JP2010111601A - External emulsion composition for skin - Google Patents
External emulsion composition for skin Download PDFInfo
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- JP2010111601A JP2010111601A JP2008283775A JP2008283775A JP2010111601A JP 2010111601 A JP2010111601 A JP 2010111601A JP 2008283775 A JP2008283775 A JP 2008283775A JP 2008283775 A JP2008283775 A JP 2008283775A JP 2010111601 A JP2010111601 A JP 2010111601A
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- emulsion composition
- skin
- extract
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 239000000839 emulsion Substances 0.000 title abstract description 26
- -1 biphenyl compound Chemical class 0.000 claims abstract description 27
- 239000002253 acid Substances 0.000 claims abstract description 12
- 235000010290 biphenyl Nutrition 0.000 claims abstract description 10
- 239000004305 biphenyl Substances 0.000 claims abstract description 10
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000013871 bee wax Nutrition 0.000 claims abstract description 9
- 239000012166 beeswax Substances 0.000 claims abstract description 9
- 239000000539 dimer Substances 0.000 claims description 14
- 229930195712 glutamate Natural products 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 5
- 150000005690 diesters Chemical class 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 4
- 150000002430 hydrocarbons Chemical group 0.000 abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 3
- 239000000600 sorbitol Substances 0.000 abstract description 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000284 extract Substances 0.000 description 21
- 238000011156 evaluation Methods 0.000 description 12
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 7
- 235000020778 linoleic acid Nutrition 0.000 description 7
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000006071 cream Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000003240 coconut oil Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000272185 Falco Species 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 3
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- 241000951471 Citrus junos Species 0.000 description 2
- 235000005903 Dioscorea Nutrition 0.000 description 2
- 244000281702 Dioscorea villosa Species 0.000 description 2
- 235000000504 Dioscorea villosa Nutrition 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 244000018633 Prunus armeniaca Species 0.000 description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 238000012644 addition polymerization Methods 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229940031569 diisopropyl sebacate Drugs 0.000 description 2
- 235000004879 dioscorea Nutrition 0.000 description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 2
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 2
- WODOUQLMOIMKAL-FJSYBICCSA-L disodium;(2s)-2-(octadecanoylamino)pentanedioate Chemical compound [Na+].[Na+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O WODOUQLMOIMKAL-FJSYBICCSA-L 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 229940124274 edetate disodium Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229940077092 sodium myristoyl glutamate Drugs 0.000 description 2
- FCBUGCHAVCFTHW-NTISSMGPSA-N sodium;(2s)-2-(tetradecanoylamino)pentanedioic acid Chemical compound [Na].CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O FCBUGCHAVCFTHW-NTISSMGPSA-N 0.000 description 2
- 235000013322 soy milk Nutrition 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- QTDJJSNTSBBCKS-UQKRIMTDSA-N (4s)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid;2-[bis(2-hydroxyethyl)amino]ethanol Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O QTDJJSNTSBBCKS-UQKRIMTDSA-N 0.000 description 1
- UCNQNZOSHKDAKL-UHFFFAOYSA-N 10-[5,6-dihexyl-2-[8-(16-methylheptadecanoyloxy)octyl]cyclohex-3-en-1-yl]dec-9-enyl 16-methylheptadecanoate Chemical compound CCCCCCC1C=CC(CCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C)C(C=CCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C)C1CCCCCC UCNQNZOSHKDAKL-UHFFFAOYSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 244000128206 Pyracantha coccinea Species 0.000 description 1
