CN108813572A - A kind of black pine composition - Google Patents

A kind of black pine composition Download PDF

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Publication number
CN108813572A
CN108813572A CN201810985912.7A CN201810985912A CN108813572A CN 108813572 A CN108813572 A CN 108813572A CN 201810985912 A CN201810985912 A CN 201810985912A CN 108813572 A CN108813572 A CN 108813572A
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CN
China
Prior art keywords
parts
black pine
preparation
matsutake
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810985912.7A
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Chinese (zh)
Inventor
王冰月
樊婷婷
王�琦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGZHOU JIAYUAN PHARMACEUTICAL TECHNOLOGY Co Ltd
Original Assignee
GUANGZHOU JIAYUAN PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by GUANGZHOU JIAYUAN PHARMACEUTICAL TECHNOLOGY Co Ltd filed Critical GUANGZHOU JIAYUAN PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority to CN201810985912.7A priority Critical patent/CN108813572A/en
Publication of CN108813572A publication Critical patent/CN108813572A/en
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00Edible extracts or preparations of fungi; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of with the black pine composition for promoting tissue repair, the technical solution adopted is that:It is matched by following raw material:1-20 parts of black pine, 1-20 parts of matsutake and 10-30 parts of Cordyceps militaris compositions, which, which has, promotes tissue repair effect.

