CN109069520A - 保护空气传播的病原体和刺激物的组合物和方法 - Google Patents
保护空气传播的病原体和刺激物的组合物和方法 Download PDFInfo
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US20170360815A1 (en) * | 2016-02-25 | 2017-12-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
US10596105B2 (en) * | 2017-06-29 | 2020-03-24 | Max Spielberg | Organic nasal treatment solution |
CN108434444A (zh) * | 2018-04-23 | 2018-08-24 | 杭州索契健康科技有限公司 | 一种滴剂、片剂和粉剂型的n-乙酰神经氨酸抗病毒组合物 |
JP7351296B2 (ja) * | 2018-04-27 | 2023-09-27 | ライオン株式会社 | 口腔内菌叢改善剤及び口腔用組成物 |
CN112439055A (zh) * | 2019-08-29 | 2021-03-05 | 湘北威尔曼制药股份有限公司 | 用于预防或治疗尿酸性疾病的组合物 |
WO2021079921A1 (ja) * | 2019-10-25 | 2021-04-29 | ライオン株式会社 | 口腔内の病原性細菌に対する生育抑制剤、口腔内の菌叢改善剤及び口腔用組成物 |
IT202000005011A1 (it) * | 2020-03-09 | 2021-09-09 | Sofar Spa | Lattoferrina per uso orale ad azione antivirale |
IT202000005026A1 (it) * | 2020-03-09 | 2021-09-09 | Sofar Spa | Lattoferrina per uso inalatorio ad azione antivirale |
IT202100002003A1 (it) * | 2021-02-01 | 2022-08-01 | Plumestars S R L | Nuove composizioni antivirali e loro utilizzo in terapia e nel trattamento di infezioni virali |
GB2620887A (en) * | 2021-04-06 | 2024-01-24 | Kapeleris John | Infant formula |
CN115886073A (zh) * | 2022-04-01 | 2023-04-04 | 北京三元食品股份有限公司 | 一种发酵乳 |
US20230321158A1 (en) * | 2022-04-08 | 2023-10-12 | Holista Biotech Sdn Bhd | Compositions for protection against pathogen infection and method thereof |
WO2024159015A1 (en) * | 2023-01-25 | 2024-08-02 | North Carolina State University | Compositions and methods relating to inhalable therapeutic compositions |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1679926A (zh) * | 2005-01-07 | 2005-10-12 | 安米 | 人溶菌酶在制备抗流行性感冒病毒药物中的应用 |
KR20100132737A (ko) * | 2009-06-10 | 2010-12-20 | 장선호 | 시알릭산-함유 유청 단백질을 유효성분으로 함유하는 인플루엔자 바이러스 감염증의 예방 및 치료용 조성물 |
US7989003B2 (en) * | 1998-09-01 | 2011-08-02 | Zicam, Llc | Method and composition for delivering zinc to the nasal membrane |
US20130034542A1 (en) * | 2010-04-23 | 2013-02-07 | Probiotec Limited | Cold treatment |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051231A (en) | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
US20010053359A1 (en) | 1994-07-26 | 2001-12-20 | Peter Watts | Drug delivery composition for the nasal administration of antiviral agents |
US5908635A (en) | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
US5879712A (en) | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
US5756122A (en) | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
IL115199A (en) | 1995-09-07 | 2005-05-17 | Opperbas Holding Bv | Composition comprising a polynucleic acid molecule in a liposome and method using said composition |
AU2911197A (en) | 1996-05-24 | 1998-01-05 | Imperial College Of Science, Technology And Medicine | Polycationic sterol derivatives as transfection agents |
US6126965A (en) | 1997-03-21 | 2000-10-03 | Georgetown University School Of Medicine | Liposomes containing oligonucleotides |
US20030229040A1 (en) | 1997-03-21 | 2003-12-11 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
IT1291366B1 (it) * | 1997-05-14 | 1999-01-07 | Angelini Ricerche Spa | Composizione farmaceutica antivirale comprendente acido glicirrizico ed almeno una proteina dotata di attivita' antivirale |
JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
ATE321882T1 (de) | 1997-07-01 | 2006-04-15 | Isis Pharmaceuticals Inc | Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre |
US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
US20030073640A1 (en) | 1997-07-23 | 2003-04-17 | Ribozyme Pharmaceuticals, Inc. | Novel compositions for the delivery of negatively charged molecules |
WO1999004819A1 (en) | 1997-07-24 | 1999-02-04 | Inex Pharmaceuticals Corporation | Liposomal compositions for the delivery of nucleic acid catalysts |
US6225118B1 (en) | 1997-10-01 | 2001-05-01 | Biocure Limited | Multicellular in vitro assay of angiogenesis |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6093417A (en) * | 1999-01-11 | 2000-07-25 | Advanced Medical Instruments | Composition to treat ear disorders |
AU3703100A (en) | 1999-02-22 | 2000-09-14 | Georgetown University | Antibody fragment-targeted immunoliposomes for systemic gene delivery |
US6365156B1 (en) * | 1999-04-16 | 2002-04-02 | Osel, Inc. | Method for improving the half-life of soluble viral-specific ligands on mucosal membranes |
US7112337B2 (en) | 1999-04-23 | 2006-09-26 | Alza Corporation | Liposome composition for delivery of nucleic acid |
US6200599B1 (en) | 1999-10-07 | 2001-03-13 | The Regents Of The University Of California | Ortho ester lipids |
US20050037086A1 (en) | 1999-11-19 | 2005-02-17 | Zycos Inc., A Delaware Corporation | Continuous-flow method for preparing microparticles |
US6649592B1 (en) | 2000-01-14 | 2003-11-18 | Science & Technology Corporation @ Unm | Peptide inhibitors of LFA-1/ICAM-1 interaction |
US20020012998A1 (en) | 2000-03-29 | 2002-01-31 | Igor Gonda | Cationic liposomes |
US20030072794A1 (en) | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
CA2416899C (en) * | 2000-07-28 | 2010-10-12 | Immupharm Aps | Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract |
US7045159B1 (en) | 2000-09-19 | 2006-05-16 | Rutgers, The State University Of New Jersey | Antiviral substances from plant cuticular and epiciticular material |
CZ308053B6 (cs) | 2000-12-01 | 2019-11-27 | Max Planck Gesellschaft | Izolovaná molekula dvouřetězcové RNA, způsob její výroby a její použití |
WO2002076427A2 (en) | 2001-03-26 | 2002-10-03 | Thomas Jefferson University | Ph sensitive liposomal drug delivery |
CN1294991C (zh) | 2001-03-26 | 2007-01-17 | 阿尔扎公司 | 用于改善治疗物质的细胞内传递的脂质体组合物 |
GB2374008B (en) * | 2001-04-04 | 2005-03-16 | John Carter | Pharmaceutical compositions comprising copper and zinc |
US20030026831A1 (en) | 2001-04-20 | 2003-02-06 | Aparna Lakkaraju | Anionic liposomes for delivery of bioactive agents |
JP2004535388A (ja) | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
US7166435B2 (en) | 2001-08-06 | 2007-01-23 | The Quigley Corporation | Compositions and methods for reducing the transmissivity of illnesses |
WO2003015698A2 (en) | 2001-08-13 | 2003-02-27 | University Of Pittsburgh | Application of lipid vehicles and use for drug delivery |
