JPH05301814A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic excellent in skin beautifying effects. CONSTITUTION:The objective cosmetic is obtained by blending epsilon-N-(gamma-glutamyl) lysine or its salt in an amount of preferably 0.001-10wt.% based on the total cosmetic. The skin roughening can be prevented or improved by improving the skin horny state and the retention of skin moisture can be enhanced without any undesired effects on touch.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition, more specifically, by improving the keratinous state of the skin, preventing or improving skin roughness, and improving the condition caused by dryness of the skin, thereby keeping the skin moisture, It is intended to provide a cosmetic having a beautiful skin effect that moisturizes the skin.

[0002]

2. Description of the Related Art Generally, when the dry skin is exacerbated in winter or due to excessive skin washing, age, constitution, etc., multiple exfoliation of the stratum corneum easily occurs, the gloss of the skin deteriorates, and fine wrinkles are noticeable. As a result, adverse effects such as poor makeup adhesion occur, resulting in the phenomenon of rough skin.

Conventionally, in order to improve the condition of the stratum corneum of the skin, it has been necessary to prevent a decrease in the moisture content of the stratum corneum and maintain normal skin function, and various methods have been studied so far. Came. As a result, the proposed method is:
A method to suppress transdermal water loss by using an occlusive agent with good adhesion to the skin and having hydrophobicity, and a moisturizing agent such as sugar alcohols or amino acids and other organic acid salts having hygroscopicity and moisturizing ability. To increase skin hydration effect by
There was also a method of blending vitamins, hormones, etc. to promote metabolic activation and repair keratin.

[0004]

However, none of the above-mentioned conventionally known methods have sufficient skin water-retaining ability, and the keratin-improving effect is small, and when an occlusive agent is used, an oil is used. It has a drawback that it gives an unpleasant feeling such as sticky, and on the other hand, even if a moisturizing agent is used, a large amount must be added to enhance the effect, and as a result, a sticky feeling and a slimy feeling etc. There was a problem of giving an unpleasant feeling. Vitamins, hormones, etc. have problems in safety and stability.

The present invention has been made in view of such circumstances, and improves the condition of the stratum corneum of the skin caused by dryness such as rough skin, lack of gloss, fine wrinkles, and moisturizes by retaining sufficient skin moisture. It is an object of the present invention to provide a cosmetic having a so-called beautiful skin effect of improving or preventing rough skin and adjusting texture, and having almost no problem in terms of feel.

[0006]

As a result of intensive studies to solve the above problems, the present inventor has found that one of the dipeptides (isopeptides), epsilon-N- (gamma-).
It was found that glutamyl) lysine has a high effect of improving skin water retention function and an effect of improving keratin to improve rough skin, and has an excellent skin beautifying effect, and based on this, the present invention was completed.

That is, the present invention relates to epsilon-N-
(Gamma-glutamyl) lysine (ε-N- (γ-glutamyl) ly
sine) or a salt thereof, and in a preferred embodiment, the amount of epsilon-N- (gamma-glutamyl) lysine or a salt thereof is 0.001 to 0.001 based on the total amount of the cosmetic. It relates to cosmetics which are 10% by weight.

The present invention will be described in detail below. Epsilon-N- (gamma-glutamyl) lysine (hereinafter, abbreviated as glutamyllysine) applied to the present invention is one of dipeptides (isopeptides) represented by the following structural formula (I), and is in a dipeptide state. Is not found in vivo as a single substance, but as a dipeptide (isopeptide) cross-link formed between a lysine residue and a glutamine residue of a protein such as in the corneal cell membrane, catalyzed by the enzyme transglutaminase. Are known.

[0009]

[Chemical 1]

As a method for obtaining such glutamyllysine, the method described in Biochemistry 2 Vol. 740-745 (1963) or JP-A-51-105014 can be used.

The glutamyl lysine obtained as described above is an odorless white powder, which is hardly soluble or insoluble in various organic solvents such as methanol, ethanol and acetone, but is soluble in alkaline water or acidic water. However, it can be added to various cosmetic bases. Furthermore, this substance does not cause a change with time such as discoloration, change in odor, decomposition and inactivation in various preparations, has no fear of human toxicity and skin damage, and can be safely used. Further, glutamyllysine is characterized by its heat stability, which is advantageous when incorporated into cosmetics.

