PT3240538T - Uso de masitinib para tratamento de uma subpopulação de pacientes com esclerose lateral amiotrófica - Google Patents
Uso de masitinib para tratamento de uma subpopulação de pacientes com esclerose lateral amiotróficaInfo
- Publication number
- PT3240538T PT3240538T PT177121753T PT17712175T PT3240538T PT 3240538 T PT3240538 T PT 3240538T PT 177121753 T PT177121753 T PT 177121753T PT 17712175 T PT17712175 T PT 17712175T PT 3240538 T PT3240538 T PT 3240538T
- Authority
- PT
- Portugal
- Prior art keywords
- masitinib
- treatment
- lateral sclerosis
- amyotrophic lateral
- patient subpopulation
- Prior art date
Links
- 239000002139 L01XE22 - Masitinib Substances 0.000 title 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 title 1
- WJEOLQLKVOPQFV-UHFFFAOYSA-N masitinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3SC=C(N=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 WJEOLQLKVOPQFV-UHFFFAOYSA-N 0.000 title 1
- 229960004655 masitinib Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16162490 | 2016-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3240538T true PT3240538T (pt) | 2021-12-07 |
Family
ID=55637258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177121753T PT3240538T (pt) | 2016-03-25 | 2017-03-24 | Uso de masitinib para tratamento de uma subpopulação de pacientes com esclerose lateral amiotrófica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10092564B2 (enExample) |
| EP (1) | EP3240538B1 (enExample) |
| JP (2) | JP7250312B2 (enExample) |
| KR (1) | KR102293847B1 (enExample) |
| CN (1) | CN108883108B (enExample) |
| AU (1) | AU2017236177B2 (enExample) |
| BR (1) | BR112018069515A2 (enExample) |
| CA (1) | CA3018635C (enExample) |
| DK (1) | DK3240538T3 (enExample) |
| EA (1) | EA038531B1 (enExample) |
| ES (1) | ES2899929T3 (enExample) |
| HU (1) | HUE057398T2 (enExample) |
| IL (1) | IL261856B (enExample) |
| MX (1) | MX390495B (enExample) |
| NZ (1) | NZ745778A (enExample) |
| PL (1) | PL3240538T3 (enExample) |
| PT (1) | PT3240538T (enExample) |
| SG (1) | SG11201808106YA (enExample) |
| SI (1) | SI3240538T1 (enExample) |
| WO (1) | WO2017162884A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| JP6499077B2 (ja) | 2012-10-25 | 2019-04-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| CA2928028A1 (en) | 2013-10-22 | 2015-04-30 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CN116889562A (zh) * | 2016-08-31 | 2023-10-17 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| CN109073634B (zh) | 2016-11-25 | 2022-07-08 | 基诺富公司 | 用于诱导神经干细胞的分化和保护的组合物及使用该组合物诱导神经再生的方法 |
| CN110475555A (zh) * | 2017-03-28 | 2019-11-19 | 诺华股份有限公司 | 治疗多发性硬化的新方法 |
| MX2019014343A (es) * | 2017-05-30 | 2020-08-03 | Deciphera Pharmaceuticals Inc | Uso de 1-[4-bromo-5-[1-etil-7-(metilamino)-2-oxo-1,2-dihidro-1,6-n aftiridin-3-il]-2-fluorofenil]-3-fenilurea y analogos para el tratamiento de canceres asociados con anomalias geneticas en el receptor alfa del factor de crecimiento derivado de plaquetas. |
| EP3762013A4 (en) * | 2018-03-05 | 2022-05-11 | The Schepens Eye Research Institute, Inc. | THERAPY FOR GLAUCOMA AND OPTICAL NEUROPATHY BY TARGETING COLONY-STIMULATING FACTORS |
| EP3817739A4 (en) | 2018-07-02 | 2022-04-13 | The General Hospital Corporation | POWDERED FORMULATIONS OF CROMOLYN SODIUM AND ALPHA-LACTOSE |
| KR20210113610A (ko) | 2018-12-10 | 2021-09-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 에스테르 및 이의 용도 |
| CN112618717A (zh) * | 2019-09-24 | 2021-04-09 | 北京大学深圳研究生院 | Btk抑制剂用于治疗肌萎缩侧索硬化症的用途 |
