CN109020835B - 一种医药中间体沙坦联苯的制备方法 - Google Patents
一种医药中间体沙坦联苯的制备方法 Download PDFInfo
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- CN109020835B CN109020835B CN201811282949.XA CN201811282949A CN109020835B CN 109020835 B CN109020835 B CN 109020835B CN 201811282949 A CN201811282949 A CN 201811282949A CN 109020835 B CN109020835 B CN 109020835B
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- reaction
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- acid
- sartanbiphenyl
- diazonium salt
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
Abstract
Description
实施例 | 选择性 | 收率 | 反应时间/min |
1 | 90.2% | 87.2% | 8.5 |
2 | 94.3% | 90.8% | 8.9 |
3 | 91.2% | 85.6% | 7.3 |
4 | 93.3% | 88.2% | 9.2 |
5 | 90.8% | 91.1% | 5.7 |
6 | 94.3% | 90.3% | 5.9 |
7 | 95.6% | 92.1% | 4.2 |
8 | 92.4% | 89.1% | 6.3 |
9 | 92.6% | 88.5% | 8.2 |
10 | 93.9% | 91.5% | 6.9 |
11 | 92.8% | 91.8% | 7.1 |
12 | 91.4% | 86.2% | 5.4 |
Claims (13)
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CN201811282949.XA CN109020835B (zh) | 2018-10-31 | 2018-10-31 | 一种医药中间体沙坦联苯的制备方法 |
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CN109020835A CN109020835A (zh) | 2018-12-18 |
CN109020835B true CN109020835B (zh) | 2021-11-16 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09176104A (ja) * | 1995-12-27 | 1997-07-08 | Mikuni Seiyaku Kogyo Kk | アリールベンゾニトリルの製造法 |
JPH11171799A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | 活性置換基を有するビフェニル誘導体の製造法 |
JPH11171802A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | アルキルビフェニル誘導体の製造法およびその中間体 |
CN107663160A (zh) * | 2016-07-27 | 2018-02-06 | 上海惠和化德生物科技有限公司 | 一种4‑氯苯肼盐的连续流合成工艺 |
-
2018
- 2018-10-31 CN CN201811282949.XA patent/CN109020835B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09176104A (ja) * | 1995-12-27 | 1997-07-08 | Mikuni Seiyaku Kogyo Kk | アリールベンゾニトリルの製造法 |
JPH11171799A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | 活性置換基を有するビフェニル誘導体の製造法 |
JPH11171802A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | アルキルビフェニル誘導体の製造法およびその中間体 |
CN107663160A (zh) * | 2016-07-27 | 2018-02-06 | 上海惠和化德生物科技有限公司 | 一种4‑氯苯肼盐的连续流合成工艺 |
Non-Patent Citations (3)
Title |
---|
Copper catalyzed Gomberg–Buchmann–Hey reaction using aryldiazonium tosylate;Ganesh U. Chaturbhuj 等;《Tetrahedron Letters》;20110723;第52卷;3950-3953 * |
Copper-catalyzed cross-coupling of arenediazonium tetrafluoroborates with polyfluoroarenes;Xingyi Zhu 等;《Tetrahedron Letters》;20130103;第54卷;1285-1289 * |
一种合成多氟联苯类化合物的新方法;计燕萍 等;《合成化学》;20161231;第24卷(第3期);259-262 * |
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