CN109195581A - Form the cosmetic composition of the dosage form of clear transdermal protective film - Google Patents
Form the cosmetic composition of the dosage form of clear transdermal protective film Download PDFInfo
- Publication number
- CN109195581A CN109195581A CN201680086243.9A CN201680086243A CN109195581A CN 109195581 A CN109195581 A CN 109195581A CN 201680086243 A CN201680086243 A CN 201680086243A CN 109195581 A CN109195581 A CN 109195581A
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- skin
- atelocollagen
- protective film
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 230000001681 protective effect Effects 0.000 title claims abstract description 18
- 239000002552 dosage form Substances 0.000 title abstract description 17
- 108010045569 atelocollagen Proteins 0.000 claims abstract description 29
- 239000006210 lotion Substances 0.000 claims abstract description 4
- 102000011782 Keratins Human genes 0.000 claims description 3
- 108010076876 Keratins Proteins 0.000 claims description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229960000448 lactic acid Drugs 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229920000832 Cutin Polymers 0.000 abstract description 15
- 210000003491 skin Anatomy 0.000 description 42
- 230000000052 comparative effect Effects 0.000 description 14
- 108010035532 Collagen Proteins 0.000 description 12
- 102000008186 Collagen Human genes 0.000 description 12
- 229920001436 collagen Polymers 0.000 description 11
- 230000003020 moisturizing effect Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000007605 air drying Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- 102000012422 Collagen Type I Human genes 0.000 description 2
- 108010022452 Collagen Type I Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000004276 hyalin Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of cosmetic compositions of dosage form for forming clear transdermal protective film.In more detail, which contains medical grade Atelocollagen with 0.01 to the 1.0 weight % compared to cosmetic composition total weight and forms clear transdermal protective film, and then whereby provides skin moisture-keeping and cutin improvement.Above-mentioned cosmetic composition is suitble to toner (skin lotion) dosage form that viscosity is low and skin sense is soft.
Description
Technical field
The present invention relates to a kind of cosmetic compositions of dosage form for forming clear transdermal protective film.In more detail, the change
Cosmetic compositions contain medical grade Atelocollagen (atelocollagen) and form clear transdermal protective film, and then whereby mention
For skin moisture-keeping and cutin improvement.
Background technique
Collagen (collagen) is the scleroprotein of the bone for being present in animal, cartilage, tooth, skin etc., also referred to as
Collagen.For collagen with the presence of fibroid solid, structure is complicated band structure.In vivo nearly all group of distribution
The collagen knitted is the structural body of a kind of support for cell and proliferation, as protein collagen mainly in combination with
The cell of connective tissue and form internal organs and tissue.The type of the collagen is respectively different in each tissue, especially since
Nearly all tissue such as skin, ligament, bone has obtained most commonly used answer containing a large amount of Type I collagen albumen in organizational project
With.Moreover, the both-side ends of Type I collagen protein molecular are there is the end peptide (telopeptide) for not forming spiral, this is to cause
The main reason for immune response.Atelocollagen (atelocollagen) is that the protein generated after the end peptide is eliminated by enzyme spreads out
Biology, distinctive triple helices structure has ideal biocompatibility, therefore people are as pharmaceuticals or cosmetics etc.
Raw material uses.
Skin includes 3 layers such as epidermis, corium, subcutaneus adipose tissue, and skin is directly exposed to external environment and to each
The external factor of formula various kinds plays defense function.Especially, skin evaporates contained by human body about 65~70% moisture
It gives and adjusts to external situation.Wherein, epidermis is respectively sequentially cuticula, stratum granulosum from outside, has spinous layer, basal layer,
The cuticula of epidermis contains about 10~20% moisture and is present in human body most gabarit and inhibits moisture from internal evaporation.Skin
Skin moisturizing degree is important factor in cosmetic field, directly influences the shape (flexibility of skin and coarse of skin
Degree).Moreover, cutin, which improves degree, can improve about skin condition and radioparent skin membrane enhancement.
Recently, compared to general cosmetic is used, people more favor the change for playing skin physical and chemical efficiency effect
Adornment material, therefore the research about the cosmetic also obtains rapid progress.Especially, for forming the protection of skin sparing film
The care of skin and the cosmetics for the content that moisturizes increasingly increases.But such cosmetics are but confined to facial mask, frost
The dosage form of the tool viscosity of class.