The glutamyllysine may be used in the form of a salt. By using glutamyl lysine in the form of a salt, it is possible to adjust the acid-base equilibrium (pK value), dissolve not only the alkaline water or acidic water but also neutral water, and dissolve in the system. The stability can be increased.

Examples of the salt form include alkali metal salts such as potassium and sodium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium and triethanolamine, and hydrochlorides. However, in view of solubility, safety, etc., an alkali metal salt is particularly preferable.

In the cosmetic of the present invention, the amount of glutamyl lysine or its salt is usually 0.001 to 10% by weight, preferably 0.01 to 5% by weight, based on the total amount of the cosmetic. is there. If the amount is less than 0.001% by weight, the skin-beautifying effect cannot be sufficiently obtained, and if the amount exceeds 10% by weight, the effect is not enhanced and it is uneconomical. As a method of blending, a method of dissolving glutamyllysine in an aqueous phase component and then mixing with an oil phase component is preferable.

In addition to the above-mentioned glutamyl lysine, the cosmetics of the present invention include various components generally used in pharmaceuticals, cosmetics, etc., that is, an aqueous component, an oil component, a powder component, a surfactant, a moisturizer, and a thickener. Agent, colorant, fragrance, antioxidant, P
An H regulator, a chelating agent, an antiseptic agent, an ultraviolet protective agent, an anti-inflammatory agent, a whitening agent and the like can be added.

As the cosmetic base of the present invention, any of the bases usually used in cosmetics can be used. Although not particularly specified, specific examples thereof include creams, emulsions, oils, lotions, packs, ointments and the like, but creams, emulsions, oils and the like are particularly preferable from the viewpoint of transdermal absorbability.

Here, to describe the features of the present invention, as described above, the amino acids similar to glutamyllysine according to the present invention have been incorporated in cosmetics such as cream and milk for the purpose of emulsifying effect. Though
In a situation where the skin water retention ability and the effect of improving the stratum corneum were not yet sufficient, glutamyllysine has a significantly higher effect of enhancing the skin moisture retention function and the effect of improving the stratum corneum than the aforementioned substances. It was discovered that there was such a thing and aimed at application to cosmetics.

Next, in order to demonstrate how the cosmetics of the present invention are excellent in terms of the skin-beautifying effect, Examples 2 and 3 described below are used.
Using the milky lotion and hand cream shown in, the actual use test was carried out to confirm the efficacy. As a comparative product, the emulsion prepared by replacing glutamyllysine in the emulsion of Example 2 described later with lysine (Comparative Product 1) and the emulsion prepared by replacing casein (Comparative Product 2) and the hand cream of Example 3 described below were used. Hand cream prepared by replacing glutamine lysine with glutamine (comparative product 3) and hand cream prepared by replacing casein (comparative product 4)
And were used. The test method is as shown below.

(Test method) 120 adult Japanese girls with dry skin, 20 each in 6 groups (A to F)
Group). On the face of group A, the emulsion of the present invention, on the face of group B, the emulsion of comparative product 1, and on the face of group C, comparative product 2
Emulsion, the hand cream of the present invention on the fingers of group D, the hand cream of comparative product 3 on the fingers of group E,
The hand cream of Comparative Product 4 was applied to the fingers of Group F for 4 weeks each. Improvement status of various evaluation factors after 4 weeks,
And the state of spontaneous exacerbation was compared between groups. The rough skin condition is evaluated by isolating the stratum corneum from the facial skin by a tape stripping method, and by the method described in JP-A-63-113358, the degree of stratum corneum detachment and the presence or absence of nucleated cells are observed by an optical microscope of the stratum corneum. Was evaluated on a 5-point scale. The results are shown in Table 1, Table 2 and Table 3.

[0020]

[Table 1]

[0021]

[Table 2]

[0022]

[Table 3]

As shown in the results of Tables 1, 2 and 3, the emulsion of the present invention gave better results in all the evaluation items than the emulsion of the comparative product, and in particular, improved dry feeling. It was proved that the rough skin was remarkably improved and the skin-beautifying effect was excellent. Further, the hand cream of the present invention also showed a remarkable improvement as compared with the hand cream of the comparative product, and it was revealed that it has an effect of suppressing natural deterioration such as rough skin.

As an opinion other than the above-mentioned evaluation factors, it was also clarified at the same time that the cosmetic material of the present invention has almost no harmful effects such as stickiness during use.

[0025]

EXAMPLES Examples of the present invention will be shown below. The mixing ratio is% by weight.

