CN108884386B - 用于诊断和体内成像的化学发光探针 - Google Patents
用于诊断和体内成像的化学发光探针 Download PDFInfo
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- CN108884386B CN108884386B CN201780020284.2A CN201780020284A CN108884386B CN 108884386 B CN108884386 B CN 108884386B CN 201780020284 A CN201780020284 A CN 201780020284A CN 108884386 B CN108884386 B CN 108884386B
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
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- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- Saccharide Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662287127P | 2016-01-26 | 2016-01-26 | |
| US62/287,127 | 2016-01-26 | ||
| US201662431618P | 2016-12-08 | 2016-12-08 | |
| US62/431,618 | 2016-12-08 | ||
| PCT/IL2017/050088 WO2017130191A1 (en) | 2016-01-26 | 2017-01-24 | Chemiluminescent probes for diagnostics and in vivo imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108884386A CN108884386A (zh) | 2018-11-23 |
| CN108884386B true CN108884386B (zh) | 2022-03-15 |
Family
ID=59397688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780020284.2A Active CN108884386B (zh) | 2016-01-26 | 2017-01-24 | 用于诊断和体内成像的化学发光探针 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10660974B2 (enExample) |
| EP (1) | EP3408349B1 (enExample) |
| JP (1) | JP6915943B2 (enExample) |
| KR (1) | KR102717614B1 (enExample) |
| CN (1) | CN108884386B (enExample) |
| CA (1) | CA3011328C (enExample) |
| ES (1) | ES2866900T3 (enExample) |
| WO (1) | WO2017130191A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11241507B2 (en) | 2017-05-24 | 2022-02-08 | Ramot At Tel-Aviv University Ltd. | Near-infrared chemiluminescent probes for in-vivo imaging |
| PL3630742T3 (pl) | 2017-05-24 | 2024-04-08 | Ramot At Tel-Aviv University Ltd. | Sondy chemiluminescencyjne do obrazowania/wykrywania proteaz |
| KR20250052483A (ko) * | 2018-05-25 | 2025-04-18 | 네미스 테크놀로지스 아게 | 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도 |
| EP3802512A1 (en) | 2018-05-25 | 2021-04-14 | Nemis Technologies AG | Long wavelength emitting chemiluminescent probes |
| CN111073633B (zh) * | 2018-10-22 | 2023-07-25 | 北京工商大学 | 一种萘环类苯硫酚荧光探针 |
| WO2020159448A1 (en) * | 2019-02-01 | 2020-08-06 | Nanyang Technological University | Molecular renal probes for detecting acute kidney injury |
| CN110437274A (zh) * | 2019-08-28 | 2019-11-12 | 南京工业大学 | 一种用于检测氟离子的探针、制备方法及应用 |
| CN110804009B (zh) * | 2019-10-10 | 2025-12-12 | 华东理工大学 | 一类化学发光强度高、波长长、稳定性好的化学发光底物及其制备方法和应用 |
| JP2022553424A (ja) * | 2019-10-28 | 2022-12-22 | ベックマン コールター, インコーポレイテッド | 急速、高強度化学発光ジオキサン |
| KR102332454B1 (ko) * | 2019-12-18 | 2021-11-29 | 고려대학교 산학협력단 | 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서 |
| WO2023018377A2 (en) * | 2021-08-11 | 2023-02-16 | Nanyang Technological University | Ultrabright chemiluminescent probes for detection and imaging |
| CN114315791B (zh) * | 2021-12-22 | 2023-12-08 | 东南大学 | 用于实现手术导航和微小转移瘤成像的小分子化学发光探针及其制备方法和用途 |
| CN114478473B (zh) * | 2022-01-25 | 2024-05-03 | 南方医科大学 | 一种亮氨酸氨基肽酶化学发光检测试剂的合成及应用 |
| JP2023110666A (ja) | 2022-01-28 | 2023-08-09 | シスメックス株式会社 | 化合物またはその塩、組成物、化学発光方法、化学発光シグナル測定方法、試薬、試薬キットおよび被検物質測定方法 |
| CN115417863B (zh) * | 2022-09-30 | 2024-02-02 | 徐州医科大学 | 一种二氧化硫近红外化学发光探针及其制备方法和应用 |
| CN115894581B (zh) * | 2022-10-26 | 2024-07-09 | 徐州医科大学 | 一种β-葡萄糖醛酸苷酶化学发光探针及其制备方法和应用 |
| CN115819416B (zh) * | 2022-11-29 | 2024-06-25 | 遵义医科大学 | 一种用于检测和区分的多模态化学发光分子及其应用 |
| CN116217515B (zh) * | 2022-12-20 | 2024-06-18 | 华南师范大学 | 一种亚甲基蓝型探针及其制备方法和在检测半胱氨酸中的应用 |
| WO2024147125A1 (en) * | 2023-01-04 | 2024-07-11 | Ramot At Tel-Aviv University Ltd. | Cyclobutyl-substituted phenoxy-dioxetanes and uses thereof |
| CN116606220A (zh) * | 2023-03-21 | 2023-08-18 | 华东理工大学 | 一种单组分有机余辉化合物及其生物检测的应用 |
| CN116410064A (zh) * | 2023-04-13 | 2023-07-11 | 西安交通大学 | 一种合成2-(α-甲氧基-3-羟基苯亚甲基)金刚烷类化合物的方法 |