| SMT202400484T1 (it) * | 2019-12-30 | 2025-01-14 | Deciphera Pharmaceuticals Llc | Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| WO2025113494A1 (zh) * | 2023-11-27 | 2025-06-05 | 浙江径科医药有限公司 | 多环类化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| MXPA05001277A (es) | 2002-08-02 | 2005-10-06 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit. |
| SI2118099T1 (sl) | 2007-02-13 | 2011-11-30 | Ab Science | Postopek za sintezo 2-aminotiazolnih spojin kot kinaznih inhibitorjev |
| TW201204360A (en) | 2010-04-20 | 2012-02-01 | Ab Science | Treatment of multiple sclerosis with MASITINIB |
| US10272082B2 (en) | 2011-07-13 | 2019-04-30 | Cytokinetics, Inc. | Combination ALS therapy |
| AU2013326463B2 (en) * | 2012-10-04 | 2018-01-18 | Ab Science | Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors |
| JP6553589B2 (ja) * | 2013-03-15 | 2019-07-31 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | ピリミド−ジアゼピノン化合物および障害の治療方法 |
| US20160263110A1 (en) * | 2013-11-04 | 2016-09-15 | Ab Science | Use of masitinib for treatment of amyotrophic lateral sclerosis |
-
2017
- 2017-03-24 NZ NZ745778A patent/NZ745778A/en not_active IP Right Cessation
- 2017-03-24 PL PL17712175T patent/PL3240538T3/pl unknown
- 2017-03-24 WO PCT/EP2017/057134 patent/WO2017162884A1/en not_active Ceased
- 2017-03-24 JP JP2018549902A patent/JP7250312B2/ja active Active
- 2017-03-24 CA CA3018635A patent/CA3018635C/en active Active
- 2017-03-24 US US15/545,800 patent/US10092564B2/en active Active
- 2017-03-24 PT PT177121753T patent/PT3240538T/pt unknown
- 2017-03-24 KR KR1020187026871A patent/KR102293847B1/ko active Active
- 2017-03-24 CN CN201780019760.9A patent/CN108883108B/zh active Active
- 2017-03-24 SI SI201730997T patent/SI3240538T1/sl unknown
- 2017-03-24 ES ES17712175T patent/ES2899929T3/es active Active
- 2017-03-24 HU HUE17712175A patent/HUE057398T2/hu unknown
- 2017-03-24 AU AU2017236177A patent/AU2017236177B2/en active Active
- 2017-03-24 SG SG11201808106YA patent/SG11201808106YA/en unknown
- 2017-03-24 DK DK17712175.3T patent/DK3240538T3/da active
- 2017-03-24 MX MX2018011349A patent/MX390495B/es unknown
- 2017-03-24 EP EP17712175.3A patent/EP3240538B1/en active Active
- 2017-03-24 BR BR112018069515A patent/BR112018069515A2/pt not_active Application Discontinuation
- 2017-03-24 EA EA201800499A patent/EA038531B1/ru unknown
-
2018
- 2018-09-20 IL IL261856A patent/IL261856B/en unknown
-
2021
- 2021-12-16 JP JP2021204244A patent/JP2022037132A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180125966A (ko) | 2018-11-26 |
| ES2899929T3 (es) | 2022-03-15 |
| CN108883108B (zh) | 2021-08-06 |
| DK3240538T3 (da) | 2021-12-06 |
| NZ745778A (en) | 2022-07-01 |
| KR102293847B1 (ko) | 2021-08-26 |
| IL261856A (en) | 2018-10-31 |
| EA201800499A1 (ru) | 2019-03-29 |
| PL3240538T3 (pl) | 2022-01-31 |
| MX2018011349A (es) | 2019-02-07 |
| US10092564B2 (en) | 2018-10-09 |
| US20180117037A1 (en) | 2018-05-03 |
| MX390495B (es) | 2025-03-20 |
| SI3240538T1 (sl) | 2022-02-28 |
| JP2022037132A (ja) | 2022-03-08 |
| AU2017236177B2 (en) | 2022-03-31 |
| IL261856B (en) | 2022-04-01 |
| EP3240538A1 (en) | 2017-11-08 |
| EP3240538B1 (en) | 2021-09-29 |
| CA3018635C (en) | 2023-09-26 |
| BR112018069515A2 (pt) | 2019-04-16 |
| AU2017236177A1 (en) | 2018-09-20 |
| JP7250312B2 (ja) | 2023-04-03 |
| WO2017162884A1 (en) | 2017-09-28 |
| HUE057398T2 (hu) | 2022-05-28 |
| EA038531B1 (ru) | 2021-09-10 |
| CA3018635A1 (en) | 2017-09-28 |
| CN108883108A (zh) | 2018-11-23 |
| JP2019515884A (ja) | 2019-06-13 |
| SG11201808106YA (en) | 2018-10-30 |
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