JP5264065B2 - Emulsion composition for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care emulsified composition excellent in skin-aging-proof effects including ameliorating rough skin and the development of wrinkles, texture and drabness and moisturizing effect, and also excellent in feeling in use and emulsion stability to temperature variation. <P>SOLUTION: The skin care emulsified composition comprises (A) one or more substances selected from the group consisting of collagen, a collagen derivative and hydrolyzed collagen, preferably atelocollagen and/or hydrolyzed collagen, (B) polyoxyethylene sorbit cerabellina, (C) an N-acylglutaminic acid salt, and (D) a fatty acid ester-type nonionic surfactant. As desired, (E) a higher alcohol and (F) a hydrogenated vegetable oil may be incorporated in the above composition. <P>COPYRIGHT: (C)2008,JPO&amp;INPIT

Description

  The present invention relates to an emulsified composition for skin.

Conventionally, collagen, as to achieve the anti-old estuary fruits such as prevention and improvement and moisturizing effect of rough skin wrinkle texture dull form, are blended in the external composition.

Previously, as a means for imparting anti-old estuary result of the combination of collagen, for example, (see Patent Document 1) and cosmetic combination with unsaturated fatty acids, seaweed extract in combination with skin external preparation (JP 2), a skin external preparation combined with a plant extract (see Patent Document 3), a moisturizing composition combined with hyaluronic acid and chondroitin sulfate (see Patent Document 4), and a skin external preparation combined with a saccharide (see Patent Document 4) (See Patent Document 5).

However, although it is possible to impart by these attempts anti old estuary results temporarily not capable of satisfactory yet in terms sustainability and feel of the effect. Furthermore, sufficient investigation has not been made on the temperature stability of the preparation, and it is not yet satisfactory.

JP-A-5-279240 JP 2000-229832 A JP 2001-39852 A JP 2002-145753 A JP 2002-348248 A

The present invention has the has been made in view of the prior art, by rough skin wrinkle texture dull excellent anti old estuary fruits such as prevention and improvement and moisturizing effects of the formation, further, feeling of use and temperature changes It is an object to provide an emulsified composition for skin that is also excellent in emulsion stability.

That is, the present invention
[1] (A) one or more selected from the group consisting of collagen, collagen derivatives and hydrolyzed collagen, (B) polyoxyethylene sorbit beeswax, (C) N-acyl glutamate, (D) glyceryl monostearate, Fatty acid ester type selected from the group consisting of glyceryl monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate and polyethylene glycol distearate A nonionic surfactant and (F) hydrogenated vegetable oil are contained, the content of the component (A) is 0.05 to 3% by weight , and the content of the component (B) is 0.5 to 4% by weight. , the content of the component (C) is 0.3 Wt%, wherein (D) content of 1-6% by weight of component, the (F) content of the component dermatological emulsion composition is 1-3% by weight,
[2] The emulsion composition for skin according to [1], wherein the component (A) is atelocollagen and / or hydrolyzed collagen,
[3] (E) The emulsified composition for skin according to the above [1] or [2] containing a higher alcohol, and [4] the content of the (E) component is 0.1 to 6% by weight It is related with the emulsion composition for skin of said [3] which is.

The emulsified composition for skin of the present invention gives a fresh, moist and elastic skin state by forming a uniform film without a feeling of film thickness after application and improving adhesion to the skin. At the same time, it has an excellent moisturizing effect. In addition, the continuous use, improving skin roughness, wrinkles, texture dull forming, an excellent effect in anti-aging. Furthermore, there exists an effect that it has the outstanding emulsification stability in the wide temperature range in a low temperature range and a high temperature range.

  The emulsified composition for skin of the present invention comprises (A) one or more selected from the group consisting of collagen, collagen derivatives and hydrolyzed collagen, (B) polyoxyethylene sorbit beeswax, (C) N-acyl glutamate, D) Contains a fatty acid ester type nonionic surfactant.

  (A) As a component, 1 or more types chosen from the group which consists of collagen, a collagen derivative, and hydrolyzed collagen contain. Collagen sources include cattle, pigs, birds, and other beasts, as well as fish, shellfish, jellyfish, and sponges. Safety and stability issues, odor issues, and productivity and economic perspectives Therefore, collagen derived from marine organisms is preferable. Among these, it is preferable to use water-soluble collagen obtained by extraction with ethanol, water, sodium chloride solution or the like.

