CN109069382A - 用于眼睛和皮肤的美容处理套件、以及施用于眼睛和皮肤的化妆品 - Google Patents
用于眼睛和皮肤的美容处理套件、以及施用于眼睛和皮肤的化妆品 Download PDFInfo
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- CN109069382A CN109069382A CN201780017558.2A CN201780017558A CN109069382A CN 109069382 A CN109069382 A CN 109069382A CN 201780017558 A CN201780017558 A CN 201780017558A CN 109069382 A CN109069382 A CN 109069382A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及用于眼睛和皮肤的局部美容处理的套件和包含于其中的施用于眼睛和皮肤上的化妆品。
Description
本发明涉及用于眼睛和皮肤的局部美容处理套件和包含于其中的施用于眼睛和皮肤上的化妆品。
从现有技术中已知的施用于眼睛的化妆品配方在其组成上与眼睛表面上的天然膜相似。这意味着它们包含水性和油性组分。这些已知组合物的一个缺点通常是它们包含界面活性物质(乳化剂)，以便能够确保持久的分散和储存寿命。
乳化剂具有两亲分子结构，其由空间上彼此分开的极性亲水性分子部分和非极性亲脂性分子部分组成。通过将它们设置在两种液体之间的界面上从而降低相之间的界面张力，并形成界面膜。通常，乳化剂混合物也用于稳定乳液。
常规的乳化剂可以根据其亲水性分子部分细分为离子型(阴离子型、阳离子型和两性型)和非离子型：阴离子乳化剂最众所周知的实例是皂，虽然饱和和不饱和高级脂肪酸的水溶性钠盐或钾盐是通常的术语。阳离子乳化剂的重要代表是季铵化合物。非离子乳化剂的亲水性分子部分通常由甘油、聚甘油、脱水山梨醇、碳水化合物或聚乙二醇组成，并且通常经由酯键和醚键与亲脂性分子部分连接。后者通常由脂肪醇、脂肪酸或异脂肪酸组成。通过改变极性和非极性分子部分的结构和尺寸，乳化剂的亲脂性和亲水性可以在宽范围内变化。
虽然在药物、化妆品或皮肤病制剂本身中使用这些乳化剂是安全的，但乳化剂可以在个体情况下引起过敏反应。特别是在眼睛受到刺激的任何情况下，这些添加剂能够导致不耐受和进一步的刺激，因为乳化剂会损伤泪膜。
除乳化剂外，施用于眼睛上的化妆品制剂通常还包含防腐剂，以避免细菌、酵母和真菌的微生物污染。通常，加入苯扎氯铵、苯度氯铵、西曲溴铵、氯己啶、氯丁醇、羟甲基甘氨酸钠、过硼酸钠、膦酸、苯氧基乙醇、醋酸苯汞、聚己缩胍、聚季铵盐、purite和硫柳汞作为防腐剂。此外，其他防腐剂是苯甲酸、丙酸、己二烯酸、甲醛、无机亚硫酸盐、2-苯氧乙醇、苯甲醇、六亚甲基四胺和氯乙酰胺。
即使是所列出的防腐剂，它们通常也会引发不耐受，特别是过敏和其他皮肤病反应。苯扎氯铵、苯度氯铵、西曲溴铵降低了例如泪膜的稳定性，并且在长期施用时会导致目涩。它们攻击眼角膜，使得最上面的角膜层在某些地方变薄并且可能发生角膜溃疡。另一方面，氯己啶导致过敏反应。
因此，从现有技术出发，本发明的目的是提供一种施用于眼睛上的化妆品，该化妆品基于水溶液，并且可以确保其储存寿命和稳定性的同时不添加乳化剂或防腐剂。此外，旨在提供一种套件，其使得用户能够以一种简单的方式且无需特殊的先前经验用相应的化妆品进行眼睛的美容处理。
该目的通过具有专利权利要求1的特征的化妆品来实现，该化妆品包含在具有专利权利要求12的特征的套件中。专利权利要求16还示出了该套件的用途。有利的实施方案和发展包含在从属权利要求中。
根据本发明的用于施用到眼睛和皮肤上的化妆品包含水溶液，或由水溶液组成，该水溶液包含透明质酸或透明质酸盐、水杨酸或水杨酸盐、山梨醇、小米草(Euphrasia)母酊剂和缓冲系统，或由其组成，溶液中不加入乳化剂。
