CN109223963A - A kind of Chinese medicine composition and preparation method thereof for treating pharyngitis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating pharyngitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of Chinese medicine composition and preparation method thereof for treating pharyngitis.The Chinese medicine composition includes following content of component: 10-15 parts of radix scrophulariae, 10-15 parts of cortex moutan, 15-25 parts of folium isatidis, 5-10 parts of honeysuckle, 6-10 parts of Oroxylum indicum, 15-25 parts of the sterculia seed, 6-10 parts of campanulaceae, 5-10 parts of lily.Preparation method is: all medicinal materials first pass through ethyl alcohol extraction and extract again through water, fine powder are spray-dried to obtain after concentration, then be mixed and made into finished product with excipient substance.The Chinese medicine composition and preparation method thereof for the treatment of pharyngitis provided by the invention, treating both manifestation and root cause of disease, actual situation and control, internal and external communication, Yin nourishing and lung moistening, antibechic are antipruritic, clearing throat.
Description
Technical field
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of Chinese medicine composition and preparation method thereof for treating pharyngitis.
Background technique
Pharyngitis (pharyngitis) is pharyngeal nonspecific inflammation, is that various microorganism infections are pharyngeal and generate inflammation
General designation, can individualism, can also with rhinitis, tonsillitis and laryngitis and deposit, or be the premonitory symptom of certain diseases.It can be divided into
Acpuei pharyngitis and chronic pharyngitis.Acpuei pharyngitis is the acute inflammation of pharyngeal mucous membrane and sub-mucosal tissues, and pharynx lymphoid tissue is often tired out
And inflammation early stage can limit to, and often can be related to entire pharyngeal cavity with disease progression, it is with the autumn and winter and at the end of winter and the beginning of spring more typical.Main performance
For pharyngeal drying, scorching hot, pain, it is obvious to swallow pain, congestion of throat swelling etc..Chronic pharyngitis can be divided into chronic simple pharynx again
Scorching, chronic hypertrophic pharyngitis and atrophic pharyngitis, wherein chronic simple pharyngitis is more common, and lesion is mainly in mucous layer, performance
For pharyngeal mucous membrane chronic congestion, connective tissue proliferation under mucous membrane and mucous membrane, mucous gland can be loose, and secreting function is hyperfunction, mucus point
It secretes and increases.Patient often brings up glutinous phlegm in pharynx, or feels pharyngeal and have foreign body sensation, can not cough up, does not swallow.Common adult, the course of disease is long,
Easy to recur, symptom is obstinate, it is more difficult to cure.
At present the most single effect of the therapeutic agent of pharyngitis, side effect is obvious, can not alleviate and treat above-mentioned symptom, treat
Effect is not obvious, and easy to recur, cannot be eradicated.Therefore, be badly in need of a kind of good effect, at low cost, height of effectively filling a bowl with rice, Small side effects,
The preparation of the low treatment pharyngitis of recurrence rate.
Summary of the invention
In order to solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of Chinese medicine composition for treating pharyngitis and
Preparation method, this preparation method can be reduced the loss of effective component in preparation process, improve effective component so that
Curative effect of this preparation in terms for the treatment of pharyngitis is better than the product of same effect formula in the market, and curative effect is stablized.
In order to achieve the above-mentioned object of the invention, the invention adopts the following technical scheme:
A kind of Chinese medicine composition for treating pharyngitis, including following content of component: 10-15 parts of radix scrophulariae, cortex moutan 10-15
Part, 15-25 parts of folium isatidis, 5-10 parts of honeysuckle, 6-10 parts of Oroxylum indicum, 15-25 parts of the sterculia seed, 6-10 parts of campanulaceae, lily 5-10
Part.
Preferably, the Chinese medicine composition of the treatment pharyngitis includes following content of component: 12 parts of radix scrophulariae, cortex moutan 12
Part, 20 parts of folium isatidis, 7 parts of honeysuckle, 8 parts of Oroxylum indicum, 20 parts of the sterculia seed, 8 parts of campanulaceae, 7 parts of lily.
