CN108815013A - A kind of skin care whitening stoste and its promote to seep technical application in skin - Google Patents
A kind of skin care whitening stoste and its promote to seep technical application in skin Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of skin care whitening stostes, including：Glycerol, moisturizer, Sodium Hyaluronate, surfactant, solvent, preservative, preservative, niacinamide, tranexamic acid, water.The present invention discloses preparation method with it in the technical application of Cutaneous permeation.The compounding that skin care whitening formula of the present invention passes through each component in formula, the effect of whitening, nutrition, moisturizing can not only be played to skin, it is combined simultaneously with Cutaneous permeation technology, promote during carrying out pricking method to skin, forming administration channel, have effects that anti-inflammatory, sterilization, promote wound healing, so that whitening product and rush infiltration technology have reached perfect combination.
Description
Technical field
The present invention relates to a kind of whitening products and its preparation method and application, and in particular to a kind of skin care whitening stoste and its
Preparation method and promote to seep technical application in skin, belongs to household chemicals technical field.
Background technique
For a long time, for people with Bai Weimei, pale skin is the target that many women chase throughout one's life, and the colour of skin is obscure to be
Skin color caused by various factors turns to be yellow, is lackluster, in addition to aging, Environment pollution, bad life habits, stress etc.
The colour of skin will be caused obscure.
For skin-whitening external application method from 20th century containing the quinhydrones at the beginning of mercurial to 21 century, effect obviously still has kidney malicious
Property and carcinogenic possibility.Kojic acid, Arbutin, vitamin C, glycyrrhizic acid etc., which mainly pass through, inhibits tyrosinase to reach whitening effect,
But having the side effects such as teratogenesis, in history existing more than 30 years for taking orally tranexamic acid treatment chloasma, improving the colour of skin, effect is bright
Really, but there are the side reactions such as gastrointestinal discomfort, hypomenorrhea.How safely and effectively to solve the problems, such as the colour of skin it is obscure be still current
Hot spot, how to seek a kind of safely and effectively method for whitening is the direction that people study always.
Currently, thering is ion to lead to increase the medicine-feeding technology that skin applies the osmotic absorption of external drug or skin care item
Enter, ultrasonic wave, electroporation, micropin and chemical enhancers etc., these methods it is sorbefacient and meanwhile all more or less there is
Drawback, for example, effect it is unobvious, using big easy infection of not easy and wound etc..
In recent years, the skin that nanometer micropin becomes emerging promotees infiltration technology, and some researches show that nanometer micropins (nanometer chip) can
Administration channel is formed in skin surface in short time, and channel 20min or so is Natural closure, skin restores continuous whole
Property.New Cutaneous permeation technology has been widely applied to beautifying skin industry, but combining with new infiltration technology simultaneously can be mutually
The whitening product of promotion is not kept up with but, and compatible degree is unsatisfactory.
Summary of the invention
To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of whitening stostes and skin to promote infiltration technology contract
It is right it is high, mutually promote, the skin care whitening stoste that effect is good and preparation method thereof and in the technical application of Cutaneous permeation.
In order to achieve the above objectives, the present invention adopts the following technical scheme that：
The moisturizer panthenol or pantothenic acid that the present invention uses have moisturizing, anti-inflammatory, profit flesh, stimulation cell division etc. to skin
Effect, bioactivity is good, while having hygroscopicity and Electrostatic Absorption, can be deeply infiltrated into skin, stimulate epithelial cell
Growth, and promote wound healing, antiinflammation is played, be combined with each other, promote with Cutaneous permeation technology, strengthen function and effect.
It include Sodium Hyaluronate, the function with anti-inflammatory and accelerating wound healing in skin care whitening lotion provided by the invention
Effect, can not only moisturize the skin, increase gloss, and can prevent the generation of chapped skin and wrinkle.
Solvent in skin care whitening lotion provided by the invention, one of which 1,2- pentanediol are a kind of guarantors haveing excellent performance
Humectant, while there is antisepsis, the product of preservative free can be prepared, reduces allergy caused by preservative, and can be improved sun-proof
The water-resistance of product formula, the active constituent for dissolving indissoluble etc., compound with the preservative decoyl hydroximic acid in inventive formulation, prevent
Rotten performance enhancement, and the ill effect without traditional preservative.
