CN109125194B - Air cushion foundation with blue light resisting effect and preparation method thereof - Google Patents

Air cushion foundation with blue light resisting effect and preparation method thereof Download PDF

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CN109125194B
CN109125194B CN201811305100.XA CN201811305100A CN109125194B CN 109125194 B CN109125194 B CN 109125194B CN 201811305100 A CN201811305100 A CN 201811305100A CN 109125194 B CN109125194 B CN 109125194B
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foundation
air
colorant
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CN109125194A (en
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苏晋峰
邓伟健
林锦雄
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Guangzhou Aibei Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides an air foundation having anti-blue light efficacy, the foundation comprising: an emollient, an active efficacy ingredient, and water as a solvent; the active effective components comprise an active effective component A accounting for 0.05-0.50% of the weight of the air cushion foundation and an active effective component B accounting for 0.50-2.0% of the weight of the air cushion foundation, wherein the active effective component A comprises melanin, pentanediol and ethylhexyl glycerin, and the active effective component B comprises a Lespedeza capitata leaf/stem extract, 1, 3-propanediol and water. The air cushion foundation of the invention has reasonable mixture ratio of the extract of the leaf/stem of the Lespedeza capitata and the melanin, protects the skin from radiation damage, controls the maintenance of physiological rhythm, resynchronizes cells and restores normal rhythm, has good effect on pre-defense and restoration of blue light, and has good effect on blue light resistance. The preparation method provided by the invention is simple in process and low in cost, and the prepared air cushion foundation with the blue light resisting effect is good in effect.

Description

Air cushion foundation with blue light resisting effect and preparation method thereof
Technical Field
The invention relates to the field of cosmetics, in particular to an air cushion foundation with a blue light resisting effect and a preparation method thereof.
Background
Blue light is adjacent to uv light, second in wavelength only. In visible light, the shorter the wavelength, the higher the energy, so blue light is more harmful to the human body than other visible light. Blue light is not only present in sunlight, but also in computer monitors, tablet computers, mobile phones, digital products, display screens, LED lights, and even neon lights for automobiles in a larger amount in modern life, so that we are exposed to blue light every day, whether indoors or outdoors.
Of the sunscreen products that we use on a daily basis, both physical and chemical sunscreen products are more or less effective against blue light. However, because the wavelength of ultraviolet light is below 400nm, the current sunscreen agents used in cosmetics mainly resist UVA and UVB, and the protection effect on harmful blue light at 400-450nm is very limited.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides the air cushion foundation with the blue light resisting effect and the preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: an air-based foundation having anti-blue efficacy, the foundation comprising: an emollient, an active efficacy ingredient, and water as a solvent;
the active effect ingredients comprise 0.05-0.50% of active effect ingredient A and 0.50-2.0% of active effect ingredient B, wherein the active effect ingredient A comprises melanin, pentanediol and ethylhexyl glycerin, and the active effect ingredient B comprises an extract of leaves/stems of Lespedeza CAPITATA (Lespedeza CAPITATA), 1, 3-propylene glycol and water;
the water used as the solvent accounts for 25.0-60.0% of the weight of the air cushion foundation.
Melanin is widely present in various animals and plants, and the precursor is leucine or tryptophan, and plays a role in protecting the skin from radiation damage in the horny layer of a human body; melanin in active ingredient A: (
Figure BDA0001851384980000021
HEV Melanin) is prepared from plant-derived tyrosine through synthesis, enzyme digestion, and selectivityThe fragments which absorb high-energy visible light of 400-500nm, such as blue light, are intercepted, the absorption of an infrared region (600-700nm) is less, and the content of collagen and elastin in dermis is improved by infrared light energy, so that the collagen and elastin plays an important role in skin; the melanin molecular weight is controlled at 5000-; warp beam
Figure BDA0001851384980000022
The number of gene changes caused by blue light irradiation is greatly reduced in the HEV Melanin treated cells.
