CN109043543A - 儿童口服益生菌组合物 - Google Patents
儿童口服益生菌组合物 Download PDFInfo
- Publication number
- CN109043543A CN109043543A CN201810966852.4A CN201810966852A CN109043543A CN 109043543 A CN109043543 A CN 109043543A CN 201810966852 A CN201810966852 A CN 201810966852A CN 109043543 A CN109043543 A CN 109043543A
- Authority
- CN
- China
- Prior art keywords
- parts
- children
- probiotic
- oral composition
- active components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 45
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 45
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 16
- 239000004615 ingredient Substances 0.000 claims abstract description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 6
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 abstract description 5
- 244000291414 Vaccinium oxycoccus Species 0.000 abstract description 5
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 abstract description 5
- 235000004634 cranberry Nutrition 0.000 abstract description 5
- 235000013399 edible fruits Nutrition 0.000 abstract description 5
- 235000021323 fish oil Nutrition 0.000 abstract description 5
- 235000016709 nutrition Nutrition 0.000 abstract description 5
- 241000186605 Lactobacillus paracasei Species 0.000 abstract description 4
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 abstract description 4
- 241000186000 Bifidobacterium Species 0.000 abstract description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 3
- 229920001353 Dextrin Polymers 0.000 abstract description 3
- 239000004375 Dextrin Substances 0.000 abstract description 3
- 240000006053 Garcinia mangostana Species 0.000 abstract description 3
- 235000017048 Garcinia mangostana Nutrition 0.000 abstract description 3
- 240000007651 Rubus glaucus Species 0.000 abstract description 3
- 235000011034 Rubus glaucus Nutrition 0.000 abstract description 3
- 235000009122 Rubus idaeus Nutrition 0.000 abstract description 3
- 235000017537 Vaccinium myrtillus Nutrition 0.000 abstract description 3
- 244000078534 Vaccinium myrtillus Species 0.000 abstract description 3
- 229930003268 Vitamin C Natural products 0.000 abstract description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 235000013734 beta-carotene Nutrition 0.000 abstract description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract description 3
- 239000011648 beta-carotene Substances 0.000 abstract description 3
- 229960002747 betacarotene Drugs 0.000 abstract description 3
- 235000019425 dextrin Nutrition 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 3
- 235000021255 galacto-oligosaccharides Nutrition 0.000 abstract description 3
- 150000003271 galactooligosaccharides Chemical class 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 235000019154 vitamin C Nutrition 0.000 abstract description 3