In addition, the preservative Sensiva SC50 in skin care whitening formula of liquid of the present invention, it can not only be added to water phase, but also can be with
It is added to oily phase, when being added to water phase, it can form an antibacterial environment, play antisepsis to entire formula, and being capable of synergy
Traditional cosmetics preservative such as Phenoxyethanol, methylisothiazolinone or methylparaben etc., while can synergy alcohols and two
Alcohols can be improved the antibacterial action of glycols such as pentanediol or ethohexadiol in an oil-in-water lotion, in addition, ethyl
Hexyl glycerol can effectively inhibit the growth and breeding for the bacterium for causing peculiar smell, while not influence the beneficial skin flora of human body.
And the niacinamide in inventive formulation, it can be used as nutritive additive in cosmetics, prevent pachylosis, nicotinoyl
Amine has the function of promotion hair follicle position capillary circulation, provides more multi-nutrient for hair follicle.
In addition, also introducing tranexamic acid in skin care whitening formula of liquid of the present invention.Tranexamic acid has whitening, Kohakuhi and side
It helps skin to releive quelling effect, and skin chromogenesis sedimentation problem can be prevented, whitening colour of skin energy protease inhibition is to peptide bond
The catalytic action of hydrolysis to prevent the activity of such as rising property protease enzyme, and then inhibits the epidermis at blackspot position thin
The confusion of born of the same parents' function, and inhibit melanin enhancement factor group, then thoroughly break off because of the melanin that ultraviolet light irradiates and is formed
The approach of generation allows blackspot no longer to thicken, expand and increase, so as to be effectively prevented and improve the pigment deposition of skin,
By the lysine-binding site on reversible plasminogen molecule, cause plasminogen that cannot be changed into fibrinolysin, from
And effectively inhibits fibrinolysis, generates anastalsis.
Specifically, including in every 100kg raw material the present invention provides a kind of skin care whitening stoste：
Glycerol：2-5kg；
Moisturizer：1kg；
Sodium Hyaluronate：0.01-1kg；
Surfactant：0.05kg；
Solvent：1-10kg；
Preservative：0.01-1kg；
Preservative：0.05-0.2kg；
Niacinamide：0.5-5kg；
Tranexamic acid：0.1-4kg；
Water：Surplus,
Form A phase after the water, glycerol and moisturizer mixing, the Sodium Hyaluronate, surfactant, solvent,
B phase is formed after preservative, preservative mixing, and the niacinamide and tranexamic acid is classified as C phase.
Further, above-mentioned moisturizer is panthenol or pantothenic acid.
Above-mentioned surfactant is EDETATE SODIUM.
Above-mentioned solvent is at least one of hexylene glycol, pentanediol, propylene glycol, pungent glycol.
Above-mentioned preservative is Sensiva SC50.
And above-mentioned preservative is then decoyl hydroximic acid.
The present invention discloses a kind of preparation methods of above-mentioned skin care whitening stoste, include the following steps：
S1：Main cooker is added according to quality proportioning in A phase each component first, and is heated to 80 DEG C, is uniformly mixed consistent；
S2：Main cooker is cooled to 50 DEG C, side pot is added according to quality proportioning in B phase each component, is uniformly mixed, and will
It is put into A phase, is uniformly mixed with A phase；
S3：Main cooker is cooled to 45 DEG C again, the niacinamide and tranexamic acid of C phase are finally sequentially added into main cooker, is stirred
It after being uniformly dissolved, is cooled to room temperature, discharging obtains skin care whitening stoste after detection is qualified.
In addition, above-mentioned skin care whitening stoste promotees to seep technical application in skin, include the following steps：In cleaning skin
Afterwards, promote to seep instrument perpendicular contact skin surface using nanometer chip and carry out pricking method point by point, every effect 1s is then other to move a core
The width of piece carries out the pricking method of next point, while skin surface formation administration channel, pricking method, imports skin care whitening stoste,
The skin of same point repeats to import three times.
Further, above-mentioned skin care whitening stoste is by the service life of Cutaneous permeation technology：Once a week.And point
The depth of thorn is then at least skin cuticula.
The invention has the beneficial effects that：Skin care whitening formula of the present invention passes through the compounding of each component in formula, no
The effect of whitening, nutrition, moisturizing can be only played to skin, while being combined with Cutaneous permeation technology, promote to skin into
Row pricking method during forming administration channel, has effects that anti-inflammatory, sterilization, promotes wound healing, so that whitening product and rush
Infiltration technology has reached perfect combination.
Specific embodiment
Below in conjunction with detailed description of the invention by specific embodiments, the advantages and features of the present invention will be with describing
And it is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Art technology
Personnel should be understood that without departing from the spirit and scope of the invention can details and form to technical solution of the present invention
It modifies or replaces, but these modifications and replacement are fallen within the protection scope of the present invention.