Glycosylated brass, echinacoside, isoschaftoside and other components in the leaf/stem extract of Lespedeza CAPITATA (Lespedeza CAPITATA) can directly control the maintenance of physiological rhythm, so that the cells can be resynchronized and recovered to normal rhythm, and the extract has good effect on pre-defense and repair of blue light; enabling AQP-3 (aquaporin) to show normal regular change and maintain the moisture balance of the skin; enhancing the Nrf2 pathway to limit blue light damage, reducing the accumulation of carbonylated proteins, and promoting skin detoxification; reducing the damage of the skin after being irradiated by blue light by inhibiting the generation of ROS (reactive oxygen species) and reducing free radicals generated by induced oxidative stress; can improve local microcirculation and has vasoconstriction effect, so that vasodilatation caused by long-term exposure to blue light, and irritation and local edema caused by oxidation reaction are avoided.
Preferably, the active effect ingredients comprise an active effect ingredient A accounting for 0.05-0.30% of the weight of the air cushion foundation and an active effect ingredient B accounting for 0.50-1.5% of the weight of the air cushion foundation, wherein melanin in the active effect ingredient A accounts for 10% of the weight of the active effect ingredient A, and the head-shaped bearded branch cotyledon/stem extract in the active effect ingredient B accounts for 2% of the weight of the active effect ingredient B.
Preferably, the active effect ingredients comprise an active effect ingredient A accounting for 0.1% of the weight of the air cushion foundation and an active effect ingredient B accounting for 1% of the weight of the air cushion foundation, wherein melanin accounts for 10% of the weight of the active effect ingredient A, and the head-shaped bearded leaf/stem extract accounts for 2% of the weight of the active effect ingredient B.
Preferably, the foundation further comprises an emulsifier; the emollient comprises phenyl trimethicone accounting for 1-10% of the weight of the air cushion foundation, isononyl isononanoate accounting for 1-5% of the weight of the air cushion foundation, diisostearyl malate accounting for 1-10% of the weight of the air cushion foundation and cyclopentasimethicone accounting for 10-30% of the weight of the air cushion foundation; the emulsifier comprises a mixture of bis-PEG/PPG-14/14 polydimethylsiloxane and cyclopenta-polydimethylsiloxane accounting for 1-4% of the weight of the air-cushion foundation and PEG-10 polydimethylsiloxane accounting for 1-4% of the weight of the air-cushion foundation.
Preferably, the emollient comprises phenyl trimethicone in an amount of 3-8% by weight of the air foundation, isononyl isononanoate in an amount of 1-3% by weight of the air foundation, diisostearyl malate in an amount of 2-5% by weight of the air foundation, and cyclopentadimethicone in an amount of 15-20% by weight of the air foundation.
Preferably, the foundation further comprises a skin feel modifier and a moisturizer; the skin feel modifier comprises boron nitride accounting for 0.10-2.0% of the weight of the air cushion foundation and chinlon-12 accounting for 0.50-4.0% of the weight of the air cushion foundation; the humectant accounts for 1% -10.0% of the weight of the air cushion foundation.
Preferably, the foundation further comprises a film former, a thickener, a preservative, a colorant, and a viscosity modifier;
the film forming agent comprises a mixture of cyclopentadidimethyl siloxane and acrylic acid (ester)/polydimethylsiloxane copolymer, and the film forming agent accounts for 1% -5% of the weight of the air cushion foundation;
the thickening agent comprises a mixture of cyclopentadimethylsiloxane, disteardimonium hectorite and propylene carbonate, and accounts for 1-6% of the weight of the air cushion foundation;
the preservative comprises phenoxyethanol, ethylhexyl glycerin and caprylyl glycol, and accounts for 0.15-0.8% of the air cushion foundation by weight;
the colorant comprises titanium dioxide, CI 77492, CI 77491 and CI 77499, and accounts for 5.17-23.0% of the air cushion foundation by weight;
the viscosity control agent accounts for 0.1-1.5% of the weight of the air cushion foundation.
Preferably, the colorants comprise colorant a in an amount of 5% to 20% by weight of the air foundation, colorant B in an amount of 0.1% to 2.0% by weight of the air foundation, colorant C in an amount of 0.05% to 0.50% by weight of the air foundation, and colorant D in an amount of 0.02% to 0.50% by weight of the air foundation; the titanium dioxide in the colorant A accounts for 92% of the weight of the colorant A, the CI 77492 in the colorant B accounts for 95% of the weight of the colorant B, the CI 77491 in the colorant C accounts for 95% of the weight of the colorant C, and the CI 77499 in the colorant D accounts for 95% of the weight of the colorant D.