- 235000003105 Pyracantha coccinea Nutrition 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 244000131415 Zanthoxylum piperitum Species 0.000 description 1
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical compound OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 108010006161 conchiolin Proteins 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940079784 disodium stearoyl glutamate Drugs 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 150000002148 esters Chemical group 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 150000002190 fatty acyls Chemical group 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940071085 lauroyl glutamate Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- RWDOCBHBDDFEQV-UQKRIMTDSA-M potassium;(4s)-4-amino-5-dodecanoyloxy-5-oxopentanoate Chemical compound [K+].CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O RWDOCBHBDDFEQV-UQKRIMTDSA-M 0.000 description 1
- XIBUKSQTWSKJMQ-QTNFYWBSSA-M potassium;(4s)-4-amino-5-hydroxy-5-oxopentanoate;hydrate Chemical compound O.[K+].[O-]C(=O)[C@@H](N)CCC(O)=O XIBUKSQTWSKJMQ-QTNFYWBSSA-M 0.000 description 1
- KCQOKZAQSWTPIL-BDQAORGHSA-M potassium;(4s)-5-hydroxy-4-(octadecanoylamino)-5-oxopentanoate Chemical compound [H+].[K+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O KCQOKZAQSWTPIL-BDQAORGHSA-M 0.000 description 1
- KYLDDUZJZSKJER-NTISSMGPSA-M potassium;(4s)-5-hydroxy-5-oxo-4-(tetradecanoylamino)pentanoate Chemical compound [H+].[K+].CCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O KYLDDUZJZSKJER-NTISSMGPSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
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Abstract
Description
本発明は、安定性に優れ、高い保湿感を付与し、使用性、使用感に優れた皮膚外用乳化組成物に関するものである。 The present invention relates to an emulsion composition for external use having excellent stability, imparting a high moisturizing feeling, and excellent usability and usability.
乳化組成物のような皮膚外用剤を形成する成分として、ポリオキシエチレンソルビタンミツロウ、N−アシルグルタミン酸塩、美白作用を持つビフェニル化合物等が、ローション、乳液、ジェル、クリーム、サンスクリーン剤、クレンジング料等に多く用いられている(例えば、特許文献1〜3参照)。 As a component for forming a skin external preparation such as an emulsified composition, polyoxyethylene sorbitan beeswax, N-acyl glutamate, biphenyl compound having a whitening effect, etc., lotion, emulsion, gel, cream, sunscreen agent, cleansing agent (See, for example, Patent Documents 1 to 3).
しかしながら、ビフェニル化合物は水や非極性油剤に対する溶解度が極めて低いために、製品中で結晶化することが多く、製品の経時安定性を低下させる懸念があった。そのため、強く望まれているにもかかわらず、この化合物を十分量配合して安定性に優れた乳化組成物を得ることは困難であり、保湿感、使用性、使用感においても満足できる特性のものを得ることは困難であった。 However, since the biphenyl compound has extremely low solubility in water and nonpolar oils, it often crystallizes in the product, and there is a concern that the stability with time of the product is lowered. Therefore, despite the strong demand, it is difficult to obtain an emulsified composition excellent in stability by blending a sufficient amount of this compound, and has satisfactory characteristics in moisturizing feeling, usability, and feeling of use. It was difficult to get things.
発明者等は上記事情に鑑み、鋭意研究した結果、特定のビフェニル化合物、ポリオキシエチレンソルビットミツロウ、N−アシルグルタミン酸塩を組み合わせることにより、上記課題が解決されることを見出した。 As a result of intensive studies in view of the above circumstances, the inventors have found that the above problem can be solved by combining a specific biphenyl compound, polyoxyethylene sorbite beeswax, and N-acyl glutamate.
即ち、本発明は、(A)下記一般式(1)で表されるビフェニル化合物、(B)ポリオキシエチレンソルビットミツロウ及び(C)N−アシルグルタミン酸塩を含有する皮膚外用乳化組成物にある。 That is, this invention exists in the emulsion composition for external skin containing (A) biphenyl compound represented by following General formula (1), (B) polyoxyethylene sorbit beeswax, and (C) N-acyl glutamate.
本発明の皮膚外用乳化組成物は、安定性に優れ、高い保湿感を付与し、使用性、使用感に優れている。 The skin external emulsion composition of the present invention is excellent in stability, imparts a high moisturizing feeling, and is excellent in usability and usability.
以下、本発明の構成について詳述する。本発明に用いられる(A)ビフェニル化合物は、下記一般式(1)で表されるものである。 Hereinafter, the configuration of the present invention will be described in detail. The (A) biphenyl compound used in the present invention is represented by the following general formula (1).
