JP2019516772A - Cosmetic composition of a dosage form forming a transparent skin protective film - Google Patents
Cosmetic composition of a dosage form forming a transparent skin protective film Download PDFInfo
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 230000001681 protective effect Effects 0.000 title claims abstract description 22
- 239000002552 dosage form Substances 0.000 title abstract description 14
- 108010045569 atelocollagen Proteins 0.000 claims abstract description 28
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 13
- 239000006210 lotion Substances 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 229940015975 1,2-hexanediol Drugs 0.000 claims 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000004299 exfoliation Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229960000448 lactic acid Drugs 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 102000011782 Keratins Human genes 0.000 abstract description 13
- 108010076876 Keratins Proteins 0.000 abstract description 13
- 210000003491 skin Anatomy 0.000 description 46
- 230000000052 comparative effect Effects 0.000 description 13
- 108010035532 Collagen Proteins 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- 102000012422 Collagen Type I Human genes 0.000 description 2
- 108010022452 Collagen Type I Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- -1 packs Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
本発明は、透明肌保護膜を形成する剤形の化粧料組成物に関する。より詳細には、医療グレードのアテロコラーゲンを化粧料組成物の総重量に対して０．０１乃至１．０重量％で含有することにより透明肌保護膜を形成し、これにより皮膚保湿及び角質改善効果を提供する化粧料組成物に関する。前記化粧料組成物は、粘度が低くて使用感が軽い化粧水（スキンローション）剤形に適する。【選択図】図１The present invention relates to a cosmetic composition of a dosage form forming a transparent skin protective film. More specifically, a transparent skin protective film is formed by containing medical grade atelocollagen in an amount of 0.01 to 1.0% by weight based on the total weight of the cosmetic composition, whereby skin moisturizing and keratin improving effects are achieved. The present invention relates to a cosmetic composition that provides The cosmetic composition is suitable for a lotion having a low viscosity and a light feeling in use (skin lotion). [Selected figure] Figure 1
Description
本発明は、透明肌保護膜を形成する剤形の化粧料組成物に関する。より詳細には、医療グレードのアテロコラーゲンを含有することにより透明肌保護膜を形成し、これにより皮膚保湿及び角質改善効果を提供する化粧料組成物に関する。 The present invention relates to a cosmetic composition of a dosage form forming a transparent skin protective film. More particularly, the present invention relates to a cosmetic composition that forms a transparent skin protective film by containing medical grade atelocollagen, thereby providing a skin moisturizing and keratin improving effect.
コラーゲン（ｃｏｌｌａｇｅｎ）は、動物の骨、軟骨、歯、腱、皮膚などにある硬タンパク質であって、膠原質とも呼ばれる。これは、繊維状固体として存在し、複雑な横紋構造を取っている。生体内のほぼすべての組織に分布するコラーゲンは、細胞の支持、増殖のための構造体であって、主に結合組織の細胞に結合して臓器や組織を形成するタンパク質である。このコラーゲンの種類は、組織ごとに異なり、特に第１型コラーゲンは、皮膚、靭帯、骨などのほぼすべての組織に多量含まれているため、組織工学で最も広く用いられている。また、第１型コラーゲン分子の両末端には、螺旋を形成していないテロペプチド（ｔｅｌｏｐｅｐｔｉｄｅ）が存在し、これは免疫反応を引き起こす主な原因である。アテロコラーゲン（ａｔｅｌｏｃｏｌｌａｇｅｎ）は、そのテロペプチドが酵素によって除去または生成されるタンパク質誘導体であり、特有の三重らせん構造により理想的な生体適合性を有するので、医薬品や化粧品などの原料として使用される。 Collagen is a hard protein found in animal bones, cartilage, teeth, tendons, skin, etc. and is also called collagen. It exists as a fibrous solid and has a complex striation structure. Collagen distributed in almost all tissues in a living body is a structure for supporting and proliferating cells, and is a protein that mainly binds to cells of connective tissues to form organs and tissues. The type of collagen differs from tissue to tissue, and in particular, type 1 collagen is most widely used in tissue engineering because it is abundantly contained in almost all tissues such as skin, ligaments and bones. Also, at both ends of the type 1 collagen molecule, there is a non-helical telopeptide (telopeptide), which is the main cause of causing an immune response. Atelocollagen is a protein derivative whose telopeptide is removed or produced by an enzyme, and is ideally used as a raw material for pharmaceuticals and cosmetics since it has an ideal biocompatibility due to its unique triple helix structure.
