CN106963268A - Application of the microneedle in skin cleaning - Google Patents

Application of the microneedle in skin cleaning Download PDF

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Publication number
CN106963268A
CN106963268A CN201710287312.9A CN201710287312A CN106963268A CN 106963268 A CN106963268 A CN 106963268A CN 201710287312 A CN201710287312 A CN 201710287312A CN 106963268 A CN106963268 A CN 106963268A
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CN
China
Prior art keywords
skin
microneedle
cleaning
application
characterised
Prior art date
Application number
CN201710287312.9A
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Chinese (zh)
Inventor
徐百
Original Assignee
苏州纳通生物纳米技术有限公司
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Publication date
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Priority to CN201710287312.9A priority Critical patent/CN106963268A/en
Publication of CN106963268A publication Critical patent/CN106963268A/en

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Classifications

    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47KSANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K7/00Body washing or cleaning implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology

Abstract

The present invention relates to a kind of application process of microneedle in skin cleaning, it is characterised in that:Using microneedle perforated skin cuticula, then extract, reach the effect of deep layer cleaning skin.4 microns to 2000 microns of described microneedle length.Cleaning is carried out to skin using the inventive method can realize that deep layer is cleared up, and improve cleaning effect.

Description

Application of the microneedle in skin cleaning

Technical field

The present invention relates to clean technologies field, application of the microneedle in skin cleaning is particularly related to.

Background technology

Microneedle, is also nanometer micropin, nanometer chip, is to be promoted to ooze special tool according to the nanometer of human body skin mechanical development Tool, it is to be formed by monocrystalline silicon (or other materials) by nanometer technology technique engraving.The surface of nanometer chip is a series of micro- Pin array, they can open the outmost cuticula of skin, while skin corium will not be injured, greatly improve the osmotic energy of nutrient Power.The bio-compatibility of monocrystalline silicon in turn ensure that the security of nano-crystal in use.At present in cutaneous penetration technical field, Microneedle is just widely used.

It is the primary condition for ensureing health to safeguard skin cleaning.Skin dirt refers to be attached to the dirt of skin surface Thing, can influence pore unobstructed, hinder the performance of skin and mucous membrane normal physiological function.Skin dirt includes following several types.

1. physiological dirt:The metabolite for being produced, secreting or being drained by human body, including aging come off cell, sebum, The excreta of sweat, mucous membrane and cavity.

2. pathologic dirt:The scales of skin that peel off, fester, scab of dermatosis patient etc.;The increased sweat of hyperpyrexia;The rows such as diarrhoea, vomiting Let out thing.

3. exogenous dirt:Include the residual of microorganism, environmental pollutants, all kinds of cosmetics and external used medicine.With graininess Thing is deposited on the dust, metal or nonmetallic oxide of skin surface, can be removed by clear water.Film-like is pasted on skin Grease, fester or dirt in molecule combined closely with electrostatic attraction or intermolecular chemical binding force and skin, then need It could be removed using cleaning agent.

In the prior art, all kinds of skin cleaners can be usually used, the wetting of cleaning agent, infiltration, emulsification, scattered etc. is utilized A variety of effects make dirt disengaging skin enter in water, after sufficiently emulsification solubilising, are stably dispersed in water, then through clear water repeatedly Rinse and remove.

Either clear water rinsing still uses cleaning agent, can only often remove the dirt of skin surface attachment, and can not be real Existing deep layer cleaning.

The T-shaped area of face, refers to forehead and nose.

Blackhead is opening acne, and there is stain the inside, and hoary hair is closo acne, is not open, and is the initial stage of blackhead, greatly More by skin dirt, to clear up in time.

Therefore, the present inventor needs a kind of new technology of design badly to improve its problem.

The content of the invention

The present invention is intended to provide a kind of application process of microneedle in skin cleaning, realizes deep layer cleaning, improves cleaning Effect.

In order to solve the above technical problems, the technical scheme is that:

Using microneedle perforated skin cuticula, then extract.

It is preferred that, after microneedle is extracted, skin is wiped and/or cleaned.

It is preferred that, the length of the microneedle is 4 microns to 2000 microns.

It is preferred that, the length of the microneedle is 20 microns to 200 microns.

It is preferred that, described microneedle is constituted micropin with the density of 20 to 20000 every square centimeter every square centimeter Array.

It is preferred that, the microneedle array is made up of monocrystalline silicon, metal, high polymer material.

It is preferred that, the microneedle is solid needle or hollow needle.

It is preferred that, described skin, which is made a living, the skin of face of blackhead and/or hoary hair.

It is preferred that, described skin is periocualr skin.

Using above-mentioned technical proposal, the present invention at least includes following beneficial effect:

The microneedle for being conventionally applied to beauty and field of medical technology is incorporated into cleaning applications by the present invention, it is possible to achieve right The deep layer cleaning of cortex, improves cleaning effect.