As a preferred air-cushion foundation of the present invention, the air-cushion foundation includes: a colorant, an emollient, a film-forming agent, an emulsifier, a thickener, a skin feel modifier, a preservative, a humectant, a viscosity controlling agent, an active efficacy ingredient and water as a solvent;
the emollient comprises phenyl trimethicone at 6% by weight of the foundation, isononyl isononanoate at 2% by weight of the foundation, diisostearyl malate at 4% by weight of the foundation, and cyclopentadimethicone at 18% by weight of the foundation;
the emulsifier comprises a mixture of bis-PEG/PPG-14/14 polydimethylsiloxane and cyclopentadimethylsiloxane accounting for 2% of the weight of the air-cushion foundation and PEG-10 polydimethylsiloxane accounting for 2% of the weight of the air-cushion foundation, wherein the weight ratio of the bis-PEG/PPG-14/14 polydimethylsiloxane to the cyclopentadimethylsiloxane in the emulsifier is as follows: 85: 15;
the active functional ingredients comprise an active functional ingredient A accounting for 0.1% of the weight of the air cushion foundation and an active functional ingredient B accounting for 1% of the weight of the air cushion foundation, wherein the active functional ingredient A comprises melanin, pentanediol and ethylhexyl glycerol, and the active functional ingredient B comprises a Lespedeza capitata leaf/stem extract, 1, 3-propanediol and water, wherein the weight ratio of the melanin, the pentanediol and the ethylhexyl glycerol is 10:70:20, and the weight ratio of the Lespedeza capitata leaf/stem extract, the 1, 3-propanediol and the water is 2:50: 48;
the skin feel modifier comprises boron nitride accounting for 0.8 percent of the weight of the air cushion foundation and chinlon-12 accounting for 2 percent of the weight of the air cushion foundation;
the film forming agent comprises a mixture of cyclopentadidimethyl siloxane and acrylic acid (ester)/polydimethylsiloxane copolymer in a weight ratio of 7:3, and the film forming agent accounts for 3% of the weight of the air foundation;
the thickener comprises a mixture of cyclopentadimethylsiloxane, disteardimonium hectorite and propylene carbonate in a weight ratio of 77:18:5, and accounts for 4% of the weight of the air cushion foundation;
the preservative comprises 0.4% of a mixture of phenoxyethanol and ethylhexyl glycerol and 0.1% of a mixture of caprylyl glycol and ethylhexyl glycerol, wherein the weight ratio of the phenoxyethanol to the ethylhexyl glycerol is 9:1, and the weight ratio of the caprylyl glycol to the ethylhexyl glycerol is 7: 3;
the colorant comprises colorant A accounting for 9 percent of the weight of the air foundation, colorant B accounting for 1.2 percent of the weight of the air foundation, colorant C accounting for 0.18 percent of the weight of the air foundation and colorant D accounting for 0.07 percent of the weight of the air foundation; the colorant A comprises titanium dioxide, isopropyl titanium triisostearate, polydimethylsiloxane and alumina in a weight ratio of 92:3:3:2, and the colorant B comprises CI 77492, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant C comprises CI 77491, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant D comprises CI 77499, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2;
the humectant is glycerin, and the glycerin accounts for 5% of the weight of the air cushion foundation;
the viscosity control agent is sodium chloride, and the sodium chloride accounts for 1% of the weight of the air cushion foundation;
the water as a solvent accounted for 38.15% by weight of the air foundation.
The invention also provides a preparation method of any one of the air foundation with the blue light resisting effect, which comprises the following steps:
(1) uniformly mixing and grinding the colorant A, the colorant B, the colorant C and the colorant D in a proper amount of emollient to obtain color paste;
(2) uniformly mixing the color paste obtained in the step (1), the balance of emollient, film-forming agent, emulsifier, thickener and skin feel modifier, homogenizing until the mixture is completely uniform, and stirring for defoaming; obtaining an oil phase;
(3) mixing glycerol and antiseptic uniformly, adding water, sodium chloride, effective active ingredient A and effective active ingredient B, and mixing uniformly to obtain water phase;
(4) and slowly adding the water phase into the stirred oil phase, homogenizing, stirring and defoaming for 10min to obtain the air cushion foundation with the blue light resisting effect.
