WO2017209334A1 - Cosmetic composition of formulation forming transparent skin protective barrier - Google Patents

Abstract

The present invention relates to a cosmetic composition of a formulation forming a transparent skin protective barrier. More specifically, the present invention relates to a cosmetic composition, which contains 0.01-1.0 wt% of a medical grade of atelocollagen relative to the total weight of the cosmetic composition to form a transparent skin protective barrier, thereby providing effects of moisturizing the skin and improving dead skin cells. The cosmetic composition is suitable as a skin tonic (skin lotion) formulation due to low viscosity and light feeling on the skin.

Description

Cosmetic composition of the formulation to form a transparent skin protective film

The present invention relates to a cosmetic composition of the formulation for forming a transparent skin protective film. More specifically, the present invention relates to a cosmetic composition which contains a medical grade atelocollagen to form a transparent skin protective film, thereby providing skin moisturizing and exfoliating effect.

Collagen is a light protein in animal bones, cartilage, teeth, tendons, skin, etc. It is also called collagen. It is present as a fibrous solid and has a complex transverse structure. Collagen, which is distributed in almost all tissues in vivo, is a protein that binds to cells of connective tissue and forms organs and tissues as a structure for supporting and proliferating cells. The type of collagen is different for each tissue, and in particular, type 1 collagen is most widely used in tissue engineering because it is contained in almost all tissues such as skin, ligaments and bones. In addition, there are heliopeptides (telopeptides) that do not form a helix at both ends of the type 1 collagen molecule, which is the main cause of the immune response. Atelocollagen (atelocollagen) is a protein derivative in which the telopeptide is removed by an enzyme and is used as a raw material for medicines and cosmetics because it has an ideal biocompatibility with its unique triple helix structure.

Skin is divided into three layers of epidermis, dermis, and subcutaneous fat tissue, and is a tissue that is directly exposed to the external environment and performs defense function from various external factors. In particular, the skin controls the evaporation of about 65-70% of the moisture in the body. Among them, the epidermis is separated from the outside in the order of the stratum corneum, granule layer, polar layer, basal layer, the stratum corneum of the epidermis contains about 10 to 20% water and is present in the outermost part of the human body to suppress evaporation of water from the body. The degree of skin moisturization is an important factor in the cosmetic field and is directly related to the appearance of the skin (skin flexibility and roughness). The extent of keratin improvement also affects skin membrane homeostasis, which is related to the condition and permeability of the skin.

Recently, as the interest in cosmetics exhibiting physicochemical effects and effects on the skin is increasing rather than the use of general cosmetics, research on this is being actively conducted. In particular, there is a growing interest in cosmetics that protect the skin and increase the moisture content by forming a skin protective film. However, these cosmetics have been limited to formulations with viscosities such as packs and creams.

The present inventors have a light usability, by containing a medical grade atelocollagen to form a transparent skin protective film, thereby producing a cosmetic composition that provides a moisturizing and keratin improvement effect. The atelocollagen used in the present invention is a medical grade produced by the method according to Patent Registration No. 10-0676285 (name: method for separating collagen from various tissues of animals and method for preparing collagen solution and matrix produced using the same) The raw material of was used, its moisturizing and keratin improving effect has been demonstrated by Patent Registration No. 10-0924643 (name: manufacturing method of liposomes that collect atelocollagen).

[Preceding technical literature]

(Patent Document 1) As a conventional prior art document, Patent Registration No. 10-0285396 (name: composite pigment, a manufacturing method thereof and a cosmetic containing the same) has been registered.

(Patent Document 2) In other words, the prior art described above provides a method for preparing a cosmetic composition such as cream containing atelocollagen, hyaluronic acid, etc., which has an effect of increasing skin moisturizing effect and suppressing wrinkle formation. . However, in the above-mentioned conventional art, atelocollagen was used as a moisturizing agent and a peeling material, and the atelocollagen of the present invention was used to implement a formulation for forming a transparent skin protective film. Therefore, the method for preparing the composition of the present invention is a separate invention different from the above-described conventional techniques.

