CN109125106A - A kind of anti-wrinkle stoste and its promote to seep technical application in skin - Google Patents
A kind of anti-wrinkle stoste and its promote to seep technical application in skin Download PDFInfo
- Publication number
- CN109125106A CN109125106A CN201810889036.8A CN201810889036A CN109125106A CN 109125106 A CN109125106 A CN 109125106A CN 201810889036 A CN201810889036 A CN 201810889036A CN 109125106 A CN109125106 A CN 109125106A
- Authority
- CN
- China
- Prior art keywords
- wrinkle
- skin
- stoste
- phase
- moisturizer
- Prior art date
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- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 description 3
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- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
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- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
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- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
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- OHWQEBAVEDXXDM-UHFFFAOYSA-N n-benzylbutanamide Chemical compound CCCC(=O)NCC1=CC=CC=C1 OHWQEBAVEDXXDM-UHFFFAOYSA-N 0.000 description 1
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- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of anti-wrinkle stostes, including EDETATE SODIUM, moisturizer, active constituent, solvent, pungent glycol, water: surplus, the active constituent is victory peptide, and A phase is formed after the mixing of the water, EDETATE SODIUM, part moisturizer, B phase is formed after part moisturizer and partial solvent mixing, part moisturizer, partial solvent, active constituent are classified as C phase, and partial solvent, pungent glycol are classified as D phase.The present invention discloses preparation methods and its application.The compounding that anti-wrinkle stoste of the present invention passes through each component in formula; replenishing water and preserving moisture can not only be played to skin, promote microcirculation, protect the skin from ultraviolet injury, remove free radical, promote collagen and elastomer synthesis, diminish inflammation and other effects; it is combined simultaneously with Cutaneous permeation technology; anti-wrinkle stoste is applied directly to skin corium; to greatly promote the resultant effect of anti-wrinkle and skin nutrition, and effect is lasting.
Description
Technical field
The present invention relates to a kind of anti-wrinkle products and its preparation method and application, and in particular to a kind of anti-wrinkle stoste and its preparation
Method and promote to seep technical application in skin, belongs to household chemicals technical field.
Background technique
The skin of the mankind is made of epidermis, corium and subcutaneous tissue, and major function is to protect body from the external world paid no attention to
The injury of environment, aging are the irresistible natural processes of life, are influenced by many factors such as heredity, environment, social mentalities,
Wrinkle is then the external manifestation of body aging on the skin, repeatedly with cutis laxa, ultraviolet light irradiation, gravity, facial expression muscle
It shrinks and the factors such as muscle tension itself is related.In general, there is initial wrinkle in forehead and lower eyelid from 25 years old, 30 years old from
There is fish tail shape fine wrinkle outward in paropia, occurs longitudinal wrinkles before 35 years old ear, wrinkle increases before 40 years old ear, and throat is downward from jaw
There is vertical wrinkle.Lower eyelid wrinkle becomes apparent within 45 years old, and the red beginning of lip is thinning.Facial wrinkles are deepened within 50 years old, and the back of the hand wrinkle increases, nose
Before beam, ear, jaw portion also there is wrinkle, gauffer is obviously indulged in throat, such as chicken neck-shaped.Start senile plaque occur within 55 years old, 60 years old deutostoma week
See radial wrinkle, 75 years old lip is red to become very thin, skin of dorsum of hand such as creping tissue sample.Therefore, from 25 years old, wrinkle almost with
People is on very close terms.
Wrinkle, which not only declares publicly, is difficult to obliterated years trace, but also seriously affects the skin beauty even social activity of people and the heart
Reason easily causes anxiety, depression, feels oneself inferior and the negative emotions such as fear to influence quality of life are the formidable enemies of people seeking beauty.
It is essential using the cosmetics with significant anti-wrinkle effect to reduce flesh age, wrinkle reduction, remaining youthful forever.However, current city
Wrinkle removing cosmetic is dazzling on face, and advertisement is also very tempting, and effect is barely satisfactory.And some anti-wrinkle effect highly significants
Cosmetics, mostly containing forbidden amphetamines such as heavy metal, hormones, there are certain security risks.And comparatively safe product also can only
Skin surface is acted on, skin corium even musculature can not be goed deep into and played a role, anti-wrinkle effect is not obvious.
Currently, thering is ion to lead to increase the medicine-feeding technology that skin applies the osmotic absorption of external drug or skin care item
Enter, ultrasonic wave, electroporation, micropin and chemical enhancers etc., these methods it is sorbefacient and meanwhile all more or less there is
Drawback, for example, effect it is unobvious, using big easy infection of not easy and wound etc..
