CN109125194A - A kind of air cushion foundation cream and preparation method thereof with anti-blue light effect - Google Patents
A kind of air cushion foundation cream and preparation method thereof with anti-blue light effect Download PDFInfo
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- CN109125194A CN109125194A CN201811305100.XA CN201811305100A CN109125194A CN 109125194 A CN109125194 A CN 109125194A CN 201811305100 A CN201811305100 A CN 201811305100A CN 109125194 A CN109125194 A CN 109125194A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of air cushion foundation cream with anti-blue light effect, the foundation cream includes: emollient, active functional component and the water as solvent；The activity functional component includes the active functional component A for accounting for the air cushion foundation cream weight 0.05%-0.50% and the active functional component B for accounting for the air cushion foundation cream weight 0.50%-2.0%, the active components A includes melanin, pentanediol and Sensiva SC50, the activity functional component B includes head shrub lespedeza leaf/stem extraction, 1,3-PD and water.Head shrub lespedeza leaf/stem extraction and melanin proportion in air cushion foundation cream of the invention is reasonable; protect skin from radiation injury; control the maintenance of circadian rhythm; make cell re-synchronization and restores normal rhythm; pre- defence and reparation to blue light have good effect, and have the effect of good anti-blue light.The air cushion foundation cream effect with anti-blue light effect of preparation method simple process and low cost of the invention, preparation is good.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of air cushion foundation cream and its preparation side with anti-blue light effect
Method.
Background technique
Blue light is adjacent with ultraviolet light, and wavelength is only second to ultraviolet light.In visible light, wavelength is shorter, and energy is higher, so blue
Light is bigger for the harm of human body is relative to other visible lights.Blue light is not only present in sunlight, in the life of modern
In a greater amount of be present in computer monitor, tablet computer, mobile phone, digital product, display screen, LED light, even auto lamp neon light
In, so either indoors or outdoor, we are exposed in blue light daily.
In our sunscreen products used in everyday, either physical sunscreen product or chemical sunscreen product, more or less
There will be some effects to the defence of blue light.But due to the wavelength of ultraviolet light in 400nm hereinafter, at present cosmetics use it is sun-proof
Agent is resisted primarily directed to UVA, UVB, extremely limited to the harmful blue light protection effect of 400-450nm.
Summary of the invention
It provides it is an object of the invention to overcome in place of the shortcomings of the prior art a kind of with anti-blue light effect
Air cushion foundation cream and preparation method thereof.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of air cushion foundation cream with anti-blue light effect, institute
Stating foundation cream includes: emollient, active functional component and the water as solvent；
It is described activity functional component include account for the air cushion foundation cream weight 0.05%-0.50% active functional component A and
The active functional component B of the air cushion foundation cream weight 0.50%-2.0% is accounted for, the active components A includes melanin, pentanediol
And Sensiva SC50, the activity functional component B include that head shrub lespedeza (LESPEDEZA CAPITATA) leaf/stem extracts
Object, 1,3- propylene glycol and water；
The water as solvent accounts for the 25.0%-60.0% of the air cushion foundation cream weight.
Melanin is widely present in various animals and plants, and precursor is tyrosine or tryptophan, the work in human keratinous layer
Be protect skin from radiation injury；In active components A melanin (HEV Melanin) by planting
The tyrosine in object source is by synthesizing with after digestion, and selectively interception absorbs 400-500nm, such as blue light high energy visible light
Segment, and infrared region (600-700nm) absorbs less, the content of collagen and elastin laminin in infrared luminous energy promotion corium,
Play a significant role to skin；Melanin molecules amount control in 5000-10000Da, will not penetrate to the skin in cause melanin
It is calm；ThroughHEV Melanin treated cell to because of gene variation quantity caused by blue light illumination significantly
It reduces.
Glycosylation brass in head shrub lespedeza (LESPEDEZA CAPITATA) leaf/stem extraction, thorn bud chrysanthemum glucoside and different
The ingredients such as Schaftoside can directly control the maintenance of circadian rhythm, make cell re-synchronization and restore normal rhythm, to blue light
Pre- defence and reparation have good effect；So that AQP-3 (aquaporin) is shown normal rule variation, maintains skin
Wetting balance；Enhance the limitation blue light damage of Nrf2 approach, reduces the accumulation of carbonylation protein, promote skin removing toxic substances；Pass through suppression
The generation of ROS (active oxygen) processed reduces free radical caused by inductivity oxidative stress, to reduce skin by after blue light illumination
Damage；Can improve local microcirculation and play the role of it is vasoconstrictive, thus because of vasodilation caused by Long Term Contact blue light,
Oxidation reaction leads to stimulation and local edema.