In the examples below, moisturizer is panthenol, it is of course also possible to be pantothenic acid, surfactant is EDETATE SODIUM, molten
Agent be hexylene glycol, pentanediol, propylene glycol mixture, preservative is Sensiva SC50, and preservative is then decoyl hydroximic acid
Embodiment 1：
It include component and content (units/kg) as shown in the table in every 100kg skin care whitening stoste：
Embodiment 2：
It include component and content (units/kg) as shown in the table in every 100kg skin care whitening stoste：
Embodiment 3：
It include component and content (units/kg) as shown in the table in every 100kg skin care whitening stoste：
The preparation method of the skin care whitening stoste of embodiment 1-3 is：
S1：Main cooker is added according to quality proportioning in A phase each component first, and is heated to 80 DEG C, is uniformly mixed consistent；
S2：Main cooker is cooled to 50 DEG C, side pot is added according to quality proportioning in B phase each component, is stirred evenly, and thrown
Enter into A phase, is uniformly mixed with A phase；
S3：Main cooker is cooled to 45 DEG C again, the niacinamide and tranexamic acid of C phase are finally sequentially added into main cooker, is stirred
It after being uniformly dissolved, is cooled to room temperature, discharging obtains skin care whitening stoste after detection is qualified.
By skin care whitening stoste described in embodiment 1 and comparative example 1 (0.5% tranexamic acid solution) and 2 (physiology of comparative example
Salt water) it is applied to skin rush infiltration technology, application process is identical with application conditions.
Specially：
One, subject's data：
200 healthy volunteers are recruited, skin type Fitzpatrick III~IV type, the age 28~55 years old, men and women was each
100, volunteer's face did not received microneedle theraphy；Body is strong usually, non-communicable disease, disease in the blood system, mental disease,
Skin neoplasin；Without skin allergy history；Women is not in gestation or nursing period；Without the bad habits such as smoke, drink, according to men and women's ratio
Example is randomly divided into five groups, and every group of 40 people, male 20, female 20.
Two, instrument and material：
Nanometer micropin：This research uses 3DL-Z type nanometer micropin, it is pasted on plastics crystal by a micro-needle array chip
It forms on head, is provided by Suzhou Natong Bionanotechnology Ltd..Chip grows (5.0 ± 2.5) mm, wide (5.0 ± 2.5)
Mm, thick 0.3mm, dot matrix quantity (100 ± 25) are a；Array heights 0.15mm；Taper (40 ± 3) °, lot number：251022-2.Nano-crystal
Promote to seep instrument (SPE-10, Suzhou Natong Bionanotechnology Ltd.), German CK Multi-functional skin tester.0.5% ammonia first
Naphthenic acid solution (common name：Acidum transamicum sodium chloride injection liquid, trade name：Victory is solidifying, specification：100ml, tranexamic acid 0.5g and chlorine
Change sodium 0.85g, national drug standard H20020442, sincere pharmaceutcal corporation, Ltd provides by long spring.)
Three, treatment method：
After cleaning face and natural air drying, the full face skin of physiological saline group subject continues soak physiological saline, then makes
Promoted to seep instrument perpendicular contact skin surface and point-by-point electronic pricking method with electronic nano-crystal, every effect 1s, the depth of pricking method is skin angle
Matter layer.Then the other width for moving a chip carries out next point pricking method, and method completes full face importing according to this, and treatment repeats 3 every time
It is secondary.The skin care whitening stoste subject of 0.5% tranexamic acid solution group subject and embodiment 1-3 are complete respectively in the same way
The skin care whitening stoste of face importing 0.5% tranexamic acid solution and embodiment 1-3.Five groups of subjects all receive weekly once to control
It treats, treats 2 months altogether, subject cannot receive other face-beauty therapeutics and take beauty related drugs or health care during treatment
Product；Every group of subject receives to shoot photo with digital camera before and after treatment and detects percutaneous loss of moist (trans- weekly
Epidermal water loss, TEWL), water content of stratum corneum, erythema dose (ED), melanocyte and skin elasticity；It is asked by skin condition
Volume investigation subject's satisfaction and adverse reaction.
Four, skin test：
Without sunlight direct projection in test cabinet, it is calm, control 22 DEG C of room temperature or so, humidity 50%~60%.Every subject is clear
Behind face cleaning portion do not use any cosmetics, before testing 30min enter in room sit quietly it is to be measured.It is first shot using digital camera former
Beginning picture reuses water loss test probe, moisture measurement probe, melanin and the blood of German CK Multi-functional skin tester
Red pigment test probe, elastic fibrous tissue test probe detection TEWL, water content of stratum corneum, erythema dose (ED), melanocyte and skin elasticity.