In recent years, the skin that nanometer micropin becomes emerging promotees infiltration technology, and some researches show that nanometer micropins (nanometer chip) can
Administration channel is formed in skin surface in short time, and channel 20min or so is Natural closure, skin restores continuous whole
Property.New Cutaneous permeation technology has been widely applied to beautifying skin industry, but combining with new infiltration technology simultaneously can be mutually
The whitening product of promotion is not kept up with but, and compatible degree is unsatisfactory.
Summary of the invention
To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of anti-wrinkle stostes and skin to promote infiltration technology contract
It is right it is high, mutually promote, the anti-wrinkle stoste that effect is good and preparation method thereof and in the technical application of Cutaneous permeation.
In order to achieve the above objectives, the present invention adopts the following technical scheme that:
Invention introduces the victory peptides with anti-wrinkle effect, such as: palmityl tetrapeptide -7: the polypeptide for promoting collagen to generate
Constituents make skin fiber even closer, and anti-carbonation, anti-oxidant, anti-saccharification make skin reply the youth, and shine skin living, alleviate thin
Crenulation line；Argireline: keeping skin more flexible, Cucumber Extract, stimulation collagen hyperplasia, compact skin；Dipeptides
Diaminobutyryl benzyl amide diacetin: it is a kind of active small peptide of simulation venom toxin Waglerin I, suppression can be passed through
Contraction of muscle processed and the generation for reducing wrinkle have outstanding smooth and rapid anti-wrinkle performance, are made by loose facial muscles
For effective smooth and anti-wrinkle biologically active prod ingredient.
And the moisturizer panthenol used: have the effects that moisturizing, anti-inflammatory, profit flesh, stimulation cell division to skin, biology is living
Property is good, while having hygroscopicity and Electrostatic Absorption, can be deeply infiltrated into skin, stimulate the growth of epithelial cell, and promote
Wound healing plays antiinflammation, be combined with each other, promotes with Cutaneous permeation technology, strengthen function and effect；Sodium Hyaluronate: tool
There is the effect of anti-inflammatory and accelerating wound healing, can not only moisturize the skin, increase gloss, and chapped skin and wrinkle can be prevented
It generates.
Solvent in skin care whitening lotion provided by the invention, one of which 1,2- pentanediol are a kind of guarantors haveing excellent performance
Humectant, while there is antisepsis, the product of preservative free can be prepared, reduces allergy caused by preservative, and can be improved sun-proof
The water-resistance of product formula, the active constituent for dissolving indissoluble etc., with preservative decoyl hydroximic acid in inventive formulation and pungent
Glycol compounding, antiseptic property enhancing；Glycine betaine: there is good moisturizing, cleaning action, and do not injure skin.
In addition, the moisturizer Sensiva SC50 in anti-wrinkle stoste formula of the present invention be both in formula can play it is antibacterial
Effect, it can not only be added to water phase, but also may be added to oily phase, and when being added to water phase, it can form an antibacterial environment, to entire
Formula plays antisepsis, and being capable of the traditional cosmetics preservative of synergy such as Phenoxyethanol, methylisothiazolinone or Ni Bo
Tortoise beetle ester etc., at the same can synergy alcohols and glycols, in an oil-in-water lotion, can be improved glycols such as pentanediol or
The antibacterial action of ethohexadiol, in addition, Sensiva SC50 can effectively inhibit the growth and breeding for the bacterium for causing peculiar smell, while not shadow
Ring the beneficial skin flora of human body.
Specifically, including: in every 100kg raw material the present invention provides a kind of anti-wrinkle stoste
EDETATE SODIUM: 0.01-0.1kg
Moisturizer: 5-20kg；
Active constituent: 0.6-1.8kg；
Solvent: 3-20kg；
Pungent glycol: 0.1-2kg；
Water: surplus,
The active constituent is victory peptide,
And A phase is formed after the mixing of the water, EDETATE SODIUM, part moisturizer, part moisturizer and partial solvent mixing
B phase is formed afterwards, and part moisturizer, partial solvent, active constituent are classified as C phase, and partial solvent, pungent glycol are classified as D phase.
Further, above-mentioned anti-wrinkle stoste, further includes thickener, and: 0.02-0.2kg is classified as C phase, and the thickening
Agent is carbomer.
It can also include preservative: 0.05-0.2kg, be classified as D phase, and the preservative is decoyl hydroximic acid.
And above-mentioned moisturizer is at least one of glycine betaine, Sodium Hyaluronate, glycerol, panthenol, Sensiva SC50
Or several combination.