The present invention relates to a cosmetic composition of the formulation for forming a transparent skin protective film by containing a medical grade atelocollagen. In addition, the composition according to the present invention can provide a skin moisturizing and keratin improvement effect by the transparent skin barrier.

The present invention is a cosmetic composition containing atelocollagen, to provide a cosmetic composition, characterized in that to form a transparent skin protective film.

As described above, an object of the present invention is to provide a cosmetic composition of the formulation containing a medical grade atelocollagen to form a transparent skin protective film, to provide a cosmetic composition having a moisturizing and exfoliating effect on the skin. The cosmetic composition has a low viscosity and is suitable for a cosmetic lotion (skin lotion) formulation having a light feeling.

1 is a photograph of the formulation after drying at room temperature of Example 1 according to the present invention (A: front of the formulation of Example 1, B: transparency of the formulation of Example 1, C: cross section of the formulation of Example 1)

Figure 2 is a photograph of observation of the transparent film formation pattern after drying at room temperature of Example 1 and Comparative Examples 1 to 4 according to the present invention (A ~ E: visual observation of the formulation of Examples 1 and Comparative Examples 1 to 4, F ~ J: implementation Microscopic observation (200 magnification) of Example 1 and Comparative Examples 1-4 formulation, K-O: Visual observation of collagen color development of Example 1 and Comparative Examples 1-4 formulation)

3 is a SDS-PAGE pattern of Example 1 and Comparative Example 3 according to the present invention (M: SDS-PAGE standard marker, 1: Example 1, 2: Comparative Example 3)

Figure 4 is the result of measuring the skin moisture change before and after the application of Example 1 according to the present invention

5 is a result of measuring the skin keratin index before, after application of Example 1 according to the present invention

The cosmetic composition of the present invention contains a medical grade atelocollagen in an amount of 0.01 to 1.0% by weight, based on the total weight of the cosmetic composition, in order to form a skin protective film to protect the skin and increase moisture content and to have a light feeling with low viscosity. It is characterized by. At this time, when the weight of the atelocollagen is less than 0.01% by weight relative to the total weight of the composition, it is difficult to form a transparent skin protective film evenly, and when it exceeds 1.0% by weight, there is a problem that it is difficult to mix when preparing cosmetics.

In addition, the cosmetic composition of the present invention is characterized by forming a transparent skin protective film by containing atelocollagen.

In addition, the cosmetic composition of the present invention is characterized by having a skin moisturizing and keratin improvement effect by forming a transparent skin protective film.

On the other hand, the transparent skin protective film in the present invention means a transparent film formed by the cosmetics containing atelocollagen, specifically, a transparent membrane formed by a cosmetic having a skin-grade moisturizing and keratin improving effect and having a medical grade atelocollagen Can be said.

The present invention may have various changes and specific examples and test examples, which will be illustrated in the drawings and described in detail. However, the invention is not necessarily limited thereto.

EXAMPLE 1 AND COMPARATIVE EXAMPLES 1-4

According to the component shown in Table 1, the cosmetic composition of Example 1 and Comparative Examples 1-4 was prepared. The following units are in weight percent.

Cosmetic Ingredients of Example 1 and Comparative Examples 1 to 4 (Unit: wt%)

Name	Example	Comparative example
	One	One	2	3	4
Purified water	87.815	-	90.000	99.000	99.900
Butylene Glycol	5.000	-	-	-	-
glycerin	4.000	-	-	-	-
1,2-hexanediol	1.500	-	-	-	-
Atelocollagen	1.000	100.000	10.000	1.000	0.100
Cellulose gum	0.400	-	-	-	-
Sodium hyaluronate	0.100	-	-	-	-
Sodium lactate	0.025	-	-	-	-
Lactic acid	0.160	-	-	-	-

Example 1 is a manufacturing ingredient of the cosmetic composition capable of forming a transparent skin protective film, which is named lucid gel. As shown in FIG. 1, it can be seen that Example 1 forms a transparent skin protective film when dried at room temperature.

Test Example 1 Determination of the Proper Mixed Content of Atelocollagen

In order to confirm the atelocollagen mixed content of the cosmetic composition capable of forming a transparent skin protective film, Examples 1 and Comparative Examples 1 to 4 were prepared at the ratios shown in Table 1, and the aspects of film formation were observed. The results were displayed.

