CN109152815B - 用于癌症免疫治疗的具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 - Google Patents
用于癌症免疫治疗的具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 Download PDFInfo
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211209646.1A CN116440176A (zh) | 2016-02-25 | 2017-02-25 | 具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662300066P | 2016-02-25 | 2016-02-25 | |
| US62/300,066 | 2016-02-25 | ||
| PCT/US2017/019548 WO2017147553A2 (en) | 2016-02-25 | 2017-02-25 | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211209646.1A Division CN116440176A (zh) | 2016-02-25 | 2017-02-25 | 具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109152815A CN109152815A (zh) | 2019-01-04 |
| CN109152815B true CN109152815B (zh) | 2022-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780025759.7A Expired - Fee Related CN109152815B (zh) | 2016-02-25 | 2017-02-25 | 用于癌症免疫治疗的具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
| CN202211209646.1A Pending CN116440176A (zh) | 2016-02-25 | 2017-02-25 | 具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211209646.1A Pending CN116440176A (zh) | 2016-02-25 | 2017-02-25 | 具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10512662B2 (https=) |
| EP (1) | EP3419648A4 (https=) |
| JP (3) | JP7025339B2 (https=) |
| KR (1) | KR20180133395A (https=) |
| CN (2) | CN109152815B (https=) |
| AU (2) | AU2017222686B2 (https=) |
| BR (1) | BR112018016949A2 (https=) |
| CA (1) | CA3015650A1 (https=) |
| IL (1) | IL261306A (https=) |
| MX (2) | MX2018010204A (https=) |
| SG (1) | SG11201807051VA (https=) |
| WO (1) | WO2017147553A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300622A (zh) | 2015-02-25 | 2022-11-08 | 纪念斯隆-凯特琳癌症中心 | 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合 |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| KR20180133395A (ko) | 2016-02-25 | 2018-12-14 | 메모리얼 슬로안 케터링 캔서 센터 | 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스 |
| IL261321B2 (en) | 2016-02-25 | 2023-12-01 | Memorial Sloan Kettering Cancer Center | Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors |
| WO2018209315A1 (en) | 2017-05-12 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| EP3703723A4 (en) | 2017-10-31 | 2021-12-15 | KaliVir Immunotherapeutics, Inc. | ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION |
| US20210177964A1 (en) * | 2017-11-06 | 2021-06-17 | Memorial Sloan Kettering Cancer Center | Heat-inactivated vaccinia virus as a vaccine immune adjuvant |
| WO2019147982A1 (en) * | 2018-01-26 | 2019-08-01 | Celldex Therapeutics, Inc. | Methods of treating cancer with dendritic cell mobilizing agents |
| CA3093696A1 (en) * | 2018-03-13 | 2019-09-19 | Memorial Sloan Kettering Cancer Center | Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy |
| MX2021003013A (es) | 2018-09-15 | 2021-08-11 | Memorial Sloan Kettering Cancer Center | Poxvirus recombinantes para inmunoterapia contra cáncer. |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| AU2020366460A1 (en) * | 2019-10-16 | 2022-03-24 | Kalivir Immunotherapeutics, Inc. | Producer viruses for generation of retroviruses in SITU |
| CN110747174A (zh) * | 2019-10-30 | 2020-02-04 | 青岛宁逸生物科技有限公司 | 一种用于肿瘤治疗的重组病毒 |
| CR20220220A (es) | 2019-11-18 | 2022-09-20 | Janssen Biotech Inc | Vacunas basadas en calr y jak2 mutantes y sus usos |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| TW202227621A (zh) | 2020-11-19 | 2022-07-16 | 美商凱立凡爾免疫治療股份有限公司 | 重塑腫瘤微環境的溶瘤免疫療法 |
| BR112023022681A2 (pt) | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
| KR102806894B1 (ko) | 2021-12-17 | 2025-05-15 | 함안군 | 분산성이 개선된 식사 대용 간식의 제조방법 |
| WO2024213767A1 (en) * | 2023-04-14 | 2024-10-17 | Institut National de la Santé et de la Recherche Médicale | Engraftment of mesenchymal stromal cells engineered to stimulate immune infiltration in tumors |
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| US20080181870A1 (en) * | 2004-08-12 | 2008-07-31 | Cedars-Sinai Medical Center | Combined Gene Therapy for the Treatment of Macroscopic Gliomas |
| EP2136633B1 (en) * | 2007-03-15 | 2015-10-28 | SillaJen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
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| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| ATE298370T1 (de) | 1994-04-29 | 2005-07-15 | Baxter Healthcare Sa | Rekombinante poxviren mit fremdenpolynukleotiden in wichtigen regionen |
| US6093700A (en) | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
| DE69519521T2 (de) | 1994-10-03 | 2001-06-28 | The Government Of The United States Of America, As Represented By The Secretary National Institute Of Health | Zusammensetzung enthaltend ein antigen exprimierendes rekombinantes virus und ein immunstimulierendes molekül exprimierendes rekombinantes virus |
| US6004777A (en) | 1997-03-12 | 1999-12-21 | Virogenetics Corporation | Vectors having enhanced expression, and methods of making and uses thereof |
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