JP2012201661A - Vesicle-containing composition, and cosmetic or skin care preparation including the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a vesicle-containing composition which has excellent massage properties by being spread and extended while maintaining skin slippage in spite of its fresh sense of use, and also has excellent stability with time.SOLUTION: The vesicle-containing composition includes the following components (A) and (B): (A) a water-soluble collagen component; and (B) mucopolysaccharide, in which the component (A) is included in vesicle, and the component (B) is present at an outer phase in which the vesicle is dispersed.

Description

  The present invention relates to a vesicle-containing composition comprising water-soluble collagen and mucopolysaccharide, and more specifically, an outer phase in which water-soluble collagen is contained in a vesicle and the mucopolysaccharide is dispersed in the vesicle. It is related to a vesicle-containing composition characterized in that it has a fresh feeling of use, and it stretches and spreads while maintaining smoothness of the skin, so it has excellent massage sustainability and is stable over time The present invention relates to a vesicle-containing composition having excellent properties. The present invention also relates to a cosmetic or a skin external preparation containing the composition.

  In general, vesicles are closed vesicles that have a bilayer structure formed by an amphiphile, but because of this specific structure, they can contain active ingredients and are carriers for drug delivery systems. It is attracting attention as. In addition, vesicles have attracted particular attention in recent years because they have a high retention in the stratum corneum and can effectively act as an active ingredient.

  There are many amphipathic substances that constitute vesicles, but vesicles composed of phospholipids derived from living bodies are called “liposomes”, and many studies have been made from the viewpoint of safety to living bodies. For example, there is a liposome containing linoleic acid, vitamin E, collagen, and chondroitin sulfate Na (see, for example, Patent Document 1).

  In addition, there is a technique for examining the improvement of the stability of liposomes. For example, a method is known in which the liposome is covered with a composition film of marine atelocollagen and chondroitin sulfate Na to increase the stability of the liposome in the preparation (see, for example, Non-Patent Document 1). Furthermore, by producing water-soluble polymers in the presence of liposomes during the formation of liposomes, not only the stability of the liposomes, but also permeates and stores in the horny layer of the skin, and the contained drug components are released in the horny layer. There is known a method capable of obtaining an excellent medicinal effect (for example, Patent Document 2).

  By the way, cosmetics have various items according to the purpose and application. One of them is massage cosmetics whose main purpose is massage effect, and can be roughly divided into water-based bases and oil-based bases. For example, the oil-type base contains a large amount of oil, and the oil used is known from liquid to semi-solid, such as squalane, olive oil, triglyceride oil and ester oil. (For example, Patent Document 3). On the other hand, as an aqueous base, it is possible by blending various water-soluble polymers, and an aqueous gel type massage cosmetic is also used (see, for example, Patent Document 4).

Japanese Patent No. 3687277 JP 2008-94809 A JP 2005-82481 A JP 2004-339110 A Fragrance Journal (Vo.33 No.8 pages 124-125)

In the technique of Patent Document 3, there is a problem with a fresh feeling of use such as a heavy feeling of use due to a large amount of oil contained, a sticky feeling due to oil remaining on the skin after massage, a feeling of glare, and a feeling of blockage. On the other hand, in the technique of Patent Document 4 which is a water-based massage material, a water-soluble polymer such as carboxyvinyl polymer having high versatility is used as an aqueous gel, but the viscosity decreases due to an electrolyte component present on the skin. There was a problem with the sustainability of the massage.
That is, in the above prior art documents, there are various massage cosmetics disclosed, but the massage persistence has not been sufficient yet.

  Furthermore, as in the techniques of Patent Documents 1 and 2 and Non-Patent Document 1, various studies on vesicles are performed, and the effects of using vesicles are diverse. For example, there is a disclosure of a component for improving the strength of a vesicle film described in Non-Patent Document 1, but even if this technique is used, temporary massage can be performed, Usability such as was not sufficient.

  In view of this situation, the present inventor has intensively studied and found that the following two points are important in order to improve the sustainability of the massage. That is, the first point is a study of a material having excellent massage properties, and the second point is a formulation study for improving the sustainability of the massage. As for the first point, we examined various ingredients, and by combining water-soluble collagen such as atelocollagen and mucopolysaccharide such as sodium chondroitin sulfate, a water-insoluble material can be created. The knowledge that it is effective was obtained. However, when these components are blended together, they may be precipitated immediately as water-insoluble substances, and it is difficult to formulate by simple combination blending. In other words, the second point was to study formulation for stable blending and effective massage. As a result of further studies based on these findings, it was noted that the vesicle structure has two aqueous phases, an aqueous phase in the vesicle and an outer phase in which the vesicles are dispersed. By containing mucopolysaccharides such as water-soluble collagen and sodium chondroitin sulfate, it can be stably formulated as a formulation without precipitating as a water-insoluble material, and it will precipitate as a water-insoluble material when the vesicle breaks during use. The present invention has been completed.