Above-mentioned victory peptide is palmityl tripeptides -1, palmityl tetrapeptide -7, Argireline, dipeptides diaminobutyryl benzyl
At least one of amide diacetin or several combinations.
Above-mentioned solvent is at least one of propylene glycol, butanediol, pentanediol, hexylene glycol or several combinations.
The present invention discloses a kind of preparation methods of above-mentioned skin care whitening stoste, comprising the following steps:
S1: being added main cooker according to quality proportioning for A phase each component first, and be heated to 80 DEG C, is uniformly mixed consistent；
S2: being cooled to 50 DEG C for main cooker, and side pot is added according to quality proportioning in B phase each component, is stirred evenly, and thrown
Enter into main cooker, is uniformly mixed with A phase；
S3: being cooled to 45 DEG C for main cooker again, and side pot is added according to quality proportioning in C phase each component, is stirred evenly, and will
It is put into main cooker, is uniformly mixed；
S4: side pot finally is added according to quality proportioning in D phase each component, stirs evenly, and put into main cooker, stirs
It mixes after mixing, is cooled to room temperature, discharging obtains anti-wrinkle stoste after detection is qualified.
In addition, above-mentioned anti-wrinkle stoste promotees to seep technical application in skin, comprising the following steps: after cleaning skin,
Promote to seep instrument perpendicular contact skin surface using nanometer chip and carry out pricking method point by point, every effect 1s is then other to move a chip
Width carry out the pricking method of next point, form administration channel in skin surface, while pricking method, import anti-wrinkle stoste, same point
The skin at place repeats to import three times.
Further, above-mentioned anti-wrinkle stoste passes through the service life of Cutaneous permeation technology are as follows: once a week.And pricking method
Depth is then at least skin cuticula.
The invention has the beneficial effects that: anti-wrinkle stoste of the present invention, can not only by the compounding of each component in formula
It is enough that replenishing water and preserving moisture is played to skin, promotes microcirculation, protect the skin from ultraviolet injury, remove free radical, promote collagen egg
The synthesis of white and elastomer diminishes inflammation and other effects, while combining with Cutaneous permeation technology, and promotion carries out a little to skin
Thorn during forming administration channel, has effects that anti-inflammatory, sterilization, promotes wound healing, so that anti-wrinkle product and rush seep skill
Art has reached perfect combination, and anti-wrinkle stoste is applied directly to skin corium, to greatly promote the comprehensive of anti-wrinkle and skin nutrition
Effect is closed, and effect is lasting.
Specific embodiment
Below in conjunction with detailed description of the invention by specific embodiments, the advantages and features of the present invention will be with describing
And it is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Art technology
Personnel should be understood that without departing from the spirit and scope of the invention can details and form to technical solution of the present invention
It modifies or replaces, but these modifications and replacement are fallen within the protection scope of the present invention.
In the examples below, moisturizer is the group of Sensiva SC50, panthenol, glycine betaine, Sodium Hyaluronate and glycerol
Object is closed, solvent 1,2- pentanediol, 1,2- hexylene glycol, butanediol, 1,3-PD and pungent glycol, thickener is carbomer, is prevented
Rotten agent is then decoyl hydroximic acid, and active component is palmityl tripeptides -1, palmityl tetrapeptide -7, Argireline and dipeptides diamino
Base butyryl benzyl amide diacetin, thickener is carbomer.And following embodiment is raw materials used, is commercially available.
Embodiment 1:
Include component and content (units/kg) as shown in the table in every 100kg anti-wrinkle stoste:
Embodiment 2:
Include component and content (units/kg) as shown in the table in every 100kg anti-wrinkle stoste:
Embodiment 3:
Include component and content (units/kg) as shown in the table in every 100kg anti-wrinkle stoste:
The preparation method of the anti-wrinkle stoste of embodiment 1-3 is equal are as follows:
S1: being added main cooker according to quality proportioning for A phase each component first, and be heated to 80 DEG C, is uniformly mixed consistent；
S2: being cooled to 50 DEG C for main cooker, and side pot is added according to quality proportioning in B phase each component, is stirred evenly, and thrown
Enter into main cooker, is uniformly mixed with A phase；
S3: being cooled to 45 DEG C for main cooker again, and side pot is added according to quality proportioning in C phase each component, is stirred evenly, and will
It is put into main cooker, is uniformly mixed；
S4: side pot finally is added according to quality proportioning in D phase each component, stirs evenly, and put into main cooker, stirs
It mixes after mixing, is cooled to room temperature, discharging obtains anti-wrinkle stoste after detection is qualified.