Preferably, the active functional component includes the active effect for accounting for the air cushion foundation cream weight 0.05%-0.30%
Black in the ingredient A and active functional component B for accounting for the air cushion foundation cream weight 0.50%-1.5%, the activity functional component A
Element accounts for the 10% of the active functional component A weight, and head shrub lespedeza leaf/stem extraction accounts for institute in the activity functional component B
State the 2% of active functional component B weight.
Preferably, the active functional component includes accounting for the active functional component A of the air cushion foundation cream weight 0.1% and accounting for
In the active functional component B of the air cushion foundation cream weight 1%, the activity functional component A melanin account for described active effect at
Divide the 10% of A weight, head shrub lespedeza leaf/stem extraction accounts for the active functional component B weight in the activity functional component B
2%.
Preferably, the foundation cream further includes emulsifier；The emollient includes accounting for the air cushion foundation cream weight 1%-10%
Phenyl trimethicone, account for the air cushion foundation cream weight 1%-5% isononyl isononanoate, account for the air cushion foundation cream weight
It measures the diisooctadecanol malate of 1%-10% and accounts for five polydimethylsiloxanes of ring of the air cushion foundation cream weight 10%-30%
Alkane；The emulsifier include account for the air cushion foundation cream weight 1%-4% double-PEG/PPG-14/14 dimethyl silicone polymers and
The mixture of ring five dimethyl silicone polymer and the PEG-10 Polydimethylsiloxane for accounting for the air cushion foundation cream weight 1%-4%.
Preferably, the emollient includes the phenyl trimethicone for accounting for the air cushion foundation cream weight 3%-8%, accounts for
The isononyl isononanoate of the air cushion foundation cream weight 1%-3%, the two isooctadecanol apples for accounting for the air cushion foundation cream weight 2%-5%
Tartaric acid ester and the ring five dimethyl silicone polymer for accounting for the air cushion foundation cream weight 15%-20%.
Preferably, the foundation cream further includes skin sense regulator and moisturizer；The skin sense regulator includes accounting for the air cushion
The borazon of foundation cream weight 0.10%-2.0% and the polyamide fibre -12 for accounting for the air cushion foundation cream weight 0.50%-4.0%；It is described
Moisturizer accounts for the 1%-10.0% of the air cushion foundation cream weight.
Preferably, the foundation cream further includes film forming agent, thickener, preservative, colorant and viscosity modifier；
The film forming agent includes ring five dimethyl silicone polymer and acrylic acid (ester) class/polydimethylsiloxanecopolymer copolymer
Mixture, the film forming agent account for the 1%-5% of the air cushion foundation cream weight；
The thickener includes ring five dimethyl silicone polymer, distearyl dimethylammonium hectorite, propylene glycol carbonate
Mixture, the thickener account for the 1%-6% of the air cushion foundation cream weight；
The preservative includes Phenoxyethanol, Sensiva SC50, pungent glycol, and the preservative accounts for the air cushion foundation cream weight
The 0.15%-0.8% of amount；
The colorant includes titanium dioxide, CI 77492, CI 77491, CI 77499, and the colorant accounts for the gas
Pad the 5.17%-23.0% of foundation cream weight；
The viscosity control agent accounts for the 0.1%-1.5% of the air cushion foundation cream weight.
Preferably, the colorant includes the colorant A for accounting for the air cushion foundation cream weight 5%-20%, accounts for the air cushion powder
The colorant B of bottom weight 0.1%-2.0%, the colorant C for accounting for the air cushion foundation cream weight 0.05%-0.50% and account for the gas
Pad the colorant D of foundation cream weight 0.02%-0.50%；Titanium dioxide accounts for the colorant A weight in the colorant A
CI 77492 accounts for the 95% of the colorant B weight in 92%, the colorant B, and CI 77491 accounts for described in the colorant C
The 95% of colorant C weight, CI 77499 accounts for the 95% of the colorant D weight in the colorant D.