That is, the present invention includes the following components (A) and (B);
A vesicle-containing composition comprising a component (A) a water-soluble collagen component (B) a mucopolysaccharide, wherein the component (A) is contained in the vesicle and the component (B) disperses the vesicle. The present invention relates to a vesicle-containing composition characterized by existing in an outer phase.

  Furthermore, the present invention provides a vesicle-containing composition, wherein the mass ratio of component (A) to component (B) is in the range of (A) :( B) = 6: 1 to 3: 4 It is about.

  Furthermore, the present invention relates to a vesicle-containing composition, wherein in the vesicle, the component (C) polyoxyethylene sterol ether and the component (D) sterol are constituents of the vesicle.

  Furthermore, this invention relates to the vesicle containing composition characterized by including the component (E) gellan gum in the outer phase which disperse | distributes a vesicle.

  Furthermore, this invention relates to the vesicle containing composition characterized by being cosmetics.

  Furthermore, the present invention relates to a vesicle-containing composition characterized by being a massage cosmetic.

Although the vesicle-containing composition of the present invention has a fresh feeling of use, the composition spreads while maintaining skin slipperiness, so that it has excellent massage properties and stability over time.

The vesicle-containing composition of the present invention comprises at least component (A) water-soluble collagen and component (B) mucopolysaccharide. In the present specification, “to” means a range including numerical values before and after.
Hereinafter, the vesicle-containing composition of the present invention will be described first.

  The component (A) water-soluble collagen used in the present invention is extracted from connective tissues such as bones and skins of animals and is subjected to treatments such as hydrolysis, atelolation and succinylation to improve water solubility. Specific examples include atelocollagen, succinyl collagen, and hydrolyzed collagen. Any water-soluble collagen used in normal cosmetics can be used without any particular limitation. These can be used alone or in combination of two or more. In the present invention, the component (A) mainly contributes to an improvement in massage effect and stability over time.

  Specifically, it is obtained by refining from marine fish such as sea bream and sea bream, and among these, using water-soluble collagen obtained from cold fish, skin has a fresher feeling of use. By stretching and spreading while maintaining the slip property, it is possible to obtain a vesicle-containing composition having excellent massage properties and excellent stability over time.

  In the present invention, the component (A) water-soluble collagen is characterized by being contained in a vesicle, and more specifically, it is characterized by being dispersed in the inner aqueous phase of the vesicle. A commercially available product of component (A) water-soluble collagen of the present invention is PANCOGENE MARIN (manufactured by GATTEFOSSE), which is provided as an aqueous solution having a pure content of 0.3%, but is not limited thereto.

  The content of the component (A) water-soluble collagen used in the present invention is not particularly limited and can be contained according to the content of other components, but is generally about 0.0006 to 0.03% by mass (hereinafter, “ % ”).

  The component (B) mucopolysaccharide used in the present invention is extracted from microorganisms, chicken crowns, skin, etc., or manufactured by biochemical methods, etc., and chondroitin sulfate, hyaluronic acid, dermatan sulfate, heparan sulfate. Heparin, keratan sulfate and salts thereof can be used, and any mucopolysaccharide used in normal cosmetics can be used, and these can be used alone or in combination of two or more. Among them, chondroitin sulfate sodium salt as component (B) can obtain particularly excellent effects. In the present invention, the component (B) mainly contributes to an improvement in massage effect and stability over time.

  In the present invention, the component (B) mucopolysaccharide is not contained in the vesicle but is present in the outer phase in which the vesicle is dispersed. The method for dispersing the vesicles in the outer layer is not particularly limited, but the vesicle system (I) and the system (II) containing the component (B) are respectively produced, and the system (I) is converted into the system (II). It is obtained by dispersing it in Here, the system (II) containing the component (B) is a system in which the component (B) is dispersed in an aqueous component such as water, and is a system for dispersing the vesicles. It will be the external phase.