WO2003051281A2 (en) | 2001-10-17 | 2003-06-26 | Ganado Research, L.L.C. | Composition and method to treat viral bacterial and parasitic infections and infestations |
DE10152145A1 (de) | 2001-10-19 | 2003-05-22 | Novosom Ag | Stabilisierung von Liposomen und Emulsionen |
WO2003041723A1 (de) | 2001-11-12 | 2003-05-22 | Reinmueller Johannes | Pharmazeutische anwendungen von hyaluronsäure-präparaten |
WO2003047633A2 (en) | 2001-12-04 | 2003-06-12 | Nanospectra Biosciences, Inc. | Treatment of angiogenesis disorders using targeted nanoparticles |
WO2003057190A1 (en) | 2001-12-31 | 2003-07-17 | Elan Pharmaceuticals, Inc. | Efficient nucleic acid encapsulation into medium sized liposomes |
AU2003205049B2 (en) | 2002-01-09 | 2009-05-28 | Transave, Inc. | Efficient nucleic acid encapsulation into medium sized liposomes |
CN101044154A (zh) * | 2002-02-14 | 2007-09-26 | 威廉·J·鲁特 | 治疗宿主中切割的嵌合分子 |
DE10207177A1 (de) | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
US7037520B2 (en) | 2002-03-22 | 2006-05-02 | Baylor College Of Medicine | Reversible masking of liposomal complexes for targeted delivery |
WO2003083443A2 (en) | 2002-03-29 | 2003-10-09 | University Of Florida | Lipid mediated screening of drug candidates for identification of active compounds |
AU2003237686A1 (en) | 2002-05-24 | 2003-12-12 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Rna interference mediating small rna molecules |
US8211448B2 (en) | 2003-07-07 | 2012-07-03 | Nares Ab | Microemulsions and its use for preventing airway diseases |
CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
US7297786B2 (en) | 2004-07-09 | 2007-11-20 | University Of Iowa Research Foundation | RNA interference in respiratory epitheial cells |
US20070135377A1 (en) | 2004-12-10 | 2007-06-14 | Roman Stephen B | Thixotropic anti-viral formulation |
US8679484B2 (en) | 2005-03-02 | 2014-03-25 | Polyrizon Ltd. | Method for removal of toxins from mucosal membranes |
US20070026085A1 (en) | 2005-07-26 | 2007-02-01 | Global Life Technologies Corp. | Antimicrobial and antiviral composition |
US20090011042A1 (en) | 2005-07-26 | 2009-01-08 | Global Life Technologies, Corp | Antimicrobial and antiviral composition |
US8999406B2 (en) | 2005-07-26 | 2015-04-07 | Global Life Technologies Corp. | Antimicrobial and antiviral composition |
US8119780B2 (en) | 2006-06-02 | 2012-02-21 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
JP5702601B2 (ja) | 2007-07-06 | 2015-04-15 | ラクレード,インコーポレーテッド | 気道中の生物膜を溶解するための加水分解酵素および酸化酵素の使用 |
EP2060257A1 (en) * | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
CA2746980C (en) | 2008-12-26 | 2016-10-11 | Nbc Meshtec, Inc. | Anti-viral composition containing univalent copper compound |
JP5018839B2 (ja) | 2009-07-22 | 2012-09-05 | 株式会社村田製作所 | 誘電体セラミックおよび積層セラミックコンデンサ |
PL2515889T3 (pl) * | 2009-12-22 | 2015-05-29 | Marinomed Biotechnologie Gmbh | Synergistyczna kompozycja przeciwwirusowa i jej stosowanie |
CN101966285B (zh) * | 2010-10-13 | 2012-05-23 | 郑州后羿制药有限公司 | 一种防治鸡呼吸道疾病的中药、中药气雾剂及其生产方法 |
JP5730041B2 (ja) | 2011-01-28 | 2015-06-03 | 日本ゼトック株式会社 | 口腔用組成物 |
WO2012142492A2 (en) * | 2011-04-15 | 2012-10-18 | University Of Georgia Research Foundation, Inc. | Methods for inhibiting virus replication |