The invention has the beneficial effects that: the invention provides an air cushion foundation with blue light resistance, the ratio of the leaf/stem extract of Lespedeza CAPITATA and melanin in the air cushion foundation is reasonable, the skin is protected from radiation damage, the maintenance of physiological rhythm is controlled, the cells are resynchronized and the normal rhythm is recovered, the air cushion foundation has good effects on pre-defense and repair of blue light, and the air cushion foundation has good blue light resistance. The preparation method provided by the invention is simple in process and low in cost, and the prepared air cushion foundation with the blue light resisting effect is good in effect.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
An air foundation having an anti-blue light effect as an embodiment of the present invention, the foundation comprising: a colorant, an emollient, a film-forming agent, an emulsifier, a thickener, a skin feel modifier, a preservative, a humectant, a viscosity controlling agent, an active efficacy ingredient and water as a solvent;
the emollient comprises phenyl trimethicone at 6% by weight of the foundation, isononyl isononanoate at 2% by weight of the foundation, diisostearyl malate at 4% by weight of the foundation, and cyclopentadimethicone at 18% by weight of the foundation;
the emulsifier comprises a mixture of bis-PEG/PPG-14/14 polydimethylsiloxane and cyclopentadimethylsiloxane accounting for 2% of the weight of the air-cushion foundation and PEG-10 polydimethylsiloxane accounting for 2% of the weight of the air-cushion foundation, wherein the weight ratio of the bis-PEG/PPG-14/14 polydimethylsiloxane to the cyclopentadimethylsiloxane is as follows: 85: 15;
the active functional ingredients comprise an active functional ingredient A accounting for 0.1% of the weight of the air cushion foundation and an active functional ingredient B accounting for 1% of the weight of the air cushion foundation, wherein the active functional ingredient A comprises melanin, pentanediol and ethylhexyl glycerol, and the active functional ingredient B comprises a Lespedeza capitata leaf/stem extract, 1, 3-propanediol and water, wherein the weight ratio of the melanin, the pentanediol and the ethylhexyl glycerol is 10:70:20, and the weight ratio of the Lespedeza capitata leaf/stem extract, the 1, 3-propanediol and the water is 2:50: 48;
the skin feel modifier comprises boron nitride accounting for 0.8 percent of the weight of the air cushion foundation and chinlon-12 accounting for 2 percent of the weight of the air cushion foundation;
the film forming agent comprises a mixture of cyclopentadidimethyl siloxane and acrylic acid (ester)/polydimethylsiloxane copolymer in a weight ratio of 7:3, and the film forming agent accounts for 3% of the weight of the air foundation;
the thickening agent comprises a mixture of 77:18:5 ring penta dimethyl siloxane, distearyl dimethyl ammonium hectorite and propylene carbonate, and accounts for 4% of the weight of the air cushion foundation;
the preservative comprises 0.4% of a mixture of phenoxyethanol and ethylhexyl glycerol and 0.1% of a mixture of caprylyl glycol and ethylhexyl glycerol, wherein the weight ratio of the phenoxyethanol to the ethylhexyl glycerol is 9:1, and the weight ratio of the caprylyl glycol to the ethylhexyl glycerol is 7: 3;
the colorant comprises colorant A accounting for 9 percent of the weight of the air foundation, colorant B accounting for 1.2 percent of the weight of the air foundation, colorant C accounting for 0.18 percent of the weight of the air foundation and colorant D accounting for 0.07 percent of the weight of the air foundation; the colorant A comprises titanium dioxide, isopropyl titanium triisostearate, polydimethylsiloxane and alumina in a weight ratio of 92:3:3:2, and the colorant B comprises CI 77492, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant C comprises CI 77491, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant D comprises CI 77499, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2;
the humectant is glycerin, and the glycerin accounts for 5% of the weight of the air cushion foundation;
the viscosity control agent is sodium chloride, and the sodium chloride accounts for 1% of the weight of the air cushion foundation;
the water as a solvent accounted for 38.15% by weight of the air foundation.
The preparation method of the air foundation with the blue light resisting effect comprises the following steps:
(1) uniformly mixing and grinding the colorant A, the colorant B, the colorant C and the colorant D in a proper amount of emollient to obtain color paste;
(2) uniformly mixing the color paste obtained in the step (1), the balance of emollient, film-forming agent, emulsifier, thickener and skin feel modifier, homogenizing until the mixture is completely uniform, and stirring for defoaming; obtaining an oil phase;
(3) mixing glycerol and antiseptic uniformly, adding water, sodium chloride, effective active ingredient A and effective active ingredient B, and mixing uniformly to obtain water phase;
(4) and slowly adding the water phase into the stirred oil phase, homogenizing, stirring and defoaming for 10min to obtain the air cushion foundation with the blue light resisting effect.