  The content of the component (B) mucopolysaccharide used in the present invention is not particularly limited and can be contained according to the content of other components, but it is generally used in the range of 0.0001 to 0.05%. Can do.

The mass ratio of the component (A) water-soluble collagen and the component (B) mucopolysaccharide used in the present invention is not particularly limited, but the massage properties of the present invention include the component (A) and the component (B). In the massage using the component (A) and component (B) more effectively, (A) :( B) = 7: 1 to 3: 5 It is preferable to contain in the range of 6: 1 to 3: 4.
When the content ratio of the component (A) and the component (B) is within this range, the vesicle structure collapses at the time of use, and the component (A) and the component (B) are gradually mixed. It can improve the sustainability of the massage effect along with it, and it has excellent fresh massage feeling while maintaining the smoothness of the skin. In addition, a vesicle-containing composition having excellent aging stability of the vesicle itself can be obtained.

  The vesicle used in the present invention is not particularly limited as long as it is a vesicle used in ordinary cosmetics, and any vesicle can be used. Vesicles are closed vesicles with a bilayer structure formed by an amphiphile, and can be classified into nonionic vesicles, anionic vesicles, and cationic vesicles depending on the ionicity of the amphiphile used. Can do. Nonionic vesicles are composed of polyoxyethylene sterol ethers and sterols, sucrose fatty acid esters and sphingosines, and anionic vesicles are phospholipids and sterols, dilauroyl glutamic acid. Examples of lysine sodium, sterols, monostearyl glyceryl etheral, and cationic vesicles include cations such as stearoyltrimethylammonium chloride and those of an ester type cation. These can be used alone or in combination of two or more. Among these, nonionic vesicles are less susceptible to the effects of active components such as electrolytes and other components contained therein, and therefore vesicle compositions containing them can be excellent in stability over time.

In the present invention, by using the component (C) polyoxyethylene sterol ether and the component (D) sterol as constituents of the vesicle, it is possible to obtain a vesicle-containing composition having more excellent temporal stability.
The component (C) polyoxyethylene (hereinafter simply referred to as “POE”) sterol ether used in the present invention is not particularly limited as long as it is used in ordinary cosmetics, and any of them may be used. Can do. Component (C) is obtained by adding ethylene oxide to a sterol skeleton such as a cholesterol skeleton or a phytosterol skeleton. The average added mole number of ethylene oxide is preferably 3 to 40, more preferably 5 to 30. These can be used alone or in combination of two or more.

Examples of the structure of the sterol skeleton include animal sterol skeletons such as cholesterol, cholestanol, lanosterol, ceregrosterol, dehydrocholesterol, and coprostanol; β-sitosterol, stigmasterol, campesterol and ergosterol, fucostosterol, spinner Examples include plant sterol skeletons such as sterols and brassicasterols; microbial sterol skeletons such as mycostosterols and timosterols; and derivatives obtained by hydrogenation or water addition thereof. Those having an animal sterol skeleton are mainly obtained from animals. Examples thereof include lanolin alcohol obtained from wool fat and mainly composed of cholesterol and lanosterol, or a hydrogenated product thereof. Those having a plant sterol skeleton are mainly obtained from plants. Phytosterol generally means one or more selected from β-sitosterol, stigmasterol, campesterol, fucostosterol, spinasterol, brassicasterol, ergosterol, and the like, and in particular, two or more types Refers to a mixture.
Component (C) is, for example, POE (5) cholesterol ether, POE (10) cholesterol ether, POE (20) cholesterol ether, POE (30) cholesterol ether, POE (5) phytosterol ether, POE (10) phytosterol ether, POE (20) phytosterol ether, POE (30) phytosterol ether, POE (5) cholestanol ether, POE (10) cholestanol ether, POE (20) cholestanol ether, POE (30) cholestanol ether, POE (5) Phytostanol ether, POE (10) phytostanol ether, POE (20) phytostanol ether, POE (30) phytostanol ether, and the like. Roll ether may be used if desired one, or two or more.

  The content of the component (C) POE sterol ether used in the present invention is not particularly limited and can be contained according to the content of other components, but can be generally used in the range of 0.1 to 5%. .

  The component (D) sterols used in the present invention contribute to the stability of the bilayer structure in vesicle formation, and the storage stability of the vesicle can be improved by containing this. The component (D) is not particularly limited as long as it is used in ordinary cosmetics, and any component can be used. Component (D) is, for example, animal sterols such as cholesterol, lanosterol, selegrosterol, dehydrocholesterol, and coprostanol; plant sterols such as β-sitosterol, stigmasterol, campesterol, and ergosterol; And sterols derived from microorganisms such as timosterol, and the like, and these sterols can be used alone or in combination of two or more.