For this purpose, the present inventor is prepared for skin sense softly and forms clear transdermal protective film containing medical grade Atelocollagen
And the cosmetic composition of moisturizing and cutin improvement is played in turn.Atelocollagen used in the present invention has used logical
Granted patent the 10-0676285th is crossed (title: to separate the method for collagen from the various tissues of animal and prepare collagen egg
The method of white solution and the matrix prepared using it) method production medical grade raw material, moisturizing and cutin improvement
The card of granted patent the 10-0924643rd (title: capturing the preparation method of the liposome of Atelocollagen) is then obtained
It is real.
Prior art document
Patent document
(patent document 1) existing prior document can illustrate No. 10-0285396 (title: composite pigment of granted patent
With preparation method and contain its cosmetic).
(patent document 2) is also that is, the above-mentioned prior art is disclosed containing the raw materials such as Atelocollagen and hyaluronic acid and sent out
Shoot the preparation method of the frost for such as enhancing skin moisture-keeping and inhibiting wrinkle and other effects etc cosmetic composition.But it is above-mentioned existing
Atelocollagen is used as moisturizer and filler in technology, and Atelocollagen of the invention is then used to realize to be formed
The dosage form of bright skin sparing film.Therefore preparation method of composition of the invention and the above-mentioned prior art are different independent inventions.
Summary of the invention
The object of the present invention is to provide one kind to form transparent skin containing medical grade Atelocollagen (atelocollagen)
The cosmetic composition of the dosage form of skin protective film.Moreover, composition of the invention can realize skin by clear transdermal protective film
Skin moisturizing and cutin improvement.
Solve the technical solution of project
The present invention discloses a kind of cosmetic composition, is the cosmetic composition containing Atelocollagen and is formed saturating
Bright skin sparing film.
Beneficial effect
Clear transdermal protection is formed containing medical grade Atelocollagen as previously mentioned, the object of the present invention is to provide one kind
The cosmetic composition of the dosage form of film provides cosmetic composition of a kind of pair of skin with moisturizing and cutin improvement, on
It states cosmetic composition and is suitble to toner (skin lotion (skin lotion)) dosage form that viscosity is low and skin sense is soft.
Detailed description of the invention
Fig. 1 be after the air drying of first embodiment of the invention dosage form photo (A: the front of first embodiment dosage form, B:
The transparency of first embodiment dosage form, C: the section of first embodiment dosage form).
Fig. 2 is that the hyaline membrane after the air drying of first embodiment of the invention and first to fourth comparative example forms pattern sight
Examining photo, (A~E: first embodiment and first to fourth comparative example dosage form visually observe, F~J: first embodiment and first
To the micro- sem observation (200 multiplying power) of the 4th comparative example dosage form, K~O: first embodiment and first to fourth comparative example dosage form
Collagen colour developing visually observes).
Fig. 3 be first embodiment of the invention and third comparative example SDS-PAGE pattern (M:SDS-PAGE standard label, 1:
First embodiment, 2: third comparative example).
Fig. 4 is the measurement result of the smearing front and back moisture of skin amount variation of first embodiment of the invention.
Fig. 5 is the measurement result of the smearing front and back skin keratin index of first embodiment of the invention.
Specific embodiment
Cosmetic composition of the invention includes doctor with 0.01 to the 1.0 weight % compared to cosmetic composition total weight
Grade Atelocollagen is treated to form skin sparing film protection skin and the content that moisturizes, moreover it is possible to realize by low viscosity light
Skin softening sense.At this point, the weight of Atelocollagen is compared to composition total weight lower than more difficult adequate relief if 0.01 weight %
At clear transdermal protective film, the more difficult mixing when preparing cosmetics more than 1.0 weight %.
Moreover, cosmetic composition of the invention contains Atelocollagen and forms clear transdermal protective film.
Moreover, cosmetic composition of the invention forms clear transdermal protective film and obtains skin moisture-keeping and cutin improvement effect
Fruit.
On the other hand, the meaning of clear transdermal protective film is the cosmetic institute shape containing Atelocollagen in the present invention
At hyaline membrane, specifically, can say is to have skin moisture-keeping and cutin improvement and containing medical grade Atelocollagen
Cosmetic be formed by transparent film.
Miscellaneous variation may be implemented in the present invention, can also have specific embodiment and test example, with reference to the accompanying drawing
It illustrates.But the present invention is not limited to this.