Examples 2 to 6
As an example of the air foundation having the blue light resistance effect according to the present invention, the formulation thereof is as shown in the following table 1:
table 1 formulation of air-cushion foundation having anti-blue light efficacy of examples 2-6
Figure BDA0001851384980000071
Figure BDA0001851384980000081
Figure BDA0001851384980000091
Examples 7 to 11
As an example of the air foundation having the blue light resistance effect according to the present invention, the formulation of the air foundation having the blue light resistance effect is shown in the following table 2:
table 2 formulation of air-cushion foundation having anti-blue light efficacy of examples 7-11
Figure BDA0001851384980000101
Figure BDA0001851384980000111
Figure BDA0001851384980000121
Comparative examples 1 to 3
The air foundation, which is a comparative example of the present invention, has the formulation shown in table 3:
TABLE 3 formulation of air-cushion foundations of comparative examples 1-3
Figure BDA0001851384980000122
Figure BDA0001851384980000131
Example 12
The use efficacy of the air foundations of examples 1 to 11 and comparative examples 1 to 3 was examined, and the results are shown in table 4:
1. ROS test
Principle of experiment
ROS (reactive oxygen species) are required to produce a series of reactive oxygen species during metabolism. Excessive ROS and other oxidants can destroy the enzyme and non-enzyme antioxidant defense system of the skin, so that the body is easily damaged and in various pathological states, skin-related diseases such as skin aging, immunosuppression, skin tumor and the like occur, and ultraviolet light and blue light are one of important factors for inducing the generation of ROS and causing photoaging.
The active Oxygen detection Kit (Reactive Oxygen specifices Assay Kit) is a Kit for detecting active Oxygen by using a fluorescent probe DCFH-DA. DCFH-DA has no fluorescence, can freely pass through cell membranes, and can be hydrolyzed by intracellular esterase to generate DCFH after entering cells. DCFH, however, does not permeate the cell membrane, thus allowing the probe to be easily loaded into the cell. Intracellular reactive oxygen species can oxidize non-fluorescent DCFH to produce fluorescent DCF. The level of active oxygen in the cells is reflected by detecting the fluorescence intensity of DCF.
Experimental methods
(1) Diluting 20 mul of DCFH-DA with 20ml of serum-free culture solution according to a ratio of 1: 1000;
(2) taking fibroblast culture solution (with cell concentration of one million to twenty million/ml), adding into 24-hole plates, making 3 parallel plates in each group, adding 1ml of cell culture solution into each hole, and culturing in a cell culture box;
(3) after 24 hours of incubation, the cell culture medium was removed and 1ml of diluted DCFH-DA was added to each well (the volume added was sufficient to cover the cells);
(4) incubating the cells in a cell culture box at 37 ℃ for 20 minutes;
(5) removing the incubated DCFH-DA diluent, adding 1ml of serum-free cell culture solution into each hole to wash the cells (washing is repeated for three times to fully remove DCFH-DA which does not enter the cells), and adding 1ml of cell culture solution into each hole after washing;
(6) the intensity of fluorescence (i.e., OD value) before stimulation was measured using 488nm excitation wavelength and 525nm emission wavelength under a microplate reader, and the average value of the fluorescence intensities measured at this time was designated as OD0；
(7) Adding 20 mul of the test sample solution of examples 1-11 and comparative examples 1-3 into each hole respectively, and continuously culturing for 4h under an artificial blue light source; (note: since the emulsions of examples 1 to 11 and comparative examples 1 to 3 were of a non-transparent structure and the formulations contained toner, which had a large influence on the observation of fluorescence intensity, the test was conducted by replacing the raw materials other than the active efficacy ingredient with an equal amount of water as a sample);
(8) after 4 hours, the fluorescence intensity of each group after stimulation is respectively detected under an enzyme-linked immunosorbent assay (ELIASA) by using 488nm excitation wavelength and 525nm emission wavelength at 1h, 2h and 4h, and the measured average values are respectively marked as OD1、OD2、OD3The results are shown in Table 4.
TABLE 4
Group of OD0(A.U.) OD1(A.U.) OD2(A.U.) OD3(A.U.)