本発明のビフェニル化合物は、公知の物質であり、容易に得ることができる(日本化学雑誌、第87巻、第6号、603頁、1966年)。その他、モクレン科ホウノキ属植物の樹皮から得られるマグノロールを用いたり、それを更に水素添加することにより容易に得ることができる。 The biphenyl compound of the present invention is a known substance and can be easily obtained (Nippon Chemical Journal, Vol. 87, No. 6, page 603, 1966). In addition, it can be easily obtained by using magnolol obtained from the bark of a magnoliaceae plant, or by hydrogenating it.
上記一般式(1)で表される本発明のビフェニル化合物は、Rが水素原子であっても炭化水素基であってもよく、炭化水素基の場合、直鎖状であっても分岐鎖状であってもよく、飽和でも不飽和の炭化水素基であってもよい。炭化水素基としては、具体的にはメチル、エチル、プロピル、イソプロピル、アリル、ブチル、イソブチル、第2ブチル、第3ブチル、ペンチル、イソペンチル等を挙げることができるが、これらに限定されるものではない。本発明では、安定性の面からは飽和炭化水素基が好ましく、効果の点からはプロピル基、イソプロピル基、アリル基が好ましい。これらのうち、本発明ではRがプロピル基である「2,2’−ジヒドロキシ−5,5’−ジ−n−プロピルビフェニル」が、特に好ましく用いられる。 The biphenyl compound of the present invention represented by the general formula (1) may be a hydrogen atom or a hydrocarbon group, and in the case of a hydrocarbon group, it may be linear or branched. It may be a saturated or unsaturated hydrocarbon group. Specific examples of the hydrocarbon group include methyl, ethyl, propyl, isopropyl, allyl, butyl, isobutyl, secondary butyl, tertiary butyl, pentyl, isopentyl, and the like. However, the hydrocarbon group is not limited thereto. Absent. In the present invention, a saturated hydrocarbon group is preferable from the viewpoint of stability, and a propyl group, an isopropyl group, and an allyl group are preferable from the viewpoint of effects. Among these, in the present invention, “2,2′-dihydroxy-5,5′-di-n-propylbiphenyl” in which R is a propyl group is particularly preferably used.
本発明の皮膚外用乳化組成物における(A)成分の含有量は、乳化組成物の総量を基準として、0.01〜5質量%(以下、単に%と記す。)が好ましく、特に好ましくは0.1〜3%である。これらの範囲であれば、本発明の効果により優れる。 The content of the component (A) in the emulsion composition for external use of the present invention is preferably 0.01 to 5% by mass (hereinafter simply referred to as%), particularly preferably 0, based on the total amount of the emulsion composition. 0.1 to 3%. Within these ranges, the effects of the present invention are superior.
本発明に用いられる(B)ポリオキシエチレンソルビットミツロウは公知の物質であり、具体的にはソルビトールに酸化エチレンを付加重合して得られるポリオキシエチレンソルビトールと、ミツロウを反応させて得られる成分である。(B)成分を配合することにより、ビフェニル化合物を配合した乳化組成物の乳化安定性を高めることができる。(B)成分は1種を単独で用いてもよく、2種以上を適宜組み合わせて用いることもできる。
尚、付加重合される酸化エチレンの付加モル数は特に限定はないが、好ましくは4〜25であり、より好ましくは6〜20である。
The (B) polyoxyethylene sorbit beeswax used in the present invention is a known substance, specifically, a component obtained by reacting beeswax with polyoxyethylene sorbitol obtained by addition polymerization of ethylene oxide to sorbitol. is there. (B) By mix | blending a component, the emulsion stability of the emulsion composition which mix | blended the biphenyl compound can be improved. As the component (B), one type may be used alone, or two or more types may be used in appropriate combination.
The number of added moles of ethylene oxide subjected to addition polymerization is not particularly limited, but is preferably 4 to 25, more preferably 6 to 20.