First embodiment and first to fourth comparative example
The cosmetic composition of first embodiment and first to fourth comparative example is prepared for according to ingredient shown in table 1.It is following
The unit of table is weight %.
Table 1
The cosmetic ingredient (unit: weight %) of first embodiment and first to fourth comparative example
First embodiment is the manufacture ingredient that can form the cosmetic composition of clear transdermal protective film, and inventor is ordered
Entitled clear gel.As shown in Figure 1, forming clear transdermal protective film when first embodiment is air drying.
The measurement of proper content of the first test example Atelocollagen in mixing
Atelocollagen in order to confirm the cosmetic composition that can form clear transdermal protective film is appropriate in mixing
Content observes the pattern of film formation, figure with ratiometric shown in above-mentioned table 1 after first embodiment and first to fourth comparative example
2 are its results.
First embodiment and first to fourth comparative example are respectively dispensed into 5.0 ± 0.1gAccompany Ti Shi
Culture dish (Petri dish) and after giving (25 DEG C) dryings of room temperature, respectively handles collagen colour reagent (sircol with 1mL
Dye reagent) react 5 minutes, the color change of each reagent is observed after colour reagent is all removed.
As a result, as shown in Fig. 2, first embodiment with first to third comparative example composition formed surface it is uniformly saturating
Bright film, Atelocollagen evenly diffuse throughout Petri dish.The composition of 4th comparative example is more difficult with the naked eye confirm it is transparent
Whether the formation of film, Atelocollagen is then distributed to the edge of Petri dish.It can whereby learn that Atelocollagen exists
It is influential on the formation of the clear transdermal protective film of first embodiment under 0.01 to 1.0 weight % concentration range.
Moreover, SDS-PAGE result is as shown in figure 3, (0.01 weight %'s goes to hold with third comparative example in first embodiment
Peptide collagen) detect similar Atelocollagen content, therefore, end peptide glue can be steadily maintained when preparing first embodiment
It is former.
The measurement of second test example skin moisturization
With direct light and the space of constant temperature and humidity condition (22 ± 2 DEG C, 50 ± 5%) is maintained to allow Korea Spro no air is mobile
20 people of state women at least waits 15 minutes or more, then the cosmetic composition of first embodiment be applied to skin of face and
Measure amount of moisture.Before smearing starts, smear after 30 minutes, smear after 3 weeks respectively use moisture of skin tester
(corneometer, Courage+Khazaka GmbH, Germany) measures amount of moisture.
As a result, as shown in figure 4, having smeared the amount of moisture of the composition rear face skin of first embodiment compared to smearing
It is preceding to increase (p < 0.05) significantly.
The measurement of third test example skin keratin improvement
With direct light and the space of constant temperature and humidity condition (22 ± 2 DEG C, 50 ± 5%) is maintained to allow Korea Spro no air is mobile
20 people of state women at least waits 15 minutes or more, then the cosmetic composition of first embodiment be applied to skin of face and
Measure cutin amount.Black is used respectively within 3 weeks before smearing starts and after smearing(Cuderm Co., beauty
State) measure cutin amount.
As a result, as shown in figure 5, having smeared the cutin amount of the composition rear face skin of first embodiment compared to smearing
It is preceding to reduce (p < 0.05) significantly.
The investigation of 4 skin sense Questionaire of Patients ' Satisfaction of test example
The cosmetic composition of first embodiment is applied to skin of face, 3 Zhou Houzhen using 20 people of South Korea women as object
Questionnaire survey has been carried out to moisturizing and cutin improvement.Moreover, having evaluated final satisfaction as cosmetics.
Table 2
The questionnaire survey assessment result of moisturizing and cutin improvement for first embodiment
Table 3
For the questionnaire survey assessment result of the total satisfactory grade of first embodiment
As shown in above-mentioned table 2 and table 3, affirmative acknowledgement (ACK) person is made for moistening effect and is 20 people (100%), cutin is improved
It is 18 people (90%) that effect, which makes affirmative acknowledgement (ACK) person, and making affirmative acknowledgement (ACK) person for total satisfactory grade is 20 people (100%).
Claims (5)
1. a kind of cosmetic composition is the cosmetic composition containing Atelocollagen, forms clear transdermal protective film.