优选地，化妆品另外不包含任何防腐剂，特别是不包含选自苯甲酸、丙酸、己二烯酸、甲醛、无机亚硫酸盐、2-苯氧基乙醇、苯甲醇、六亚甲基四胺、氯乙酰胺、苯扎氯铵、苯度氯铵、西曲溴铵、氯己啶、氯丁醇、羟甲基甘氨酸钠、过硼酸钠、膦酸、醋酸苯汞、聚己缩胍、聚季铵盐、purite、硫柳汞及其混合物的防腐剂。因此这是有益的，因为许多防腐剂会产生角膜毒性作用。相比之下，不含防腐剂的化妆品可以尤其被隐形眼镜佩戴者和在整个花粉季节中过敏的人施用而没有风险。
在根据本发明的化妆品中，水杨酸无法实现防腐剂的功能，但起到对眼睑和眼睛部位的清洁和护理的作用，并有助于眼睛上的黏性和结壳沉积物的分解，并且还具有局部舒缓和缓解疼痛的效果。
此外，如果化妆品或形成化妆品基质的溶液不含磷酸盐，则是有益的。在根据本发明的意义上，磷酸盐被理解为所有含磷酸根的离子，例如磷酸二氢盐、磷酸氢盐、磷酸盐、以及二磷酸盐、三磷酸盐或偏磷酸盐。如果化妆品或形成基质的溶液不包含磷酸根离子，即通过目前的分析方法不能在化妆品中检测到磷酸根离子，则提供了不含磷酸盐的体系。
根据特别优选的实施方案，化妆品不含防腐剂和磷酸盐。
优选地，水溶液的pH值为6.0至8.0，优选为7.0至7.2。
此外，化妆品包含重量比例为0.01重量％至2.00重量％、优选为0.01重量％至0.3重量％、特别为0.1重量％的水杨酸或水杨酸盐是有益的。在该浓度下，水杨酸具有抗炎和缓解疼痛的作用。
此外，溶液包含重量比例为0.01重量％至1.00重量％、特别优选为0.01重量％至0.03重量％、特别为0.02重量％的透明质酸或透明质酸钠盐是优选的。由于其高度亲水的特性，这可以保护眼睛免于干燥。
在本发明的有利的变化方案中，溶液包含重量比例为1.0重量％至4.0重量％、优选为2.8重量％的山梨醇。其被用作渗透压并有助于溶液的等渗性。
此外，优选的溶液包含重量比例为0.001重量％至0.4重量％、优选为0.3重量％的小米草母酊剂。
因此，小米草母酊剂代表了植物提取物。根据本发明，可以从植物或其部分获得提取物，例如使用水。此外，提取物在性质上可以是液体或固体。
优选地，小米草母酊剂从小米草(Euphrasia officinalis)的新鲜或干燥的地上部分获得，例如叶、花和/或茎。小米草的整株植物的提取物是特别优选的。
在本发明的意义上，“小米草”(明亮草)被理解为在该术语中通常表示所有类型的小米草属，例如大叶胡杨(Euphrasia stricta)、蒙大纳胡杨(Euphrasia montana)和/或Euphrasia rostkoviana。
在本发明意义上的术语“母酊剂”被理解为，使用溶剂如水和/或醇(如乙醇)产生的来自植物或其部分的提取物、植物提取物、或溶剂混合物如醇-水混合物中的干燥植物溶液。
此外，根据本发明的化妆品或形成基质的溶液包含至少一种缓冲系统是有益的，该缓冲系统选自柠檬酸盐缓冲液、硼酸盐缓冲液、磷酸盐、三羟甲基氨基甲烷缓冲液、氨丁三醇/马来酸缓冲液、或其混合物或组合。如前所述，在化妆品配置为优选不含磷酸盐的情况下，当然必须排除磷酸盐缓冲液的存在。
可以提供的是，化妆品包含缓冲系统，该缓冲系统含有以下成分，或由以下成分组成：
·柠檬酸钠或柠檬酸钠水合物，优选重量比例为0.2重量％至1.5重量％，特别优选为0.5重量％至1.0重量％，特别为0.9重量％，
·柠檬酸，优选重量比为0.002重量％至0.008重量％，特别优选为0.002重量％，以及
·NaOH。
借助于缓冲系统的这种组合物，可以确保化妆品具有生理pH值。
至此作为替代方案，可以提供不包含缓冲系统的溶液或化妆品。
化妆品的优选实施方案由一种溶液组成，该溶液含有比例为0.01重量％至1.0重量％、特别优选为0.01重量％至0.03重量％、特别为0.02重量％的透明质酸钠盐，比例为0.01重量％至2.00重量％、特别优选为0.01重量％至0.03重量％、特别为0.02重量％的水杨酸，比例为0.5重量％至5.0重量％、特别为2.80重量％的山梨醇，比例为0.25重量％至2.50重量％、特别为0.85重量％的柠檬酸钠二水合物，比例为0.05重量％至1.50重量％、特别为0.30重量％的小米草母酊剂，并且pH值为7.0至7.2。