It keeps instrument probe to act perpendicularly to skin when test, and chooses face and fix position everywhere, read after numerical stability every time,
It is averaged and statisticallys analyze；Hair and other articles is avoided to cover, contact measured position.
Five, efficacy assessment standard：
1. subjective assessment：Please subject to treatment before and last time treat after skin condition give a mark.The colour of skin and glossiness
Scoring is very dissatisfied=1 point ,=2 points dissatisfied, general=3 points ,=4 points satisfied, very satisfied=5 points by 1 point to 5 points,
Full marks 10 divide, and subjective scoring is higher, i.e., more satisfied to skin condition；
2. objective evaluation：German CK Multi-functional skin tester index compares the number before treating and after last time treatment
Value changes.
Six, statistical analysis：
Using 17.0 version of SPSS software, detection data is with x-± s is indicated, is examined using t, P < 0.05 is considered having
It is statistically significant.
Seven, result：
(1) MC760 digital skin analyzer testing result：
TEWL, water content of stratum corneum, erythema dose (ED), skin elasticity：It is shown in Table 1.Two groups of volunteers survey the warp of skin before the treatment
Skin loss of moist, water content of stratum corneum, erythema index, elasticity indexes, all no difference of science of statistics, that is, be comparable；It is long through needle
The nanometer micropin of 0.15mm is handled, and it is aqueous that physiological saline group 72h after last time is treated surveys percutaneous loss of moist, cuticula
Skin care whitening stoste described in amount, erythema index, elasticity indexes and 0.5% tranexamic acid solution group and embodiment 1-3 is most
Afterwards after seance 72h result.No difference of science of statistics.
TEWL, the water content of stratum corneum, erythema that 1 five groups of volunteers of table are before the treatment and 72h is measured after last time treatment
Index, elasticity indexes, melanocyte value compare (x-±s)
As shown in Table 1：After the processing of nanometer micropin the percutaneous loss of moist of 72h skin, erythema index, elasticity indexes, with
Than no difference of science of statistics before treatment, but the effect of obvious embodiment 1-3 of the present invention is better than comparative example 1 and comparative example 2；
And in terms of cuticula moisture content, 1-3 of the embodiment of the present invention has significant difference (P < 0.05) compared with pre-treatment, in addition, right
All there were significant differences (P < 0.05) with the melanocyte value before first treatment for ratio 1 and the melanocyte value of the embodiment of the present invention 1-3, and
The effect of 1-3 of the embodiment of the present invention is far superior to comparative example 1.
(2) satisfaction investigation result：
Five groups of volunteers are to the skin condition marking respectively (4.600 ± 1.466) point before treatment, (5.0 ± 1.925)
Point, no difference of science of statistics is comparable.1 volunteer of comparative example to after treatment skin condition marking for (6.287 ±
1.622) divide, compared with pre-treatment no difference of science of statistics；2 volunteer of comparative example to after treatment skin condition marking for (5.244 ±
1.573) divide, compared with pre-treatment no difference of science of statistics, and the volunteer of embodiment 1-3 is to the skin condition marking point after treatment
It is not：(8.468 ± 1.975) divide, (9.077 ± 0.952) point, (8.276 ± 1.385) point, all have compared with pre-treatment aobvious
It writes sex differernce (P < 0.05).
It is all to there is the volunteer for participating in studying not occur the adverse reactions such as infection, erythema, oedema.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the above embodiments do not limit the invention in any form, all obtained by the way of equivalent substitution or equivalent transformation
Technical solution is fallen within the scope of protection of the present invention.
Claims (10)
1. a kind of skin care whitening stoste, which is characterized in that include in every 100kg raw material：
Glycerol：2-5kg；
Moisturizer：1kg；
Sodium Hyaluronate：0.01-1kg；
Surfactant：0.05 kg；
Solvent：1-10kg；
Preservative：0.01-1kg；
Preservative：0.05-0.2kg；
Niacinamide：0.5-5kg；
Tranexamic acid：0.1-4kg；
Water：Surplus,
Water, glycerol and the moisturizer forms A phase, the Sodium Hyaluronate, surfactant, solvent, anti-corrosion after mixing
B phase is formed after agent, preservative mixing, and the niacinamide and tranexamic acid is classified as C phase.