A kind of preparation method of Chinese medicine composition that treating pharyngitis, comprising the following steps:
(1) it by ethanol water refluxing extraction 1 time that whole medicinal material concentration are 70%, flows back 2 hours, filters to obtain the dregs of a decoction
And medical fluid, ethyl alcohol is recycled, medical fluid is concentrated under reduced pressure to give the medicinal extract of relative density 1.1-1.3 under room temperature；
(2) step (1) dregs of a decoction are added water to cook 2 times, the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was medicine respectively
Filtrate, is condensed into the clear cream of relative density 1.15-1.25 under room temperature by 6 times, 5 times of material total weight, filtration；
(3) step (1) and the resulting clear cream of step (2) and medicinal extract are merged, it is spray-dried at fine powder；
(4) powder, granule or capsule is made through granulation, whole grain, total mix in fine powder obtained in step (3).
Preferably, the preparation method of the powder is that fine powder is crossed 80-120 mesh, obtains powder.
Preferably, the preparation method of the capsule is that filling obtains glue to Capsules after fine powder crushed to No. 5-6 sieve
Wafer.
Preferably, the preparation method of the granule is to mix fine powder with pharmaceutic adjuvant, using dry granulation obtained
Granula, the fine powder and pharmaceutic adjuvant volume ratio are 4-5:1.
Preferably, the pharmaceutic adjuvant includes lubricant, diluent, disintegrating agent and adhesive；The lubricant, dilution
Agent, disintegrating agent and adhesive volume ratio are 2:3:2-3:1.
Compared with prior art, the invention has the following advantages: preparation method of the invention not only can be reduced preparation
The loss of effective component in the process improves effective component so that curative effect of this preparation in terms for the treatment of pharyngitis is better than city
The product of same effect formula on field, and curative effect is stablized.
Specific embodiment
Below by specific embodiment, invention is further described in detail.But those skilled in the art will manage
Solution, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Specific skill is not specified in embodiment
Art or condition person, described technology or conditions carry out to specifications according to the literature in the art.Agents useful for same or instrument
Production firm person is not specified, being can be with conventional products that are commercially available.
The effect of each ingredient is as follows in composition:
Radix scrophulariae: the dried root of [source] scrophulariaceae radix scrophulariae.[meridian distribution of property and flavor] is bitter, sweet, salty, cold.Return lung, stomach, kidney
Through.[effect] clearing heat and cooling blood, nourishing yin and lessening fire, detoxicating and resolving a mass, ease constipation.
Cortex moutan: the dry root skin of [source] ranunculaceae peony.[meridian distribution of property and flavor] is bitter, pungent, slightly cold.Return heart, liver, kidney
Through.[effect] clearing heat and cooling blood, promoting blood circulation to remove blood stasis, reducing the asthenic fever.
Folium isatidis: the dried leaf of [source] cruciferae isatis.[meridian distribution of property and flavor] is bitter, cold.Return heart, lung, stomach meridian.
[effect] is clearing heat and detoxicating, blood cooling and ecchymoses removing, reducing pharyngeal swelling.
Honeysuckle: the dry flower of [source] caprifoliaceae plant honeysuckle or with the flower just opened.[meridian distribution of property and flavor] is sweet, cold.Return
Lung, stomach, large intestine channel.[effect] is clearing heat and detoxicating, dispelling wind and heat from the body.
Oroxylum indicum: the dry mature seed of [source] Bignoniaceae plant oroxylum indicum.[meridian distribution of property and flavor] is bitter, sweet, cool.Return lung,
Liver, stomach meridian.[effect] clearing heat, relieving sore-throat, soothing liver and harmonizing stomach.
The sterculia seed: the dry mature seed of [source] Sterculiaceae plant sterculia seed.[meridian distribution of property and flavor] is sweet, cold.Return lung, large intestine
Through.[effect] clear promoting the dispersing function of the lung gas, gut purge defaecation.
Campanulaceae: the dry root of [source] Campanulaceae campanulaceae.[meridian distribution of property and flavor] is bitter, pungent, flat.It is distributed in lung channel.[effect] a surname
Lung, relieving sore-throat, eliminating the phlegm, apocenosis.
Lily: the dry meat scale leaf of [source] liliaceous plant tiger lily, lily or Lilium tenuifolium.[meridian distribution of property and flavor] sweet,
It is slightly cold.Return lung, the heart channel of Hang-Shaoyin.[effect] Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.