化妆品或形成基质的溶液可以以美容为目的直接施用于例如眼睑上，但也可间接地将化妆品施用于化妆棉或纸巾上并用其润湿或清洁眼睑。
根据本发明的用于眼睛的美容处理的套件包括上述化妆品，并且至少还包括与化妆品分开的化妆棉、纸巾和/或眼罩。
因此，优选通过可加热的眼罩来区分该套件，且该眼罩特别优选地包括潜热储层，特别是含有三水醋酸钠的潜热储层。
此外，可以配置化妆棉、化妆纸巾和/或眼罩以接收化妆品或者可以配置眼罩以接收棉绒垫。
化妆品或形成化妆品基质的溶液可以以多剂量系统、一次性剂量系统储存于先前描述的套件中，或储存在用化妆品润湿的纸巾中。多剂量系统可以包括例如具有泵压头的储存容器，借助于该储存容器可以重复分配单剂量的化妆品。一次性剂量系统包括化妆品的单个的单独包装的部分。因此，湿纸巾可以是卫生的和无菌的，例如可以将单独一张或几张湿纸巾分别密封在袋子中。因此可以确保易用性和长的储存寿命。
因此，湿纸巾可以单独使用，但也可以与前面提到的眼罩一起结合使用，因此也可以作为化妆棉的替代品。
根据本发明，上述化妆品和/或同样已经描述的套件可以用于眼睛和皮肤的美容处理，特别是用于眼部区域的皮肤的局部美容处理，用于眼睑、上眼睑、下眼睑、泪囊、眼角、睫毛、Moll腺、Zeis腺、睑板腺区域的皮肤的局部美容处理，优选用于分离眼睛区域中的污垢、结壳的沉积物和黏性沉积物。
在此，优选将化妆品施用于闭合眼睛的眼部区域中，特别是施用于眼睑上。因此，在施用化妆品之前，通过将加热罩或温暖毛巾置于眼睑上将眼睑加热到45℃的温度是有益的。因此，Moll腺、Zeis腺和睑板腺的任何可能的黏性的和厚的分泌物变成液体，并且对于大部分，可以实际上通过简单地用手指进行眼睑按摩而去除。然后，在眼睑按摩期间的运动应该沿睑板腺的出口方向进行。为此，应该用手指从上到下抚摸几次上眼睑，从下到上抚摸几次下眼睑。因此，液化的分泌物可以被分离并朝向眼睑的内角而除去。
然后可以借助于液体饱和的化妆棉垫实现最终清洁并完全去除所分离的分泌物、沉积物和病菌。由此，简单地用手指进行的眼睑按摩期间就已经完成了相同的运动。
同样地，用化妆品饱和浸透的化妆棉或无菌湿纸巾可以放置在闭合眼睑之上的加热眼罩下方，或者插入眼罩中，该眼罩适于在置于闭合眼睛上之前容纳化妆棉。热量与化妆品的处理成分相结合，实现了软化和分离结壳的沉积物和黏性沉积物。随后可以使用化妆棉或湿纸巾轻松地去除它们，由此可以清洁闭合眼睛。
参考随后的实施方案以更详细地解释本发明，而不是将本发明限制于此。
实施例给出的化妆品由水性组合物形成，该水性组合物每升包含0.20g的透明质酸钠盐、1.00g的水杨酸、28.00g的山梨醇、3.00g的小米草母酊剂和作为缓冲系统的柠檬酸以及柠檬酸钠，测试了该化妆品的储存寿命和稳定性。用氢氧化钠将该化妆品的pH值调至7.0至7.2。该化妆品不包含乳化剂和防腐剂。
该化妆品的组成列于下表1中：
表1：所测试的化妆品的组成
| 透明质酸钠盐 | 0.2g |
| 水杨酸 | 1.0g |
| 山梨醇 | 28.0g |
| 柠檬酸钠二水合物 | 8.5g |
| 无水柠檬酸 | 0.05g |
| 小米草母酊剂，DHU | 3.0g |
| 氢氧化钠 | 适量pH 7.0-7.2 |
| 水f.l. | 加至1.000ml |
如下所述，对实施例给出的该化妆品的储存寿命和稳定性进行测试。
将该化妆品的样品在25℃±2℃和60±5％相对大气湿度下储存12个月的时间，或在40℃和75％相对大气湿度下储存6个月的时间。
由此确定了化妆品的各种性能的稳定性和储存寿命。重要的是外观、气味、渗透压、pH值、颗粒自由度、黏度、水杨酸含量、分解量、UV-Vis光谱一致性、喷雾行为和水溶液的体积。