(B)成分は、市販品を用いることができる。具体的には、酸化エチレンの付加モル数が6であるNIKKOL GBW−25、酸化エチレンの付加モル数が20であるNIKKOL GBW−125(商品名、いずれも日光ケミカルズ社製)等を例示することができる。 (B) A commercial item can be used for a component. Specifically, NIKOL GBW-25 having an addition mole number of ethylene oxide of 6, NIKKOL GBW-125 having an addition mole number of ethylene oxide of 20 (trade names, both manufactured by Nikko Chemicals), etc. Can do.
本発明の皮膚外用乳化組成物における(B)成分の含有量は特に限定されるものではないが、通常乳化組成物の総量を基準として0.1〜5%が好ましく、特に好ましくは0.3〜3%である。この範囲内であれば乳化系の安定性に特に優れると同時に、べたつきの点でより優れた使用感が得られる。 The content of the component (B) in the external skin emulsion composition of the present invention is not particularly limited, but is usually preferably 0.1 to 5%, particularly preferably 0.3 based on the total amount of the emulsion composition. ~ 3%. Within this range, the stability of the emulsified system is particularly excellent, and at the same time, a better feeling in use can be obtained in terms of stickiness.
本発明に用いられる(C)N−アシルグルタミン酸塩は公知の物質であり、例えばヤシ油脂肪酸アシルグルタミン酸カリウム、ヤシ油脂肪酸アシルグルタミン酸ナトリウム、ヤシ油脂肪酸アシルグルタミン酸トリエタノールアミン、ラウロイルグルタミン酸カリウム、ラウロイルグルタミン酸ナトリウム、ラウロイルグルタミン酸トリエタノールアミン、ミリストイルグルタミン酸カリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸カリウム、ステアロイルグルタミン酸ナトリウム、ステアロイルグルタミン酸二ナトリウム、硬化牛脂脂肪酸アシルグルタミン酸ナトリウム、ヤシ油脂肪酸・硬化牛脂脂肪酸アシルグルタミン酸ナトリウム等を挙げることができる。(C)成分は、1種を単独で用いてもよく、2種以上を適宜組み合わせて用いることもできる。本発明では、高温保存時の乳化安定性を飛躍的に向上させることから、ラウロイルグルタミン酸ナトリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ナトリウムが好ましく、ステアロイルグルタミン酸ナトリウムがより好ましい。 (C) N-acyl glutamate used in the present invention is a known substance, for example, coconut oil fatty acid acyl glutamate potassium, coconut oil fatty acid acyl glutamate sodium, coconut oil fatty acyl glutamate triethanolamine, lauroyl glutamate potassium, lauroyl glutamate List sodium, lauroyl glutamate triethanolamine, potassium myristoyl glutamate, sodium myristoyl glutamate, potassium stearoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium hard beef fatty acid acyl glutamate, coconut oil fatty acid / hardened beef fatty acid acyl glutamate, etc. Can do. As the component (C), one type may be used alone, or two or more types may be used in appropriate combination. In the present invention, sodium lauroyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate are preferable, and sodium stearoyl glutamate is more preferable because it greatly improves the emulsion stability during high-temperature storage.
本発明の皮膚外用乳化組成物における(C)成分の含有量は特に限定されるものではないが、通常乳化組成物の総量を基準として0.1〜3%が好ましく、特に好ましくは0.3〜2%である。この範囲内であれば高温保存時の乳化系の安定性に特に優れると同時に、べたつきの点でより優れた使用感が得られる。 The content of the component (C) in the external skin emulsion composition of the present invention is not particularly limited, but is usually preferably 0.1 to 3%, particularly preferably 0.3 based on the total amount of the emulsion composition. ~ 2%. Within this range, the stability of the emulsification system during high-temperature storage is particularly excellent, and at the same time, a better feeling in terms of stickiness can be obtained.