- 239000011718 vitamin C Substances 0.000 abstract description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract description 3
- 241000917009 Lactobacillus rhamnosus GG Species 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 abstract description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 2
- 235000011869 dried fruits Nutrition 0.000 abstract description 2
- 229940059406 lactobacillus rhamnosus gg Drugs 0.000 abstract description 2
- 101100161412 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) aap-2 gene Proteins 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 230000001953 sensory effect Effects 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- 235000019640 taste Nutrition 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000013350 formula milk Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- 241000193171 Clostridium butyricum Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000020237 cranberry extract Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000008773 effect on children Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/204—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3571—Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/165—Paracasei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明涉及一种儿童口服益生菌组合物，包括益生菌成分和功能活性成分，其中：以质量计，益生菌成分包括：副干酪乳杆菌GM‑080 0.5‑2份；副干酪乳杆菌AAP‑2 0.5‑2份；鼠李糖乳杆菌GG 0.5‑2份；动物双歧杆菌B94 0.5‑2份；布拉迪酵母3‑8份；功能活性成分包括：鱼油粉10‑30份；越橘提取物1‑7份；蔓越莓粉25‑35份；接骨木莓果汁粉3‑9份；维生素C5‑15份；β‑胡萝卜素3‑7份；低聚果糖7‑12份；低聚半乳糖25‑35份；罗汉果粉3‑9份；抗性糊精7‑12份；香兰素0.5‑2份。本发明提供的一种儿童口服益生菌组合物具有安全性好、没有副作用营养搭配均衡等优点。
Description
技术领域
本发明属于食品工程领域，具体涉及一种儿童口服益生菌组合物。
背景技术
益生菌是一类对宿主有益的活性微生物，是定植于人体肠道、生殖系统内，能产生确切健康功效从而改善宿主微生态平衡、发挥有益作用的活性有益微生物的总称。人体、动物体内有益的细菌或真菌主要有：酪酸梭菌、乳杆菌、双歧杆菌、放线菌、酵母菌等。目前世界上研究的功能最强大的产品主要是以上各类微生物组成的复合活性益生菌，其广泛应用于生物工程、工农业、食品安全以及生命健康领域。
益生菌适用于抵抗力较低的儿童，但是传统的益生菌产品，由于添加了鱼油等物质，会有特有的鱼腥味和其他让儿童不喜欢的味道的功能活性成分，会大大影响儿童发的接受程度。
蔓越莓一直以来被应用于胃溃疡和胃癌的相关治疗中，能够抑制幽门螺杆菌的滋生，并且改善便秘，但是在儿童肠道健康领域很少有应用的报道。
发明内容
发明目的：本发明的目的在于提供一种儿童口服益生菌组合物，其能够有效改善儿童肠道功能紊乱，并且能够有效提高儿童免疫力。
技术方案：儿童口服益生菌组合物，包括益生菌成分和功能活性成分，其中：以质量计，
所述益生菌成分包括：
所述功能活性成分包括：
进一步地，所述功能活性成分中的所有粉料的粒径为100目。
优选的，所述益生菌成分，以质量计，包括
优选的，所述功能活性成分，以质量计，包括：
进一步地，所述功能活性成分的所有粉料的粒径为100目。
有益效果：本发明提供的一种儿童口服益生菌组合物，具有如下有益效果：
1、本发明的口服益生菌组合物具有良好的安全性和产品感官特性，在保证营养价值的同时，口感好，适合儿童服用,对儿童展开口感测试，容易接受并喜欢，并且安全性好，没有副作用。
2、本发明的口服益生菌组合物配方有利于抑制有害菌，限制致病微生物的生长与繁殖。
3、本发明的特定原料选择优势，因多酚类或鱼油含一定的不良味道，需要食用香精改良，经口感测试得出香兰素与配方结合能有效改善苦味、腥味同时丰富口感，完美解决了不良味道可能引起的不适问题。
4、本发明的原料，使蔓越莓提取物(蔓越莓粉)有了新的应用，不仅优化和丰富了益生菌产品的营养成分，而且和益生菌搭配使用，对儿童肠道的健康起到了协同促进的效果。
附图说明
图1为本发明公开的儿童口服益生菌组合物的抑菌效果示意图。
具体实施方式：
下面对本发明的具体实施方式详细说明。
益生菌组合物的配置
具体实施例1(优选例)
于电子天平上称取副干酪乳杆菌GM-080 1份，副干酪乳杆菌A AP-2 1份，鼠李糖乳杆菌GG 1份，动物双歧杆菌B94 1份，布拉迪酵母5份。
将鱼油粉、越橘提取物、蔓越莓粉、接骨木莓果汁粉、维生素C、β-胡萝卜素、低聚果糖、低聚半乳糖、罗汉果粉、抗性糊精和香兰素烘干，烘干温度为40℃，烘干时间为3h；
将上述烘干的物料分别过筛，过筛目数为100目。