在下表2中列出了储存于25℃±2℃和60±5％大气湿度下的所得结果。
在此，“一致”意为所获得的测量结果在可容许范围内，因此确保了化妆品法规为消费者而要求的化妆品安全性。
表2：在25±2℃和60±5％相对大气湿度下的稳定性结果
在下表3中列出了储存于40±2℃和75±5％大气湿度下的所得结果。
在此，“一致”意为所获得的测量结果在可容许范围内，因此确保了化妆品法规为消费者而要求的化妆品安全性。
表3：在40±2℃和75±5％相对大气湿度下的稳定性结果
以3个月的间隔进行的测试分别表明，在测量精度范围内，除了体积以外，对于储存于25±2℃和60±5％大气湿度下和储存于40±2℃和75±5％大气湿度下的这些上述值的测量值都是相同的。在12个月的时间内，已确定的最大体积损失同样小至0.39％。
表中上述化妆品同样可以以无菌方式储存于剂量装置中，记录不到微生物的侵染。
为此目的，实施所谓的“顶封完整性测试”(TSIT)，利用该测试可以检测用于存储化妆品的剂量系统的上部出口阀是否可靠地保护了内容物免受污染。因此，在测试过程中，剂量系统经由头部致动若干次，同时剂量系统的滴管尖端浸入包含高浓度细菌的病菌悬浮液中(每毫升107个“菌落形成单位”)。
随后，在相应的孵育之后进行测试，以确定剂量系统的内容物是否是无菌的。可以确定的是，即使出口周围有非常高浓度的病菌也不会导致所包含的化妆品被污染。
对于上表1中所示的化妆品，同样实施所谓的“闭合和通气完整性测试”(CVIT)。CVIT证明，剂量系统的泵和容器显示出完美的装配精度。已经确定的是，即使在真空条件下，剂量系统本身的内容物也免受病菌的超微孢子气溶胶的影响。由于泵的一系列快速连续致动，在剂量系统暴露于含有高密度(100CFU/cm2)的超微孢子的湿气溶胶期间，系统中产生真空。此外，结果表明，在相应的孵育后，不会导致所包含的化妆品被污染。
先前描述的测试结果表明，根据本发明的化妆品不仅具有优异的储存寿命，而且具有低的细菌侵染倾向。
Claims (17)
1.一种施用于眼睛和皮肤上的化妆品，其包含水溶液或由水溶液组成，所述水溶液包含透明质酸或透明质酸盐、水杨酸或水杨酸盐、山梨醇、小米草母酊剂和缓冲液系统，或由其组成，其特征在于不向所述溶液中加入乳化剂。
2.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液不包含任何防腐剂，特别是不含选自苯甲酸、丙酸、己二烯酸、甲醛、无机亚硫酸盐、2-苯氧基乙醇、苯甲醇、六亚甲基四胺、氯乙酰胺、苯扎氯铵、苯度氯铵、西曲溴铵、氯己啶、氯丁醇、羟甲基甘氨酸钠、过硼酸钠、膦酸、醋酸苯汞、聚己缩胍、聚季铵盐、purite、硫柳汞的防腐剂。
3.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液不含磷酸盐。
4.根据前述权利要求中任一项所述的化妆品，其特征在于所述水溶液的pH值为6.0至8.0，优选为7.0至7.2。
5.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含重量比例为0.01重量％至2.00重量％，优选为0.01重量％至0.3重量％，特别优选为0.1重量％的水杨酸或水杨酸盐。
6.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含重量比例为0.01重量％至1.00重量％，优选为0.01重量％至0.03重量％，特别优选为0.02重量％的透明质酸或透明质酸钠盐。
7.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含重量比例为1.0重量％至4.0重量％，优选为2.8重量％的山梨醇。
8.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含重量比例为0.001重量％至0.4重量％，优选为0.3重量％的小米草母酊剂。