  The content of the component (D) sterols used in the present invention is not particularly limited, and can be contained depending on the content of other components, but can be generally used in the range of 0.02 to 1%.

The present invention can further contain gellan gum as component (E). The component (E) is a polysaccharide produced outside the cell by a microorganism called Sphingomonas elodea, and is not particularly limited as long as it can be used for cosmetics and the like. As gellan gum, a native type and a deacylated type are known, and any component (E) of the present invention can be used, but a native type is more preferable.
In the present invention, the above-described component (A) and component (B) are gradually mixed by disintegrating the vesicle structure in the application to the skin by providing the composition contained in the outer phase in which the vesicle is dispersed. As a result, the massage effect can be improved. Here, by containing gellan gum, the massage effect of the gel-like composition becomes more continuous, and further, it is excellent in terms of stability over time. In addition, the component (E) gellan gum can be expected to have an effect of imparting a firmness to the skin after massage.

  Content of the component (E) gellan gum used for this invention is not specifically limited, Although it can contain according to other component content, it can be used in 0.005 to 0.5% of range in general. .

  In addition to the above components, the vesicle-containing composition obtained by the present invention includes components used for ordinary cosmetics, surfactants, oils, humectants, water-soluble polymers, powders, cosmetic ingredients, preservatives, A fragrance | flavor can be contained in the range which does not impair the effect of this invention.

Then, the manufacturing method of the vesicle containing composition of this invention is demonstrated.
The component (A) water-soluble collagen, component (B) mucopolysaccharide, component (C) polyoxyethylene sterol ether, component (D) sterols, component (E) gellan gum used in the following are as described above. Are the same.

  The vesicle-containing composition of the present invention is a vesicle-containing composition comprising a component (A) water-soluble collagen and a component (B) mucopolysaccharide, wherein the component (A) is contained in the vesicle. The component (B) is present in the outer phase in which the vesicle is dispersed. In the present invention, the component (A) is contained in the vesicle and is preferably not present in the outer phase in which the vesicle is dispersed.

  That is, in the present invention, it is important that the component (A) and the component (B) are separately contained inside and outside the vesicle. Therefore, it can be manufactured by the following manufacturing method. In this example, phospholipid, component (C), and component (D) are used as vesicle components. However, the present invention is not limited to this.

(Production method)
System (I) and system (II) are each prepared as follows.
[Preparation of Vesicle System (I) Containing Component (A)]
A 60-90 ° C. aqueous phase containing phospholipid, component (C), and component (D) (hereinafter abbreviated as aqueous phase X) is mixed and dissolved. The aqueous phase X may contain a polyhydric alcohol or the like as desired. Separately, the component (A) water-soluble collagen is mixed and dissolved in advance in an aqueous phase (hereinafter abbreviated as aqueous phase Y) at 40 to 90 ° C., preferably 60 to 80 ° C. Subsequently, the aqueous phase Y and the aqueous phase Y are mixed with stirring with a disper mixer and cooled to 40 ° C. to obtain a vesicle system (I). Thereby, a component (A) can be contained in the inner water phase of a vesicle.

[Preparation of System (II) Containing Component (B)]
An aqueous phase containing component (B) mucopolysaccharide (hereinafter abbreviated as aqueous phase Z) is prepared by mixing and dissolving in advance. At this time, the temperature of the aqueous phase Z is not particularly limited, but is preferably 10 ° C to 40 ° C. In this way, system (II) containing component (B) and dispersing vesicles is obtained.

[Preparation of vesicle-containing composition]
The vesicle-containing composition of the present invention can be obtained by adding and mixing the system (II) to the vesicle system (I) or by adding and mixing the system (II) to the vesicle system (I).

(Manufacturing equipment)
The equipment for preparing the aqueous phase X, the aqueous phase Y, and the aqueous phase Z is not particularly limited, and any equipment can be used as long as it is usually used when producing cosmetics and the like. Specifically, a homomixer, a disper mixer, a paddle mixer, or the like can be used. In addition to these, it can also be prepared by processing with a strong shearing force such as an emulsifier that can apply a stronger shearing force than a homomixer, such as a colloid mill, a microfluidizer, or an ultrasonic emulsifying machine. Further, the injection rate and the like can be manufactured without any particular limitation.