  Examples of the collagen derivative include the above-described collagen atelolation, acylation, succinylation, and the like, and specific examples include atelocollagen, acylation collagen, succinylated atelocollagen and the like. Examples of the hydrolyzed collagen include hydrolysates obtained by hydrolyzing the above-described collagen in the presence of an alkali, an acid, or an enzyme according to a conventional method.

  These components may be used alone or in combination of two or more. As a suitable component (A), it is preferable to use a collagen derivative or hydrolyzed collagen, and among the collagen derivatives, it is preferable to use atelocollagen. In addition, atelocollagen refers to collagen obtained by removing telopeptides present at the end of collagen molecules by enzymatic treatment.

The amount of the component (A) is applied is not particularly limited as long as the desired effect is applied, usually, anti-old estuary fruits such as prevention and improvement and moisturizing effect of rough skin wrinkle texture dull formed In view of the above, it is preferably 0.01% by weight or more, more preferably 0.05% by weight or more in the composition. Further, from the viewpoint of suppressing coloring and odor and suppressing deterioration of feeling in use, 5% by weight or less is preferable, and 3% by weight or less is more preferable. From these viewpoints, the content of the component (A) is preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight in the composition.

  In addition, a commercial item can also be used for (A) component. Specifically, for example, Promois W-32, W-32LS, W-32NO, W-32R, W-52, W-52P, W-52Q (trade names, all manufactured by Seiwa Kasei Co., Ltd.), marine collagen Peptides, ateloinated marine collagen solutions (trade names, both manufactured by Ihara Suisan Co., Ltd.) and the like can be exemplified.

  The component (B) polyoxyethylene sorbit beeswax is a component obtained by reacting beeswax with polyoxyethylene sorbitol obtained by addition polymerization of ethylene oxide to sorbitol. Thereby, while forming the uniform membrane | film | coat without a film thickness feeling and providing the adhesiveness to skin, the outstanding emulsion stability can be provided. The number of moles of ethylene oxide to be polymerized is not particularly limited.

  The content of the component (B) is not particularly limited as long as the desired effect is imparted, but usually from the viewpoint of forming a film and imparting adhesion to the skin and from the viewpoint of imparting stability of the emulsion system. In the composition, 0.1% by weight or more is preferable, and more preferably 0.5% by weight or more. Moreover, from a viewpoint which suppresses that a emulsification system by a sticky feeling and a temperature change collapses, 5 weight% or less is preferable, More preferably, it is 4 weight% or less. From these viewpoints, the content of the component (B) is preferably 0.1 to 5% by weight, more preferably 0.5 to 4% by weight in the composition.

  In addition, a commercial item can also be used for (B) component. Specifically, for example, NIKKOL GBW-25, 125 (trade names, both manufactured by Nikko Chemicals) can be exemplified.

  Specific examples of the (C) component N-acyl glutamate include, for example, coconut oil fatty acid acyl glutamate potassium, coconut oil fatty acid acyl glutamate sodium, coconut oil fatty acid acyl glutamate triethanolamine, lauroyl glutamate potassium, lauroyl glutamate sodium, lauroyl Examples include triethanolamine glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, potassium stearoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium hardened tallow fatty acid acyl glutamate, coconut oil fatty acid / hardened tallow fatty acid sodium acyl glutamate, etc. . These components may be used alone or in combination of two or more. As a preferable component (C), sodium lauroyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate are preferable, and sodium stearoyl glutamate is more preferably used from the viewpoint of dramatically improving the emulsion stability during high temperature storage.

  The content of the component (C) is not particularly limited as long as the desired effect is imparted, but usually 0.1% by weight in the composition from the viewpoint of improving the stability of the emulsion system during high-temperature storage. The above is preferable, and more preferably 0.3% by weight or more. Moreover, from a viewpoint which suppresses that an emulsification system by a sticky feeling and a temperature change collapses, 3 weight% or less is preferable, More preferably, it is 2 weight% or less. From these viewpoints, the content of the component (C) is preferably 0.1 to 3% by weight, more preferably 0.3 to 2% by weight in the composition.