本発明の皮膚外用乳化組成物では、上記(A)〜(C)の必須成分に加えて、(D)ダイマー酸のジエステルを併用することにより、本発明の効果をより優れたものとすることができる。本発明に用いられる(D)ダイマー酸のジエステルは、ダイマー酸とダイマージオールとのエステル体等を指し、具体的にはダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ジ(イソステアリル/フィトステリル)、ダイマージリノール酸ダイマージリノレイル、ダイマージリノール酸ジリノレイル(ベヘニル/イソステアリル/フィトステリル)、ジイソステアリン酸ダイマージリノレイル等が挙げられ、抱水エモリエント成分として知られている。これらは1種又は2種以上を組み合わせて使用される。上記ダイマー酸のジエステルの中でも、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ジ(イソステアリル/フィトステリル)が好ましい。 In the emulsion composition for external use of the present invention, in addition to the essential components (A) to (C) above, the effect of the present invention is further improved by using (D) a diester of dimer acid in combination. Can do. The diester of (D) dimer acid used in the present invention refers to an ester form of dimer acid and dimer diol, specifically dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer Dimerinolinoleate (isostearyl / phytosteryl), dimerinolinoleic acid dimerinolinoleyl, dimerinolinoleic acid dilinoleyl (behenyl / isostearyl / phytosteryl), diisostearic acid dimerinolinoleyl, etc., are known as emollient hydrate components It has been. These are used alone or in combination of two or more. Among the diesters of dimer acid, dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) and dimer linoleic acid di (isostearyl / phytosteryl) are preferable.
市販品としては、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)として「Plandool−S、−H」、ダイマージリノール酸ジ(イソステアリル/フィトステリル)として「LUSPLAN PI−DA」、ダイマージリノール酸ダイマージリノレイルとして「LUSPLAN DD−DA」、ダイマージリノール酸ジリノレイルとして「Plandool−G」、ジイソステアリン酸ダイマージリノレイルとして「LISPLAN DD−IS」(以上、日本精化社製)を挙げることができる。 Commercially available products include “Plandool-S, —H” as dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), “LUSPLAN PI-DA” as dimer linoleic acid di (isostearyl / phytosteryl), "LUSPLAN DD-DA" as dimerinolinoleic acid dimerinolinole, "Plandool-G" as dimerinolinoleic acid dilinoleyl, and "LISPLAN DD-IS" as diisostearic acid dimerinolinole (above, manufactured by Nippon Seika Co., Ltd.) Can be mentioned.
本発明の皮膚外用乳化組成物における(D)成分の含有量は特に限定されるものではないが、通常乳化組成物の総量を基準として0.1〜20%が好ましく、特に好ましくは0.5〜10%である。この範囲内であれば特に保湿感に優れ、べたつきの点でより優れた使用感が得られる。 The content of the component (D) in the external skin emulsion composition of the present invention is not particularly limited, but is usually preferably 0.1 to 20%, particularly preferably 0.5 based on the total amount of the emulsion composition. -10%. Within this range, the moisturizing feeling is particularly excellent, and a more excellent feeling in use is obtained in terms of stickiness.
本発明の皮膚外用乳化組成物としては、特に限定されないが、クリーム、乳液、美容液、サンスクリーン等が挙げられる。 Although it does not specifically limit as an emulsion composition for skin external use of this invention, Cream, a milky lotion, a cosmetic liquid, a sunscreen, etc. are mentioned.
本発明の皮膚外用乳化組成物は、前記の成分に加え必要に応じて、本発明の効果を損なわない範囲で、通常使用される各種の成分を任意で使用することができる。これらの成分としては、アニオン性界面活性剤、カチオン性界面活性剤、非イオン性界面活性剤、油分、紫外線吸収剤、防腐剤、保湿剤、ポリマー類、アミノ酸誘導体、糖誘導体、香料、水、アルコール、増粘剤、色材、金属イオン封鎖剤、酸化防止剤、薬剤等が挙げられる。 In the emulsion composition for external skin of the present invention, various components that are usually used can be optionally used within the range not impairing the effects of the present invention, if necessary, in addition to the above components. These components include anionic surfactants, cationic surfactants, nonionic surfactants, oils, UV absorbers, preservatives, moisturizers, polymers, amino acid derivatives, sugar derivatives, perfumes, water, Alcohols, thickeners, coloring materials, sequestering agents, antioxidants, drugs and the like can be mentioned.