按质量称量过筛后物料：鱼油粉20份，越橘提取物5份，蔓越莓粉30份，接骨木莓果汁粉7份，维生素C 10份,β-胡萝卜素5份，低聚果糖10份，低聚半乳糖30份，罗汉果粉6份，抗性糊精10份，香兰素1份。
将上述所有称量好的物料，放入混合机中进行混合，调节震动频率在40Hz,混合时间控制在15min，混合好后即得到儿童口服益生菌组合物。
将上述混合好的儿童口服益生菌组合物进行分装，每份15g，封装。室温保存。
具体实施例2(下限例)
儿童口服益生菌组合物，包括益生菌成分和功能活性成分，其中：以质量计，
益生菌成分包括：
功能活性成分包括：
进一步地，功能活性成分的所有粉料的粒径为100目。
具体实施例3(上限例)
儿童口服益生菌组合物，包括益生菌成分和功能活性成分，其中：以质量计，
益生菌成分包括：
功能活性成分包括：
进一步地，功能活性成分的所有粉料的粒径为100目。
益生菌组合物的营养成分检测
将具体实施例1得到的儿童口服益生菌组合物按照相关的国家/行业标准进行营养成分检测，参考标准如下：
GB 10765-2010食品安全国家标准婴儿配方食品；
其中，
蛋白质、脂肪和碳水化合物的检测结果如表1所示：
表1蛋白质、脂肪和碳水化合物的检测结果
本发明所提供的儿童口服益生菌组合物，在蛋白质、脂肪和碳水化合物的含量上符合标准GB 10765-2010的规定。
维生素指标如表2所示：
表2维生素指标检测结果
本发明所提供的儿童口服益生菌组合物，在维生素的含量上复合标准GB 10765-2010的规定。
营养安全性评估
2018年2月至3月间，选择20名5-9岁的儿童志愿者服用本发明所提供的益生菌组合物固体饮料，服用剂量为每次10g，服用方式不限；每天早饭及午饭后1小时内各服用1次，于3个月后进行回访调查，调查结果如表3所示：
表3营养安全性评估结果
结果可知，服用本发明所提供的益生菌组合物固体饮料的儿童，总体反应良好，没有出现上火、便秘、湿疹和胀气的不良反应。
产品感官特性评估
对服用该组合物的20名儿童进行问卷调查，进行各项感官评价参数的打分，具体结果如表4所示：
表4感官评价结果
抑菌能力检测
为评估具体实施例1得到的儿童口服益生菌组合物中的活性物质成分的抑菌能力，将G组链球菌、化脓性链球菌、C组链球菌、卡他布兰汉球菌以及金黄色葡萄球菌，5种常见的好氧致病细菌分别用标准LB平板37℃培养48h后挑取单克隆，接入LB摇瓶后在摇床上继续37℃，120rpn培养16h。将摇瓶培养后的菌液以5％的接种量接入到标准肉汤培养基中，37℃,120rpm培养16h。将培养完成的培养基均匀分成5份，分别按质量比加入1％，3％，5％和7％的活性物质，以不添加活性物质的肉汤培养基作为空白对照，继续37℃培养16h后对其活菌数进行测量。测量结果如图1所示，结果表明，该A物质有显著的抑菌效果。
上面对本发明的实施方式做了详细说明。但是本发明并不限于上述实施方式，在所属技术领域普通技术人员所具备的知识范围内，还可以在不脱离本发明宗旨的前提下做出各种变化。
Claims (4)
1.儿童口服益生菌组合物，其特征在于，包括益生菌成分和功能活性成分，其中：以质量计，
所述益生菌成分包括：
所述功能活性成分包括：
2.根据权利要求1所述的儿童口服益生菌组合物，其特征在于，所述功能活性成分中的所有粉料的粒径为100目。
3.根据权利要求1所述的儿童口服益生菌组合物，其特征在于，所述益生菌成分，以质量计，包括
4.根据权利要求1所述的儿童口服益生菌组合物，其特征在于，所述功能活性成分，以质量计，包括：
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810966852.4A CN109043543A (zh) | 2018-08-23 | 2018-08-23 | 儿童口服益生菌组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810966852.4A CN109043543A (zh) | 2018-08-23 | 2018-08-23 | 儿童口服益生菌组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109043543A true CN109043543A (zh) | 2018-12-21 |
Family
ID=64756610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810966852.4A Pending CN109043543A (zh) | 2018-08-23 | 2018-08-23 | 儿童口服益生菌组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109043543A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771470A (zh) * | 2019-03-21 | 2019-05-21 | 慕恩（广州）生物科技有限公司 | 一种含益生菌的组合物及其制备方法 |
| CN109805413A (zh) * | 2019-03-14 | 2019-05-28 | 广州普维君健药业有限公司 | 补叶酸用组合物及其制备方法和应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341918A (zh) * | 2015-11-22 | 2016-02-24 | 威海百合生物技术股份有限公司 | 一种儿童益生菌咀嚼片 |
| CN105661245A (zh) * | 2016-01-29 | 2016-06-15 | 江苏微康生物科技有限公司 | 一种益生菌型果蔬酵素固体饮料 |
| CN106954847A (zh) * | 2017-03-30 | 2017-07-18 | 广州能靓生物技术有限公司 | 具有润肠通便功能的酵素益生菌组合物、应用及加工制剂 |
| US20170296598A1 (en) * | 2016-04-19 | 2017-10-19 | Akay Flavours and Aromatics Pvt, Ltd | Method of preparing stable, water soluble probiotic compositions based on millets and similar cereals |
| CN108066375A (zh) * | 2017-12-28 | 2018-05-25 | 仲恺农业工程学院 | 一种能实现改善肠胃功能的益生菌组合物及其制备方法 |