Embodiment 1
Weigh 10 parts of radix scrophulariae, 12 parts of cortex moutan, 15 parts of folium isatidis, 10 parts of honeysuckle, 8 parts of Oroxylum indicum, 15 parts of the sterculia seed, tangerine
8 parts, 10 parts of lily of stalk.
(1) it by ethanol water refluxing extraction 1 time that whole medicinal material concentration are 70%, flows back 2 hours, filters to obtain the dregs of a decoction
And medical fluid, ethyl alcohol is recycled, filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) by step (1) dregs of a decoction
It adds water to cook 2 times, the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, was filtered, will
Filtrate is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) by step (1) and the resulting clear cream of step (2) and medicinal extract
Merge, it is spray-dried at fine powder.(4) by fine powder obtained in step (3), 80 mesh is crushed to, powder is obtained.
Embodiment 2
Weigh 15 parts of radix scrophulariae, 10 parts of cortex moutan, 20 parts of folium isatidis, 8 parts of honeysuckle, 10 parts of Oroxylum indicum, 20 parts of the sterculia seed, tangerine
6 parts, 8 parts of lily of stalk.
Be 70% ethanol water refluxing extraction for 1 time by whole medicinal material concentration, flow back 2 hours, filter the dregs of a decoction and
Medical fluid, recycles ethyl alcohol, and filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) step (1) dregs of a decoction are added
Water decocts 2 times, and the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, and filtration will filter
Liquid is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) step (1) and the resulting clear cream of step (2) and medicinal extract are closed
And it is spray-dried at fine powder.(4) by fine powder obtained in step (3), 100 mesh is crushed to, powder is obtained.
Embodiment 3
Weigh 12 parts of radix scrophulariae, 15 parts of cortex moutan, 25 parts of folium isatidis, 5 parts of honeysuckle, 6 parts of Oroxylum indicum, 25 parts of the sterculia seed, tangerine
10 parts, 5 parts of lily of stalk.
Be 70% ethanol water refluxing extraction for 1 time by whole medicinal material concentration, flow back 2 hours, filter the dregs of a decoction and
Medical fluid, recycles ethyl alcohol, and filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) step (1) dregs of a decoction are added
Water decocts 2 times, and the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, and filtration will filter
Liquid is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) step (1) and the resulting clear cream of step (2) and medicinal extract are closed
And it is spray-dried at fine powder.(4) by fine powder obtained in step (3), fine powder is filled after crushed No. 5 sieves to Capsules,
Capsule is obtained after polishing.
Embodiment 4
Weigh 10 parts of radix scrophulariae, 15 parts of cortex moutan, 20 parts of folium isatidis, 8 parts of honeysuckle, 6 parts of Oroxylum indicum, 25 parts of the sterculia seed, tangerine
6 parts, 8 parts of lily of stalk.
Be 70% ethanol water refluxing extraction for 1 time by whole medicinal material concentration, flow back 2 hours, filter the dregs of a decoction and
Medical fluid, recycles ethyl alcohol, and filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) step (1) dregs of a decoction are added
Water decocts 2 times, and the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, and filtration will filter
Liquid is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) step (1) and the resulting clear cream of step (2) and medicinal extract are closed
And it is spray-dried at fine powder.(4) by fine powder obtained in step (3), fine powder is filled after crushed No. 6 sieves to Capsules,
Capsule is obtained after polishing.
Embodiment 5
Weigh 15 parts of radix scrophulariae, 12 parts of cortex moutan, 15 parts of folium isatidis, 5 parts of honeysuckle, 8 parts of Oroxylum indicum, 20 parts of the sterculia seed, tangerine
8 parts, 10 parts of lily of stalk.