以下、実施例、比較例により本発明を詳説するが、本発明はそれらに限定されるものではない。尚、配合組成の%は質量%である。 EXAMPLES Hereinafter, although this invention is explained in full detail according to an Example and a comparative example, this invention is not limited to them. In addition,% of a compounding composition is the mass%.
実施例に先立ち、実施例において行った保存安定性試験並び官能評価方法について述べる。 Prior to the examples, storage stability tests and sensory evaluation methods performed in the examples will be described.
(保存安定性試験)
評価試料をガラスビンに入れ、室温で1週間放置し、その外観及び状態の変化を目視にて観察した。分離、析出といった異常が認められる場合を「×」、特に異常が認められない場合を「○」と評価した。
(Storage stability test)
The evaluation sample was put in a glass bottle and allowed to stand at room temperature for 1 week, and changes in its appearance and state were visually observed. The case where abnormality such as separation and precipitation was observed was evaluated as “×”, and the case where no abnormality was observed was evaluated as “◯”.
(官能評価)
専門判定員10名が評価試料を使用し、「保湿感」、「のび、つき」及び「べたつき感やきしみ感の有無」の各評価項目に関して1点から5点の5段階により評点をつけ(点数が大きい程評価に優れる。)、その平均点により評価した。
(sensory evaluation)
Ten expert judges use the evaluation samples and give them a five-point scale from 1 to 5 for each of the evaluation items of “moisturizing feeling”, “nobbling and sticking” and “presence of stickiness and squeaking” ( The larger the score, the better the evaluation.), The evaluation was based on the average score.
実施例1〜7、比較例1〜4
表1記載の配合組成により皮膚外用乳化組成物を常法により作製し、前記の評価試験を実施した。結果を表1に併せて示す。
Examples 1-7, Comparative Examples 1-4
An emulsion composition for external application to skin was prepared by the conventional method using the formulation composition shown in Table 1, and the evaluation test was carried out. The results are also shown in Table 1.
(表1)
(Table 1)
表1より明らかなように、本発明の乳化組成物(実施例1〜7)は、比較例1〜4と比
べて、優れた保存安定性が認められた。また、本発明の乳化組成物は、官能評価のいずれの項目においても優れた性能を有していたが、必須成分を書いた比較例では、官能評価のいずれかの項目において劣っており、本発明の目的を達成できなかった。
As is apparent from Table 1, the emulsion compositions (Examples 1 to 7) of the present invention exhibited superior storage stability compared to Comparative Examples 1 to 4. The emulsified composition of the present invention had excellent performance in any item of sensory evaluation, but in the comparative example in which the essential components were written, it was inferior in any item of sensory evaluation. The object of the invention could not be achieved.