皮膚は表皮、真皮、皮下脂肪組織の３層に区分され、外部環境に直接さらされており、様々な外部要因からの防御機能を行う組織である。特に皮膚は、人体が持っている約６５〜７０％の水分が体外に蒸発することを調節してくれる。その中でも、表皮は、外部から角質層、顆粒層、有棘層、基底層の順に区分されるが、表皮の角質層は、約１０〜２０％の水分を含有し、人体の最外殻に存在して体内からの水分蒸発を抑制する。皮膚保湿の度合いは、化粧品分野で重要な要素であって、皮膚の外形（皮膚の柔軟性及び荒い度合い）と直接関連している。また、角質改善の度合いは、皮膚のコンディション及び透過性に関連する皮膚膜恒常性に影響を及ぼす。 The skin is divided into three layers, the epidermis, the dermis, and the subcutaneous fat tissue, which is directly exposed to the external environment, and is a tissue that performs a protective function from various external factors. In particular, the skin regulates the evaporation of about 65 to 70% of water contained in the human body. Among them, the epidermis is divided from the outside in the order of stratum corneum, granular layer, spinous layer, and basal layer, but the stratum corneum of the epidermis contains about 10 to 20% of water, and is the outermost layer of the human body. Present to inhibit water evaporation from the body. The degree of skin moisturization is an important factor in the cosmetic field and is directly related to the skin profile (skin softness and roughness). Also, the degree of keratin improvement affects skin membrane homeostasis related to skin condition and permeability.
最近、一般的な化粧料の使用よりも皮膚に物理化学的な効能・効果を示す化粧料への関心が増加するにつれて、これについての研究が盛んに行われている。特に皮膚保護膜を形成して皮膚を保護し、水分含量を増やす化粧品への関心が増大している。ところが、このような化粧品は、粘度のある剤形、例えばパック、クリームなどに限定されてきた。 Recently, as the interest in cosmetics showing physicochemical effects and effects on the skin has increased rather than the use of general cosmetics, research on this has been actively conducted. In particular, there is an increasing interest in cosmetics that form a skin protective film to protect the skin and increase the water content. However, such cosmetics have been limited to viscous dosage forms, such as packs, creams and the like.
そこで、本発明者らは、軽い使用感を持ち、医療グレードのアテロコラーゲンを含有することにより透明肌保護膜を形成し、これにより保湿及び角質改善効果を提供する化粧料組成物を製造した。本発明で使用されたアテロコラーゲンは、韓国特許登録第１０−０６７６２８５号（名称：動物の様々な組織からのコラーゲン分離方法、コラーゲン溶液の製造方法及びこれを用いて生産したマトリクス）による方法で生産された医療グレードの原料を使用し、その保湿及び角質改善効果は、韓国特許登録第１０−０９２４６４３号（名称：アテロコラーゲンを捕集したリポソームの製造方法）によって立証されたことがある。 Therefore, the present inventors have produced a cosmetic composition having a light feeling in use and forming a transparent skin protective film by containing medical grade atelocollagen, thereby providing a moisturizing and keratin improving effect. The atelocollagen used in the present invention is produced by a method according to Korean Patent Registration No. 10-0676285 (name: method of separating collagen from various tissues of animal, method of producing collagen solution and matrix produced using it) Using the medical grade raw material, its moisturizing and keratin improving effect has been proved by Korean Patent Registration No. 10-0924643 (name: method of producing liposome having collected atelocollagen).
従来の先行技術文献としては、韓国特許登録第１０−０２８５３９６号（名称：複合顔料、その製造方法及びこれを含有する化粧料）が登録されている。 As conventional prior art documents, Korean Patent Registration No. 10-0285396 (name: composite pigment, method for producing the same, and cosmetic containing the same) are registered.