As currently preferred air cushion foundation cream, the air cushion foundation cream includes: colorant, emollient, film forming agent, emulsification
Agent, thickener, skin sense regulator, preservative, moisturizer, viscosity control agent, active functional component and the water as solvent；
The emollient includes the phenyl trimethicone for accounting for the air cushion foundation cream weight 6%, accounts for the air cushion powder
The isononyl isononanoate of bottom weight 2%, the diisooctadecanol malate for accounting for the air cushion foundation cream weight 4% and account for the air cushion
The ring five dimethyl silicone polymer of foundation cream weight 18%；
The emulsifier include account for the air cushion foundation cream weight 2% double-PEG/PPG-14/14 dimethyl silicone polymers and
The mixture of ring five dimethyl silicone polymer and the PEG-10 Polydimethylsiloxane for accounting for the air cushion foundation cream weight 2%, wherein
The weight ratio of double-PEG/PPG-14/14 dimethyl silicone polymers and ring five dimethyl silicone polymer in the emulsifier are as follows: 85:
15；
The activity functional component includes accounting for the active functional component A of the air cushion foundation cream weight 0.1% and accounting for the gas
The active functional component B of foundation cream weight 1% is padded, the active components A includes melanin, pentanediol and Sensiva SC50, institute
Stating active functional component B includes head shrub lespedeza leaf/stem extraction, 1,3-PD and water, wherein melanin, pentanediol and second
The weight ratio of base hexyl glycerol is 10:70:20, and head shrub lespedeza leaf/stem extraction, 1,3-PD and water weight ratio is 2:
50:48；
The skin sense regulator includes accounting for the borazon of the air cushion foundation cream weight 0.8% and accounting for the air cushion foundation cream weight
The polyamide fibre -12 of amount 2%；
The film forming agent includes the ring five dimethyl silicone polymer and acrylic acid (ester) class/poly dimethyl that weight ratio is 7:3
The mixture of silicone copolymers, the film forming agent account for the 3% of the air cushion foundation cream weight；
The thickener includes that weight ratio is de- for ring five dimethyl silicone polymer, the distearyl dimethylammonium lithium illiteracy of 77:18:5
The mixture of stone, propylene glycol carbonate, the thickener account for the 4% of the air cushion foundation cream weight；
The preservative include 0.4% Phenoxyethanol and the mixture of Sensiva SC50 and 0.1% pungent glycol and
The weight ratio of the mixture of Sensiva SC50, the Phenoxyethanol and Sensiva SC50 is 9:1, pungent glycol and ethylhexyl
The weight ratio of glycerol is 7:3；
The colorant includes the colorant A for accounting for the air cushion foundation cream weight 9%, accounts for the air cushion foundation cream weight 1.2%
Colorant B, account for the colorant C of the air cushion foundation cream weight 0.18% and account for the colorant of the air cushion foundation cream weight 0.07%
D；The colorant A includes titanium dioxide, the three isostearic acid isopropyl oxygen titanium salts, polydimethylsiloxanes that weight ratio is 92:3:3:2
Alkane, aluminium oxide, the colorant B include CI 77492, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；The colorant C includes CI 77491, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；The colorant D includes CI 77499, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；
The moisturizer is glycerol, and glycerol accounts for the 5% of the air cushion foundation cream weight；
The viscosity control agent is sodium chloride, and sodium chloride accounts for the 1% of the air cushion foundation cream weight；
The water as solvent accounts for the 38.15% of the air cushion foundation cream weight.
The present invention also provides a kind of preparation method of any of the above-described air cushion foundation cream with anti-blue light effect, the sides
Method the following steps are included:
(1) colorant A, colorant B, colorant C and colorant D mixed in suitable emollient, grind and obtains color
Slurry；
(2) emollient, film forming agent, emulsifier, thickener and the skin sense regulator of the mill base, surplus that obtain step (1)
It is uniformly mixed, homogeneous to substantially uniformity, stirring defoaming；Obtain oily phase；
(3) glycerol and preservative are uniformly mixed, water, sodium chloride, efficacy active component A and efficacy active component B are added,
It is uniformly mixed and obtains water phase；
(4) water phase is slowly added to the oily phase in stirring, homogeneous, stirring defoaming 10min is obtained described with anti-blue light function
The air cushion foundation cream of effect.