  In the production of the vesicle-containing composition of the present invention, it is also possible to add and mix polyhydric alcohol to the aqueous phase X as described above. By containing a polyhydric alcohol, the dispersibility of surfactants such as phospholipids can be improved, and a vesicle system having better temporal stability can be obtained. Such polyhydric alcohols are not particularly limited, and preferred examples include polyethylene glycol, 1,2-pentanediol, 1,3-butylene glycol, dipropylene glycol, glycerin, diglycerin and the like.

  The vesicle-containing composition of the present invention can be used as a cosmetic for various applications. For example, cosmetics such as lotion, milky lotion, cream, cosmetic liquid, massage cosmetics, hand cream, body lotion, body cream, and makeup cosmetics can be exemplified. Examples of the use method include a method of using hands and fingers, a method of impregnating a nonwoven fabric, and the like.

  The vesicle-containing composition of the present invention may be used as an external preparation for skin, such as an external solution, gel, cream, ointment, liniment, lotion, hap, plaster, spray, aerosol, etc. Can be mentioned. Moreover, the usage method can be mentioned similarly to the above-mentioned cosmetics.

  Among the above-mentioned applications, the product of the present invention has excellent massage properties and excellent temporal stability, while maintaining a smooth skin while having a fresh feeling of use. It is particularly preferable to use as a cosmetic for massage.

  The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

Examples 1-11 and Comparative Examples 1-4
Vesicle-containing compositions were prepared by the following production method using the components shown in the columns of Examples 1 to 11 and Comparative Examples 1 to 4 shown in Table 1. A fresh feeling of use, massage properties and stability over time were evaluated by the following methods. The results are also shown in Table 1.

(Production method)
A: Components 1 to 6 are heated to 80 ° C.
B: Components 7 to 9 are heated to 70 ° C.
C: A is added to B and mixed and stirred with a disperser mixer.
D: C is cooled to 40 ° C. to obtain vesicle system (I).
E: Components 10 to 14 are mixed and dissolved to obtain system (II).
F: After dispersing D in E, components 15 to 18 were mixed to obtain a vesicle-containing composition.

(Evaluation method)
The vesicle-containing compositions prepared according to the formulations described in Tables 1 to 3 were evaluated by the method shown. Twenty persons in their 20s and 40s who were specialized in cosmetics evaluation put 2g of the vesicle-containing composition on both cheeks, massaged them while drawing a circle with both hands, and evaluated the use. Each evaluation was evaluated in four stages according to the following evaluation criteria, given a score, and the average value was calculated from the total score of all the panel members for each sample, and judged according to the following four-step determination criteria.

(Evaluation 1: Fresh feeling)
Score 4 points of evaluation results: 3 points that are very fresh: 2 points that are fresh and fresh: 1 point that is not very fresh: criteria that are not fresh
Evaluation Average point of evaluation ◎: 3.5 or more ○: 2.5 or more and less than 3.5 Δ: 1.5 or more and less than 2.5 ×: Less than 1.5

(Evaluation 2: Massage)
Evaluation score 4 points: 3 points that can be massaged for 90 seconds or more: 2 points that can be massaged for 60 seconds or more: 1 point that can be massaged for 30 seconds or more: Can massage for less than 30 seconds Judgment criteria:
Evaluation Average point of evaluation ◎: 3.5 or more ○: 2.5 or more and less than 3.5 Δ: 1.5 or more and less than 2.5 ×: Less than 1.5

(Evaluation method: Stability over time)
With respect to the aging stability of the vesicle-containing composition, a comparison was made with a sample that had been allowed to stand at 5 ° C. and 50 ° C. for one month at room temperature (25 ° C.) for one month. Judgment was made using the criteria.

(B) Four-stage criteria (Judgment): (Evaluation)
A: Almost no precipitation is observed.
◯: Level where precipitation is slightly observed but no problem Δ: Level where precipitation is slightly recognized and problematic x: Precipitation is considerably recognized.