Especially, by the skin of face with blackhead and/or hoary hair, especially T-shaped area's skin (such as strawberry nose) Cleaning, can remove the dirt of skin deep part, improve facial appearance.By the cleaning to periocualr skin, part can be promoted Microcirculation, improves livid ring around eye and reduces wrinkle near the eyes.

Embodiment

The present invention will be hereafter clearly and completely described, it is clear that described embodiment is only the one of the present invention Section Example.Disclosure based on this specification, those of ordinary skill in the related art are not making creative work premise Lower obtained every other embodiment, belongs to the scope of protection of the invention.

The skin of face of embodiment 1 cleans (acupuncture)

Method:Take microneedle to be vertically pierced into cheek skin, extract.

Effect experiment 1:Skin of face acupuncture cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, experimental group volunteer face leading microneedle (monocrystalline silicon microneedle array, 20 microns of micropin length, array density:Often put down Have 10000 microneedles on square centimetre of monocrystalline silicon) cuticula perforation, then wipe face 1 time with dry sterile gauze.Control group Volunteer is in addition to the processing of not all right microneedle, remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Method is that 5cm × 5cm sterility specifications plates are lain against into will On hope person's skin, round skin is embrocated anyhow in dimension board with the cotton swab for being soaked with the sterile eluent containing corresponding nertralizer each 5 times, hand contact portion is cut off, is thrown in sterile eluent test tubes of the 10mL containing corresponding nertralizer, is shaken 1min, take 1mL to train Support, put culture 48h in 37 DEG C of insulating boxs, bacterial colony count is carried out with viable bacteria counting method.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 1:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of skin of face.

1 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 33.74±19.28 Experimental group 30 19.65±11.37*

Note:Compared with control group, p≤0.01 is expected, similarly hereinafter in * p≤0.05.

The skin of face of embodiment 2 cleans (clear water)

Method:Take microneedle to be vertically pierced into cheek skin, extract, then using clear water cleaning.

Effect experiment 2:Skin of face acupuncture+clear water cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, experimental group volunteer face leading microneedle (steel microneedle array, 4 microns of micropin length, array density:Every square Centimetre have 20 microneedles) cuticula perforation, the clear water that 30-40 DEG C is then drawn with towel cleans 5 times to face.Control group will Hope person is in addition to the processing of not all right microneedle, remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Method is that 5cm × 5cm sterility specifications plates are lain against into will On hope person's skin, round skin is embrocated anyhow in dimension board with the cotton swab for being soaked with the sterile eluent containing corresponding nertralizer each 5 times, hand contact portion is cut off, is thrown in sterile eluent test tubes of the 10mL containing corresponding nertralizer, is shaken 1min, take 1mL to train Support, put culture 48h in 37 DEG C of insulating boxs, bacterial colony count is carried out with viable bacteria counting method.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 2:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of skin of face.

2 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 14.66±5.67 Experimental group 30 9.25±4.37*

The skin of face of embodiment 3 cleans (mildy wash)

Method:Take microneedle to be vertically pierced into cheek skin, extract, then using mildy wash cleaning.

Effect experiment 3:Skin of face acupuncture+mildy wash cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, experimental group volunteer face leading microneedle (monocrystalline silicon microneedle array, 200 microns of micropin length, array density:Often Have 20000 microneedles on square centimeter monocrystalline silicon) cuticula perforation, 1-2g mildy wash is then taken, painting of gently being drawn a circle with finger Smear after skin of face, the clear water for drawing 30-40 DEG C with towel is cleaned to face.Control group volunteer is except the processing of not all right microneedle Outside, remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Sampling and method for cultivation of bacteria are with effect experiment 1.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 3:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of skin of face.

3 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 10.32±4.76 Experimental group 30 7.94±2.79*

The skin of face of embodiment 4 cleans (acupuncture after mildy wash)

Method:Take mildy wash to smear skin of face, be then vertically pierced into cheek with microneedle, extract, then using clear water Cleaning.

Effect experiment 4:Skin of face mildy wash+acupuncture cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, experimental group volunteer takes 1-2g mildy wash, after smearing of gently being drawn a circle with finger skin of face, with microneedle (macromolecule Microneedle array, 100 microns of micropin length, array density:It is every square centimeter to have 1000 microneedles) cutin is carried out to skin of face Layer perforation, then, the clear water for drawing 30-40 DEG C with towel are cleaned to face.Control group volunteer except not all right microneedle processing in addition to, Remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Sampling and method for cultivation of bacteria are with effect experiment 1.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 4:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of skin of face.

4 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 11.07±5.35 Experimental group 30 8.12±3.28*

The hand skin of embodiment 5 cleans (clear water)

Method:Take microneedle perpendicular insertion to enter hand skin, extract, then using clear water cleaning.