つまり、上述した従来の技術は、アテロコラーゲン、ヒアルロン酸などを含有して皮膚保湿効果を増大させ、しわ形成を抑えるなどの効果を有するクリームなどの化粧料組成物を製造する方法を提供した。ところが、前述した従来の技術におけるアテロコラーゲンは
、保湿剤及びピーリング剤として使用されたのに対し、本発明のアテロコラーゲンは、透明肌保護膜を形成する剤形を実現するための用途で使用された。よって、本発明の組成物の製造方法は、上述した従来の技術とは異なる別個の発明である。
That is, the above-mentioned prior art provides a method for producing a cosmetic composition such as cream having an effect such as containing atelocollagen, hyaluronic acid and the like to increase the skin moisturizing effect and suppressing the formation of wrinkles. However, while atelocollagen in the prior art described above was used as a moisturizer and a peeling agent, atelocollagen of the present invention was used in applications for realizing a dosage form that forms a transparent skin protective film. Thus, the method of producing the composition of the present invention is a separate invention different from the above-mentioned prior art.
本発明は、医療グレードのアテロコラーゲンを含有することにより透明肌保護膜を形成する剤形の化粧料組成物に関する。また、本発明に係る組成物は、透明肌保護膜によって皮膚保湿及び角質改善効果を提供することができる。 The present invention relates to a cosmetic composition of a dosage form which forms a transparent skin protective film by containing medical grade atelocollagen. In addition, the composition according to the present invention can provide skin moisturizing and keratin improving effects by means of a transparent skin protective film.
本発明は、アテロコラーゲンを含有する化粧料組成物であって、透明肌保護膜を形成することを特徴とする化粧料組成物を提供する。 The present invention provides a cosmetic composition containing atelocollagen, which is characterized in that a transparent skin protective film is formed.
上述したように、本発明は、医療グレードのアテロコラーゲンを含有して透明肌保護膜を形成する剤形の化粧料組成物を提供することを目的とするもので、皮膚保湿及び角質改善効果を有する化粧料組成物を提供する。この化粧料組成物は、粘度が低くて使用感が軽い化粧水（スキンローション）剤形に適する。 As described above, the present invention aims to provide a cosmetic composition of a dosage form containing medical grade atelocollagen to form a transparent skin protective film, and having skin moisturizing and keratin improving effects Provided is a cosmetic composition. This cosmetic composition is suitable for a skin lotion having a low viscosity and a light feeling in use.
本発明の化粧料組成物は、皮膚保護膜を形成して皮膚を保護し、水分含量を増やしながらも粘度が低くて軽い使用感を持つために、医療グレードのアテロコラーゲンを化粧料組成物の総重量に対して０．０１〜１．０重量％で含有することを特徴とする。このとき、アテロコラーゲンの重量が組成物の総重量に対して、０．０１重量％未満である場合には、透明肌保護膜を均一に形成することが難しく、１．０重量％を超える場合には、化粧品製造の際に混合が難しいという問題点がある。 The cosmetic composition of the present invention forms a skin protective film to protect the skin, and has medical grade atelocollagen as a total of cosmetic composition because it has a low viscosity and a light feeling of use while increasing the water content. It is characterized by containing by 0.01 to 1.0 weight% with respect to weight. At this time, when the weight of atelocollagen is less than 0.01% by weight based on the total weight of the composition, it is difficult to uniformly form a transparent skin protective film, and when it exceeds 1.0% by weight. There is a problem that mixing is difficult during cosmetic production.
また、本発明の化粧料組成物は、アテロコラーゲンを含有することにより、透明肌保護膜を形成することを特徴とする。 In addition, the cosmetic composition of the present invention is characterized by forming a transparent skin protective film by containing atelocollagen.
また、本発明の化粧料組成物は、透明肌保護膜の形成によって皮膚保湿及び角質改善効果を有することを特徴とする。 The cosmetic composition of the present invention is also characterized by having a skin moisturizing and keratin improving effect by forming a transparent skin protective film.
一方、本発明における透明肌保護膜とは、アテロコラーゲンの含有された化粧料が形成する透明な膜であるという意味で、具体的には、皮膚保湿及び角質改善効果を有し、医療グレードのアテロコラーゲンを有する化粧料が形成する透明な膜であるといえる。 On the other hand, the transparent skin protective film in the present invention is a transparent film formed by a cosmetic containing atelocollagen, and specifically has a skin moisturizing and keratin improving effect, and is a medical grade atelocollagen. It can be said that it is a transparent film formed by a cosmetic having the
本発明は、様々な変更を加えることができ、特定の実施例及び試験例を有することができるので、これを図面に例示し、具体的に説明する。ところが、本発明は必ずしもこれに限定されるものではない。
［実施例１及び比較例１〜４］
Since the present invention can be variously modified and can have specific examples and test examples, it is illustrated in the drawings and specifically described. However, the present invention is not necessarily limited to this.