  As is clear from the results of Tables 1 to 3, Examples 1 to 11 have a fresh feeling of use, and are excellent in massage properties by extending and spreading while maintaining skin slipperiness. It was a vesicle-containing composition excellent in stability. On the other hand, the comparative example 1 which does not contain a component (A) water-soluble collagen was inferior in skin slipperiness, and inferior in the sustainability of a massage. Moreover, the comparative example 2 which does not contain a component (B) mucopolysaccharide was inferior in skin slipperiness and inferior in the sustainability of a massage. Next, in Comparative Example 3 in which the component (B) is contained in the vesicle and the component (A) is present in the outer phase in which the vesicle is dispersed, precipitation is considerably observed, the skin slipping property is inferior, and the massage continues. It was inferior in nature. That is, it is understood that the component (A) and the component (B) are contained in the vesicle and its outer phase opposite to the present invention, so that the effect of the present invention cannot be obtained and the contained system is important. it can. Furthermore, when the component (B) was not contained and xanthan gum, which is another water-soluble polymer, was contained instead, a fresh feeling of use was not obtained.

[Example 12: Cosmetic liquid]
(Ingredient) (%)
1. POE (5) Phytosterol 0.1
2. Phytosterol 0.1
3. Stearyl glycerin ether 0.05
4). Dipropylene glycol 8.0
5. Purified water 20
6). Atelocollagen 0.001
7). Purified water 4.0
8). Sodium chondroitin sulfate 0.001
9.1,3-butylene glycol 8.0
10. Lactic acid 0.01
11. Sodium lactate 0.01
12 Gellan gum 0.1
13. Methyl paraoxybenzoate Appropriate amount14. Perfume appropriate amount 15. Purified water remaining (production method)
A: Components 1 to 4 are heated and dissolved at 90 ° C.
B: Components 5 to 6 are heated to 70 ° C.
C: A is added to B, mixed and stirred, and then cooled to 40 ° C.
D: Components 7 to 8 are added to C and mixed.
E: Components 9 to 15 were added to D and mixed to obtain a cosmetic liquid.

  The beauty essence of Example 12 was a beauty essence having excellent massage properties and excellent temporal stability by maintaining the smoothness of the skin and spreading while maintaining a fresh feeling of use.

[Example 13: Massage cosmetics]
(Ingredient) (%)
1. Hydrogenated soybean lysophospholipid 4.0
2. Hydrogenated egg yolk phospholipids 1.0
3. Phytosterol 1.0
4). Dipropylene glycol 15.0
5. Purified water 30.0
6). Hydrolyzed collagen 0.002
7). Purified water 4.0
8). Sodium hyaluronate 0.002
9. 1,3-Butylene glycol 2.0
10. Succinic acid 0.1
11. Disodium succinate 0.05
12 Alkaligenes acidic polysaccharide (* 1) 0.2
13. Carboxyvinyl polymer 0.05
14 Acrylic acid / alkyl methacrylate copolymer 0.05
14 Sodium hydroxide 0.1
15. Perfume appropriate amount 16. Ethanol 3.0
17. Purified water remaining * 1: Arcasiran (made by Hakutosha)
(Manufacturing method)
A: Components 1 to 4 are heated and dissolved at 80 ° C.
B: Components 5 to 6 are heated to 80 ° C.
C: A is added to B, mixed and stirred, and then cooled to 40 ° C.
D: Disperse C with a microfluidizer.
E: Add 7-8 to D.
F: 9 to 17 were added to E and mixed to obtain a massage cosmetic.

  The massage cosmetic of Example 13 was a massage cosmetic having excellent massage properties and excellent temporal stability by maintaining the smoothness of the skin and spreading while maintaining a fresh feeling of use.

Claims (7)

The following components (A), (B);
A vesicle-containing composition comprising a component (A) a water-soluble collagen component (B) a mucopolysaccharide, wherein the component (A) is contained in the vesicle and the component (B) disperses the vesicle. A vesicle-containing composition characterized by being present in an outer phase.   The vesicle-containing composition according to claim 1, wherein the mass ratio of the component (A) and the component (B) is in the range of (A) :( B) = 6: 1 to 3: 4.   The vesicle-containing composition according to claim 1 or 2, wherein in the vesicle, the component (C) polyoxyethylene sterol ether and the component (D) sterol are constituents of the vesicle.   Furthermore, component (E) gellan gum is contained in the outer phase which disperse | distributes a vesicle, The vesicle containing composition in any one of Claims 1-3 characterized by the above-mentioned.   It is a cosmetic, The vesicle containing composition in any one of Claims 1-4 characterized by the above-mentioned.   The vesicle-containing composition according to claim 5, which is a massage cosmetic. It is a skin external preparation, The vesicle containing composition in any one of Claims 1-4 characterized by the above-mentioned.