Effect experiment 5:Hand skin acupuncture+clear water cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, the leading microneedle of experimental group volunteer's hand (monocrystalline silicon microneedle array, 20 microns of micropin length, array density:Often put down Have 10000 microneedles on square centimetre of monocrystalline silicon) cuticula perforation, 1min then is rinsed to hand with flowing water.Control group Volunteer is in addition to the processing of not all right microneedle, remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Sampling and method for cultivation of bacteria are with effect experiment 1.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 5:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of hand skin.

5 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 22.36±10.24 Experimental group 30 15.72±9.74*

The hand skin of embodiment 6 cleans (soap)

Method:Take microneedle perpendicular insertion to enter hand skin, extract, then using soap cleaning.

Effect experiment 6:Hand skin acupuncture+soap cleaning effect

Experimental method selects 60 healthy adult volunteers at random, and men and women half and half.It is divided into two groups:Experimental group and control group. During experiment, the leading microneedle of experimental group volunteer's hand (monocrystalline silicon microneedle array, 30 microns of micropin length, array density:Often put down Have 10000 microneedles on square centimetre of monocrystalline silicon) cuticula perforation, then hand is cleaned with soap.Control group is volunteered Person is in addition to the processing of not all right microneedle, remaining experiment condition and the same experimental group of method.

Cleaning carries out microbe sampling to skin immediately after terminating.Sampling and method for cultivation of bacteria are with effect experiment 1.

Experimental result is represented with mean ± s, and t inspections are carried out using SPSS10.0 statistical softwares.

Results Test results are shown in Table 6:The mean skin clump count of experimental group is less than control group, and its difference has system Meter learns meaning (p≤0.05), as a result shows, microneedle processing skin can significantly improve the cleaning effect of hand skin.

6 two groups of volunteer's skin sampling clump count (cfu/cm of table2)

Group Number of cases Clump count Control group 30 18.41±10.16 Experimental group 30 13.32±7.83*

Microneedle in the present invention can be conventional microneedle array of the prior art, can also be preferably Suzhou Na Tongsheng The microneedle array of thing Nanosolutions GmbH research and development, its concrete structure may refer to corresponding patent application, such as a kind of passage Type nanometer beauty instrument etc..

It is well known that being just used for beauty and field of medical technology, main research and development and innovation at the beginning of microneedle array birth Direction is transdermal to liquid, but then has no precedent application in cleaning applications, it is also difficult to recognize that it can be produced in cleaning applications Come into force really.Applicant in this case is found surprisingly that can realize that, to skin progress deep clean, cleaning effect is excellent by crystallite array In existing clean method.

The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or using the present invention. A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one The most wide scope caused.

Claims (9)

1. application of the microneedle in skin cleaning, it is characterised in that:Using microneedle perforated skin cuticula, then extract.
2. application of the microneedle as claimed in claim 1 in skin cleaning, it is characterised in that:After microneedle is extracted, to skin Skin is wiped and/or cleaned.
3. application of the microneedle in skin cleaning as described in claim 1,2, it is characterised in that:The length of the microneedle For 4 microns to 2000 microns.
4. application of the microneedle as claimed in claim 3 in skin cleaning, it is characterised in that:The length of the microneedle is 20 microns to 200 microns.
5. application of the microneedle in skin cleaning as described in claim 1-4, it is characterised in that:Described microneedle is with every The density of square centimeter 20 to 20000 every square centimeter constitutes microneedle array.
6. application of the microneedle as claimed in claim 5 in skin cleaning, it is characterised in that:The microneedle array is by monocrystalline Silicon, metal, high polymer material are made.
7. application of the microneedle in skin cleaning as described in claim 1-6 is any, it is characterised in that:The microneedle is Solid needle or hollow needle.
8. the application of microneedle as described in claim 1-7 is any in skin cleaning, it is characterised in that described skin is There are blackhead and/or the skin of face of hoary hair.
9. the application of microneedle as described in claim 1-7 is any in skin cleaning, it is characterised in that described skin is Periocualr skin.
CN201710287312.9A 2017-04-27 2017-04-27 Application of the microneedle in skin cleaning CN106963268A (en)

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CN201710287312.9A CN106963268A (en) 2017-04-27 2017-04-27 Application of the microneedle in skin cleaning
PCT/CN2017/087781 WO2018196109A1 (en) 2017-04-27 2017-06-09 Application of micro-needle in skin cleaning

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CN104888343A (en) * 2015-05-07 2015-09-09 北京化工大学 Macromolecule solid micro needle and batched preparing method thereof
US20170028184A1 (en) * 2015-07-27 2017-02-02 Catura Corporation Device and method of skin care and treatment via microneedles having inherent anode and cathode properties, with or without cosmetic or pharmacological compositions
CN205251367U (en) * 2015-12-24 2016-05-25 广州远想生物科技有限公司 A equipment that is used for skin degree of depth cleanness and nurses

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