Example 1 and Comparative Examples 1-4 were dispensed in a Ø50 × 10 mm Petri dish by 5.0 ± 0.1 g and dried at room temperature (25 ° C.). After removing all color development reagents, the color change of each sample was observed.

As a result, as shown in FIG. 2, the compositions of Example 1 and Comparative Examples 1 to 3 form a transparent film having a uniform surface, and atelocollagen was evenly spread in Petri dishes. In the composition of Comparative Example 4, it was difficult to visually confirm the formation of a transparent film, and atelocollagen was distributed on the Petri dish edge. It can be seen that the atelocollagen may affect the formation of the transparent skin barrier of Example 1 in the concentration range of 0.01 to 1.0% by weight.

In addition, as shown in Figure 3, SDS-PAGE, atelocollagen content was similarly detected in Example 1 and Comparative Example 3 (0.01% by weight of atelocollagen). It could be confirmed that it remains stable.

Test Example 2 Measurement of Skin Moisturizing Effect

After waiting for at least 15 minutes for 20 Korean women in a space free of air movement and direct sunlight and maintaining constant temperature and humidity conditions (22 ± 2 ° C, 50 ± 5%), the cosmetic composition of Example 1 was applied to the facial skin. The moisture content was measured by application. The moisture content was measured using a corneometer (Courage + Khazaka GmbH, Germany) before the start of application, 30 minutes after application, and 3 weeks after application.

As a result, as shown in FIG. 4, the moisture content of the facial skin after application of the composition of Example 1 was found to be significantly increased as compared with before application (p <0.05).

Test Example 3 Measurement of Skin Exfoliation Effect

After waiting for at least 15 minutes for 20 Korean women in a space free of air movement and direct sunlight and maintaining constant temperature and humidity conditions (22 ± 2 ° C, 50 ± 5%), the cosmetic composition of Example 1 was applied to the facial skin. It applied and the angular mass was measured. Angular mass was measured before and after 3 weeks of application using Black D-squame ^® (Cuderm Co., USA).

As a result, as shown in FIG. 5, the angular mass of the facial skin after application of the composition of Example 1 was found to be significantly decreased as compared with before application (p <0.05).

Test Example 4. Usability Satisfaction Survey

Twenty Korean women were applied to the facial skin of the cosmetic composition of Example 1, and three weeks later, a questionnaire survey was conducted regarding the effects of moisturizing and keratin improvement. In addition, the final satisfaction as a cosmetic was evaluated.

Moisturizing and keratin improvement effect questionnaire evaluation result about Example 1

division	Moisturizing effect		Keratin improvement effect
	Number of subjects	percentage(%)	Number of subjects	percentage(%)
very good	8	40	3	15
good	12	60	13	65
A little good	0	0	2	10
no effect	0	0	2	10
Sum of positive responses (very good to little good)	20	100	18	90

Overall satisfaction questionnaire evaluation result about Example 1

division	Overall sample satisfaction
	Number of subjects	percentage(%)
very good	4	20
good	14	70
A little good	2	10
is average	0	0
Not good	0	0
Sum of positive responses (very good to little good)	20	100

As shown in Tables 2 and 3, 20 positive responses to the moisturizing effect (100%), 18 positive responses to the keratin improvement effect (90%), and 20 positive responses to overall satisfaction (100) %).

Claims (5)

1. Cosmetic composition containing atelocollagen, characterized in that to form a transparent skin protective film
2. The cosmetic composition according to claim 1, wherein the atelocollagen is contained in an amount of 0.01 to 1.0 wt% based on the total weight of the cosmetic composition.
3. According to claim 1, wherein the composition is a cosmetic composition, characterized in that for moisturizing the skin or improve skin keratin
4. The cosmetic composition according to claim 1, wherein the composition is a skin lotion formulation.
5. The method of claim 1, wherein the composition comprises purified water, butylene glycol, glycerin, 1,2-hexanediol, atelocollagen, cellulose gum, sodium hyaluronate, sodium lactate, lactic acid Cosmetic composition

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