15份,泽泻5-15份,三棱5-15份,莪术5-15份,淫羊藿5-15份,炙甘草3-6份。
2.根据权利要求1所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其基础方剂的重量份配比范围是:
党参20-30份,白术10-15份,茯苓10-15份,桂枝6-9份,大黄3-6份,茵陈10-15份,泽泻10-15份,三棱10-15份,莪术10-15份,淫羊藿10-15份,炙甘草3-6份。
3.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括巴戟天和菟丝子,针对肾精不足病证的配方,按下列重量份配比称取中药原料:
党参20份,白术5份,茯苓5份,桂枝6份,大黄3份,茵陈10份,泽泻10份,三棱10份,莪术10份,淫羊藿10份,巴戟天10份,菟丝子10份,炙甘草3份。
4.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括法半夏,针对痰湿内蕴型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝9份,大黄3份,茵陈5份,泽泻10份,三棱5份,莪术5份,淫羊藿10份,法半夏9份,炙甘草3份。
5.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括青皮和香附,针对肝郁气滞型病证配方,按下列重量份配比称取中药原料:
党参10份,白术10份,茯苓10份,桂枝3份,大黄3份,茵陈5份,泽泻5份,三棱10份,莪术10份,淫羊藿10份,青皮6份,香附10份,炙甘草6份。
6.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括赤芍、桃仁和红花,针对血瘀型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝6份,大黄9份,茵陈5份,泽泻5份,三棱10份,莪术10份,淫羊藿5份,赤芍10份,桃仁10份,红花9份,炙甘草6份。
7.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括当归和阿胶,针对气血两虚型病证配方,按下列重量份配比称取中药原料:
党参30份,白术10份,茯苓10份,桂枝6份,大黄3份,茵陈5份,泽泻5份,三棱5份,莪术5份,淫羊藿10份,当归8份,阿胶10份,炙甘草3份。
8.根据权利要求1或2所述的一种治疗超重/肥胖型多囊卵巢综合征的中药方剂,其特征在于:所述中药方剂还包括生地和龟板,针对阴虚内热型病证配方,按下列重量份配比称取中药原料:
党参20份,白术10份,茯苓10份,桂枝6份,大黄6份,茵陈10份,泽泻10份,三棱10份,莪术10份,淫羊藿10份,生地10份,龟板20份,炙甘草6份。
9.权利要求1~8所述一种治疗超重/肥胖型多囊卵巢综合征的中药方剂是任何一种药剂学上所说的剂型,包括传统汤药,还包括按常规方法制备成胶囊剂、颗粒剂、口服液或片剂。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109224054A (zh) * | 2018-11-28 | 2019-01-18 | 辽宁中医药大学 | 一种用于肥胖型pcos穴位贴敷的中药组合物及其制备方法 |
CN117323371A (zh) * | 2023-10-30 | 2024-01-02 | 四川大学华西第二医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895456A (zh) * | 2011-07-25 | 2013-01-30 | 刘艳萍 | 治疗多囊卵巢综合征的药物 |
CN104162057A (zh) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物及其应用 |
CN105816617A (zh) * | 2016-04-29 | 2016-08-03 | 山东省立医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物 |
CN106334060A (zh) * | 2016-11-03 | 2017-01-18 | 山东中医药大学附属医院 | 一种治疗肥胖型多囊卵巢综合征的药物组合物 |
-
2018
- 2018-08-02 CN CN201810870044.8A patent/CN108853427A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895456A (zh) * | 2011-07-25 | 2013-01-30 | 刘艳萍 | 治疗多囊卵巢综合征的药物 |
CN104162057A (zh) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物及其应用 |
CN105816617A (zh) * | 2016-04-29 | 2016-08-03 | 山东省立医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物 |
CN106334060A (zh) * | 2016-11-03 | 2017-01-18 | 山东中医药大学附属医院 | 一种治疗肥胖型多囊卵巢综合征的药物组合物 |
Non-Patent Citations (2)
Title |
---|
冯丽萍: ""基于中医传承辅助平台系统的多囊卵巢综合征中医证候及用药规律研究"", 《甘肃中医药大学》 * |
杨玉彬等: ""健脾化痰方联合热量控制对肥胖型多囊卵巢综合征患者的治疗效果研究"", 《中国全科医学》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109224054A (zh) * | 2018-11-28 | 2019-01-18 | 辽宁中医药大学 | 一种用于肥胖型pcos穴位贴敷的中药组合物及其制备方法 |
CN109224054B (zh) * | 2018-11-28 | 2021-08-13 | 辽宁中医药大学 | 一种用于肥胖型pcos穴位贴敷的中药组合物及其制备方法 |
CN117323371A (zh) * | 2023-10-30 | 2024-01-02 | 四川大学华西第二医院 | 一种治疗肥胖型多囊卵巢综合征的中药组合物及其制备方法 |
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