CA3018635C - Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation - Google Patents

Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation Download PDF

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Publication number
CA3018635C
CA3018635C CA3018635A CA3018635A CA3018635C CA 3018635 C CA3018635 C CA 3018635C CA 3018635 A CA3018635 A CA 3018635A CA 3018635 A CA3018635 A CA 3018635A CA 3018635 C CA3018635 C CA 3018635C
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CA
Canada
Prior art keywords
masitinib
pharmaceutically acceptable
acceptable salt
solvate
als
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3018635A
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English (en)
French (fr)
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CA3018635A1 (en
Inventor
Alain Moussy
Jean-Pierre Kinet
Colin Mansfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AB Science SA
Original Assignee
AB Science SA
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Publication of CA3018635A1 publication Critical patent/CA3018635A1/en
Application granted granted Critical
Publication of CA3018635C publication Critical patent/CA3018635C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3018635A 2016-03-25 2017-03-24 Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation Active CA3018635C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16162490.3 2016-03-25
EP16162490 2016-03-25
PCT/EP2017/057134 WO2017162884A1 (en) 2016-03-25 2017-03-24 Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation

Publications (2)

Publication Number Publication Date
CA3018635A1 CA3018635A1 (en) 2017-09-28
CA3018635C true CA3018635C (en) 2023-09-26

Family

ID=55637258

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3018635A Active CA3018635C (en) 2016-03-25 2017-03-24 Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation

Country Status (20)

Country Link
US (1) US10092564B2 (enExample)
EP (1) EP3240538B1 (enExample)
JP (2) JP7250312B2 (enExample)
KR (1) KR102293847B1 (enExample)
CN (1) CN108883108B (enExample)
AU (1) AU2017236177B2 (enExample)
BR (1) BR112018069515A2 (enExample)
CA (1) CA3018635C (enExample)
DK (1) DK3240538T3 (enExample)
EA (1) EA038531B1 (enExample)
ES (1) ES2899929T3 (enExample)
HU (1) HUE057398T2 (enExample)
IL (1) IL261856B (enExample)
MX (1) MX390495B (enExample)
NZ (1) NZ745778A (enExample)
PL (1) PL3240538T3 (enExample)
PT (1) PT3240538T (enExample)
SG (1) SG11201808106YA (enExample)
SI (1) SI3240538T1 (enExample)
WO (1) WO2017162884A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
JP6499077B2 (ja) 2012-10-25 2019-04-10 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病と関連疾患の治療のための併用療法
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CA2928028A1 (en) 2013-10-22 2015-04-30 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
CN116889562A (zh) * 2016-08-31 2023-10-17 通用医疗公司 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞
CN109073634B (zh) 2016-11-25 2022-07-08 基诺富公司 用于诱导神经干细胞的分化和保护的组合物及使用该组合物诱导神经再生的方法
CN110475555A (zh) * 2017-03-28 2019-11-19 诺华股份有限公司 治疗多发性硬化的新方法
MX2019014343A (es) * 2017-05-30 2020-08-03 Deciphera Pharmaceuticals Inc Uso de 1-[4-bromo-5-[1-etil-7-(metilamino)-2-oxo-1,2-dihidro-1,6-n aftiridin-3-il]-2-fluorofenil]-3-fenilurea y analogos para el tratamiento de canceres asociados con anomalias geneticas en el receptor alfa del factor de crecimiento derivado de plaquetas.
EP3762013A4 (en) * 2018-03-05 2022-05-11 The Schepens Eye Research Institute, Inc. THERAPY FOR GLAUCOMA AND OPTICAL NEUROPATHY BY TARGETING COLONY-STIMULATING FACTORS
EP3817739A4 (en) 2018-07-02 2022-04-13 The General Hospital Corporation POWDERED FORMULATIONS OF CROMOLYN SODIUM AND ALPHA-LACTOSE
KR20210113610A (ko) 2018-12-10 2021-09-16 더 제너럴 하스피탈 코포레이션 크로몰린 에스테르 및 이의 용도
CN112618717A (zh) * 2019-09-24 2021-04-09 北京大学深圳研究生院 Btk抑制剂用于治疗肌萎缩侧索硬化症的用途
SMT202400484T1 (it) * 2019-12-30 2025-01-14 Deciphera Pharmaceuticals Llc Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea
US12458622B2 (en) 2020-04-06 2025-11-04 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
WO2025113494A1 (zh) * 2023-11-27 2025-06-05 浙江径科医药有限公司 多环类化合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (enExample) 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
SI2118099T1 (sl) 2007-02-13 2011-11-30 Ab Science Postopek za sintezo 2-aminotiazolnih spojin kot kinaznih inhibitorjev
TW201204360A (en) 2010-04-20 2012-02-01 Ab Science Treatment of multiple sclerosis with MASITINIB
US10272082B2 (en) 2011-07-13 2019-04-30 Cytokinetics, Inc. Combination ALS therapy
AU2013326463B2 (en) * 2012-10-04 2018-01-18 Ab Science Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors
JP6553589B2 (ja) * 2013-03-15 2019-07-31 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド ピリミド−ジアゼピノン化合物および障害の治療方法
US20160263110A1 (en) * 2013-11-04 2016-09-15 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis

Also Published As

Publication number Publication date
KR20180125966A (ko) 2018-11-26
ES2899929T3 (es) 2022-03-15
CN108883108B (zh) 2021-08-06
DK3240538T3 (da) 2021-12-06
NZ745778A (en) 2022-07-01
KR102293847B1 (ko) 2021-08-26
IL261856A (en) 2018-10-31
EA201800499A1 (ru) 2019-03-29
PL3240538T3 (pl) 2022-01-31
MX2018011349A (es) 2019-02-07
US10092564B2 (en) 2018-10-09
US20180117037A1 (en) 2018-05-03
MX390495B (es) 2025-03-20
SI3240538T1 (sl) 2022-02-28
JP2022037132A (ja) 2022-03-08
AU2017236177B2 (en) 2022-03-31
IL261856B (en) 2022-04-01
EP3240538A1 (en) 2017-11-08
EP3240538B1 (en) 2021-09-29
PT3240538T (pt) 2021-12-07
BR112018069515A2 (pt) 2019-04-16
AU2017236177A1 (en) 2018-09-20
JP7250312B2 (ja) 2023-04-03
WO2017162884A1 (en) 2017-09-28
HUE057398T2 (hu) 2022-05-28
EA038531B1 (ru) 2021-09-10
CA3018635A1 (en) 2017-09-28
CN108883108A (zh) 2018-11-23
JP2019515884A (ja) 2019-06-13
SG11201808106YA (en) 2018-10-30

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LI Newsletter May 2018

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