The beneficial effects of the present invention are: the present invention provides a kind of air cushion foundation cream with anti-blue light effect, the present invention
Air cushion foundation cream in head shrub lespedeza (LESPEDEZA CAPITATA) leaf/stem extraction and melanin proportion rationally, protection
Skin controls the maintenance of circadian rhythm from radiation injury, makes cell re-synchronization and restores normal rhythm, the prevention to blue light
Imperial and reparation has good effect, and has the effect of good anti-blue light.Preparation method simple process of the invention, cost
Low, the air cushion foundation cream effect with anti-blue light effect of preparation is good.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
As a kind of air cushion foundation cream with anti-blue light effect of the embodiment of the present invention, the foundation cream includes: colorant, profit
Skin agent, film forming agent, emulsifier, thickener, skin sense regulator, preservative, moisturizer, viscosity control agent, active functional component and
Water as solvent；
The emollient includes the phenyl trimethicone for accounting for the air cushion foundation cream weight 6%, accounts for the air cushion powder
The isononyl isononanoate of bottom weight 2%, the diisooctadecanol malate for accounting for the air cushion foundation cream weight 4% and account for the air cushion
The ring five dimethyl silicone polymer of foundation cream weight 18%；
The emulsifier include account for the air cushion foundation cream weight 2% double-PEG/PPG-14/14 dimethyl silicone polymers and
The mixture of ring five dimethyl silicone polymer and the PEG-10 Polydimethylsiloxane for accounting for the air cushion foundation cream weight 2%, wherein
The weight ratio of double-PEG/PPG-14/14 dimethyl silicone polymers and ring five dimethyl silicone polymer are as follows: 85:15；
The activity functional component includes accounting for the active functional component A of the air cushion foundation cream weight 0.1% and accounting for the gas
The active functional component B of foundation cream weight 1% is padded, the active components A includes melanin, pentanediol and Sensiva SC50, institute
Stating active functional component B includes head shrub lespedeza leaf/stem extraction, 1,3-PD and water, wherein melanin, pentanediol and second
The weight ratio of base hexyl glycerol is 10:70:20, and head shrub lespedeza leaf/stem extraction, 1,3-PD and water weight ratio is 2:
50:48；
The skin sense regulator includes accounting for the borazon of the air cushion foundation cream weight 0.8% and accounting for the air cushion foundation cream weight
The polyamide fibre -12 of amount 2%；
The film forming agent includes the ring five dimethyl silicone polymer and acrylic acid (ester) class/poly dimethyl that weight ratio is 7:3
The mixture of silicone copolymers, the film forming agent account for the 3% of the air cushion foundation cream weight；
The thickener include weight ratio be 77:18:5 ring five dimethyl silicone polymer, distearyl dimethylammonium hectorite,
The mixture of propylene glycol carbonate, the thickener account for the 4% of the air cushion foundation cream weight；
The preservative include 0.4% Phenoxyethanol and the mixture of Sensiva SC50 and 0.1% pungent glycol and
The weight ratio of the mixture of Sensiva SC50, the Phenoxyethanol and Sensiva SC50 is 9:1, pungent glycol and ethylhexyl
The weight ratio of glycerol is 7:3；
The colorant includes the colorant A for accounting for the air cushion foundation cream weight 9%, accounts for the air cushion foundation cream weight 1.2%
Colorant B, account for the colorant C of the air cushion foundation cream weight 0.18% and account for the colorant of the air cushion foundation cream weight 0.07%
D；The colorant A includes titanium dioxide, the three isostearic acid isopropyl oxygen titanium salts, polydimethylsiloxanes that weight ratio is 92:3:3:2
Alkane, aluminium oxide, the colorant B include CI 77492, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；The colorant C includes CI 77491, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；The colorant D includes CI 77499, the three isostearic acid isopropyl oxygen titanium salts, poly- diformazan that weight ratio is 95:3:2
Radical siloxane；
The moisturizer is glycerol, and glycerol accounts for the 5% of the air cushion foundation cream weight；
The viscosity control agent is sodium chloride, and sodium chloride accounts for the 1% of the air cushion foundation cream weight；
The water as solvent accounts for the 38.15% of the air cushion foundation cream weight.
The preparation method of the above-mentioned air cushion foundation cream with anti-blue light effect, the described method comprises the following steps:
(1) colorant A, colorant B, colorant C and colorant D mixed in suitable emollient, grind and obtains color
Slurry；
(2) emollient, film forming agent, emulsifier, thickener and the skin sense regulator of the mill base, surplus that obtain step (1)
It is uniformly mixed, homogeneous to substantially uniformity, stirring defoaming；Obtain oily phase；
(3) glycerol and preservative are uniformly mixed, water, sodium chloride, efficacy active component A and efficacy active component B are added,
It is uniformly mixed and obtains water phase；
(4) water phase is slowly added to the oily phase in stirring, homogeneous, stirring defoaming 10min is obtained described with anti-blue light function
The air cushion foundation cream of effect.