Description

A kind of black pine composition
Technical field
The invention belongs to field of food, relate in particular to a kind of with the black pine composition for promoting tissue repair.
Background technique
Agglutination after tissue trauma is counted as various repairing cell proliferations, differentiation, migration, apoptosis and the mistake of disappearance Journey is that series of different cell, structural proteins, growth factor and protein kinase etc. form network type reciprocation.Tissue Reparation is the repair process after the various damages of body, is also that by external force wound and portion are occurred for the entirety of organism or organ Point lose, grown again on the basis of remainder and lost part form and functionally identical structure process.Tissue With the proliferation of a variety of repair cells, differentiation and inflammatory mediator, the release of cell factor, Collagen Proliferation in repair process.It is impaired Tissue types it is different, repair cell type is not also identical.
China Patent Publication No. CN105726971A discloses a kind of " Chinese traditional medicine composition that can promote articular cartilage tissue reparation Object and application ", the Chinese medicine composition is by dried human placenta, the bletilla striata, ground beetle, centipede, leech, catechu, blood are brown, Radix Salviae Miltiorrhizae, the rhizome of davallia, cream Perfume, myrrh, elephant hide, Yun Ling, radix achyranthis bidentatae and elder composition;China Patent Publication No. CN104984392A discloses a kind of " muscle groups Knit repair materials and preparation method thereof ", the musculature repair materials are by actin, myosin, aminoglucan, transparent Matter acid, chitosan, Fibronectin, keratin, valine, proline and glycine composition.In terms of current report and invention It substantially is the composition of raw material with Chinese medicine composition and bioprotein etc., and using food materials as raw material, it is suitable for crowd and takes for a long time Food has no.
The present invention uses mushroom food materials black pine, matsutake and Cordyceps militaris for raw material, is prepared into the convenient food mouth easily taken Formulation is suitble to various people conveniently to take for a long time.
Summary of the invention
It is an object of the present invention to provide a kind of black pine compositions for promoting tissue repair, rationally match using mushroom food materials as raw material Than the purpose for promoting tissue repair is played in long-term consumption.
To achieve the above object, the technical solution adopted by the present invention is that:A kind of black pine composition promoting tissue repair, It is characterized in that be made from the following raw materials in parts by weight:1-20 parts of black pine, 1-20 parts of matsutake, 10-30 parts of Cordyceps militaris.
It is preferred that there are the black pine composition material parts by weight for promoting tissue repair to be:10 parts of black pine, 10 parts of matsutake, 20 parts of Cordyceps militaris.
The above-mentioned appropriate combination and compatibility of food materials raw material plays the role of promoting tissue repair, is suitable for various people and takes.This hair The bright preparation method for promoting tissue repair composition, it is characterised in that:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3-5 times to measure water heating and decoct 1 Hour, the filtered dregs of a decoction add 2-3 times to measure water heating decoction, and filtering merges filtrate twice, stands 1 hour, pour out supernatant; Relative density 1.05-1.10 clear cream when supernatant is concentrated into 60 DEG C, 60 DEG C of vacuum drying, obtains dry solid content;
3) the drying solid content for crushing above-mentioned 2) preparation, obtains fine powder after sieving, be present composition active constituent.
Specific implementation and experimental example
The present invention is further elaborated with experimental example with reference to embodiments, and described embodiment and experimental example are only this Invention a part of the embodiment and experimental example, and it is not limited to following embodiment and experimental example.
The preparation of 1 present composition of embodiment
(1) raw material medicines in portions by weight matches:
1 part of black pine, 1 part of matsutake, 10 parts of Cordyceps militaris
(2) preparation method is as follows:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3 times of amount water heating to decoct 1 small When, the filtered dregs of a decoction add 2 times of amount water heating to decoct, and filtering merges filtrate twice, stand 1 hour, pour out supernatant;Supernatant 1.05 clear cream of relative density when liquid is concentrated into 60 DEG C, 60 DEG C of vacuum drying, obtains dry solid content;
3) the drying solid content for crushing above-mentioned 2) preparation, obtains fine powder after sieving, be present composition active constituent.
The tablet of 2 present composition of embodiment preparation
(1) raw material medicines in portions by weight matches:
20 parts of black pine, 20 parts of matsutake, 30 parts of Cordyceps militaris
(2) preparation method is as follows:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3 times of amount water heating to decoct 1 small When, the filtered dregs of a decoction add 2 times of amount water heating to decoct, and filtering merges filtrate twice, stand 1 hour, pour out supernatant;Supernatant 1.10 clear cream of relative density when liquid is concentrated into 60 DEG C, 60 DEG C of vacuum drying, obtains dry solid content;
3) the drying solid content for crushing above-mentioned 2) preparation, obtains fine powder, obtains present composition active constituent after sieving;
4) the composition active constituent of above-mentioned 3) preparation, is added conventional tablet auxiliary material, and tabletting sterilizes, packing.
The oral solution of 3 present composition of embodiment preparation
(1) raw material medicines in portions by weight matches:
10 parts of black pine, 10 parts of matsutake, 20 parts of Cordyceps militaris
(2) preparation method is as follows:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3 times of amount water heating to decoct 1 small When, the filtered dregs of a decoction add 2 times of amount water heating to decoct, and filtering merges filtrate twice, stand 1 hour, pour out supernatant;Supernatant 1.10 clear cream of relative density, spare when liquid is concentrated into 60 DEG C;
3) clear cream of above-mentioned 2) preparation, is added Conventional thickeners, flavoring agent, pure water, and sterilizing is filling.
The exterior-applied emulsion of 4 present composition of embodiment preparation
(1) raw material medicines in portions by weight matches:
15 parts of black pine, 15 parts of matsutake, 20 parts of Cordyceps militaris
(2) preparation method is as follows:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3 times of amount water heating to decoct 1 small When, the filtered dregs of a decoction add 2 times of amount water heating to decoct, and filtering merges filtrate twice, stand 1 hour, pour out supernatant;Supernatant 1.10 clear cream of relative density when liquid is concentrated into 60 DEG C, 60 DEG C of vacuum drying, obtains dry solid content;
3) the drying solid content for crushing above-mentioned 2) preparation, obtains fine powder, obtains present composition active constituent after sieving;
4) the composition active constituent of above-mentioned 3) preparation, is added to conventional creams auxiliary material, reconciles, and homogeneous sterilizes, packing.
1 present invention of experimental example is to experimental animal scald repair function evaluation
Experimental material and method
Experimental animal:Male SD rat 30;It 180-220 grams of the scale of construction, is raised under SPF grades of environment.
Experiment reagent:Betagen Solution, exterior-applied emulsion prepared by above-described embodiment 4.
Animal packet:30 burned rats a few days ago claim the scale of construction, and it is molten to be randomly divided into simple burn group, povidone iodine by the scale of construction Liquid external application group and external application observation group of the present invention, every group 10.
Animal Model:Animal scalds the depilation of preceding 1 day back, using carbrital intraperitoneal injection of anesthesia when experiment, Hair removal section is placed in 70 degree of waters bath with thermostatic control 15 seconds, the shallow II degree scalding model of 10% body surface area is made through pathological section determination. The each group surface of a wound uses physiological saline gauze, povidone iodine gauze, external application gauze of the present invention covering respectively, after sterile gauze wrapping is fixed Put back to sub-cage rearing in cage, 1 times/day of dressing.
Wound healing time:Observation wound healing situation daily, using the covering of complete epithelium as wound healing time according to According to.
Wound healing rate:Rat is first described surface of a wound area in 7,10,14 days observation wound healing situations of burnt degree On transparent membrane, then as template, homogeneous hard paper is cut into onesize, then claims matter with assay balance Amount.Surface of a wound size is indirectly indicative with cardboard tablet quality.
Wound healing rate is calculated by formula:Wound healing rate (%)=(original surface of a wound area one do not heal surface of a wound area)/ Original surface of a wound area
Experimental result
1. groups of animals healing time comparison result, is shown in Table 1.
The visible povidone iodine group of result, present invention group have significant difference P < 0.05 compared with simple scald group in table.
1 each group burned rats healing time of table compares
Δ represents compared with simple scald group with significant difference P < 0.05
2. groups of animals Wound healing rate is as a result, be shown in Table 2.
Result is visible 7,10,14 day three time point in table, and povidone iodine group, present invention group are compared with simple scald group There is significant difference P < 0.05.
2 each group Rat Wound Healing rate of table compares
Δ represents compared with simple scald group with significant difference P < 0.05.