Be 70% ethanol water refluxing extraction for 1 time by whole medicinal material concentration, flow back 2 hours, filter the dregs of a decoction and
Medical fluid, recycles ethyl alcohol, and filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) step (1) dregs of a decoction are added
Water decocts 2 times, and the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, and filtration will filter
Liquid is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) step (1) and the resulting clear cream of step (2) and medicinal extract are closed
And it is spray-dried at fine powder.(4) by fine powder obtained in step (3), then after fine powder is mixed with pharmaceutic adjuvant, using dry
Method, which is pelletized, is made granule.Wherein, medicinal powder and pharmaceutic adjuvant volume ratio are 4:1, and pharmaceutic adjuvant includes lubricant, diluent, collapses
Agent and adhesive are solved, lubricant, diluent, disintegrating agent and adhesive volume ratio are 2:3:2:1.
Embodiment 6
Weigh 12 parts of radix scrophulariae, 10 parts of cortex moutan, 25 parts of folium isatidis, 10 parts of honeysuckle, 10 parts of Oroxylum indicum, 15 parts of the sterculia seed,
10 parts of campanulaceae, 5 parts of lily.
Be 70% ethanol water refluxing extraction for 1 time by whole medicinal material concentration, flow back 2 hours, filter the dregs of a decoction and
Medical fluid, recycles ethyl alcohol, and filtrate decompression is concentrated to get the medicinal extract of relative density 1.1-1.3 under room temperature.(2) step (1) dregs of a decoction are added
Water decocts 2 times, and the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was 6 times of medicinal material total weight, 5 times respectively, and filtration will filter
Liquid is condensed into the clear cream of relative density 1.15-1.25 under room temperature.(3) step (1) and the resulting clear cream of step (2) and medicinal extract are closed
And it is spray-dried at fine powder.(4) by fine powder obtained in step (3), then after fine powder is mixed with pharmaceutic adjuvant, using dry
Method, which is pelletized, is made granule.Wherein, medicinal powder and pharmaceutic adjuvant volume ratio are 4:1, and pharmaceutic adjuvant includes lubricant, diluent, collapses
Agent and adhesive are solved, lubricant, diluent, disintegrating agent and adhesive volume ratio are 2:3:3:1.
Chinese medicine of the invention meets the existing standards of pharmacopoeia of country, dosage of the invention are as follows: capsule is each taking 6
Grain, 3 times a day, every weight 0.5g, warm water take.Granule: each taking 2 bags, 2 times a day, every bag of weight 8g, warm water is taken.It dissipates
Agent: each taking 2 bags, 2 times a day, every bag of weight 8g, warm water is taken.
Experimental example
One, experimental program
1. case selection:
Clinic is chosen 300 patients and is counted, between patient 25-65；The course of disease -25 years 3 months；All patients have not
With the pharyngitis of degree, does, itches with throat, foreign body sensation, cough, abundant expectoration, the symptoms such as cusalgia.
2. curative effect judgment criteria
Effective: symptom mitigates in various degree, and partial symptoms disappear.
Cure: simultaneous phenomenon disappears.
Invalid: symptom is not improved.
Two, treatment results:
By taking pharmaceutical composition of the invention, the statistical result showed of 300 tested patients, the effective percentage for the treatment of
90%, cure rate 80%.
Three, specific example is implemented as follows:
1, so-and-so is thanked, female, 33 years old, industry company clerk.
Symptom: continuous cough has foreign body sensation.
Treatment: powder made of pharmaceutical composition of the present invention, each taking 2 bags, 2 times a day, every bag of weight 8g, warm water is taken.
Through taking drug of the present invention, symptom improves after taking 15 days, and cough disappears substantially, and foreign body sensation is relieved earlier above.
2, Liu, male, 38 years old, industry professional.
Symptom: hoarseness is had sore throat.
Treatment: granule made of pharmaceutical composition of the present invention, each taking 2 bags, 2 times a day, every bag of weight 8g, warm water is sent
Clothes.Through taking drug of the present invention, hoarseness improves after taking 7 days, disappearance of having sore throat.
The Chinese medicine composition for the treatment of pharyngitis provided by the invention has treating both manifestation and root cause of disease, actual situation and controls, internal and external communication, yin-nourishing profit
Lung, antibechic is antipruritic, clearing throat curative effect, through clinical test, the effective percentage 90% for the treatment of, cure rate 80%, and does not find not
Good reaction is one of the Chinese medicine composition for the treatment of pharyngitis ideal at present.