Embodiment 2-6
As the air cushion foundation cream with anti-blue light effect of the embodiment of the present invention, the air cushion powder with anti-blue light effect
Sole formula is as shown in table 1 below:
The formula of the air cushion foundation cream with anti-blue light effect of 1 embodiment 2-6 of table
Embodiment 7-11
As the air cushion foundation cream with anti-blue light effect of the embodiment of the present invention, the air cushion powder with anti-blue light effect
Sole formula is as shown in table 2 below:
The formula of the air cushion foundation cream with anti-blue light effect of 2 embodiment 7-11 of table
Comparative example 1-3
As the air cushion foundation cream of comparative example of the present invention, the formula of the air cushion foundation cream is as shown in table 3:
The formula of the air cushion foundation cream of 3 comparative example 1-3 of table
Embodiment 12
Use effect of the air cushion foundation cream of embodiment 1-11, comparative example 1-3 is detected, the results are shown in Table 4:
1, ROS is tested
Experimental principle
ROS (reactive oxygen species) is need to generate a series of reactive oxygen species in the metabolic process.It is excessive
A variety of oxidants such as ROS can destroy the enzyme and non-enzymatic Antioxidative Defense System of skin, keep body easily damaged and be in various diseases
The skin-related conditions such as skin aging, immunosupress, skin neoplasin occur for reason state, and ultraviolet light and blue light are to induce ROS
One of an important factor for generating, causing light aging.
Active oxygen detection kit (Reactive Oxygen Species Assay Kit) is a kind of using fluorescence probe
The kit of DCFH-DA progress active oxygen detection.DCFH-DA itself can pass freely through cell membrane without fluorescence, into cell
After interior, DCFH can be generated by intracellular esterase hydrolyzed.And DCFH is unable to permeabilized cells film, so that probe be made to be easy to be filled
It is downloaded to intracellular.Intracellular active oxygen can aoxidize non-blooming DCFH and generate the DCF for having fluorescence.Pass through the glimmering of detection DCF
The level of luminous intensity reflection reactive oxygen species.
Experimental method
(1) 20 μ l DCFH-DA is taken to dilute DCFH-DA according to 1:1000 20ml serum-free medium；
(2) it draws Fibroblast culture solution (cell concentration is 1,000,000 to 20,000,000/milliliter) to be added in 24 orifice plates, often
Group does 3 parallel, every hole addition 1ml cell culture fluids respectively), it is put into cell incubator and cultivates；
(3) remove cell culture fluid after cultivating 24 hours, every hole be added DCFH-DA that 1ml diluted (volume of addition with
Cell can sufficiently be covered is advisable)；
It is incubated for 20 minutes in (4) 37 DEG C of cell incubators；
(5) the DCFH-DA dilution after removal is incubated for, every hole are added 1ml serum-free cell culture medium washing cell and (repeat
Washing does not enter intracellular DCFH-DA three times, with abundant removal), 1ml cell culture fluid is added in every hole after having washed；
(6) 488nm excitation wavelength, 525nm launch wavelength are used under microplate reader, detection stimulates the power of preceding fluorescence (i.e.
OD value), the mean value of fluorescence intensity that each group at this time measures is denoted as OD0；
(7) every hole is separately added into the 20 μ l of test sample solution of embodiment 1-11, comparative example 1-3, in artificial blue light source
Under continue cultivate 4h；(note: since the lotion of embodiment 1-11, comparative example 1-3 are nontransparent structure, and containing toner in formula,
There is larger impact to the observation of fluorescence intensity, therefore the raw material in addition to active functional component is substituted for the water of equivalent in the experiment
It is tested as sample)；
After (8) 4 hours, 488nm excitation wavelength is used under microplate reader, 525nm launch wavelength is distinguished in 1h, 2h, 4h
The post-stimulatory fluorescence intensity of each group is detected, the average value measured is denoted as OD respectively1、OD2、OD3, the results are shown in Table 4.