  As the fatty acid ester type nonionic surfactant of component (D), glycerin fatty acid ester to which polyoxyethylene may be added, sorbitan fatty acid ester to which polyoxyethylene may be added, polyethylene glycol fatty acid ester, etc. Can be mentioned. Specific examples of the glyceryl fatty acid ester to which polyoxyethylene may be added include glyceryl fatty acid esters such as glyceryl monomyristate, glyceryl monostearate, glyceryl monooleate, glyceryl monoisostearate, and glyceryl monocaprylate; mono Examples thereof include polyoxyethylene glyceryl fatty acid esters such as polyoxyethylene glyceryl stearate and polyoxyethylene glyceryl monooleate. Specific examples of the sorbitan fatty acid ester to which polyoxyethylene may be added include sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, sesquiolein Sorbitan fatty acid esters such as sorbitan acid, sorbitan trioleate, sorbitan monoisostearate, sorbitan sesquiisostearate, coconut oil fatty acid sorbitan; monococonut oil fatty acid polyoxyethylene sorbitan, polyoxyethylene sorbitan monopalmitate, polyoxyethylene monostearate Sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, trioleic acid poly Polyoxyethylene sorbitan, polyoxyethylene sorbitan fatty acid esters such as monoisostearate, polyoxyethylene sorbitan and the like can be exemplified. Specific examples of polyethylene glycol fatty acid esters include polyethylene glycol monolaurate, polyethylene glycol monostearate, polyethylene glycol monooleate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate, polyethylene glycol distearate, polyethylene glycol dioleate, etc. can do. These components may be used singly or in combination of two or more, from the viewpoint of further improving the emulsion stability. Suitable components (D) include glyceryl monostearate, glyceryl monooleate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, and tristearic acid from the viewpoint of improving emulsion stability during storage at low and high temperatures. It is preferable to use polyoxyethylene sorbitan, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, or polyethylene glycol distearate.

(D) The content of the component, normally, from the viewpoint of improving emulsion stability at low and high temperature storage, the composition, is 0.1% by weight or more, more preferably 1 wt% or more. Further, stickiness, from the viewpoint of suppressing the emulsification system collapses due to deterioration and temperature variation of the washout, no more than 8 wt%, more preferably 6 wt% or less. From these viewpoints, the content of the component (D) is 0.1 to 8% by weight, more preferably 1 to 6% by weight in the composition.

  From the viewpoint of further improving the emulsion stability during storage at low and high temperatures, the emulsion composition for skin of the present invention can contain a higher alcohol as the component (E). Specific examples thereof include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol and the like. These components may be used alone or in combination of two or more. From the above viewpoint, cetyl alcohol, stearyl alcohol, and behenyl alcohol are preferably used as suitable higher alcohols.

  The content of the component (E) is not particularly limited as long as a desired effect is imparted, but usually, 0.1% by weight in the composition from the viewpoint of further improving the emulsion stability during storage at low temperatures and high temperatures. % Or more is preferable, and more preferably 1% by weight or more. Moreover, from a viewpoint of suppressing a sticky feeling, 6 weight% or less is preferable, More preferably, it is 4 weight% or less. From these viewpoints, the content of the component (E) is preferably 0.1 to 6% by weight, more preferably 1 to 4% by weight in the composition.

  Furthermore, the emulsion composition for skin of this invention can contain the hydrogenated vegetable oil of (F) component from a viewpoint which further improves the adhesiveness to skin. Specific examples thereof include hydrogenated jojoba oil, hydrogenated coconut oil, hydrogenated perilla oil and the like. These components may be used alone or in combination of two or more.

  The content of the component (F) is not particularly limited as long as a desired effect is imparted, but usually 0.1% by weight or more is preferable in the composition from the viewpoint of further improving the adhesion to the skin. More preferably, it is 1% by weight or more. Moreover, from a viewpoint of suppressing a sticky feeling, 4 weight% or less is preferable, More preferably, it is 3 weight% or less. From these viewpoints, the content of the component (F) is preferably 0.1 to 4% by weight, more preferably 1 to 3% by weight in the composition.

  In addition, in the emulsion composition for skin of the present invention, within the range not impairing the effects of the present invention, in addition to the above-described components, components commonly used in cosmetics such as oily components, lower alcohols, sugar alcohols, Ultraviolet absorbers, thickeners, amino acids, fragrances, dyes, chelating agents, antioxidants, preservatives, vitamins, pH adjusters, and the like can be appropriately blended depending on the purpose.