9.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含缓冲系统，所述缓冲系统选自柠檬酸盐缓冲液、硼酸盐缓冲液、磷酸盐缓冲液、三羟甲基氨基甲烷缓冲液、氨丁三醇/马来酸缓冲系统、以及其混合物和组合。
10.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含缓冲系统，所述缓冲系统包含以下成分或由以下成分组成：
·柠檬酸钠或柠檬酸钠水合物，优选的重量比例为0.2重量％至1.5重量％，特别优选为0.5重量％至1.0重量％，特别为0.9重量％，
·柠檬酸，优选的重量比例为0.002重量％至0.008重量％，特别优选为0.002重量％，
·NaOH。
11.根据前述权利要求中任一项所述的化妆品，其特征在于所述溶液包含比例为0.01重量％至1.0重量％、优选为0.01重量％至0.03重量％、特别为0.02重量％的透明质酸钠盐，比例为0.01重量％至2.00重量％、优选为0.01重量％至0.03重量％、特别为0.10重量％的水杨酸，比例为0.5重量％至5.0重量％、特别为2.80重量％的山梨醇，比例为0.25重量％至2.50重量％、特别为0.85重量％的柠檬酸钠二水合物，比例为0.05重量％至1.50重量％、特别为0.30重量％的小米草母酊剂，并且pH值为7.0至7.2。
12.一种用于眼睛的美容处理的套件，所述套件包括根据前述权利要求中任一项所述的化妆品，以及与所述化妆品分开的至少化妆棉、化妆纸巾和/或眼罩。
13.根据前述权利要求所述的套件，其特征在于所述眼罩是可加热的并且所述眼罩优选包括潜热储层，特别是含有三水醋酸钠的潜热储层。
14.根据权利要求12和13中任一项所述的套件，其特征在于所述化妆棉、纸巾和/或眼罩被配置为接收所述化妆品，或者所述眼罩被配置为接收所述化妆棉。
15.根据权利要求12至14中任一项所述的套件，其特征在于所述化妆品储存于多剂量系统、一次性剂量系统或用化妆品润湿的纸巾中。
16.根据权利要求1至10中任一项所述的化妆品、和/或根据权利要求11至15中任一项所述的套件用于眼睛和皮肤的美容处理的用途，特别是用于眼部区域皮肤的局部美容处理，用于眼睑、上眼睑、下眼睑、泪囊、眼角、睫毛、Moll腺、Zeis腺、睑板腺区域皮肤的局部美容处理，优选用于分离眼睛区域中的污垢、结壳的沉积物、黏性沉积物。
17.根据权利要求16所述的用途，其特征在于所述化妆品施用于闭合眼睛的眼部区域，特别是施用于眼睑上。
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| DE102016204472.9A DE102016204472A1 (de) | 2016-03-17 | 2016-03-17 | Kit zur kosmetischen Behandlung des Auges und der Haut und Kosmetikum zur Anwendung am Auge und auf der Haut |
| PCT/EP2017/056390 WO2017158157A1 (de) | 2016-03-17 | 2017-03-17 | Kit zur kosmetischen behandlung des auges und der haut und kosmetikum zur anwendung am auge und auf der haut |
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| CN1671400A (zh) * | 2002-07-03 | 2005-09-21 | 派瑞克科学公司 | 透明质酸组合物以及使用方法 |
| FR2902290A1 (fr) * | 2005-04-28 | 2007-12-21 | Derma Dev Sarl | Nouvel agent conservateur anti bacterien et son procede d'obtention |