The above is only preferred embodiments of the present invention, is not intended to limit the scope of the present invention,
Therefore any trickle amendment, equivalent variations and modification made to the above embodiment according to the technical essence of the invention, belong to
In the range of technical solution of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating pharyngitis, which is characterized in that including following content of component: 10-15 parts of radix scrophulariae, tree peony
10-15 parts of skin, 15-25 parts of folium isatidis, 5-10 parts of honeysuckle, 6-10 parts of Oroxylum indicum, 15-25 parts of the sterculia seed, 6-10 parts of campanulaceae, hundred
Close 5-10 parts.
2. a kind of Chinese medicine composition for treating pharyngitis according to claim 1, which is characterized in that including following mass parts group
Point: 12 parts of radix scrophulariae, 12 parts of cortex moutan, 20 parts of folium isatidis, 7 parts of honeysuckle, 8 parts of Oroxylum indicum, 20 parts of the sterculia seed, 8 parts of campanulaceae, lily
7 parts.
3. a kind of preparation method of Chinese medicine composition for treating pharyngitis described in claim 1, which is characterized in that including following step
It is rapid:
(1) it by ethanol water refluxing extraction 1 time that whole medicinal material concentration are 70%, flows back 2 hours, filters to obtain the dregs of a decoction and medicine
Liquid, recycles ethyl alcohol, and medical fluid is concentrated under reduced pressure to give the medicinal extract of relative density 1.1-1.3 under room temperature；
(2) step (1) dregs of a decoction are added water to cook 2 times, the 1st time 2 hours, the 2nd time 1 hour, wherein amount of water was that medicinal material is total respectively
Filtrate, is condensed into the clear cream of relative density 1.15-1.25 under room temperature by 6 times, 5 times of weight, filtration；
(3) step (1) and the resulting clear cream of step (2) and medicinal extract are merged, it is spray-dried at fine powder；
(4) powder, granule or capsule is made through granulation, whole grain, total mix in fine powder obtained in step (3).
4. a kind of preparation method of Chinese medicine composition for treating pharyngitis according to claim 3, which is characterized in that described to dissipate
The preparation method of agent is that fine powder is crossed 80-120 mesh, obtains powder.
5. a kind of preparation method of Chinese medicine composition for treating pharyngitis according to claim 3, which is characterized in that the glue
The preparation method of wafer is that filling obtains capsule to Capsules after fine powder crushed to No. 5-6 sieve.
6. a kind of preparation method of Chinese medicine composition for treating pharyngitis according to claim 3, which is characterized in that described
The preparation method of granula is to mix fine powder with pharmaceutic adjuvant, is made granule using dry granulation, the fine powder with it is medicinal auxiliary
Material volume ratio is 4-5:1.
7. a kind of preparation method of Chinese medicine composition for treating pharyngitis according to claim 6, which is characterized in that the medicine
It include lubricant, diluent, disintegrating agent and adhesive with auxiliary material；The lubricant, diluent, disintegrating agent and adhesive volume ratio
For 2:3:2-3:1.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085198A (en) * | 2007-06-29 | 2007-12-12 | 王海锋 | Internal-applied traditional Chinese medicine composition for treating chronic pharyngitis |
| CN101773601A (en) * | 2010-02-03 | 2010-07-14 | 孙成春 | Throat-care granules in bag for treatment of pharyngitis |
| CN103566169A (en) * | 2013-11-09 | 2014-02-12 | 济南伟传信息技术有限公司 | Traditional Chinese medicine composition for treating pharyngitis |
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2018
- 2018-10-22 CN CN201811228118.4A patent/CN109223963A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085198A (en) * | 2007-06-29 | 2007-12-12 | 王海锋 | Internal-applied traditional Chinese medicine composition for treating chronic pharyngitis |
| CN101773601A (en) * | 2010-02-03 | 2010-07-14 | 孙成春 | Throat-care granules in bag for treatment of pharyngitis |
| CN103566169A (en) * | 2013-11-09 | 2014-02-12 | 济南伟传信息技术有限公司 | Traditional Chinese medicine composition for treating pharyngitis |
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| 薛天乐等: "《天然药物化学与药物管理》", 31 July 2018, 云南科技出版社 * |
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Application publication date: 20190118 |