2. a kind of skin care whitening stoste according to claim 1, which is characterized in that the moisturizer is panthenol or general
Acid.
3. a kind of skin care whitening stoste according to claim 1, which is characterized in that the surfactant is EDTA bis-
Sodium.
4. a kind of skin care whitening stoste according to claim 1, which is characterized in that the solvent is hexylene glycol, penta 2
At least one of alcohol, propylene glycol.
5. a kind of skin care whitening stoste according to claim 1, which is characterized in that the preservative is that ethylhexyl is sweet
Oil.
6. a kind of skin care whitening stoste according to claim 1, which is characterized in that the preservative is decoyl hydroxyl oxime
Acid.
7. the preparation method of skin care whitening stoste described in a kind of any one of claim 1-6 claim, which is characterized in that packet
Include following steps：
S1：Main cooker is added according to quality proportioning in A phase each component first, and is heated to 80 DEG C, is uniformly mixed consistent；
S2：Main cooker is cooled to 50 DEG C, side pot is added according to quality proportioning in B phase each component, is stirred evenly, and put into
In A phase, it is uniformly mixed with A phase；
S3：Main cooker is cooled to 45 DEG C again, the niacinamide and tranexamic acid of C phase, stirring and dissolving are finally sequentially added into main cooker
It after uniformly, is cooled to room temperature, discharging obtains skin care whitening stoste after detection is qualified.
8. a kind of skin care whitening stoste described in claim 1 promotees to seep technical application in skin, which is characterized in that including with
Lower step：After cleaning skin, promotees to seep instrument perpendicular contact skin surface using nanometer chip and carry out pricking method point by point, every effect
1s, then the other width for moving a chip carries out the pricking method of next point, while skin surface formation administration channel, pricking method,
Skin care whitening stoste is imported, the skin of same point repeats to import three times.
9. a kind of skin care whitening stoste according to claim 8 promotees to seep technical application in skin, which is characterized in that shield
Skin whitening stoste is by the service life of Cutaneous permeation technology：Once a week.
10. a kind of skin care whitening stoste according to claim 8 promotees to seep technical application in skin, which is characterized in that
The depth of pricking method is at least skin cuticula.
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| CN201810888403.2A CN108815013B (en) | 2018-08-06 | 2018-08-06 | Skin care and whitening stock solution and application thereof in skin permeation promoting technology |
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| CN201810888403.2A CN108815013B (en) | 2018-08-06 | 2018-08-06 | Skin care and whitening stock solution and application thereof in skin permeation promoting technology |
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| CN108815013B CN108815013B (en) | 2021-12-03 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453095A (en) * | 2018-11-26 | 2019-03-12 | 广州秉科医药科技有限公司 | A kind of niacinamide stoste and preparation method thereof |
| CN109464315A (en) * | 2019-01-02 | 2019-03-15 | 广东天源生物科技有限公司 | A kind of niacinamide stoste and preparation method thereof with the low and deep skin performance of improvement |
| CN109793757A (en) * | 2019-03-28 | 2019-05-24 | 北京刷新活力健康科技有限公司 | A kind of composition and its preparation method and application inhibiting cicatrix of skin growth |
| CN111494234A (en) * | 2020-05-08 | 2020-08-07 | 无锡元旭生物技术有限公司 | Compound whitening and freckle-removing patch with function components quantitatively released and preparation method thereof |
| CN114028258A (en) * | 2021-12-10 | 2022-02-11 | 朱学军 | Whitening essence |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453095A (en) * | 2018-11-26 | 2019-03-12 | 广州秉科医药科技有限公司 | A kind of niacinamide stoste and preparation method thereof |
| CN109464315A (en) * | 2019-01-02 | 2019-03-15 | 广东天源生物科技有限公司 | A kind of niacinamide stoste and preparation method thereof with the low and deep skin performance of improvement |
| CN109793757A (en) * | 2019-03-28 | 2019-05-24 | 北京刷新活力健康科技有限公司 | A kind of composition and its preparation method and application inhibiting cicatrix of skin growth |
| CN109793757B (en) * | 2019-03-28 | 2021-06-22 | 北京刷新活力健康科技有限公司 | Composition for inhibiting growth of skin scar and preparation method and application thereof |
| CN111494234A (en) * | 2020-05-08 | 2020-08-07 | 无锡元旭生物技术有限公司 | Compound whitening and freckle-removing patch with function components quantitatively released and preparation method thereof |
| CN114028258A (en) * | 2021-12-10 | 2022-02-11 | 朱学军 | Whitening essence |
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