Anti-wrinkle stoste described in embodiment 1-3 is applied to skin and promotees infiltration technology, application process is identical with application conditions.
Specifically:
One, subject's data:
120 healthy volunteers are recruited, the age 36~45 years old, men and women each 60, volunteer's face did not received micropin and controls
It treats；Body is strong usually, non-communicable disease, disease in the blood system, mental disease, skin neoplasin；Without skin allergy history；Women does not exist
In gestation or nursing period；Without the bad habits such as smoke, drink, according to male to female ratio, it is randomly divided into four groups, every group of 30 people, male 15,
Female 15.
Two, instrument and material:
Nanometer micropin: this research uses 3DL-Z type nanometer micropin, it is pasted on plastics crystal by a micro-needle array chip
It forms on head, is provided by Suzhou Natong Bionanotechnology Ltd..Chip grows (5.0 ± 2.5) mm, wide (5.0 ± 2.5)
Mm, thick 0.3mm, dot matrix quantity (100 ± 25) are a；Array heights 0.15mm；Taper (40 ± 3) °, lot number: 251022-2.Nano-crystal
Promote to seep instrument (SPE-10, Suzhou Natong Bionanotechnology Ltd.), German CK Multi-functional skin tester.
Three, treatment method:
After cleaning face and natural air drying, promote to seep instrument perpendicular contact skin surface and point-by-point electric point using electronic nano-crystal
Thorn, every effect 1s, the depth of pricking method are skin cuticula.Then the other width for moving a chip carries out next point pricking method, according to
The method is completed full face and is imported, and treatment is repeated 3 times every time.The anti-wrinkle stoste subject of embodiment 1-3 distinguishes in the same way
Full face imports anti-wrinkle stoste.Full face coating is carried out using anti-wrinkle stoste as described in example 2, is repeated 3 times, is control group, four groups
Subject all receives weekly seance, altogether treat 2 months, during treatment subject cannot receive other face-beauty therapeutics and
Take beauty related drugs or health care product.
Four, skin test:
Without sunlight direct projection in test cabinet, it is calm, control 22 DEG C of room temperature or so, humidity 50%~60%.Every subject is clear
Behind face cleaning portion do not use any cosmetics, before testing 30min enter in room sit quietly it is to be measured.Use German CK Multi-functional skin
Tester measures water content (%), moisture of skin windage [TEWL, g/ (hm2)], skin wrinkle in facial skin cuticula
Line (first with silicon mould duplication institute's measurement site wrinkle of skin model, computer according to wrinkle of skin depth carry out grade separation with
Statistical disposition), before calculating sample use, the skin mean roughness R3 after use is (that is: to 5 equal lengths, different segment institute
The R1 value measured takes arithmetic mean number, and wherein R1 is indicated at a distance from peak value in certain length is between minimum, μm).As a result
Indicate that numerical value is higher, represents wrinkle with Δ R3 (that is: using before sample with the difference that uses the skin mean roughness after sample)
Improvement is better.Facial skin elasticity (it is 450mpa that negative pressure is constant in test process) is tested, as a result (is taken with springback capacity Ur
The recovery value of skin after the negative pressure that disappears 0.1 second) with the ratio of the maximum tension amount Uf of skin indicate that numerical value illustrates skin closer to 1
Elasticity is better.Pass through skin condition questionnaire survey subject satisfaction and adverse reaction.
Five, efficacy assessment standard:
1. subjective assessment: asking subject to skin condition is given a mark before treatment and after last time treatment.Skin elasticity and wrinkle
Line improves degree scoring by 1 point to 5 points ,=2 points very dissatisfied=1 point, dissatisfied, general=3 points ,=4 points satisfied, very
=5 points satisfied, full marks 10 divide, and subjective scoring is higher, i.e., more satisfied to skin condition；
2. objective evaluation: German CK Multi-functional skin tester index compares the number before treating and after last time treatment
Value changes.
Six, statistical analysis:
Using 17.0 version of SPSS software, detection data is indicated with x- ± s, is examined using t, and P < 0.05 is considered having
It is statistically significant.
Seven, result:
(1) MC760 digital skin analyzer testing result:
Moisture content of skin, water loss amount, skin elasticity and skin mean roughness see the table below:
As seen from the above table: it is obvious that the effect of embodiment 1-3 of the present invention 72h skin after the processing of nanometer micropin
Can be learnt simultaneously far better than control group by upper table: anti-wrinkle stoste of the present invention is due between each component
Mutual synergistic function, skin hydration degree, elasticity and in terms of due on the market anti-at present
Cosmetics.