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| EP2815740A1 (de) * | 2013-06-18 | 2014-12-24 | Apomedica pharmazeutische Produkte GmbH | Ophtalmische Zusammensetzung |
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| JP2005139070A (ja) * | 2003-11-04 | 2005-06-02 | Kanebo Cosmetics Inc | 皮膚化粧料 |
| CA2896646A1 (en) * | 2012-12-27 | 2014-07-03 | Hayashibara Co., Ltd. | Skin-exterior anti-ageing composition and production method therefor |
| DE102014007423A1 (de) * | 2014-05-22 | 2015-11-26 | Bitop Ag | Zusammensetzung zur Behandlung des Auges |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1671400A (zh) * | 2002-07-03 | 2005-09-21 | 派瑞克科学公司 | 透明质酸组合物以及使用方法 |
| FR2902290A1 (fr) * | 2005-04-28 | 2007-12-21 | Derma Dev Sarl | Nouvel agent conservateur anti bacterien et son procede d'obtention |
| KR20080024426A (ko) * | 2006-09-13 | 2008-03-18 | 유니메드제약주식회사 | 히아루론산 유도체의 안정화 조성물 |
| CN102421425A (zh) * | 2009-05-14 | 2012-04-18 | 乌尔萨法姆药物两合公司 | 用于治疗青光眼的不含磷酸盐的药物组合物 |
| EP2815740A1 (de) * | 2013-06-18 | 2014-12-24 | Apomedica pharmazeutische Produkte GmbH | Ophtalmische Zusammensetzung |
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| KR20180118676A (ko) | 2018-10-31 |
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| US20190167542A1 (en) | 2019-06-06 |
| BR112018068811A2 (pt) | 2019-01-22 |
| CA3018000A1 (en) | 2017-09-21 |
| MX2018011250A (es) | 2019-03-28 |
| RU2018132390A (ru) | 2020-04-17 |
| EP3429553A1 (de) | 2019-01-23 |
| RU2018132390A3 (zh) | 2020-04-17 |
| AU2017235505A1 (en) | 2018-10-04 |
| WO2017158157A1 (de) | 2017-09-21 |
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