  When manufacturing the emulsion composition for skin of this invention, it can manufacture by mixing each said component and emulsifying by the well-known method, for example, the phase inversion emulsification method using a homomixer.

The emulsified composition for skin of the present invention forms a uniform film with no film thickness, has an excellent effect of maintaining the moisturizing power, and has an anti-aging effect such as improvement of rough skin, wrinkles, texture and dullness formation. since achieving the estuary fruit, for example, it can be preferably applied to a dosage form such as a facial, milk for the body, cream.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited only to these Examples. The content represents “% by weight” unless otherwise specified.

(Sample preparation)
According to the composition described in Table 1 and 2, each sample of Examples 1-5 and Comparative Examples 1-4 was prepared according to the conventional method, respectively, and it used for the following evaluation. The results are shown in Tables 1 and 2, respectively.

(Test Example 1: Evaluation of low-temperature stability)
The emulsified composition for skin obtained in each example and each comparative example was sealed in a 50 mL jar, freezed and thawed at −20 ° C. to room temperature for 24 hours, and this operation was repeated 10 times. The state of the system was visually observed and evaluated according to the following evaluation criteria.

<Evaluation criteria for low-temperature stability>
◎: No change observed immediately after production ○: Almost no change observed immediately after production Δ: Slight aggregation / separation observed X: Clear aggregation / separation observed

(Test Example 2: Evaluation of high-temperature stability)
The emulsified composition for skin obtained in each example and each comparative example was sealed in a 50 mL jar, stored in a thermostatic bath at 50 ° C. for 120 hours, and then the state of the emulsified system was visually observed to evaluate the following. Evaluation was made according to criteria.

<Evaluation criteria for high-temperature stability>
◎: No change observed immediately after production ○: Almost no change observed immediately after production Δ: Slight aggregation / separation observed X: Clear aggregation / separation observed

(Test Example 3: Evaluation of no stickiness)
20 female specialist panels apply the skin emulsified composition obtained in each Example and each Comparative Example to the face, conduct a use test, and evaluate the following five grades regarding the lack of stickiness immediately after application. Sensory evaluation was performed according to The evaluation was made according to the following criteria based on the average score calculated according to the following criteria.

<Evaluation criteria for non-stickiness>
5 points: very good 4 points: good 3 points: normal 2 points: defective 1 point: very bad

<Criteria for non-stickiness>
A: Average 4.0 points or more ○: Average 3.0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average less than 2.0 points

(Test Example 4: Evaluation of elasticity)
In the same specialized panel, the emulsified composition for skin obtained in each Example and each Comparative Example was applied to the face to perform a use test, and the following five-stage evaluation criteria for skin firmness after application 30 Sensory evaluation was performed according to The evaluation was made according to the following criteria based on the average score calculated according to the following criteria. Note that firm skin refers to a fresh, moist and elastic skin condition.

<Evaluation criteria for the sense of elasticity>
5 points: very good 4 points: good 3 points: normal 2 points: defective 1 point: very bad

<Judgment criteria for sharpness>
A: Average 4.0 points or more ○: Average 3.0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average less than 2.0 points

(Test Example 5: Evaluation of sustainability of moisturizing effect)
Using the same panel, the moisturizing effect 12 hours after the implementation of Test Example 3 was sensory evaluated according to the following five-stage evaluation criteria. The evaluation was made according to the following criteria based on the average score calculated according to the following criteria.

<Evaluation criteria for sustainability of moisturizing effect>
5 points: very good 4 points: good 3 points: normal 2 points: defective 1 point: very bad

<Criteria for sustainability of moisturizing effect>
A: Average 4.0 points or more ○: Average 3.0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average less than 2.0 points

(Test Example 6: Evaluation of improvement in rough skin, wrinkles, texture, dullness)
The skin emulsified composition obtained in each Example and each Comparative Example was applied to the face every day at bedtime on the same panel, and the effects of improving rough skin, wrinkles, texture and dullness after 4 weeks were as follows. Sensory evaluation was performed according to the evaluation criteria of the stage. The evaluation was made according to the following criteria based on the average score calculated according to the following criteria.