実施例8(乳液)
原 料 名 配合量(%)
――――――――――――――――――――――――――――――――――――
2,2'−ジヒドロキシ−5,5'−ジ−n−プロピルビフェニル 0.5
ポリオキシエチレンソルビットミツロウ(注1) 0.5
N−ステアロイル−L−グルタミン酸ナトリウム 0.7
カルボキシビニルポリマー 0.2
水酸化ナトリウム 0.1
グリセリン 5.0
スクワラン 3.0
セバシン酸ジイソプロピル 2.0
デカメチルシクロペンタシロキサン 1.0
ダイマージリノール酸(フィトステリル/イソステアリル 3.0
/セチル/ステアリル/ベヘニル)(注4)
火棘抽出物(注5) 0.1
アンズ果汁(注6) 0.1
キョウニンエキス(注7) 0.1
加水分解コンキオリン液(注8) 0.1
加水分解シルク液(注9) 0.1
紫蘭根エキス(注10) 0.1
オウバクエキス(注11) 0.1
グリチルリチン酸ジカリウム 0.1
エデト酸二ナトリウム 0.05
フェノキシエタノール 0.4
キサンタンガム 0.1
香料 0.1
精製水 残 部
――――――――――――――――――――――――――――――――――――
注5:火棘(サントリー社製)
注6:アプリコットエキスK(エスペリス社製)
注7:キョウニン抽出液LA(丸善製薬社製)
注8:真珠タンパク抽出液(丸善製薬社製)
注9:シルクプロテインエキスK(一丸ファルコス社製)
注10:ランヴェール−EX(テクノーブル社製)
注11:オウバク抽出液J(丸善製薬社製)
Example 8 (milky lotion)
Raw material name Compounding amount (%)
――――――――――――――――――――――――――――――――――――
2,2′-dihydroxy-5,5′-di-n-propylbiphenyl 0.5
Polyoxyethylene sorbit beeswax (Note 1) 0.5
N-stearoyl-L-glutamate sodium 0.7
Carboxyvinyl polymer 0.2
Sodium hydroxide 0.1
Glycerin 5.0
Squalane 3.0
Diisopropyl sebacate 2.0
Decamethylcyclopentasiloxane 1.0
Dimer linoleic acid (phytosteryl / isostearyl 3.0)
/ Cetyl / stearyl / behenyl) (Note 4)
Fire thorn extract (Note 5) 0.1
Apricot juice (Note 6) 0.1
Kyonin extract (Note 7) 0.1
Hydrolyzed conchiolin solution (Note 8) 0.1
Hydrolyzed silk solution (Note 9) 0.1
Purple orchid root extract (Note 10) 0.1
Oat extract (Note 11) 0.1
Dipotassium glycyrrhizinate 0.1
Edetate disodium 0.05
Phenoxyethanol 0.4
Xanthan gum 0.1
Fragrance 0.1
Purified water balance ――――――――――――――――――――――――――――――――――――
Note 5: Fire Thorn (Suntory)
Note 6: Apricot extract K (Esperis)
Note 7: Kyonin extract LA (Maruzen Pharmaceutical Co., Ltd.)
Note 8: Pearl protein extract (Maruzen Pharmaceutical Co., Ltd.)
Note 9: Silk protein extract K (Ichimaru Falcos)
Note 10: Lambert-EX (manufactured by Technoble)
Note 11: Awaku extract J (Maruzen Pharmaceutical Co., Ltd.)
上記組成の皮膚外用乳化組成物(乳液)を常法により調製し評価した結果、保存安定性、官能評価のいずれの項目においても優れていた。 As a result of preparing and evaluating the emulsion composition for external skin (milky lotion) having the above composition by a conventional method, it was excellent in both storage stability and sensory evaluation.
実施例9(クリーム)
原 料 名 配合量(%)
――――――――――――――――――――――――――――――――――――
2,2'−ジヒドロキシ−5,5'−ジ−n−プロピルビフェニル 0.5
ポリオキシエチレンソルビットミツロウ(注1) 2.0
N−ステアロイル−L−グルタミン酸ナトリウム 1.2
ジプロピレングリコール 6.0
ベヘニルアルコール 2.5
マイクロクリスタリンワックス 3.0
グリセリン 5.0
セバシン酸ジイソプロピル 4.0
流動パラフィン 8.0
メチルフェニルポリシロキサン 2.0
ジメチルポリシロキサン(0.1m2/s;25℃) 1.0
ダイマージリノール酸(フィトステリル/イソステアリル 3.0
/セチル/ステアリル/ベヘニル)(注4)
オレス−2 0.5
オレンジ果汁(注12) 0.1
オウバクエキス(注13) 0.1
酵母エキス(注14) 0.1
チョウジエキス(注15) 0.1
海草エキス(注16) 0.1
キイチゴエキス(注17) 0.1
ディオスコレアコンポジタエキス(注18) 0.1
豆乳発酵液(注19) 0.1
ユズエキス(注20) 0.1
岩白菜エキス(注21) 0.1
グリチルリチン酸ジカリウム 0.1
エデト酸二ナトリウム 0.05
フェノキシエタノール 0.4
クロロフェネシン 0.1