2. cosmetic composition according to claim 1, which is characterized in that compared to cosmetic composition total weight
0.01 to 1.0 weight % contains above-mentioned Atelocollagen.
3. cosmetic composition according to claim 1, which is characterized in that above-mentioned composition is used for skin moisture-keeping or improvement
Skin keratin.
4. cosmetic composition according to claim 1, which is characterized in that above-mentioned composition is toner (skin lotion) agent
Type.
5. cosmetic composition according to claim 1, which is characterized in that above-mentioned composition include Purified Water, butanediol,
Glycerine, 1,2- hexylene glycol, Atelocollagen, cellulose gum, Sodium Hyaluronate, sodium lactate, lactic acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160068385A KR20170136375A (en) | 2016-06-01 | 2016-06-01 | Cosmetic compositions of the formulation forming transparent skin protective film |
| KR10-2016-0068385 | 2016-06-01 | ||
| PCT/KR2016/006304 WO2017209334A1 (en) | 2016-06-01 | 2016-06-14 | Cosmetic composition of formulation forming transparent skin protective barrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109195581A true CN109195581A (en) | 2019-01-11 |
Family
ID=60478642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680086243.9A Pending CN109195581A (en) | 2016-06-01 | 2016-06-14 | Form the cosmetic composition of the dosage form of clear transdermal protective film |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2019516772A (en) |
| KR (1) | KR20170136375A (en) |
| CN (1) | CN109195581A (en) |
| WO (1) | WO2017209334A1 (en) |
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|---|---|---|---|---|
| JP2002145753A (en) * | 2000-11-06 | 2002-05-22 | Orbis Inc | Heumectant composition and cosmetic including the same |
| CN104921987A (en) * | 2015-06-02 | 2015-09-23 | 广州智媛生物科技有限公司 | Anti-aging essence containing triple collagen and preparation method of anti-aging essence |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54154683A (en) * | 1978-05-26 | 1979-12-05 | Koken Kk | Undercoating material for ornamentation and method of making said material |
| JPS62410A (en) * | 1985-06-25 | 1987-01-06 | Shiseido Co Ltd | Cosmetic |
| JPS62266064A (en) * | 1986-05-14 | 1987-11-18 | 株式会社 高研 | Production of collagen membrane |
| KR100465015B1 (en) * | 2002-03-04 | 2005-01-13 | 이재관 | Process for a soluble collagen using organic solvents |
| JP2007136118A (en) * | 2005-11-17 | 2007-06-07 | Kazuhisa Matsubara | Composition component and using method for the purpose of interaction of toilet water and sheet pack for makeup |
| JP5264065B2 (en) * | 2006-09-22 | 2013-08-14 | 株式会社マンダム | Emulsion composition for skin |
| JP2009007307A (en) * | 2007-06-29 | 2009-01-15 | Towa Kagaku Kk | Cosmetic or skin preparation for external use |
| JP5642002B2 (en) * | 2011-03-28 | 2014-12-17 | 株式会社コーセー | Vesicle-containing composition, cosmetic or external preparation containing the same |
| JP2013001664A (en) * | 2011-06-14 | 2013-01-07 | Ihara Suisan Kk | Water-soluble collagen for cosmetic, and cosmetic containing the collagen |
| JP6174854B2 (en) * | 2012-12-17 | 2017-08-02 | 片倉コープアグリ株式会社 | Bluefin tuna skin-derived atelocollagen and / or derivative thereof and method for producing the same, and cosmetics containing the atelocollagen and / or derivative thereof |
-
2016
- 2016-06-01 KR KR1020160068385A patent/KR20170136375A/en active Search and Examination
- 2016-06-14 CN CN201680086243.9A patent/CN109195581A/en active Pending
- 2016-06-14 JP JP2018562037A patent/JP2019516772A/en active Pending
- 2016-06-14 WO PCT/KR2016/006304 patent/WO2017209334A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002145753A (en) * | 2000-11-06 | 2002-05-22 | Orbis Inc | Heumectant composition and cosmetic including the same |
| CN104921987A (en) * | 2015-06-02 | 2015-09-23 | 广州智媛生物科技有限公司 | Anti-aging essence containing triple collagen and preparation method of anti-aging essence |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170136375A (en) | 2017-12-11 |
| JP2019516772A (en) | 2019-06-20 |
| WO2017209334A1 (en) | 2017-12-07 |
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