Table 4
| Group | OD0(A.U.) | OD1(A.U.) | OD2(A.U.) | OD3(A.U.) |
| Embodiment 1 | 103.4 | 211.7 | 165.1 | 114.5 |
| Embodiment 2 | 102.6 | 402.1 | 373.1 | 334.2 |
| Embodiment 3 | 103.1 | 371.2 | 331.9 | 297.4 |
| Embodiment 4 | 102.9 | 208.9 | 164.3 | 114.1 |
| Embodiment 5 | 103.2 | 208.2 | 163.9 | 113.5 |
| Embodiment 6 | 102.8 | 205.8 | 162.5 | 112.4 |
| Embodiment 7 | 103.0 | 226.1 | 215.1 | 202.8 |
| Embodiment 8 | 103.1 | 224.3 | 194.5 | 173.1 |
| Embodiment 9 | 102.8 | 211.3 | 164.9 | 114.4 |
| Embodiment 10 | 102.8 | 211.0 | 164.9 | 113.9 |
| Embodiment 11 | 103.3 | 211.1 | 164.5 | 113.5 |
| Comparative example 1 | 102.8 | 428.2 | 373.8 | 328.6 |
| Comparative example 2 | 103.0 | 283.2 | 274.2 | 243.7 |
| Comparative example 3 | 102.9 | 498.3 | 471.2 | 422.4 |
(1) from embodiment 1-5 it can be seen that the concentration with active functional component A increases, the ROS amount of generation gradually subtracts
It is few, but when additive amount is more than 0.1%, the reduction amount of ROS is unobvious, resists effect and tends to be saturated；
(2) from embodiment 1 and 7-11 it can be seen that the concentration with active functional component B increases, the ROS amount of generation by
It is decrescence few, but when additive amount is more than 1%, the reduction amount of ROS is unobvious, and repairing effect tends to be saturated；
(3) from embodiment 1 and comparative example 1-3 it can be seen that activity functional component A, which has blue light, preferably resists work
With can effectively reduce the generation of ROS, but more general to generated ROS eradicating efficacy；And activity functional component B is to indigo plant
Light to resist effect weaker, but when stop blue light illumination after to the ROS generated with preferable elimination effect.When active effect
When ingredient A and B is compounded according to the ratio of 0.1%+1%, directly resisting for blue light can be obtained with post-stimulatory reparation
Preferable effect.
2, ultraviolet light color spot is tested
Experimental principle: black after UV Spots (ultraviolet light color spot) is skin by the irradiation of the high energy light such as ultraviolet light, blue light
Pigment result caused by subepidermal agglutination.Can not be observed under ordinary light conditions, it need be by peak value
The ultraviolet light of 365nm shoots and obtains, it can objectively reflect that potential pigmented spots are (with skin photoage in positive under epidermis
Close), this experiment measures ultraviolet light color spot by " UV Spots " detection function of Visia skin detection instrument, shoots
The pigment point that the picture come has black is distributed in entire face, is scored, is commented by the cloud database and its algorithm of instrument
Divide lower expression ultraviolet light color spot more.
Experimental method
(1) before receiving blue light stimulation test, ultraviolet light color is carried out to subject's skin of face with Visia skin detection instrument
Spot test, the time point are denoted as T0；Then it allows subject to irradiate 10min under artificial blue light, carries out color spot survey again after 2h
Amount, the time point are denoted as T1；
Start within (2) the 2nd days, subject smear embodiment 1-11, comparative example 1-3 air cushion foundation cream sample be followed by by
The artificial blue light illumination of 10min carries out color spot measurement after 2h, which is denoted as T2；
(3) so analogize, repeat within the 3-7 days the operation of step (2), testing time point is remembered respectively, makees T3、T4、T5、T6、T7；
(4) 5 subjects of each embodiment/comparative example carry out using test, everyone by each sample coating in face, every group
The scoring of total all subjects, calculates its average value, the results are shown in Table 5, it should be noted that assessment item by sample
It is coated on face, subject tries out 1 time daily, continuous one week on probation.
Table 5
(1) from embodiment 1-5 it can be seen that with active functional component A concentration increase, the color spot as caused by blue light by
It is decrescence few, but when additive amount is more than 0.1%, the reduction amount of color spot is unobvious, and anti-blue light effect tends to be saturated；
(2) from embodiment 1 and 7-11 it can be seen that with active functional component B concentration increase, the color as caused by blue light
Spot gradually decreases, but when additive amount is more than 1%, the reduction amount of color spot is unobvious, and anti-blue light effect tends to be saturated；
(3) from embodiment 1 and comparative example 1-3 it can be seen that activity functional component A, which has blue light, preferably resists work
With can be effectively prevented blue light and shine directly on skin, but due to the lasting irradiation of blue light in experiment, can not evaluate whether
There is elimination effect to the color spot generated；And activity functional component B has preferable elimination effect to color spot has been generated.Work as activity
When functional component A and B is compounded according to the ratio of 0.1%+1%, to blue light directly resist and blue light illumination after reparation
Preferable effect can be obtained.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of air cushion foundation cream with anti-blue light effect, which is characterized in that the foundation cream include: emollient, active effect at
Point and as solvent water；
The activity functional component includes accounting for the active functional component A of the air cushion foundation cream weight 0.05%-0.50% and accounting for institute
The active functional component B of air cushion foundation cream weight 0.50%-2.0% is stated, the active components A includes melanin, pentanediol and second
Base hexyl glycerol, the activity functional component B includes head shrub lespedeza leaf/stem extraction, 1,3-PD and water；
The water as solvent accounts for the 25.0%-60.0% of the air cushion foundation cream weight.