[0026]

Example 1 Lotion (Prescription) (A) POE (20) sorbitan monolaurate 1.5 POE (20) lauryl ether 0.5 ethanol 10.0 γ-tocopherol 0.02 (B) glycerin 5.0 Propylene glycol 4.0 Citric acid 0.15 Sodium citrate 0.1 Glutamyl lysine sodium salt 0.03 Purified water 78.7

(Production Method) The components of (A) are combined and dissolved at room temperature. on the other hand,
Each component of (B) is also dissolved at room temperature and added to the formulation of (A) to be solubilized.

[0028]

Example 2 Emulsion (prescription) (A) POE (20) hydrogenated castor oil 1.5 coconut oil fatty acid monoglyceride 1.0 oleic acid triglyceride 7.5 (B) glycerin 2.5 refined water 86.3 glutamyllysine 1.0 (C) Perfume 0.2

(Preparation Method) The ingredients of (A) are combined and mixed by heating to 70 ° C.
The respective components of (B) are combined and mixed by heating at 70 ° C., the formulation amount of (A) is added thereto to emulsify, and (C) is added while cooling.

[0030]

Example 3 Hand Cream (Formulation) (A) Vaseline 18.0 Cetanol 8.0 POE (20) Oleyl ether 1.4 Sorbitan monostearate 0.8 (B) Preservative 0.3 Purified water 69 .3 Glutamyllysine 2.0 (C) Fragrance 0.2

(Preparation Method) The ingredients of (A) are combined, heated and mixed to 70 ° C.
The respective components of (B) are combined and mixed by heating at 70 ° C., the formulation amount of (A) is added thereto to emulsify, and (C) is added while cooling.

[0032]

Example 4 Oil-in-water cream (prescription) (A) POE (30) cetyl ether 2.0 glycerin monostearate 10.0 liquid paraffin 10.0 vaseline 4.0 cetanol 5.0 γ-tocopherol 0.05 BHT 0.01 2-Hydroxy-4-methoxybenzophenone 0.5 Butylparaben 0.2 (B) Propylene glycol 10.0 Glutamyllysine sodium salt 3.0 Purified water 55.24

(Preparation Method) The components of (A) are combined and heated to 80.degree. The components of (B) are combined and heated to 80 ° C. The formulation of (A) is added to the formulation of (B) with stirring to emulsify, and then cooled.

[0034]

Example 5 Emulsion (Formulation) (A) Synthetic Geyrow 2.5 Cetanol 1.0 Squalane 4.0 Polyethylene glycol monostearate (25EO) 2.2 Glycerin monostearate 0.5 Butylparaben 0.1 γ- Tocopherol 0.05 BHT 0.01 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane 0.5 (B) 1,3-butylene glycol 3.0 propylene glycol 7.0 xanthan gum 0.1 Carboxy vinyl polymer 0.2 Caustic potassium 0.2 Glutamyl lysine 0.5 Purified water 78.14

(Preparation Method) (A) and (B) are dissolved at 70 ° C. with stirring. (A) is added to (B), preliminary emulsification is performed, and the mixture is homogenized with a homomixer. After emulsification, the mixture is cooled to 30 ° C. with stirring.

[0036]

EFFECTS OF THE INVENTION According to the present invention, compared with conventionally known rough skin improving agents and moisturizers, skin conditions such as rough skin, lack of gloss and fine wrinkles are improved, and moisture is imparted by retaining skin moisture. It is of course possible to use the cosmetics with excellent skin-beautifying effects and without any harmful effect on the touch.

 ----------------------------------------------------------------------------------------------------------------------------------------- ─── Continuation of the front page (72) Inventor Yumiko Otakachi 27, Takashimadai, Kanagawa-ku, Yokohama, Kanagawa 1 Polar Chemical Industry Co., Ltd. Yokohama Research Institute (72) Masahiro Sato, Takashima, Kanagawa-ku, Yokohama, Japan Address 27, No. 1 Polar Chemical Industry Co., Ltd. Yokohama Laboratory

Claims (2)

[Claims] 1. A cosmetic composition comprising epsilon-N- (gamma-glutamyl) lysine (ε-N- (γ-glutamyl) lysine) or a salt thereof. 2. The cosmetic according to claim 1, wherein the amount of epsilon-N- (gamma-glutamyl) lysine or a salt thereof is 0.001 to 10% by weight based on the total amount of the cosmetic.