CN108883108B - 马赛替尼用于治疗肌萎缩侧索硬化症患者亚群的用途 - Google Patents

马赛替尼用于治疗肌萎缩侧索硬化症患者亚群的用途 Download PDF

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Publication number
CN108883108B
CN108883108B CN201780019760.9A CN201780019760A CN108883108B CN 108883108 B CN108883108 B CN 108883108B CN 201780019760 A CN201780019760 A CN 201780019760A CN 108883108 B CN108883108 B CN 108883108B
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masitinib
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pharmaceutically acceptable
acceptable salt
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CN108883108A (zh
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阿兰·穆塞
珍-皮埃尔·基内特
科林·曼斯菲尔德
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AB Science SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780019760.9A 2016-03-25 2017-03-24 马赛替尼用于治疗肌萎缩侧索硬化症患者亚群的用途 Active CN108883108B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16162490.3 2016-03-25
EP16162490 2016-03-25
PCT/EP2017/057134 WO2017162884A1 (en) 2016-03-25 2017-03-24 Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation

Publications (2)

Publication Number Publication Date
CN108883108A CN108883108A (zh) 2018-11-23
CN108883108B true CN108883108B (zh) 2021-08-06

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CN201780019760.9A Active CN108883108B (zh) 2016-03-25 2017-03-24 马赛替尼用于治疗肌萎缩侧索硬化症患者亚群的用途

Country Status (20)

Country Link
US (1) US10092564B2 (enExample)
EP (1) EP3240538B1 (enExample)
JP (2) JP7250312B2 (enExample)
KR (1) KR102293847B1 (enExample)
CN (1) CN108883108B (enExample)
AU (1) AU2017236177B2 (enExample)
BR (1) BR112018069515A2 (enExample)
CA (1) CA3018635C (enExample)
DK (1) DK3240538T3 (enExample)
EA (1) EA038531B1 (enExample)
ES (1) ES2899929T3 (enExample)
HU (1) HUE057398T2 (enExample)
IL (1) IL261856B (enExample)
MX (1) MX390495B (enExample)
NZ (1) NZ745778A (enExample)
PL (1) PL3240538T3 (enExample)
PT (1) PT3240538T (enExample)
SG (1) SG11201808106YA (enExample)
SI (1) SI3240538T1 (enExample)
WO (1) WO2017162884A1 (enExample)

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US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
CN104869993B (zh) 2012-10-25 2019-01-15 通用医疗公司 治疗阿尔茨海默病及相关疾病的组合疗法
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
HK1223541A1 (zh) 2013-10-22 2017-08-04 The General Hospital Corporation 色甘酸衍生物以及成像和治疗的相关方法
JP2019524865A (ja) * 2016-08-31 2019-09-05 ザ ジェネラル ホスピタル コーポレイション 神経変性疾患と関連する神経炎症におけるマクロファージ／ミクログリア
ES2848720T3 (es) 2016-11-25 2021-08-11 Genuv Inc Composición para promover la diferenciación y la protección de células madre neurales y método para inducir la regeneración neural utilizando la misma
BR112019020093A2 (pt) * 2017-03-28 2020-04-28 Novartis Ag métodos para o tratamento de esclerose múltipla
CN111328283A (zh) * 2017-05-30 2020-06-23 德西费拉制药有限责任公司 1-[4-溴-5-[1-乙基-7-(甲氨基)-2-氧代-1，2-二氢-1，6-萘啶-3-基]-2-氟苯基]-3-苯基脲和类似物用于治疗与血小板衍生的生长因子受体α中的遗传异常相关的癌症的用途
KR102874471B1 (ko) 2018-03-05 2025-10-31 매사추세츠 아이 앤드 이어 인퍼머리 콜로니 자극 인자의 표적화에 의한 녹내장 및 시신경병증 치료법
JP2021529771A (ja) 2018-07-02 2021-11-04 ザ ジェネラル ホスピタル コーポレイション クロモリンナトリウムおよびα−ラクトースの粉末製剤
US12383528B2 (en) 2018-12-10 2025-08-12 The General Hospital Corporation Cromolyn esters and uses thereof
CN112618717A (zh) * 2019-09-24 2021-04-09 北京大学深圳研究生院 Btk抑制剂用于治疗肌萎缩侧索硬化症的用途
CN118948773A (zh) * 2019-12-30 2024-11-15 德西费拉制药有限责任公司 1-(4溴-5-(1乙基-7-(甲氨基)-2侧氧基-1,2-二氢-1,6-萘啶-3基)-2氟苯基)-3-苯基脲的组合物
IL297023A (en) 2020-04-06 2022-12-01 Massachusetts Gen Hospital Methods for treating inflammatory conditions caused by the corona virus
WO2025113494A1 (zh) * 2023-11-27 2025-06-05 浙江径科医药有限公司 多环类化合物及其应用

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WO2014145909A2 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
WO2015063318A1 (en) * 2013-11-04 2015-05-07 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis
CN104968347A (zh) * 2012-10-04 2015-10-07 Ab科学有限公司 马赛替尼用于治疗使用预测因素鉴别的患者亚群的癌症的用途

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PT1525200E (pt) 2002-08-02 2008-01-10 Ab Science 2-(3-aminoaril)amino-4-aril-tiazóis para o tratamento de doenças
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WO2011131705A1 (en) 2010-04-20 2011-10-27 Ab Science Treatment of multiple sclerosis with masitinib
EA201791043A1 (ru) 2011-07-13 2017-09-29 Сайтокинетикс, Инк. Комбинированная терапия бокового амиотрофического склероза

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CN104968347A (zh) * 2012-10-04 2015-10-07 Ab科学有限公司 马赛替尼用于治疗使用预测因素鉴别的患者亚群的癌症的用途
WO2014145909A2 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
WO2015063318A1 (en) * 2013-11-04 2015-05-07 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis

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Also Published As

Publication number Publication date
CA3018635A1 (en) 2017-09-28
US20180117037A1 (en) 2018-05-03
PL3240538T3 (pl) 2022-01-31
EA038531B1 (ru) 2021-09-10
WO2017162884A1 (en) 2017-09-28
KR102293847B1 (ko) 2021-08-26
JP2022037132A (ja) 2022-03-08
DK3240538T3 (da) 2021-12-06
EP3240538A1 (en) 2017-11-08
NZ745778A (en) 2022-07-01
AU2017236177A1 (en) 2018-09-20
EA201800499A1 (ru) 2019-03-29
PT3240538T (pt) 2021-12-07
KR20180125966A (ko) 2018-11-26
EP3240538B1 (en) 2021-09-29
HUE057398T2 (hu) 2022-05-28
IL261856B (en) 2022-04-01
MX390495B (es) 2025-03-20
BR112018069515A2 (pt) 2019-04-16
MX2018011349A (es) 2019-02-07
CA3018635C (en) 2023-09-26
US10092564B2 (en) 2018-10-09
CN108883108A (zh) 2018-11-23
AU2017236177B2 (en) 2022-03-31
SI3240538T1 (sl) 2022-02-28
JP7250312B2 (ja) 2023-04-03
ES2899929T3 (es) 2022-03-15
SG11201808106YA (en) 2018-10-30
JP2019515884A (ja) 2019-06-13
IL261856A (en) 2018-10-31

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