2. air cushion foundation cream according to claim 1, which is characterized in that the activity functional component includes accounting for the air cushion powder
The active functional component A of bottom weight 0.05%-0.30% and the active effect for accounting for the air cushion foundation cream weight 0.50%-1.5%
Melanin accounts for the 10% of the active functional component A weight in ingredient B, the activity functional component A, the activity functional component
Head shrub lespedeza leaf/stem extraction accounts for the 2% of the active functional component B weight in B.
3. air cushion foundation cream according to claim 2, which is characterized in that the activity functional component includes accounting for the air cushion powder
The active functional component A of the bottom weight 0.1% and active functional component B for accounting for the air cushion foundation cream weight 1%.
4. air cushion foundation cream according to claim 1 to 3, which is characterized in that the foundation cream further includes emulsifier；
The emollient includes the phenyl trimethicone for accounting for the air cushion foundation cream weight 1%-10%, accounts for the air cushion powder
The isononyl isononanoate of bottom weight 1%-5%, the diisooctadecanol malate for accounting for the air cushion foundation cream weight 1%-10% and
Account for the ring five dimethyl silicone polymer of the air cushion foundation cream weight 10%-30%；
The emulsifier include account for the air cushion foundation cream weight 1%-4% double-PEG/PPG-14/14 dimethyl silicone polymers and
The mixture of ring five dimethyl silicone polymer and the PEG-10 Polydimethylsiloxane for accounting for the air cushion foundation cream weight 1%-4%.
5. air cushion foundation cream according to claim 4, which is characterized in that the emollient includes accounting for the air cushion foundation cream weight
The phenyl trimethicone of 3%-8%, accounts for the gas at the isononyl isononanoate for accounting for the air cushion foundation cream weight 1%-3%
It pads the diisooctadecanol malate of foundation cream weight 2%-5% and accounts for the ring five poly- two of the air cushion foundation cream weight 15%-20%
Methylsiloxane.
6. air cushion foundation cream according to claim 5, which is characterized in that the foundation cream further includes skin sense regulator and moisturizing
Agent；
The skin sense regulator includes accounting for the borazon of the air cushion foundation cream weight 0.10%-2.0% and accounting for the air cushion powder
The polyamide fibre -12 of bottom weight 0.50%-4.0%；
The moisturizer accounts for the 1%-10.0% of the air cushion foundation cream weight.
7. air cushion foundation cream according to claim 5 or 6, which is characterized in that the foundation cream further include film forming agent, thickener,
Preservative, colorant and viscosity modifier；
The film forming agent includes the mixing of ring five dimethyl silicone polymer and acrylic acid (ester) class/polydimethylsiloxanecopolymer copolymer
Object, the film forming agent account for the 1%-5% of the air cushion foundation cream weight；
The thickener includes the mixing of ring five dimethyl silicone polymer, distearyl dimethylammonium hectorite, propylene glycol carbonate
Object, the thickener account for the 1%-6% of the air cushion foundation cream weight；
The preservative includes Phenoxyethanol, Sensiva SC50, pungent glycol, and the preservative accounts for the air cushion foundation cream weight
0.15%-0.8%；
The colorant includes titanium dioxide, CI 77492, CI 77491, CI 77499, and the colorant accounts for the air cushion powder
The 5.17%-23.0% of bottom weight；
The viscosity control agent accounts for the 0.1%-1.5% of the air cushion foundation cream weight.
8. air cushion foundation cream according to claim 7, which is characterized in that the colorant includes accounting for the air cushion foundation cream weight
The colorant A of 5%-20%, the colorant B for accounting for the air cushion foundation cream weight 0.1%-2.0%, the air cushion foundation cream weight is accounted for
The colorant C of the 0.05%-0.50% and colorant D for accounting for the air cushion foundation cream weight 0.02%-0.50%；The colorant A
Middle titanium dioxide accounts for the 92% of the colorant A weight, and CI 77492 accounts for the colorant B weight in the colorant B
CI 77491 accounts for the 95% of the colorant C weight in 95%, the colorant C, and CI 77499 accounts for described in the colorant D
The 95% of colorant D weight.