(2) satisfaction investigation result:
Four groups of volunteers are respectively that (5.2 ± 1.8) are divided, (5.2 ± 2.3) are divided to the skin condition marking before treatment, and (5.0
± 1.6) divide, (4.9 ± 1.5) point, (5.3 ± 1.2) point, no difference of science of statistics is comparable.And the will of embodiment 1-3
Hope person is respectively as follows: (9.0 ± 0.9) point, (9.2 ± 0.8) point, (8.9 ± 0.9) point to the skin condition after treatment, and controls
Compared to all having significant difference (P < 0.05) before treating, the skin condition of control group volunteer after the treatment is given a mark are as follows: (8.2 ±
1.4) divide, it may have significant difference, but the obvious satisfaction by promoting infiltration technology is higher than and directly smears.
It is all to there is the volunteer for participating in studying not occur the adverse reactions such as infection, erythema, oedema.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the above embodiments do not limit the invention in any form, all obtained by the way of equivalent substitution or equivalent transformation
Technical solution is fallen within the scope of protection of the present invention.
Claims (10)
1. a kind of anti-wrinkle stoste, which is characterized in that include: in every 100kg raw material
EDETATE SODIUM: 0.01-0.1kg；
Moisturizer: 5-20kg；
Active constituent: 0.6-1.8kg；
Solvent: 3-20kg；
Pungent glycol: 0.1-2kg；
Water: surplus,
The active constituent is victory peptide,
And A phase is formed after the mixing of the water, EDETATE SODIUM, part moisturizer, shape after part moisturizer and partial solvent mixing
At B phase, part moisturizer, partial solvent, active constituent are classified as C phase, and partial solvent, pungent glycol are classified as D phase.
2. a kind of anti-wrinkle stoste according to claim 1, which is characterized in that further include thickener: 0.02-0.2kg sorts out
For C phase, and the thickener is carbomer.
3. a kind of anti-wrinkle stoste according to claim 1, which is characterized in that further include preservative: 0.05-0.2kg sorts out
For D phase, and the preservative is decoyl hydroximic acid.
4. a kind of anti-wrinkle stoste according to claim 1, which is characterized in that the moisturizer is glycine betaine, hyalomitome
At least one of sour sodium, glycerol, panthenol, Sensiva SC50 or several combinations.
5. a kind of anti-wrinkle stoste according to claim 1, which is characterized in that the victory peptide is palmityl tetrapeptide -7, second
At least one of acyl group hexapeptide -8, dipeptides diaminobutyryl benzyl amide diacetin or several combinations.
6. a kind of anti-wrinkle stoste according to claim 1, which is characterized in that the solvent is propylene glycol, butanediol, penta
At least one of glycol, hexylene glycol or several combinations.
7. the preparation method of anti-wrinkle stoste described in a kind of any one of claim 1-6 claim, which is characterized in that including with
Lower step:
S1: being added main cooker according to quality proportioning for A phase each component first, and be heated to 80 DEG C, is uniformly mixed consistent；
S2: being cooled to 50 DEG C for main cooker, and side pot is added according to quality proportioning in B phase each component, is stirred evenly, and put into
In main cooker, it is uniformly mixed with A phase；
S3: being cooled to 45 DEG C for main cooker again, and side pot is added according to quality proportioning in C phase each component, is stirred evenly, and thrown
Enter into main cooker, is uniformly mixed；
S4: side pot finally is added according to quality proportioning in D phase each component, is stirred evenly, and put into main cooker, stirring is mixed
It after closing uniformly, is cooled to room temperature, discharging obtains anti-wrinkle stoste after detection is qualified.
8. a kind of anti-wrinkle stoste described in claim 1 promotees to seep technical application in skin, which is characterized in that including following step
It is rapid: after cleaning skin, promotees to seep instrument perpendicular contact skin surface using nanometer chip and carry out pricking method point by point, every effect 1s,
Then the other width for moving a chip carries out the pricking method of next point, while skin surface formation administration channel, pricking method, imports
Anti-wrinkle stoste, the skin of same point repeat to import three times.
9. a kind of anti-wrinkle stoste according to claim 8 promotees to seep technical application in skin, which is characterized in that anti-wrinkle is former
Liquid passes through the service life of Cutaneous permeation technology are as follows: once a week.
10. a kind of anti-wrinkle stoste according to claim 8 promotees to seep technical application in skin, which is characterized in that pricking method
Depth be at least skin cuticula.
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Application publication date: 20190104 |
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