キサンタンガム 0.15
香料 0.1
精製水 残 部
――――――――――――――――――――――――――――――――――――
注12:ホモフルーツ(オレンジ)N(香栄興業社製)
注13:オウバク抽出液J(丸善製薬社製)
注14:ディスムチンBTJ(ペンタファーム社製)
注15:チョウジ抽出液(丸善製薬社製)
注16:マリンパージ(一丸ファルコス社製)
注17:ファルコレックスキイチゴB(一丸ファルコス社製)
注18:ディオスコレアコンポジタ根エキス(三井化学社製)
注19:豆乳発酵液(三省製薬社製)
注20:ユズ抽出液(丸善製薬社製)
注21:厚葉岩白菜抽出液BG(丸善製薬社製)
Example 9 (cream)
Raw material name Compounding amount (%)
――――――――――――――――――――――――――――――――――――
2,2′-dihydroxy-5,5′-di-n-propylbiphenyl 0.5
Polyoxyethylene sorbite beeswax (Note 1) 2.0
Sodium N-stearoyl-L-glutamate 1.2
Dipropylene glycol 6.0
Behenyl alcohol 2.5
Microcrystalline wax 3.0
Glycerin 5.0
Diisopropyl sebacate 4.0
Liquid paraffin 8.0
Methylphenylpolysiloxane 2.0
Dimethylpolysiloxane (0.1 m 2 / s; 25 ° C.) 1.0
Dimer linoleic acid (phytosteryl / isostearyl 3.0)
/ Cetyl / stearyl / behenyl) (Note 4)
Ores-2 0.5
Orange juice (Note 12) 0.1
Oat extract (Note 13) 0.1
Yeast extract (Note 14) 0.1
Clove extract (Note 15) 0.1
Seaweed extract (Note 16) 0.1
Raspberry extract (Note 17) 0.1
Dioscorea compositor extract (Note 18) 0.1
Soymilk fermented liquid (Note 19) 0.1
Yuzu Extract (Note 20) 0.1
Rock cabbage extract (Note 21) 0.1
Dipotassium glycyrrhizinate 0.1
Edetate disodium 0.05
Phenoxyethanol 0.4
Chlorophenesin 0.1
Xanthan gum 0.15
Fragrance 0.1
Purified water balance ――――――――――――――――――――――――――――――――――――
Note 12: Homofruit (orange) N (manufactured by Koei Kogyo Co., Ltd.)
Note 13: Awaku extract J (Maruzen Pharmaceutical Co., Ltd.)
Note 14: Dismutin BTJ (Penta Farm)
Note 15: Clove extract (Maruzen Pharmaceutical Co., Ltd.)
Note 16: Marine purge (Ichimaru Falcos)
Note 17: Falco Rex Raspberry B (Ichimaru Falcos)
Note 18: Dioscorea compositor root extract (Mitsui Chemicals)
Note 19: Soymilk fermentation broth (manufactured by Sansho Pharmaceutical Co., Ltd.)
Note 20: Yuzu extract (Maruzen Pharmaceutical Co., Ltd.)
Note 21: Atsuba Iwanaka extract BG (Maruzen Pharmaceutical Co., Ltd.)
上記組成の皮膚外用乳化組成物(クリーム)を常法により調製し評価した結果、保存安定性、官能評価のいずれの項目においても優れていた。 As a result of preparing and evaluating the emulsion composition for external skin (cream) having the above composition by a conventional method, it was excellent in both storage stability and sensory evaluation.
尚、上記の実施例において使用した香料の組成を表2に示す。 The composition of the fragrance used in the above examples is shown in Table 2.
(表2)
(Table 2)
以上記載の如く、本発明により、安定性に優れ、高い保湿感を付与し、使用性、使用感に優れた皮膚外用乳化組成物(クリーム、乳液、美容液、サンスクリーン等)を提供することができる。 As described above, the present invention provides an emulsion composition for external use on the skin (cream, milky lotion, cosmetic liquid, sunscreen, etc.) that is excellent in stability, imparts a high moisturizing feeling, and is excellent in usability and usability. Can do.
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