US20130028882A1 (en) * | 2011-07-07 | 2013-01-31 | Humanitas Technology, LLC | Antiviral compositions and methods of their use |
FR2980974B1 (fr) | 2011-10-10 | 2014-02-21 | Alaxia | Composition comprenant un sel d'hypothiocyanite d'un cation alcalin, a l'etat solide |
EP2845606B1 (en) * | 2014-07-10 | 2018-09-05 | Symrise AG | Medicament for the prevention, curing or abating cough and inflammations of the respiratory system |
-
2017
- 2017-02-24 EP EP17757390.4A patent/EP3419629A4/en active Pending
- 2017-02-24 SG SG11201806868TA patent/SG11201806868TA/en unknown
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- 2017-02-24 US US15/442,604 patent/US20170246262A1/en active Pending
- 2017-02-24 WO PCT/US2017/019535 patent/WO2017147540A1/en active Application Filing
- 2017-02-24 KR KR1020187027589A patent/KR20180120204A/ko not_active Application Discontinuation
- 2017-02-24 CN CN201780013703.XA patent/CN109069520A/zh active Pending
- 2017-02-24 MX MX2018010198A patent/MX2018010198A/es unknown
- 2017-02-24 AU AU2017224113A patent/AU2017224113B2/en active Active
- 2017-02-24 CN CN202311743844.0A patent/CN117942405A/zh active Pending
- 2017-02-24 JP JP2018563765A patent/JP7071933B2/ja active Active
-
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- 2018-08-22 ZA ZA201805615A patent/ZA201805615B/en unknown
- 2018-08-23 IL IL261345A patent/IL261345B/en unknown
- 2018-08-23 MX MX2023002533A patent/MX2023002533A/es unknown
-
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- 2020-11-06 US US17/092,184 patent/US20220218798A9/en not_active Abandoned
-
2022
- 2022-05-09 JP JP2022076870A patent/JP7458438B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7989003B2 (en) * | 1998-09-01 | 2011-08-02 | Zicam, Llc | Method and composition for delivering zinc to the nasal membrane |
CN1679926A (zh) * | 2005-01-07 | 2005-10-12 | 安米 | 人溶菌酶在制备抗流行性感冒病毒药物中的应用 |
KR20100132737A (ko) * | 2009-06-10 | 2010-12-20 | 장선호 | 시알릭산-함유 유청 단백질을 유효성분으로 함유하는 인플루엔자 바이러스 감염증의 예방 및 치료용 조성물 |
US20130034542A1 (en) * | 2010-04-23 | 2013-02-07 | Probiotec Limited | Cold treatment |
Non-Patent Citations (1)
Title |
---|
MARLIN S等: "A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection", 《NATURE》 * |
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EP3419629A4 (en) | 2019-10-30 |
IL261345A (en) | 2018-10-31 |
AU2017224113B2 (en) | 2022-04-21 |
RU2018133581A (ru) | 2020-03-25 |
EP3419629A1 (en) | 2019-01-02 |
RU2018133581A3 (ja) | 2020-08-11 |
WO2017147540A1 (en) | 2017-08-31 |
US20220218798A9 (en) | 2022-07-14 |
ZA201805615B (en) | 2019-11-27 |
JP2022115999A (ja) | 2022-08-09 |
JP7071933B2 (ja) | 2022-05-19 |
CA3014764A1 (en) | 2017-08-31 |
CN117942405A (zh) | 2024-04-30 |
US20170246262A1 (en) | 2017-08-31 |
US20210052710A1 (en) | 2021-02-25 |
MX2018010198A (es) | 2019-06-12 |
MX2023002533A (es) | 2023-03-14 |
BR112018067914A2 (pt) | 2019-01-29 |
IL261345B (en) | 2022-04-01 |
JP2019506460A (ja) | 2019-03-07 |
SG11201806868TA (en) | 2018-09-27 |
AU2017224113A1 (en) | 2018-09-06 |
JP7458438B2 (ja) | 2024-03-29 |
KR20180120204A (ko) | 2018-11-05 |
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