Example 1 103.4 211.7 165.1 114.5
Example 2 102.6 402.1 373.1 334.2
Example 3 103.1 371.2 331.9 297.4
Example 4 102.9 208.9 164.3 114.1
Example 5 103.2 208.2 163.9 113.5
Example 6 102.8 205.8 162.5 112.4
Example 7 103.0 226.1 215.1 202.8
Example 8 103.1 224.3 194.5 173.1
Example 9 102.8 211.3 164.9 114.4
Example 10 102.8 211.0 164.9 113.9
Example 11 103.3 211.1 164.5 113.5
Comparative example 1 102.8 428.2 373.8 328.6
Comparative example 2 103.0 283.2 274.2 243.7
Comparative example3 102.9 498.3 471.2 422.4
(1) From examples 1-5 it can be seen that: with the increase of the concentration of the active efficacy component A, the amount of generated ROS is gradually reduced, but when the addition amount exceeds 0.1%, the reduction amount of ROS is not obvious, and the defense effect tends to be saturated;
(2) from examples 1 and 7-11 it can be seen that: with the increase of the concentration of the active effective component B, the amount of generated ROS is gradually reduced, but when the addition amount exceeds 1%, the reduction amount of ROS is not obvious, and the repairing effect tends to be saturated;
(3) from example 1 and comparative examples 1 to 3, it can be seen that: the active functional component A has a good effect of resisting blue light, can effectively reduce the generation of ROS, but has a relatively general effect of eliminating the generated ROS; the active efficacy ingredient B has weak effect on resisting blue light, but has better effect of eliminating generated ROS after stopping blue light irradiation. When the active functional components A and B are compounded according to the proportion of 0.1% + 1%, the blue light direct resisting and stimulated repairing effects can be better achieved.
2. Ultraviolet spot test
The experimental principle is as follows: UV Spots are the result of aggregation of melanin pigment under the epidermis when the skin is irradiated with high-energy light such as ultraviolet light or blue light. The ultraviolet spot test experiment can objectively reflect potential pigment Spots under the epidermis (positively correlated with skin photoaging) by shooting through ultraviolet light with a peak value of 365nm, the ultraviolet spot test experiment measures the ultraviolet spot through the 'UV Spots' detection function of a Visia skin detector, the shot picture has black pigment Spots distributed on the whole face, the score is carried out through a cloud database of the instrument and an algorithm of the instrument, and the lower the score is, the more the ultraviolet spot is.
Experimental methods
(1) Before receiving the blue light stimulation test, the facial skin of the subject was subjected to an ultraviolet spot test using a Visia skin tester, and the time point was designated as T0(ii) a The subjects were then exposed to artificial blue light for 10min, and after 2h the stain measurements were again performed, and the time point was recorded as T1；
(2) Starting on day 2, the subjects were irradiated with artificial blue light for 10min after applying the air-cushion foundation samples of examples 1 to 11 and comparative examples 1 to 3, and the time point was designated as T after 2h for color spot measurement2；
(3) Repeating the operation of the step (2) on the 3 th to 7 th days by analogy, and respectively recording the test time points as T3、T4、T5、T6、T7；
(4) The use test was carried out for 5 subjects in each example/comparative example, each subject was applied to the face, the scores of all subjects were summed up for each group, and the average value was calculated, and the results are shown in table 5, wherein the test subjects were applied to the face for evaluation items, and the subjects were tried 1 time per day for one week continuously.