<Evaluation criteria for improvement of rough skin, wrinkles, texture and dullness>
5 points: very good 4 points: good 3 points: normal 2 points: defective 1 point: very bad

<Criteria for improving rough skin, wrinkles, texture, and dullness>
A: Average 4.0 points or more ○: Average 3.0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average less than 2.0 points

From the results shown in Tables 1 and 2, the emulsified composition for skin obtained in each example is broader in the low temperature range and the high temperature range than the emulsified composition for skin obtained in each comparative example. It can be seen that the emulsion has excellent emulsion stability in the temperature range. In addition, it can be seen that there is no stickiness after application, the skin is moisturized, moisturized, and has a moisturizing effect excellent in sustainability. Furthermore, by continuous use, improving skin roughness, wrinkles, texture dull formed, it can be seen that combines an excellent anti-old estuary fruit.

  Hereinafter, the formulation example of the emulsion composition for skin which concerns on this invention is shown. The content is% by weight.

(Formulation example 1: Treatment cream)
Hydrolyzed collagen 1.0
Atelocollagen 0.2
Polyoxyethylene sorbit beeswax 1.5
N-stearoyl-sodium L-glutamate 0.5
Glyceryl monooleate 1.0
Polyoxyethylene sorbitan monostearate 1.0
Polyoxyethylene sorbitan trioleate 2.0
1,2-octanediol 1.0
Xanthan gum 0.3
Stearyl alcohol 6.0
Stearic acid 2.0
Hydrogenated jojoba oil 2.0
Squalane 5.0
Octyldodecanol 7.0
Trehalose 3.0
Glycerin 10.0
Edetate 0.1
Dye proper amount Antioxidant proper amount
Purified water balance part Total 100.0

(Formulation Example 2: Cream Pack)
Hydrolyzed collagen 0.8
Atelocollagen 1.0
Polyoxyethylene Sorbit Beeswax 2.0
N-stearoyl-L-glutamate sodium 1.0
Glyceryl monostearate 2.0
Polyoxyethylene sorbitan monostearate 1.0
Monooleic acid polyoxyethylene sorbitan 1.0
1,2-octanediol 1.0
Polyethylene glycol 10.0
Sorbitol 5.0
Carboxyvinyl polymer 0.5
Xanthan gum 0.3
Behenyl alcohol 4.0
Potassium hydroxide 0.25
Phytosterol 0.4
Hydrogenated jojoba oil 1.0
Glycerin 5.0
Edetate 0.1
Dye proper amount Antioxidant proper amount
Purified water balance part Total 100.0

(Prescription Example 3: Makeup Base)
Hydrolyzed collagen 0.5
Atelocollagen 0.5
Polyoxyethylene sorbit beeswax 1.5
N-stearoyl-L-glutamate sodium 1.5
Glyceryl monostearate 1.0
Trioleic acid polyoxyethylene sorbitan 3.0
1,2-octanediol 1.0
Polyethylene glycol 5.0
Dipropylene glycol 5.0
Xanthan gum 0.3
Stearyl alcohol 1.0
Stearic acid 15.0
Hydrogenated jojoba oil 0.5
Isononyl isononanoate 5.0
Triethanolamine 0.3
Glycerin 5.0
Edetate 0.05
Dye proper amount Antioxidant proper amount
Purified water balance part Total 100.0

Claims (4)

(A) one or more selected from the group consisting of collagen, collagen derivatives and hydrolyzed collagen, (B) polyoxyethylene sorbit beeswax, (C) N-acyl glutamate, (D) glyceryl monostearate, monooleic acid Fatty acid ester type nonionic interface selected from the group consisting of glyceryl, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate and polyethylene glycol distearate An activator and (F) hydrogenated vegetable oil, the content of the component (A) is 0.05 to 3% by weight , the content of the component (B) is 0.5 to 4% by weight , the content of C) component 0.3 to 2 weight The (D) content of 1-6% by weight of component, the (F) content of the component dermatological emulsion composition is 1 to 3 wt%.   The emulsion composition for skin according to claim 1, wherein the component (A) is atelocollagen and / or hydrolyzed collagen.   (E) The emulsified composition for skin according to claim 1 or 2, comprising a higher alcohol.   The emulsified composition for skin according to claim 3, wherein the content of the component (E) is 0.1 to 6% by weight.