Example 1 and Comparative Examples 1 to 4
表１に示されている成分に基づいて、実施例１及び比較例１〜４の化粧料組成物を製造した。下記の単位は重量％である。 Based on the components shown in Table 1, cosmetic compositions of Example 1 and Comparative Examples 1 to 4 were produced. The following units are% by weight.
実施例１は、透明肌保護膜を形成することができる化粧料組成物の製造成分であり、これはルーシッドジェルと命名した。図１に示すように、実施例１は常温乾燥の際に透明肌保護膜を形成することが分かる。 Example 1 is a production component of a cosmetic composition capable of forming a transparent skin protective film, which was named Lucid gel. As shown in FIG. 1, it can be seen that Example 1 forms a transparent skin protective film during normal temperature drying.
試験例１．アテロコラーゲンの適正混合含量の測定 Test Example 1 Measurement of appropriate mixed content of atelocollagen
透明肌保護膜を形成することができる化粧料組成物のアテロコラーゲン混合含量を確認するために、前記表１に示されている割合で実施例１及び比較例１〜４を製造して膜形成の様相を観察し、結果を図２に示した。 In order to confirm the atelocollagen mixed content of the cosmetic composition capable of forming a transparent skin protective film, Example 1 and Comparative Examples 1 to 4 are manufactured at a ratio shown in Table 1 to form a film The appearance was observed, and the results are shown in FIG.
実施例１及び比較例１〜４をリ５０×１０ｍｍのペトリ皿に５．０±０．１ｇずつ分注して常温（２５℃）で乾燥させた後、コラーゲン発色試薬（ｓｉｒｃｏｌ ｄｙｅ ｒｅａｇｅｎｔ）を１ｍＬずつ処理して５分間反応させ、発色試薬をすべて除去した後、各試料の色の変化を観察した。 Example 1 and Comparative Examples 1 to 4 were each dispensed at 5.0 ± 0.1 g into a 50 × 10 mm petri dish and dried at normal temperature (25 ° C.), and then a collagen coloring reagent (sircol dye reagent) was added. One mL each was treated and allowed to react for 5 minutes, and after removing all the color development reagents, a change in color of each sample was observed.
その結果、図２に示すように、実施例１及び比較例１〜３の組成物は、表面が均一な透明膜を形成し、アテロコラーゲンがペトリ皿に均一に広がる様相を示した。比較例４の組成物は、透明膜の形成有無を肉眼で確認することが難しく、アテロコラーゲンがペトリ皿の縁に分布する様相を示した。これにより、アテロコラーゲンが０．０１〜１．０重量％の濃度範囲で実施例１の透明肌保護膜の形成に影響を及ぼす可能性があることが分かる。また、ＳＤＳ−ＰＡＧＥの結果、図３に示すように、アテロコラーゲン含量は、実施例１と比較例３（０．０１重量％のアテロコラーゲン）でほぼ同様に検出されたので、実施例１の製造の際にアテロコラーゲンは安定的に維持されることを確認することができた。 As a result, as shown in FIG. 2, the compositions of Example 1 and Comparative Examples 1 to 3 formed a transparent film having a uniform surface, and exhibited a state in which atelocollagen spreads uniformly in a petri dish. The composition of Comparative Example 4 had difficulty in visually confirming the formation of a transparent film, and exhibited a distribution of atelocollagen at the edge of the petri dish. This shows that atelocollagen may affect the formation of the transparent skin protective film of Example 1 at a concentration range of 0.01 to 1.0% by weight. Further, as a result of SDS-PAGE, as shown in FIG. 3, the atelocollagen content was detected in substantially the same manner as in Example 1 and Comparative Example 3 (0.01% by weight atelocollagen). At the same time, it could be confirmed that atelocollagen is stably maintained.