TABLE 5
Figure BDA0001851384980000171
(1) From examples 1-5 it can be seen that: with the increase of the concentration of the active efficacy component A, the color spots caused by blue light are gradually reduced, but when the addition amount exceeds 0.1%, the reduction amount of the color spots is not obvious, and the blue light resistant effect tends to be saturated;
(2) from examples 1 and 7-11 it can be seen that: with the increase of the concentration of the active efficacy component B, the color spots caused by blue light are gradually reduced, but when the addition amount exceeds 1%, the reduction amount of the color spots is not obvious, and the blue light resistant effect tends to be saturated;
(3) from example 1 and comparative examples 1 to 3, it can be seen that: the active functional component A has a good resistance effect on blue light, can effectively prevent the blue light from directly irradiating the skin, but cannot evaluate whether the generated color spots are eliminated or not due to the continuous irradiation of the blue light in the experiment; the active functional component B has better effect of eliminating the generated color spots. When the active functional components A and B are compounded according to the proportion of 0.1% + 1%, the blue light can be directly resisted and the blue light can be repaired after being irradiated, so that a good effect can be achieved.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. An air-cushion foundation having anti-blue light efficacy, said foundation comprising: an emollient, an active efficacy ingredient, and water as a solvent;
the active effect ingredients comprise an active effect ingredient A accounting for 0.1-0.50% of the weight of the air cushion foundation and an active effect ingredient B accounting for 0.50-2.0% of the weight of the air cushion foundation, wherein the active effect ingredient A comprises melanin, pentanediol and ethylhexyl glycerin, and the active effect ingredient B comprises a Lespedeza capitata leaf/stem extract, 1, 3-propanediol and water;
the emollient comprises phenyl trimethicone accounting for 1-10% of the weight of the air cushion foundation, isononyl isononanoate accounting for 1-5% of the weight of the air cushion foundation, diisostearyl malate accounting for 1-10% of the weight of the air cushion foundation and cyclopentasimethicone accounting for 10-30% of the weight of the air cushion foundation;
the water used as the solvent accounts for 25.0-60.0% of the weight of the air cushion foundation.
2. The air foundation of claim 1, wherein the active effect ingredients comprise 0.1-0.30% by weight of the air foundation of active effect ingredient a in which melanin is 10% by weight of the active effect ingredient a and 0.50-1.5% by weight of the air foundation of active effect ingredient B in which the cotyledon/stem extract of capitulum is 2% by weight of the active effect ingredient B.
3. The air foundation of claim 2, wherein the active efficacy ingredient comprises 0.1% active efficacy ingredient a and 1% active efficacy ingredient B by weight of the air foundation.
4. Air-cushion foundation according to any one of claims 1 to 3, wherein the foundation further comprises an emulsifier;
the emulsifier comprises a mixture of bis-PEG/PPG-14/14 polydimethylsiloxane and cyclopenta-polydimethylsiloxane accounting for 1-4% of the weight of the air-cushion foundation and PEG-10 polydimethylsiloxane accounting for 1-4% of the weight of the air-cushion foundation.
5. The air foundation of claim 4, wherein the emollient comprises phenyl trimethicone at 3% -8% by weight of the air foundation, isononyl isononanoate at 1% -3% by weight of the air foundation, diisostearyl malate at 2% -5% by weight of the air foundation, and cyclopentadimethicone at 15% -20% by weight of the air foundation.
6. The air foundation of claim 5, wherein the foundation further comprises a skin feel modifier and a moisturizer;
the skin feel modifier comprises boron nitride accounting for 0.10-2.0% of the weight of the air cushion foundation and chinlon-12 accounting for 0.50-4.0% of the weight of the air cushion foundation;
the humectant accounts for 1% -10.0% of the weight of the air cushion foundation.
7. The air foundation of claim 5 or 6, wherein the foundation further comprises film formers, thickeners, preservatives, colorants and viscosity modifiers;
the film forming agent comprises a mixture of cyclopentadidimethyl siloxane and acrylic acid (ester)/polydimethylsiloxane copolymer, and the film forming agent accounts for 1% -5% of the weight of the air cushion foundation;
the thickening agent comprises a mixture of cyclopentadimethylsiloxane, disteardimonium hectorite and propylene carbonate, and accounts for 1-6% of the weight of the air cushion foundation;
the preservative comprises phenoxyethanol, ethylhexyl glycerin and caprylyl glycol, and accounts for 0.15-0.8% of the air cushion foundation by weight;
the colorant comprises titanium dioxide, CI 77492, CI 77491 and CI 77499, and accounts for 5.17-23.0% of the air cushion foundation by weight;
the viscosity control agent accounts for 0.1-1.5% of the weight of the air cushion foundation.
8. The air foundation of claim 7, wherein the colorants comprise colorant a at 5% -20% by weight of the air foundation, colorant B at 0.1% -2.0% by weight of the air foundation, colorant C at 0.05% -0.50% by weight of the air foundation, and colorant D at 0.02% -0.50% by weight of the air foundation; the titanium dioxide in the colorant A accounts for 92% of the weight of the colorant A, the CI 77492 in the colorant B accounts for 95% of the weight of the colorant B, the CI 77491 in the colorant C accounts for 95% of the weight of the colorant C, and the CI 77499 in the colorant D accounts for 95% of the weight of the colorant D.