9. air cushion foundation cream according to claim 1, which is characterized in that the foundation cream includes: colorant, emollient, film forming
Agent, emulsifier, thickener, skin sense regulator, preservative, moisturizer, viscosity control agent, active functional component and as solvent
Water；
The emollient includes the phenyl trimethicone for accounting for the air cushion foundation cream weight 6%, accounts for the air cushion foundation cream weight
The isononyl isononanoate of amount 2% accounts for the diisooctadecanol malate of the air cushion foundation cream weight 4% and accounts for the air cushion foundation cream
The ring five dimethyl silicone polymer of weight 18%；
The emulsifier includes the double-PEG/PPG-14/14 dimethyl silicone polymers and ring five for accounting for the air cushion foundation cream weight 2%
The mixture of dimethyl silicone polymer and the PEG-10 Polydimethylsiloxane for accounting for the air cushion foundation cream weight 2%, wherein described
The weight ratio of double-PEG/PPG-14/14 dimethyl silicone polymers and ring five dimethyl silicone polymer is 85:15 in emulsifier；
The activity functional component includes accounting for the active functional component A of the air cushion foundation cream weight 0.1% and accounting for the air cushion powder
The active functional component B of bottom weight 1%, the active components A include melanin, pentanediol and Sensiva SC50, the work
Property functional component B includes head shrub lespedeza leaf/stem extraction, 1,3-PD and water, wherein melanin, pentanediol and ethyl hexyl
The weight ratio of base glycerol is 10:70:20, and head shrub lespedeza leaf/stem extraction, 1,3-PD and water weight ratio is 2:50:
48；
The skin sense regulator includes accounting for the borazon of the air cushion foundation cream weight 0.8% and accounting for the air cushion foundation cream weight
2% polyamide fibre -12；
The film forming agent includes the ring five dimethyl silicone polymer and acrylic acid (ester) class/polydimethylsiloxanes that weight ratio is 7:3
The mixture of alkyl copolymer, the film forming agent account for the 3% of the air cushion foundation cream weight；
The thickener includes that weight ratio is the ring five dimethyl silicone polymer of 77:18:5, distearyl dimethylammonium hectorite, carbon
The mixture of acid propylene glycol ester, the thickener account for the 4% of the air cushion foundation cream weight；
The preservative includes the pungent glycol and ethyl of 0.4% Phenoxyethanol and the mixture of Sensiva SC50 and 0.1%
The weight ratio of the mixture of hexyl glycerol, the Phenoxyethanol and Sensiva SC50 is 9:1, pungent glycol and Sensiva SC50
Weight ratio be 7:3；
The colorant include the colorant A for accounting for the air cushion foundation cream weight 9%, account for the air cushion foundation cream weight 1.2%
Toner B, the colorant C for accounting for the air cushion foundation cream weight 0.18% and the colorant D for accounting for the air cushion foundation cream weight 0.07%；Institute
State colorant A include weight ratio be the titanium dioxide of 92:3:3:2, three isostearic acid isopropyl oxygen titanium salts, dimethyl silicone polymer,
Aluminium oxide, the colorant B include CI 77492, the three isostearic acid isopropyl oxygen titanium salts, poly dimethyl that weight ratio is 95:3:2
Siloxanes；The colorant C includes CI 77491, the three isostearic acid isopropyl oxygen titanium salts, poly dimethyl that weight ratio is 95:3:2
Siloxanes；The colorant D includes CI 77499, the three isostearic acid isopropyl oxygen titanium salts, poly dimethyl that weight ratio is 95:3:2
Siloxanes；
The moisturizer is glycerol, and glycerol accounts for the 5% of the air cushion foundation cream weight；
The viscosity control agent is sodium chloride, and sodium chloride accounts for the 1% of the air cushion foundation cream weight；
The water as solvent accounts for the 38.15% of the air cushion foundation cream weight.
10. a kind of preparation method of the air cushion foundation cream as described in claim 1-9 is any with anti-blue light effect, feature exist
In the described method comprises the following steps:
(1) colorant A, colorant B, colorant C and colorant D mixed in suitable emollient, grind and obtains mill base；
(2) emollient, film forming agent, emulsifier, thickener and the mixing of skin sense regulator of the mill base, surplus that obtain step (1)
Uniformly, homogeneous to substantially uniformity, stirring defoams；Obtain oily phase；
(3) glycerol and preservative are uniformly mixed, water, sodium chloride, efficacy active component A and efficacy active component B, mixing is added
Uniformly obtain water phase；
(4) water phase is slowly added to the oily phase in stirring, homogeneous, stirring defoaming 10min is obtained described with anti-blue light effect
Air cushion foundation cream.
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| CN114159360A (en) * | 2021-12-13 | 2022-03-11 | 武汉百思凯瑞生物科技有限公司 | Cubilose acid blue light resistant nano composition, preparation method and application thereof |
| CN114159360B (en) * | 2021-12-13 | 2023-08-22 | 武汉百思凯瑞生物科技有限公司 | Anti-blue light nanometer composition of bird's nest acid, preparation method and application thereof |
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