試験例２．皮膚保湿効果の測定 Test Example 2 Measurement of skin moisturizing effect
空気の移動と直射日光がなく、恒温恒湿条件（２２±２℃、５０±５％）が維持される空間で韓国人女性２０人を少なくとも１５分待機させた後、実施例１の化粧料組成物を顔皮膚に塗布して水分量を測定した。水分量は、コルネオメーター（ｃｏｒｎｅｏｍｅｔｅｒ、Ｃｏｕｒａｇｅ＋Ｋｈａｚａｋａ ＧｍｂＨ、ドイツ）を用いて塗布開始前、塗布３０分後、塗布３週間後にそれぞれ測定した。 Cosmetics of Example 1 after waiting for at least 15 minutes for 20 Korean women in a space where there is no air movement and no direct sunlight and constant temperature and humidity conditions (22 ± 2 ° C., 50 ± 5%) are maintained. The composition was applied to facial skin and the amount of water was measured. The water content was measured using a corneometer (corneometer, Courage + Khazaka GmbH, Germany) before the start of application, 30 minutes after application, and 3 weeks after application.
その結果、図４に示すように、実施例１の組成物塗布後の顔皮膚の水分量は塗布前と比較して有意に増加したことが分かる（ｐ＜０．０５）。
試験例３．皮膚角質改善効果の測定
As a result, as shown in FIG. 4, it can be seen that the water content of the facial skin after application of the composition of Example 1 was significantly increased as compared to that before application (p <0.05).
Test Example 3 Measurement of skin keratin improvement effect
空気の移動と直射日光がなく、恒温恒湿条件（２２±２℃、５０±５％）が維持される空間で韓国人女性２０人を少なくとも１５分待機させた後、実施例１の化粧料組成物を顔皮膚に塗布して角質量を測定した。角質量は、Ｂｌａｃｋ Ｄ−ｓｑｕａｍｅョ（Ｃｕｄｅｒｍ Ｃｏ．，米国）を用いて塗布開始前と塗布３週間後にそれぞれ測定した。 Cosmetics of Example 1 after waiting for at least 15 minutes for 20 Korean women in a space where there is no air movement and no direct sunlight and constant temperature and humidity conditions (22 ± 2 ° C., 50 ± 5%) are maintained. The composition was applied to facial skin and the angular mass was measured. The angular mass was measured before the start of application and after 3 weeks of application using Black D-squame (Cuderm Co., USA).
その結果、図５に示すように、実施例１の組成物塗布後の顔皮膚の角質量は塗布前と比較して有意に減少したことが分かる（ｐ＜０．０５）。
試験例４．使用感満足度のアンケート調査
As a result, as shown in FIG. 5, it can be seen that the angular mass of the facial skin after application of the composition of Example 1 was significantly reduced as compared to that before application (p <0.05).
Test Example 4 Questionnaire survey on usability satisfaction
韓国人女性２０人を対象に、実施例１の化粧料組成物を顔皮膚に塗布して、３週間後に保湿及び角質改善効果に対するアンケート調査を実施した。また、化粧品としての最終満足度を評価した。 The cosmetic composition of Example 1 was applied to the face skin of 20 Korean women, and after 3 weeks, a questionnaire survey was conducted on the moisturizing and keratin improving effect. In addition, the final satisfaction as a cosmetic was evaluated.
実施例１に対する全体的な満足度のアンケート評価結果前記表２及び表３に示すように、調査の結果、保湿効果に対する肯定的回答２０人（１００％）、角質改善効果に対する肯定的回答１８人（９０％）、全体的な満足度に対する肯定的回答２０人（１００％）であった。 Questionnaire evaluation results of overall satisfaction with Example 1 As shown in Tables 2 and 3 above, as a result of the survey, 20 positive responses (100%) to the moisturizing effect and 18 positive responses to the keratin improving effect There were 20 positive responses (100%) to overall satisfaction (90%).
Claims (5)
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| KR10-2016-0068385 | 2016-06-01 | ||
| KR1020160068385A KR20170136375A (en) | 2016-06-01 | 2016-06-01 | Cosmetic compositions of the formulation forming transparent skin protective film |
| PCT/KR2016/006304 WO2017209334A1 (en) | 2016-06-01 | 2016-06-14 | Cosmetic composition of formulation forming transparent skin protective barrier |
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| KR20170136375A (en) | 2017-12-11 |
| CN109195581A (en) | 2019-01-11 |
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