9. The air foundation of claim 1, wherein the foundation comprises: a colorant, an emollient, a film-forming agent, an emulsifier, a thickener, a skin feel modifier, a preservative, a humectant, a viscosity controlling agent, an active efficacy ingredient and water as a solvent;
the emollient comprises phenyl trimethicone at 6% by weight of the foundation, isononyl isononanoate at 2% by weight of the foundation, diisostearyl malate at 4% by weight of the foundation, and cyclopentadimethicone at 18% by weight of the foundation;
the emulsifier comprises a mixture of bis-PEG/PPG-14/14 polydimethylsiloxane and cyclopentadimethylsiloxane accounting for 2% of the weight of the air-cushion foundation and PEG-10 polydimethylsiloxane accounting for 2% of the weight of the air-cushion foundation, wherein the weight ratio of the bis-PEG/PPG-14/14 polydimethylsiloxane to the cyclopentadimethylsiloxane in the emulsifier is 85: 15;
the active functional ingredients comprise an active functional ingredient A accounting for 0.1% of the weight of the air cushion foundation and an active functional ingredient B accounting for 1% of the weight of the air cushion foundation, wherein the active functional ingredient A comprises melanin, pentanediol and ethylhexyl glycerol, and the active functional ingredient B comprises a Lespedeza capitata leaf/stem extract, 1, 3-propanediol and water, wherein the weight ratio of the melanin, the pentanediol and the ethylhexyl glycerol is 10:70:20, and the weight ratio of the Lespedeza capitata leaf/stem extract, the 1, 3-propanediol and the water is 2:50: 48;
the skin feel modifier comprises boron nitride accounting for 0.8 percent of the weight of the air cushion foundation and chinlon-12 accounting for 2 percent of the weight of the air cushion foundation;
the film forming agent comprises a mixture of cyclopentadidimethyl siloxane and acrylic acid (ester)/polydimethylsiloxane copolymer in a weight ratio of 7:3, and the film forming agent accounts for 3% of the weight of the air foundation;
the thickener comprises a mixture of cyclopentadimethylsiloxane, disteardimonium hectorite and propylene carbonate in a weight ratio of 77:18:5, and accounts for 4% of the weight of the air cushion foundation;
the preservative comprises 0.4% of a mixture of phenoxyethanol and ethylhexyl glycerol and 0.1% of a mixture of caprylyl glycol and ethylhexyl glycerol, wherein the weight ratio of the phenoxyethanol to the ethylhexyl glycerol is 9:1, and the weight ratio of the caprylyl glycol to the ethylhexyl glycerol is 7: 3;
the colorant comprises colorant A accounting for 9 percent of the weight of the air foundation, colorant B accounting for 1.2 percent of the weight of the air foundation, colorant C accounting for 0.18 percent of the weight of the air foundation and colorant D accounting for 0.07 percent of the weight of the air foundation; the colorant A comprises titanium dioxide, isopropyl titanium triisostearate, polydimethylsiloxane and alumina in a weight ratio of 92:3:3:2, and the colorant B comprises CI 77492, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant C comprises CI 77491, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2; the colorant D comprises CI 77499, isopropyl titanium triisostearate and polydimethylsiloxane in a weight ratio of 95:3: 2;
the humectant is glycerin, and the glycerin accounts for 5% of the weight of the air cushion foundation;
the viscosity control agent is sodium chloride, and the sodium chloride accounts for 1% of the weight of the air cushion foundation;
the water as a solvent accounted for 38.15% by weight of the air foundation.
10. A method of preparing the air foundation having anti-blue light efficacy according to claim 9, comprising the steps of:
(1) uniformly mixing and grinding the colorant A, the colorant B, the colorant C and the colorant D in a proper amount of emollient to obtain color paste;
(2) uniformly mixing the color paste obtained in the step (1), the balance of emollient, film-forming agent, emulsifier, thickener and skin feel modifier, homogenizing until the mixture is completely uniform, and stirring for defoaming; obtaining an oil phase;
(3) mixing glycerol and antiseptic uniformly, adding water, sodium chloride, effective active ingredient A and effective active ingredient B, and mixing uniformly to obtain water phase;
(4) and slowly adding the water phase into the stirred oil phase, homogenizing, stirring and defoaming for 10min to obtain the air cushion foundation with the blue light resisting effect.
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