Claims (7)

1. a kind of black pine composition for promoting tissue repair, it is characterised in that be to be made from the following raw materials in parts by weight:Black pine Reveal 1-20 parts, 1-20 parts of matsutake, 10-30 parts of Cordyceps militaris.
2. the black pine composition according to claim 1 for promoting tissue repair, wherein the dosage of each bulk pharmaceutical chemicals is:Black pine Reveal 10 parts, 10 parts of matsutake, 20 parts of Cordyceps militaris.
3. the black pine preparation method of composition according to claim 1 or 2 for promoting tissue repair, includes the following steps:
1) each raw material black pine, matsutake and Cordyceps militaris are quantitatively weighed, it is spare;
2) black pine, matsutake and Cordyceps militaris by weight ratio mix after crushing respectively, add 3-5 times measure water heating decoct it is 1 small When, the filtered dregs of a decoction add 2-3 times to measure water heating decoction, and filtering merges filtrate twice, stands 1 hour, pour out supernatant;On Relative density 1.05-1.10 clear cream when clear liquid is concentrated into 60 DEG C, 60 DEG C of vacuum drying, obtains dry solid content;
3) the drying solid content for crushing above-mentioned 2) preparation, obtains fine powder after sieving, be present composition active constituent.
4. preparation method according to claim 3 mixes the active component that step 3) obtains with common auxiliary material, it is prepared into solid Internal formulation.
5. preparation method according to claim 3, by step 3) active component and common auxiliary material, flavoring agent, pure Water mixing, is prepared into liquid and uses preparation.
6. preparation method according to claim 3, the active component and external application conventional substrate that step 3) is obtained, auxiliary material are mixed It closes, is prepared into external preparation.
7. composition of any of claims 1 or 2, which has, promotes tissue repair effect.
CN201810985912.7A 2018-08-20 2018-08-20 A kind of black pine composition Withdrawn CN108813572A (en)

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Application Number Priority Date Filing Date Title
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101766658A (en) * 2010-03-22 2010-07-07 江门市鸿豪生物科技有限公司 Method for preparing traditional Chinese medicinal liquor
CN104172408A (en) * 2014-07-29 2014-12-03 北京上尚品生物科技有限公司 Truffle health oral solution and production process of truffle health oral solution
CN106879727A (en) * 2017-04-09 2017-06-23 湖南易科生物工程有限公司 A kind of compound method of leaf vegetables antistaling agent
CN107997125A (en) * 2017-12-14 2018-05-08 于葵 Edible mushroom mycelium and or edible mushroom mycelium powder manufacture craft and products thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101766658A (en) * 2010-03-22 2010-07-07 江门市鸿豪生物科技有限公司 Method for preparing traditional Chinese medicinal liquor
CN104172408A (en) * 2014-07-29 2014-12-03 北京上尚品生物科技有限公司 Truffle health oral solution and production process of truffle health oral solution
CN106879727A (en) * 2017-04-09 2017-06-23 湖南易科生物工程有限公司 A kind of compound method of leaf vegetables antistaling agent
CN107997125A (en) * 2017-12-14 2018-05-08 于葵 Edible mushroom mycelium and or edible mushroom mycelium powder manufacture craft and products thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
刘阳等: "优化蛹虫草浸提条件对金黄色葡萄球菌的控制效果 ", 《食品工业科技》 *
吴漾等: "利用响应面法优化蛹虫草、松茸混菌共酵废料培养基 ", 《食品研究与开发》 *
呼鑫荣等: "松露的组成成分及功能活性研究进展", 《食品工业科技》 *
戴肖东等: "姬松茸抑菌作用的初步研究 ", 《中国食用菌》 *
韩燕峰等: "蛹虫草菌株发酵液和菌丝提取物的抑菌活性初探 ", 《湖北农业科学》 *
高燕燕等: "蛹虫草抗菌活性物质的初步研究 ", 《广东农业科学》 *

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Application publication date: 20181116