| CN116655716A (zh) * | 2023-04-27 | 2023-08-29 | 湖南师范大学 | 一种检测β-半乳糖苷酶的化学发光探针、制备方法及其应用 |
| US12393660B2 (en) | 2023-05-17 | 2025-08-19 | The Government of the United States of America, as represented by the Secretary of Homeland Security | DNA access control systems |
| CN117059804B (zh) * | 2023-10-13 | 2024-03-19 | 瑞浦兰钧能源股份有限公司 | 一种化学预锂剂、锂离子电池及其制备方法 |
| CN117442269B (zh) * | 2023-12-22 | 2024-12-20 | 中日友好医院(中日友好临床医学研究所) | 一种手术缝合针的搜寻系统及方法 |
| CN119409748A (zh) * | 2025-01-06 | 2025-02-11 | 四川省医学科学院·四川省人民医院 | 一种N-乙酰-β-D-氨基葡萄糖酶的化学发光探针、试剂盒及其制备方法和应用 |
| CN119798211A (zh) * | 2025-01-23 | 2025-04-11 | 西安交通大学 | 一种巯基化合物激活型化学发光探针及其合成方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990007511A1 (en) * | 1988-12-27 | 1990-07-12 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| CN1052478A (zh) * | 1989-12-14 | 1991-06-26 | 书恩州立大学校董会 | 制备乙烯基醚的改进方法 |
| WO2006073424A2 (en) * | 2004-04-14 | 2006-07-13 | Giri Brij P | New ultra-sensitive chemiluminescent substrates for enzymes and their conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0709466B1 (en) * | 1994-10-28 | 2006-09-27 | Gen-Probe Incorporated | Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences |
| US5783381A (en) * | 1995-10-19 | 1998-07-21 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| JP3852140B2 (ja) * | 1996-09-11 | 2006-11-29 | 東ソー株式会社 | 1,2−ジオキセタン誘導体 |
| WO2001055446A1 (en) * | 2000-01-28 | 2001-08-02 | Brij Pal Giri | Novel stabilized formulations for chemiluminescent assays |
| WO2015105014A1 (ja) | 2014-01-08 | 2015-07-16 | 住友化学株式会社 | 金属錯体およびそれを用いた発光素子 |
| JP6631508B2 (ja) | 2014-03-17 | 2020-01-15 | 住友化学株式会社 | 金属錯体およびそれを用いた発光素子 |
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2017
- 2017-01-24 CA CA3011328A patent/CA3011328C/en active Active
- 2017-01-24 JP JP2018539034A patent/JP6915943B2/ja active Active
- 2017-01-24 US US16/072,848 patent/US10660974B2/en active Active
- 2017-01-24 WO PCT/IL2017/050088 patent/WO2017130191A1/en not_active Ceased
- 2017-01-24 ES ES17743844T patent/ES2866900T3/es active Active
- 2017-01-24 KR KR1020187024288A patent/KR102717614B1/ko active Active
- 2017-01-24 CN CN201780020284.2A patent/CN108884386B/zh active Active
- 2017-01-24 EP EP17743844.7A patent/EP3408349B1/en active Active
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2020
- 2020-04-16 US US16/850,333 patent/US11179482B2/en active Active
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2021
- 2021-10-20 US US17/451,536 patent/US11931429B2/en active Active
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2024
- 2024-01-31 US US18/428,591 patent/US12357709B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990007511A1 (en) * | 1988-12-27 | 1990-07-12 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| CN1052478A (zh) * | 1989-12-14 | 1991-06-26 | 书恩州立大学校董会 | 制备乙烯基醚的改进方法 |
| WO2006073424A2 (en) * | 2004-04-14 | 2006-07-13 | Giri Brij P | New ultra-sensitive chemiluminescent substrates for enzymes and their conjugates |
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| US20190290787A1 (en) | 2019-09-26 |
| KR102717614B1 (ko) | 2024-10-16 |
| KR20180108697A (ko) | 2018-10-04 |
| US20240197924A1 (en) | 2024-06-20 |
| US12357709B2 (en) | 2025-07-15 |
| WO2017130191A1 (en) | 2017-08-03 |
| US20200237932A1 (en) | 2020-07-30 |
| US10660974B2 (en) | 2020-05-26 |
| EP3408349B1 (en) | 2021-03-31 |
| CA3011328A1 (en) | 2017-08-03 |
| JP2019509981A (ja) | 2019-04-11 |
| JP6915943B2 (ja) | 2021-08-11 |
| US11931429B2 (en) | 2024-03-19 |
| BR112018015334A2 (pt) | 2018-12-18 |
| ES2866900T3 (es) | 2021-10-20 |
| US20220047725A1 (en) | 2022-02-17 |
| CN108884386A (zh) | 2018-11-23 |
| EP3408349A4 (en) | 2019-10-23 |
| US11179482B2 (en) | 2021-11-23 |
| CA3011328C (en) | 2024-09-17 |
| EP3408349A1 (en) | 2018-12-05 |
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