| CN108065398A (zh) * | 2017-12-14 | 2018-05-25 | 广州普维君健药业有限公司 | 婴幼儿口服益生菌组合物及其制备方法和应用 |
-
2018
- 2018-08-23 CN CN201810966852.4A patent/CN109043543A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341918A (zh) * | 2015-11-22 | 2016-02-24 | 威海百合生物技术股份有限公司 | 一种儿童益生菌咀嚼片 |
| CN105661245A (zh) * | 2016-01-29 | 2016-06-15 | 江苏微康生物科技有限公司 | 一种益生菌型果蔬酵素固体饮料 |
| US20170296598A1 (en) * | 2016-04-19 | 2017-10-19 | Akay Flavours and Aromatics Pvt, Ltd | Method of preparing stable, water soluble probiotic compositions based on millets and similar cereals |
| CN106954847A (zh) * | 2017-03-30 | 2017-07-18 | 广州能靓生物技术有限公司 | 具有润肠通便功能的酵素益生菌组合物、应用及加工制剂 |
| CN108065398A (zh) * | 2017-12-14 | 2018-05-25 | 广州普维君健药业有限公司 | 婴幼儿口服益生菌组合物及其制备方法和应用 |
| CN108066375A (zh) * | 2017-12-28 | 2018-05-25 | 仲恺农业工程学院 | 一种能实现改善肠胃功能的益生菌组合物及其制备方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109805413A (zh) * | 2019-03-14 | 2019-05-28 | 广州普维君健药业有限公司 | 补叶酸用组合物及其制备方法和应用 |
| CN109771470A (zh) * | 2019-03-21 | 2019-05-21 | 慕恩（广州）生物科技有限公司 | 一种含益生菌的组合物及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Beheshtipour et al. | Supplementation of Spirulina platensis and Chlorella vulgaris algae into probiotic fermented milks | |
| Hasani et al. | Physicochemical and sensory attributes assessment of functional low‐fat yogurt produced by incorporation of barley bran and Lactobacillus acidophilus | |
| CN105661245A (zh) | 一种益生菌型果蔬酵素固体饮料 | |
| CN101120747B (zh) | 一种鹅用复合饲料 | |
| CN111387395A (zh) | 一种益生菌固体饮品及其制备方法 | |
| Muzzafar et al. | Microencapsulation of probiotics for incorporation in cream biscuits | |
| CN109771470A (zh) | 一种含益生菌的组合物及其制备方法 | |
| CN102125105A (zh) | 一种添加新型益生元的奶片及其制备方法 | |
| CN110140773A (zh) | 一种益生菌固体饮料、制备方法及其应用 | |
| CN100553473C (zh) | 一种羊饲料添加剂 | |
| CN106070943A (zh) | 一种益生菌无糖型软糖组合物及其制备方法 | |
| CN110432494A (zh) | 防治婴幼儿过敏性湿疹和/或腹泻的益生菌组合物和应用 | |
| CN109288063A (zh) | 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 | |
| CN109043543A (zh) | 儿童口服益生菌组合物 | |
| CN111000247B (zh) | 一种复合益生菌粉的制备方法 | |
| CN105875952A (zh) | 一种益生菌红茶及其制备方法 | |
| CN104328076A (zh) | 一种产胆盐水解酶副干酪乳杆菌益生菌片的制备方法 | |
| CN107343585A (zh) | 一种含蔓越莓的益生菌固体饮料及其制备方法 | |
| Kore et al. | Effect of feeding traditionally prepared fermented milk dahi (curd) as a probiotics on nutritional status, hindgut health and haematology in dogs | |
| CN110192595A (zh) | 一种奶牛饲料用复合微生物添加剂及其制备方法和应用 | |
| CN104146312B (zh) | 调理胃肠功能的保健品 | |
| CN110037124A (zh) | 一种益生菌水果牛乳粉 | |
| Subhasree et al. | Evaluation of brown rice and germinated brown rice as an alternative substrate for probiotic food formulation using Lactobacillus spp. isolated from goat milk. | |
| CN101597585B (zh) | 一种适合工业化生产双歧杆菌的培养基及其配制方法 | |
| CN109363183A (zh) | 一种菊粉益生菌伴侣及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181221 |